Tumor tissue fine cutting sampler
By designing a tumor tissue fine cutting sampler including a sample placement table and a sampling tool, the problem of poor tumor tissue cutting in the prior art is solved, and the rapid and accurate acquisition of tumor cell samples with high consistency is achieved, and the accuracy of tumor detection is improved.
Patent Information
- Application Number
- CN202421679806.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-16
- Publication Date
- 2025-06-20
- Estimated Expiration
- 2034-07-16
AI Technical Summary
The prior art is difficult to perform fine cutting of tumor tissue quickly and accurately, resulting in poor accuracy of subsequent experimental detection and lack of specialized devices for such operations.
A tumor tissue fine cutting sampler is designed, including a sample placement table and sampling tool. The sample placement table has a movable storage plate and a leveling blade, while the sampling tool has a mesh blade and a piston rod. Through the coordinated work of these components, uniform and fine cutting of tumor tissue can be achieved.
Acquire several blocked tumor cell samples of the same size in one operation to ensure the consistency of the test samples, thereby improving the accuracy of tumor detection.
Smart Images
Figure CN223005743U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of auxiliary instruments for tumor tissue fine cutting and extraction experiments, and relates to a tumor tissue fine cutting sampler. Background Art
[0002] For nearly a hundred years, the study of human tumors has been a hot topic in medical research. Tumor-related experimental studies are all based on tumor tissues that were initially removed from the human body. Therefore, the fine segmentation and extraction of tumor tissue is crucial for subsequent laboratory testing. It is mainly used in the separation of primary cells from tumor tissue, the extraction of DNA and RNA, related tumor marker detection, and gene testing. Recently, the rise of organoid culture has put forward higher requirements for the fine segmentation of tumor tissue (tumor tissue is minced into 1-3 mm 3 fragments).
[0003] In the past, most hospitals and laboratories mainly used scissors or surgical blades to divide fresh tumor tissues, which was time-consuming and could not effectively divide the samples evenly and finely. Tumor tissues of different sizes were not convenient for subsequent laboratory testing, which had a certain impact on the experimental analysis results, resulting in poor accuracy of tumor detection. At present, there is a lack of devices on the market for fine division of fresh tumor tissues. Summary of the invention
[0004] The purpose of the utility model is to solve the above problems in the existing technology and propose a tumor tissue fine cutting sampler. The technical problem to be solved by the utility model is how to quickly improve the accuracy of tumor crushing to facilitate subsequent separation and detection.
[0005] The purpose of the utility model can be achieved through the following technical solutions:
[0006] A tumor tissue fine cutting sampler, characterized in that it includes a sample placement table and a sampling tool, the sample placement table includes a seat shell with an open upper end and a cylindrical shape, and a placement plate arranged in the seat shell and movable along the axial direction of the seat shell, a leveling blade is arranged in the seat shell and is located above the placement plate and can move along the radial direction of the seat shell, the side wall of the seat shell has a clearance notch for inserting or removing the leveling blade, the sampling tool includes a knife shell that is cylindrical and can be extended into the seat shell, and a piston rod is arranged in the knife shell and can slide back and forth along the inner wall of the knife shell, a mesh blade is fixedly provided at the lower end of the knife shell, the mesh blade includes a plurality of cutting knife strips arranged in an interlaced manner, and the meshes formed between the cutting knife strips are of the same size.
[0007] The tumor cell sampler can obtain several block tumor cell samples of the same size through one operation. Several block tumor cell samples of the same size can be used for multiple examinations such as pathological histological examination, imaging examination, hematological examination, tumor marker detection and gene detection to ensure the consistency of the test samples, thereby improving the accuracy of tumor detection.
