Liquid phase synthesis equipment and complex small molecule drug synthesis system

Abstract

The utility model relates to the technical field of biopharmacy, in particular to liquid phase synthesis equipment and a complex small molecule drug synthesis system, which comprise a bottom plate, a magnetic sleeve fixedly connected to the upper surface of the bottom plate, a magnetic rod inserted in the magnetic sleeve, a connecting frame arranged on one side of the magnetic rod, and a support plate arranged on the upper side of the connecting frame, a liquid box is fixedly mounted on the upper surface of the supporting plate, a flow pump is arranged on the lower side of the liquid box, a reactor is arranged on the lower side of the flow pump, an electromagnetic valve is fixedly mounted on the upper side of the reactor, and a temperature sensor is arranged on one side of the electromagnetic valve; the device has the beneficial effects that the whole device is disassembled, equipment can be conveniently transferred, operation is convenient and fast, meanwhile, through cooperation of a flow pump, an electromagnetic valve, a temperature sensor, an electric heating block, a motor, a stirring rod and other components, temperature control, stirring control, flow control and the like do not need manual operation, and the problem of poor reproducibility caused by manual disturbance and experience factor influence is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of biopharmaceuticals, and specifically relates to a liquid-phase synthesis device and a complex small molecule drug synthesis system. Background Art

[0002] The liquid-phase synthesis device is mainly used for the liquid-phase reaction process in chemical synthesis, including various technologies such as liquid chromatography and liquid-phase synthesis.

[0003] In the prior art, the existing liquid-phase synthesis device is not easy to disassemble, so it is more troublesome during the transportation process. At the same time, the control of temperature, the control of the stirring box flow rate, etc. all need to be manually operated, which is affected by human disturbance and experience factors, resulting in a poor liquid-phase synthesis effect. Therefore, the utility model proposes a liquid-phase synthesis device and a complex small molecule drug synthesis system to solve the above problems. Content of the Utility Model

[0004] The purpose of the utility model is to provide a liquid-phase synthesis device to solve the problems put forward in the above background art.

[0005] To achieve the above purpose, the utility model provides the following technical solutions: A liquid-phase synthesis device and a complex small molecule drug synthesis system, including: a bottom plate, a magnetic suction sleeve is fixedly connected to the upper surface of the bottom plate, a magnetic suction rod is inserted into the magnetic suction sleeve, a connecting frame is arranged on one side of the magnetic suction rod, and a support plate is arranged on the upper side of the connecting frame.

[0006] A liquid agent box is fixedly installed on the upper surface of the support plate, a flow pump is arranged below the liquid agent box, a reactor is arranged below the flow pump, an electromagnetic valve is fixedly installed on the upper side of the reactor, and a temperature sensor is arranged on one side of the electromagnetic valve.

[0007] Preferably, there are two bottom plates, which are symmetrically arranged about the central plane of the support plate. The magnetic suction rod and the magnetic suction sleeve are magnetically connected, and the top of the magnetic suction rod is fixedly connected to the lower surface of the support plate.

[0008] Preferably, an electric heating block is fixedly sleeved at the bottom of the connecting frame. The connecting frame and the bottom plate are fixedly connected by a connecting rod. A bolt is sleeved inside the two connecting frames, and one end of the bolt is threadedly connected with a nut.

[0009] Preferably, a protective sleeve is fixedly sleeved on the outer circumferential surface of the reactor, and the outer circumferential surface of the protective sleeve abuts against the inner wall of the connecting frame.

[0010] Preferably, there are three liquid agent boxes, which are arranged in a circumferential array. A motor is arranged on one side of the liquid agent box, and the motor is fixedly installed on the upper surface of the support plate.

[0011] Preferably, the flow pump is fixedly installed on the lower surface of the support plate, and the flow pump is communicated with the liquid agent box through a connecting pipe. A limiting sleeve is arranged on one side of the flow pump, the upper end of the limiting sleeve is fixedly connected with the support plate, and a stirring rod is rotatably sleeved in the limiting sleeve. One end of the stirring rod penetrates through the support plate and is fixedly connected with the output end of the motor.

[0012] Preferably, the temperature sensor is fixedly installed on one side of the reactor. A small electric cylinder is arranged on one side of the solenoid valve. The output end of the small electric cylinder is fixedly connected with a cover plate. The cover plate is slidably connected with the upper surface of the reactor. The small electric cylinder is fixedly connected with the upper surface of the reactor. A sterilization sleeve is arranged on one side of the cover plate, and the sterilization sleeve is fixedly sleeved on the stirring rod.

[0013] A complex small molecule drug synthesis system includes the above-mentioned liquid phase synthesis equipment.

