Microsphere washing and purifying system

Abstract

The utility model relates to the technical field of pharmacy, and discloses a microsphere washing and purifying system which comprises a tank body and a washing and filtering device, the tank body is used for containing microsphere solution, and a material returning opening and a material discharging opening are formed in the tank body. The washing and filtering device comprises a barrel and a filter screen, the filter screen is arranged in the barrel in a penetrating manner, an included angle is formed between the axial direction of the barrel and the horizontal plane, the two axial ends of the barrel are communicated, the first end of the barrel is communicated with the material returning opening, the second end of the barrel is communicated with the discharging opening, and a discharging opening is further formed in the side wall of the barrel. A microsphere solution in the tank body can flow into the washing and filtering device through the discharging port, the microsphere solution is filtered through the filter screen in the washing and filtering device, namely, after the microsphere solution enters the filter screen through the second end, substances such as small balls and dichloromethane which do not meet requirements in the microsphere solution are discharged out of the filter screen through holes in the filter screen and are discharged out of the cylinder through the discharging port, and then the microsphere solution is discharged out of the cylinder through the discharging port. And the residual microsphere solution flows out of the washing and filtering device through the first end and then returns to the tank body through the material return port, so that repeated washing and purification can be realized by the circulation, and the purification quality is ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical manufacturing, and particularly relates to a microsphere washing and purification system. Background Art

[0002] In the pharmaceutical industry, the washing and purification of microspheres generally uses a vacuum fiber column or a screening machine for washing and purification. Although the traditional vacuum fiber column can effectively separate and purify, it is extremely easy to be blocked and cannot be reused. The screening machine can be reused and has much less blockage effect, but the disadvantage is that the processing capacity is limited and it is not suitable for large-scale washing and purification of microspheres.

[0003] Therefore, there is an urgent need for a microsphere washing and purification system to solve the above problems. Summary of the Utility Model

[0004] The purpose of the utility model is to provide a microsphere washing and purification system with a large processing capacity, not easy to be blocked, capable of being reused, and high purification efficiency and output.

[0005] With the above concept, the technical solution adopted by the utility model is as follows:

[0006] Provide a microsphere washing and purification system, including:

[0007] A tank body for accommodating a microsphere solution, and a return port and a discharge port are arranged on the tank body;

[0008] A washing and filtering device, including a cylinder body and a filter screen, the filter screen is penetrated in the cylinder body, the axis of the cylinder body is arranged at an angle with the horizontal plane, both ends of the axis of the cylinder body are through, the first end of the cylinder body is communicated with the return port, the second end of the cylinder body is communicated with the discharge port, and a discharge port is also arranged on the side wall of the cylinder body.

[0009] Optionally, a plurality of the washing and filtering devices are provided, and the plurality of washing and filtering devices are arranged in parallel. The first end of each washing and filtering device is communicated with the return port, and the second end of each washing and filtering device is communicated with the discharge port.

[0010] Optionally, at least two discharge ports are arranged, and the at least two discharge ports are arranged at intervals along the axis of the cylinder body.

[0011] Optionally, the microsphere washing and purification system further includes a return pipe and a first discharge pipe. One end of the return pipe is communicated with the return port, the other end of the return pipe is communicated with the first end, one end of the first discharge pipe is communicated with the discharge port, and the other end of the first discharge pipe is communicated with the second end.

[0012] Optionally, the return pipe has a first diameter-changing section, and the cross-sectional area of the first diameter-changing section gradually increases along the flow direction of the fluid in the return pipe.

[0013] Optionally, the first discharge pipe has a second diameter-changing section, and the cross-sectional area of the second diameter-changing section gradually decreases along the flow direction of the fluid in the first discharge pipe.

[0014] Optionally, the washing and filtering device further includes a sealing chuck. The sealing chuck is provided at both the first end and the second end. The first end is in sealed communication with the return pipe through the sealing chuck, and the second end is in sealed communication with the first discharge pipe through the sealing chuck. The part of the sealing chuck extending into the cylinder body abuts against the filter screen.

[0015] Optionally, a low-shear pump is provided on the first discharge pipe.

[0016] Optionally, the microsphere washing and purification system further includes a second discharge pipe, and the second discharge pipe is communicated with the discharge port.

[0017] Optionally, a sampling port is further provided on the tank body, and a sampling valve is provided on the sampling port.

[0018] The beneficial effects of the present utility model are as follows:

[0019] The microsphere washing and purification system proposed by the present utility model includes a tank body and a washing and filtering device. The tank body is used to hold a microsphere solution, and a return port and a discharge port are provided on the tank body. The washing and filtering device includes a cylinder body and a filter screen. The filter screen is disposed through the cylinder body. The axis of the cylinder body is disposed at an angle with the horizontal plane. The two ends of the axis of the cylinder body are through. The first end of the cylinder body is communicated with the return port, and the second end of the cylinder body is communicated with the discharge port. A discharge port is further provided on the side wall of the cylinder body. When washing and purifying the microsphere solution, it is necessary to make the microsphere solution in the tank body flow into the washing and filtering device through the discharge port, and use the filter screen in the washing and filtering device to filter the microsphere solution. That is, after the microsphere solution enters the filter screen through the second end, the small balls and substances such as dichloromethane that do not meet the requirements in the microsphere solution are discharged outside the filter screen through the holes in the filter screen and discharged from the cylinder body through the discharge port, while the remaining microsphere solution flows out of the washing and filtering device through the first end and then returns to the tank body through the return port, that is, one-time washing and purification is completed. By analogy, the microsphere solution in the tank body can pass through the washing and filtering device multiple times according to requirements to achieve multiple times of washing and purification and ensure the purification quality. The axis of the cylinder body of the washing and filtering device is disposed at an angle with the horizontal plane, so that the flow rate of the microsphere solution in the cylinder body is slower under the influence of gravity, which can effectively ensure the filtering efficiency of the microsphere solution. Description of the Drawings