[0008] Specifically, when using, the user first places the sample placement table on the workbench, then takes out the flattening blade on the sample placement table base shell for use, and then places the tumor cell sample on the placement plate of the sample placement table. According to the difference between the thickness of the actual tumor cell sample and the thickness of the required tumor cell sample, the user moves the placement plate up and down until the distance between the placement plate and the clearance gap matches the thickness of the required tumor cell sample. Then, the user reinserts the flattening blade into the base shell. The inserted flattening blade cuts off the upper surface of the tumor cell sample, making the upper surface of the tumor tissue sample flatter. Then, the user moves the flattening blade and the cut tumor tissue sample out of the sample placement table, and then the user inserts the sampling tool into the base shell from top to bottom. (the inner diameter of the cylindrical seat shell is larger than the outer diameter of the cylindrical knife shell) until the lower end of the knife shell abuts against the storage plate; at this time, the mesh blade at the lower end of the knife shell cuts the tumor cell sample on the storage plate into several blocks of the same size, and the cut block tumor cell samples are respectively embedded in the mesh holes of the mesh blade, and then the user moves the sampling tool and the cut block tumor cell sample out of the sample placement table together, and then the user places the sampling tool in the vessel, and then squeezes the piston rod downward, so that the air pressure in the knife shell is used to press the block tumor cell sample embedded in the mesh hole out of the mesh hole and fall off in the vessel for standby use (similar to the working principle of a syringe), so that several block tumor cell samples of the same size can be obtained through one operation.
[0009] In the above-mentioned tumor tissue fine cutting sampler, the inner wall of the base shell opposite to the clearance notch is provided with a positioning groove for the leveling blade to be inserted, and the leveling blade is provided with a handle portion, which extends out of the clearance notch. The leveling blade is inserted into the positioning groove, so that the leveling blade can be kept horizontal as much as possible during cutting to avoid skewing, and the provision of the handle portion can facilitate the insertion or removal of the leveling blade.
[0010] In the above-mentioned tumor tissue fine cutting sampler, the edge of the mesh blade is fixedly connected to the blade housing, and the cutting blade strips are arranged vertically and horizontally in an interlaced manner. The edge of the mesh blade can be bent upward and fixedly connected to the inner wall of the blade housing, so that the mesh blade is more firmly arranged at the lower end of the blade housing, and the cutting blade strips are arranged vertically and horizontally in an interlaced manner, so that the mesh of the mesh blade is in a regular block shape, and the size of the mesh can be better kept consistent.
[0011] In the above-mentioned tumor tissue fine cutting sampler, the bottom of the placement plate has a push plate portion, and the push plate portion extends out of the bottom of the base shell. The position of the placement plate can be conveniently adjusted by simply driving the push plate portion. In addition, since the push plate portion extends out of the bottom of the base shell, the sample placement table can be placed on a dedicated placement rack during placement so that the sample placement table can be kept stably placed.
[0012] In the above-mentioned tumor tissue fine cutting sampler, a cylinder is provided on the push plate part, and the piston rod of the cylinder is connected to the push plate part. The cylinder drives the placement plate to move up and down, so that the distance between the placement plate and the clearance gap can be adjusted more conveniently. At the same time, the cylinder can make the sample placement table be placed stably on the workbench, and the cylinder can lock the position of the placement plate after movement, so that the thickness of the tumor cell sample after cutting is consistent with the thickness of the tumor cell sample actually required.
[0013] In the above-mentioned tumor tissue fine cutting sampler, the top of the piston rod extends out of the top of the blade housing, and the bottom of the piston rod has a rubber plug, and the rubber plug is slidably connected to the inner wall of the blade housing. When in use, only the piston rod needs to be pushed, and the gas pressure in the blade housing can be used to press the block tumor cell sample embedded in the mesh of the mesh blade out of the mesh and fall into the vessel for standby use (similar to the working principle of a syringe).
[0014] In the above-mentioned tumor tissue fine cutting sampling sampler, the seat shell is made of a transparent material, and the side wall of the seat shell has scale lines arranged along the axial direction. By making the seat shell of a transparent material, the tumor tissue sample on the placement plate can be visually seen from the outside, and by setting scale lines on the side wall of the seat shell, the tumor tissue sample can be flattened and cut more finely, so that the thickness of the cut tumor tissue sample is more consistent with the actual thickness of the tumor tissue sample required.
[0015] Compared with the prior art, the advantages of the present tumor tissue fine cutting sampler are: the present tumor tissue fine cutting sampler can obtain several block tumor cell samples of the same size through one operation, and several block tumor cell samples of the same size can be used for multiple examinations such as pathological histological examination, imaging examination, hematological examination, tumor marker detection and gene detection to ensure the consistency of the test samples, thereby improving the accuracy of tumor detection. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] Figure 1 It is a schematic diagram of the structure of the tumor tissue fine cutting sampler.