[0014] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0015] Place the reactor between the connecting frames, so that the protective sleeve is sleeved in the connecting frames. The protective sleeve can prevent the reactor from being squeezed, thus affecting its normal use. At this time, through the cooperation of the bolts and nuts, a group of connecting frames are fixedly connected, so as to fix and limit the reactor through the connecting frames, and prevent it from shaking during the stirring process. Then, when the stirring rod is inserted into the reactor, the magnetic attraction rod slides and is inserted into the magnetic attraction sleeve. The magnetic attraction sleeve not only limits the magnetic attraction rod, but also makes the support plate more stable through the magnetic attraction fixation between the magnetic attraction rod and the magnetic attraction sleeve, thus completing the installation of the entire device, and then facilitating the disassembly of the entire device and the transportation of the equipment, with convenient operation.

[0016] Through the cooperation of components such as the flow pump, solenoid valve, temperature sensor, electric heating block, motor, and stirring rod, the control of temperature, stirring, and flow control do not require manual operation, avoiding problems such as poor reproducibility caused by human disturbance and experience factors. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a schematic diagram of the overall structure of the present utility model;

[0018] Figure 2 is a schematic top view of the overall structure of the present utility model;

[0019] Figure 3 is a schematic bottom view of the overall structure of the present utility model;

[0020] Figure 4 is a schematic diagram of the internal structure of the present utility model.

[0021] In the figure: 1, bottom plate; 2, magnetic suction sleeve; 3, magnetic suction rod; 4, connecting frame; 5, support plate; 6, liquid agent box; 7, flow pump; 8, reactor; 9, solenoid valve; 10, temperature sensor; 11, electric heating block; 12, connecting rod; 13, bolt; 14, nut; 15, protective sleeve; 16, motor; 17, limit sleeve; 18, stirring rod; 19, small electric cylinder; 20, cover plate; 21, sterilization sleeve. Specific implementation mode

[0022] In order to clearly and completely describe the purpose and technical solution of the present utility model, and make the advantages more clear, the following further details the embodiments of the present utility model with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are part of the embodiments of the present utility model, rather than all of the embodiments, and are only used to explain the embodiments of the present utility model, not to limit the embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present utility model.

[0023] In the description of the present utility model, it should be noted that the terms "center", "middle", "upper", "lower", "left", "right", "inner", "outer", "top", "bottom", "side", "vertical", "horizontal", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus cannot be understood as a limitation of the present utility model. In addition, the terms "one", "first", "second", "third", "fourth", "fifth", "sixth" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0024] In the description of the present utility model, it should be noted that unless otherwise clearly defined and limited, the terms "installation", "connection", "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.

[0025] For the purposes of simplicity and illustration, the principles of the embodiments are mainly described by reference to examples. In the following description, many specific details are set forth to provide a thorough understanding of the embodiments. However, it is obvious that, for those of ordinary skill in the art, these embodiments may not be limited to these specific details in practice. In some instances, well-known methods and structures are not described in detail to avoid unnecessarily obscuring these embodiments. Additionally, all embodiments may be used in combination with each other.

[0026] Please refer to Figures 1 to 4 , the present utility model provides a technical solution: a liquid-phase synthesis device and a complex small molecule drug synthesis system, comprising: a bottom plate 1, a magnetic attraction sleeve 2 is fixedly connected to the upper surface of the bottom plate 1, a magnetic attraction rod 3 is inserted into the magnetic attraction sleeve 2, a connecting frame 4 is arranged on one side of the magnetic attraction rod 3, a support plate 5 is arranged on the upper side of the connecting frame 4, the bottom plate 1 stably supports the whole device, the magnetic attraction sleeves 2 fixedly installed on both sides of the upper surface of the bottom plate 1 facilitate the sliding insertion of the magnetic attraction rod 3, the connecting frame 4 limits the reactor 8, there are two bottom plates 1 which are symmetrically arranged with respect to the central plane of the support plate 5, the magnetic attraction rod 3 and the magnetic attraction sleeve 2 are magnetically connected, the top of the magnetic attraction rod 3 is fixedly connected to the lower surface of the support plate 5, and there is a set of two bottom plates 1, so as to facilitate the installation and disassembly of the whole device from both sides. The magnetic attraction rod 3 slides into the magnetic attraction sleeve 2, so that the magnetic attraction sleeve 2 limits and fixes the magnetic attraction rod 3, and the magnetic attraction rod 3 fixedly supports the support plate 5 fixedly connected to its top. An electric heating block 11 is fixedly sleeved at the bottom of the connecting frame 4, and the connecting frame 4 and the bottom plate 1 are fixedly connected by a connecting rod 12. A bolt 13 is sleeved inside the two connecting frames 4, and a nut 14 is threadedly connected to one end of the bolt 13. The electric heating block 11 fixedly installed at the bottom of the connecting frame 4 facilitates the auxiliary heating of the reactor 8, which is beneficial to accelerating the reaction of the reactants. A protective sleeve 15 is fixedly sleeved on the outer circumferential surface of the reactor 8, the outer circumferential surface of the protective sleeve 15 abuts against the inner wall of the connecting frame 4, and the connecting frame 4 covers the outer circumferential surface of the protective sleeve 15, so as to fix the protective sleeve 15 and further fix and limit the reactor 8.