[0017] Figure 2 It is a schematic diagram of the local structure of the mesh blade of the tumor tissue fine cutting sampler.
[0018] Figure 3It is a structural schematic diagram of the flattening blade of the tumor tissue fine cutting sampler.
[0019] Figure 4 It is a structural schematic diagram of the sample placement table of the tumor tissue fine cutting sampler.
[0020] In the figure, 1. sample placement table; 1a. base shell; 1a1. clearance gap; 1a2. positioning groove; 1b. storage plate; 1b1. push plate; 2. sampling tool; 2a. knife shell; 2b. piston rod; 3. leveling blade; 3a. handle; 4. mesh blade; 4a. cutting blade; 4b. mesh; 5. rubber plug. DETAILED DESCRIPTION
[0021] The following are specific embodiments of the present invention and the accompanying drawings to further describe the technical solution of the present invention, but the present invention is not limited to these embodiments.
[0022] A tumor tissue fine cutting sampler, referring to Figures 1-4 , including a sample placement table 1 and a sampling tool 2, the sample placement table 1 includes a base shell 1a with an open upper end and a cylindrical shape, and a placement plate 1b arranged in the base shell 1a and movable along the axial direction of the base shell 1a, the base shell 1a is provided with a flattening blade 3 located above the placement plate 1b and movable along the radial direction of the base shell 1a, the side wall of the base shell 1a has a clearance notch 1a1 for inserting or removing the flattening blade 3, the sampling tool 2 includes a cylindrical shape and can be inserted into the base shell 1 a and a piston rod 2b arranged in the knife housing 2a and capable of sliding back and forth along the inner wall of the knife housing 2a. Specifically, the top of the piston rod 2b extends out of the top of the knife housing 2a, the bottom of the piston rod 2b has a rubber plug 5, and the rubber plug 5 is slidably connected to the inner wall of the knife housing 2a; a mesh blade 4 is fixedly provided at the lower end of the knife housing 2a, and the mesh blade 4 includes a plurality of cutting blade strips 4a arranged in an interlaced manner, and the mesh holes 4b formed between the cutting blade strips 4a are of the same size.
[0023] Further, refer to Figures 1-4 The inner wall of the seat shell 1a opposite to the clearance gap 1a1 is provided with a positioning groove 1a2 for the leveling blade 3 to be embedded. The leveling blade 3 has a handle portion 3a, and the handle portion 3a extends out of the clearance gap 1a1.
[0024] In this embodiment, the edge of the mesh blade 4 is preferably fixedly connected to the blade housing 2a, and the cutting blade strips 4a are arranged vertically and horizontally in an interlaced manner; preferably, the bottom of the storage plate 1b has a push plate portion 1b1, and the push plate portion 1b1 extends out of the bottom of the seat shell 1a, and a cylinder (not shown in the figure) is arranged on the push plate portion 1b1, and the output shaft of the cylinder is connected to the push plate portion 1b1; preferably, the seat shell 1a is made of a transparent material, and the side wall of the seat shell 1a has scale lines arranged along the axial direction, specifically, the zero point of the scale line is located at the position of the positioning groove 1a2, and the scale value of the scale line is extended downward from the zero point along the axial direction of the seat shell 1a.