[0027] Place the bottom plates 1 symmetrically so that one side of a set of connecting frames 4 abuts, place the reactor 8 between the connecting frames 4, and make the protective sleeve 15 fit into the connecting frames 4. The protective sleeve 15 can prevent the reactor 8 from being squeezed, thus affecting its normal use. At this time, through the cooperation of the bolt 13 and the nut 14, a set of connecting frames 4 are fixedly connected, so as to fix and limit the reactor 8 through the connecting frames 4 and prevent it from shaking during stirring. Then, while inserting the stirring rod 18 into the reactor 8, the magnetic attraction rod 3 slides into the magnetic attraction sleeve 2. The magnetic attraction sleeve 2 not only limits the magnetic attraction rod 3, but also makes the support plate 5 more stable through the magnetic fixation between the magnetic attraction rod 3 and the magnetic attraction sleeve 2, thus completing the installation of the whole device, facilitating the disassembly of the whole device, and facilitating the transportation of the equipment, with convenient operation.

[0028] A liquid agent box 6 is fixedly installed on the upper surface of the support plate 5. A flow pump 7 is arranged below the liquid agent box 6. A reactor 8 is arranged below the flow pump 7. An electromagnetic valve 9 is fixedly installed on the upper side of the reactor 8. A temperature sensor 10 is arranged on one side of the electromagnetic valve 9. The liquid agent box 6 is fixedly installed on the support plate 5. The liquid agent box 6 can store different drug reagents. The flow pump 7 measures the amount of the required liquid agent. The electromagnetic valve 9 facilitates controlling the liquid medicine to enter the reactor 8. The flow pump 7 is fixedly installed on the lower surface of the support plate 5 and is communicated with the liquid agent box 6 through a connecting pipe. A limit sleeve 17 is arranged on one side of the flow pump 7. The upper end of the limit sleeve 17 is fixedly connected with the support plate 5. A stirring rod 18 is rotatably sleeved in the limit sleeve 17. One end of the stirring rod 18 penetrates through the support plate 5 and is fixedly connected with the output end of the motor 16. The flow pump 7 is communicated with the liquid agent box 6 through a connecting pipe, so as to facilitate the output of the liquid medicine. The limit sleeve 17 is fixed at the center position of the lower surface of the support plate 5, so as to limit the stirring rod 18 rotatably sleeved therein and make the stirring rod 18 rotate more stably. The temperature sensor 10 is fixedly installed on one side of the reactor 8. A small electric cylinder 19 is arranged on one side of the electromagnetic valve 9. The output end of the small electric cylinder 19 is fixedly connected with a cover plate 20. The cover plate 20 is slidably connected with the upper surface of the reactor 8. The small electric cylinder 19 is fixedly connected with the upper surface of the reactor 8. A sterilization sleeve 21 is arranged on one side of the cover plate 20. The sterilization sleeve 21 is fixedly sleeved on the stirring rod 18. The temperature sensor 10 is fixedly installed on one side of the reactor 8, so as to monitor the internal temperature of the reactor 8 and facilitate regulating the reaction temperature required through the electric heating block 11. The small electric cylinder 19 is fixedly installed on the upper surface of the reactor 8. By the telescopic movement of the output end of the small electric cylinder 19, the cover plate 20 is driven to slide on the upper surface of the reactor 8, so that the cover plate 20 can block or open the through hole formed on the surface of the reactor 8, so as to seal the reactor 8 when it is not in use and prevent impurities from entering. The sterilization sleeve 21 fixedly sleeved at the bottom of the stirring rod 18 can rotate at the circular hole formed on the reactor 8 when the stirring rod 18 rotates, so as to prevent external bacteria from entering the reactor 8 and further interfering with the synthesis.

[0029] The flow pump 7, solenoid valve 9, temperature sensor 10, electric heating block 11, motor 16, and small electric cylinder 19 are all connected to an external terminal control device through telecommunications. The input end of the flow pump 7 is connected to the liquid agent box 6 through a connecting pipe, and the output end of the flow pump 7 is fixedly connected to the input end of the solenoid valve 9 through a hose. The output end of the solenoid valve 9 is fixedly installed on the upper surface of the reactor 8. By starting the flow pump 7, the liquid medicine in the liquid agent box 6 is pumped out. The solenoid valve 9 is opened, and the required liquid medicine is poured into the reactor 8 through the connection of the hose. The flow pump 7 monitors the metering of the liquid medicine. When the preset value is reached, the control device closes the solenoid valve 9 and the flow pump 7, and the liquid medicine no longer enters the reactor 8. At this time, by starting the motor 16, the motor 16 drives the stirring rod 18 to rotate within the limit sleeve 17, so that the stirring rod 18 mixes and stirs the liquid medicine. At the same time, the temperature inside the reactor 8 can be monitored through the temperature sensor 10. When heating is required, heating is carried out through the electric heating block 11 installed at the bottom of the connecting frame 4, which is conducive to the rapid progress of the reaction. During the rotation of the stirring rod 18, the sterilization sleeve 21 fixedly sleeved thereon seals the opening on the upper surface of the reactor 8, thus preventing external bacteria and impurities from entering the reactor 8 and affecting the subsequent synthesis results. The small electric cylinder 19 is fixedly installed on the upper surface of the reactor 8. By extending and retracting the output end of the small electric cylinder 19, it drives the cover plate 20 to slide on the upper surface of the reactor 8, so that the cover plate 20 can block or open the through hole provided on the surface of the reactor 8, and thus the reactor 8 can be sealed when not in use to prevent the entry of impurities.

[0030] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A liquid phase synthesis device, comprising a base plate (1), characterized in that: The upper surface of the bottom plate (1) is fixedly connected with a magnetic suction sleeve (2), a magnetic suction rod (3) is inserted into the magnetic suction sleeve (2), a connecting frame (4) is arranged on one side of the magnetic suction rod (3), and a supporting plate (5) is arranged on the upper side of the connecting frame (4); A liquid agent box (6) is fixedly mounted on the upper surface of the support plate (5), a flow pump (7) is arranged at the lower side of the liquid agent box (6), a reactor (8) is arranged at the lower side of the flow pump (7), a solenoid valve (9) is fixedly mounted at the upper side of the reactor (8), and a temperature sensor (10) is arranged at one side of the solenoid valve (9).

2. A liquid phase synthesis device according to claim 1, characterized in that: The bottom plate (1) is provided with two and is symmetrically arranged about the central plane of the support plate (5); the magnetic attraction rod (3) is magnetically connected to the magnetic attraction sleeve (2); and the top of the magnetic attraction rod (3) is fixedly connected to the lower surface of the support plate (5).

3. A liquid phase synthesis device according to claim 2, characterized in that: The bottom of the connecting frame (4) is fixedly sleeved with an electric heating block (11); the connecting frame (4) and the bottom plate (1) are fixedly connected via a connecting rod (12); a bolt (13) is sleeved between the two connecting frames (4); one end of the bolt (13) is threadedly connected with a nut (14).

4. A liquid phase synthesis device according to claim 3, characterized in that: The outer ring surface of the reactor (8) is fixedly sleeved with a protective sleeve (15), and the outer ring surface of the protective sleeve (15) abuts against the inner wall of the connecting frame (4).

5. A liquid phase synthesis device according to claim 4, characterized in that: The liquid agent boxes (6) are provided in three numbers and arranged in a circular array. A motor (16) is provided on one side of the liquid agent boxes (6), and the motor (16) is fixedly mounted on the upper surface of the support plate (5).

6. A liquid phase synthesis device according to claim 5, characterized in that: The flow pump (7) is fixedly mounted on the lower surface of the support plate (5) and the flow pump (7) is connected to the liquid agent box (6) via a connecting pipe. A limiting sleeve (17) is provided on one side of the flow pump (7). The upper end of the limiting sleeve (17) is fixedly connected to the support plate (5). A stirring rod (18) is rotatably provided inside the limiting sleeve (17). One end of the stirring rod (18) passes through the support plate (5) and is fixedly connected to the output end of the motor (16).

7. A liquid phase synthesis device according to claim 6, characterized in that: The temperature sensor (10) is fixedly installed on one side of the reactor (8); a small electric cylinder (19) is provided on one side of the solenoid valve (9); a cover plate (20) is fixedly connected to the output end of the small electric cylinder (19); the cover plate (20) is slidably connected to the upper surface of the reactor (8); the small electric cylinder (19) is fixedly connected to the upper surface of the reactor (8); a sterilization sleeve (21) is provided on one side of the cover plate (20); and the sterilization sleeve (21) is fixedly sleeved on the stirring rod (18).

8. A complex small molecule drug synthesis system, characterized by: A liquid phase synthesis device comprising any one of claims 1 to 7.

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