[0025] The following describes the working principle of this tumor tissue fine cutting sampler:
[0026] During use, the user first places the sample placement table 1 on the workbench, then takes out the flattening blade 3 on the base shell 1a of the sample placement table 1 for use, and then places the tumor tissue sample on the placement plate 1b of the sample placement table 1. According to the difference between the thickness of the actual tumor tissue sample and the thickness of the required tumor tissue sample, the user turns on the cylinder to drive the placement plate 1b to move up and down until the distance between the placement plate 1b and the clearance gap 1a1 matches the thickness of the required tumor tissue sample. Then, the user reinserts the flattening blade 3 into the base shell 1a. The inserted flattening blade 3 cuts off the upper surface of the tumor tissue sample, making the upper surface of the tumor tissue sample smoother. Then, the user moves the flattening blade 3 and the cut tumor tissue sample out of the sample placement table 1, and then the user inserts the sampling tool 2 into the base shell 1a from top to bottom (the inner diameter of the cylindrical base shell 1a is larger than the outer diameter of the cylindrical knife shell 2a) until the lower end of the knife shell 2a is aligned with the placement plate 1b. At this time, the mesh blade 4 at the lower end of the knife shell 2a cuts the tumor tissue sample on the placement plate 1b into several blocks of the same size, and the cut block tumor tissue samples are respectively embedded in the mesh holes 4b of the mesh blade 4. Then the user moves the sampling tool 2 and the cut block tumor tissue sample out of the sample placement table 1 together, and then the user places the sampling tool 2 in the container, and then squeezes the piston rod 2b downward, so that the air pressure in the knife shell 2a is used to press the block tumor tissue sample embedded in the mesh hole 4b out of the mesh hole 4b and fall off in the container for standby use (similar to the working principle of a syringe), so that several block tumor tissue samples of the same size can be obtained through one operation, and several block tumor tissue samples of the same size can be used for multiple examinations such as pathological histological examination, imaging examination, hematological examination, tumor marker detection and gene detection to ensure the consistency of the test samples, thereby improving the accuracy of tumor detection.
[0027] It should be noted that if both the seat housing 1a and the knife housing 2a are cylindrical, there are some irregular holes at the edge of the mesh blade 4. These irregular holes do not belong to the uniformly sized mesh holes 4b described in this article, and the tumor tissue samples embedded in these holes are not used for multiple examinations such as histopathological examination, imaging examination, hematological examination, tumor marker detection, and gene detection.
[0028] The specific embodiments described herein are merely illustrative of the spirit of the present invention. Those skilled in the art to which the present invention pertains can make various modifications or supplements to the described specific embodiments or use similar means for substitution, but will not deviate from the spirit of the present invention or exceed the scope defined by the appended claims.
Claims
1. A tumor tissue fine cutting sampler, characterized in that: The invention comprises a sample placement table (1) and a sampling tool (2), wherein the sample placement table (1) comprises a cylindrical seat shell (1a) with an open upper end and a placement plate (1b) arranged in the seat shell (1a) and movable along the axial direction of the seat shell (1a), wherein a flattening blade (3) is arranged in the seat shell (1a) and is located above the placement plate (1b) and movable along the radial direction of the seat shell (1a), and the side wall of the seat shell (1a) has a slot for inserting or removing the flattening blade (3). The sampling tool (2) comprises a knife shell (2a) which is cylindrical and can be inserted into the seat shell (1a), and a piston rod (2b) which is arranged in the knife shell (2a) and can slide back and forth along the inner wall of the knife shell (2a). A mesh blade (4) is fixedly provided at the lower end of the knife shell (2a). The mesh blade (4) comprises a plurality of cutting blade strips (4a) which are arranged in an interlaced manner, and the mesh holes (4b) formed between the cutting blade strips (4a) are of the same size.
2. A tumor tissue fine cutting sampler according to claim 1, characterized in that: The inner wall of the seat shell (1a) opposite to the clearance notch (1a1) is provided with a positioning groove (1a2) for the leveling blade (3) to be embedded, and the leveling blade (3) is provided with a handle portion (3a) extending out of the clearance notch (1a1).
3. A tumor tissue fine cutting sampler according to claim 1, characterized in that: The edge of the mesh blade (4) is fixedly connected to the blade housing (2a), and the cutting blade strips (4a) are arranged in a vertical and horizontal staggered manner.
4. A tumor tissue fine cutting sampler according to claim 1, 2 or 3, characterized in that: The bottom of the storage plate (1b) has a push plate portion (1b1), and the push plate portion (1b1) extends out of the bottom of the seat shell (1a).
5. A tumor tissue fine cutting sampler according to claim 4, characterized in that: The push plate part (1b1) is provided with a cylinder, and an output shaft of the cylinder is connected to the push plate part (1b1).
6. A tumor tissue fine cutting sampler according to claim 4, characterized in that: The top of the piston rod (2b) extends out of the top of the knife housing (2a), and the bottom of the piston rod (2b) is provided with a rubber plug (5), and the rubber plug (5) is slidably connected to the inner wall of the knife housing (2a).
7. A tumor tissue fine cutting sampler according to claim 4, characterized in that: The seat shell (1a) is made of a transparent material, and the side wall of the seat shell (1a) has scale lines arranged along the axial direction.