[0020] Figure 1 is a schematic structural diagram of the microsphere washing and purification system provided by an embodiment of the present utility model;

[0021] Figure 2 It is a schematic structural diagram of the cylinder body provided by an embodiment of the present utility model;

[0022] Figure 3 It is a schematic structural diagram of the filter screen provided by an embodiment of the present utility model;

[0023] Figure 4 It is a schematic structural diagram of the sealing chuck provided by an embodiment of the present utility model.

[0024] In the figure:

[0025] 1. Tank body; 11. Return material port; 12. Discharge port; 13. Sampling port; 14. Feeding port; 15. Cleaning port; 16. Exhaust port; 17. Magnetic stirrer; 18. Pressure transmitter; 19. Pressure gauge; 110. Rupture disc; 111. Sight glass with light; 112. Temperature sensor;

[0026] 2. Washing and filtering device; 21. Cylinder body; 211. First end; 212. Second end; 213. Discharge port; 22. Filter screen; 23. Sealing chuck; 231. Cylinder body connection end; 232. Pipeline connection end;

[0027] 101. Return material main pipe; 1011. First reduced diameter section; 102. Return material sub-pipe; 103. First discharge main pipe; 1031. Second reduced diameter section; 104. Discharge sub-pipe; 105. Second discharge pipe; 106. Low shear force pump; 107. Discharge pipe; 108. First valve; 109. Second valve. Detailed implementation manners

[0028] To make the technical problems solved by the present utility model, the technical solutions adopted and the achieved technical effects clearer, the technical solutions of the present utility model will be further described below with reference to the accompanying drawings and through specific implementation manners. It can be understood that the specific embodiments described herein are only used to explain the present utility model, rather than limiting the present utility model. Additionally, it should be noted that for the sake of convenience of description, only parts related to the present utility model are shown in the accompanying drawings rather than all of them.

[0029] In the description of the present utility model, unless otherwise clearly defined and limited, the terms "connected", "connected to", and "fixed" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection, an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two components or the interaction relationship between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.

[0030] In the present utility model, unless otherwise clearly defined and limited, the first feature being "above" or "below" the second feature may include direct contact between the first and second features, or may include the situation where the first and second features are not in direct contact but in contact through additional features therebetween. Moreover, the first feature being "above", "over" and "on the top of" the second feature includes the first feature being directly above and obliquely above the second feature, or simply indicating that the horizontal height of the first feature is higher than that of the second feature. The first feature being "below", "under" and "beneath" the second feature includes the first feature being directly below and obliquely below the second feature, or simply indicating that the horizontal height of the first feature is lower than that of the second feature.

[0031] In the description of this embodiment, the orientation or positional relationship terms such as "above", "below", "left" and "right" are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of description and simplifying the operation, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, so it cannot be understood as a limitation to the present utility model. In addition, the terms "first" and "second" are only used for distinction in description and have no special meaning.

[0032] The technical solution of the present utility model will be further described below in conjunction with the drawings and through specific embodiments.

[0033] As Figures 1 to 4 shown, this embodiment provides a microsphere washing and purification system, which includes a tank body 1 and a washing and filtering device 2. The tank body 1 is used to hold the microsphere solution, and a return port 11 and a discharge port 12 are provided on the tank body 1. The washing and filtering device 2 includes a cylinder body 21 and a filter screen 22. The filter screen 22 is disposed through the cylinder body 21. The axis of the cylinder body 21 is arranged at an angle with the horizontal plane. Both ends of the axis of the cylinder body 21 are through. The first end 211 of the cylinder body 21 is communicated with the return port 11, and the second end 212 of the cylinder body 21 is communicated with the discharge port 12. A discharge port 213 is further provided on the side wall of the cylinder body 21. When washing and purifying the microsphere solution, it is necessary to make the microsphere solution in the tank body 1 flow into the washing and filtering device 2 through the discharge port 12, and use the filter screen 22 in the washing and filtering device 2 to filter the microsphere solution. That is, after the microsphere solution enters the filter screen 22 through the second end 212, the non-conforming small balls and substances such as dichloromethane in the microsphere solution are discharged out of the filter screen 22 through the holes on the filter screen 22 and discharged out of the cylinder body 21 through the discharge port 213, while the remaining microsphere solution flows out of the washing and filtering device 2 through the first end 211 and then returns to the tank body 1 through the return port 11, that is, one-time washing and purification of the microspheres is completed. By analogy, the microsphere solution in the tank body 1 can pass through the washing and filtering device 2 multiple times according to requirements to achieve multiple washing and purification of the microspheres and ensure the purification quality. Since the axis of the cylinder body 21 of the washing and filtering device 2 is arranged at an angle with the horizontal plane, the flow rate of the microsphere solution in the cylinder body 21 is slower under the influence of gravity, which can effectively ensure the filtering efficiency of the microsphere solution.

[0034] In this embodiment, the cylinder body 21 is vertically arranged, that is, the axial direction of the cylinder body 21 is perpendicular to the horizontal plane, so as to slow down the flow rate of the microsphere solution flowing through the washing and filtering device 2 and ensure the effective filtration of the microsphere solution by the filter screen 22.

[0035] Optionally, a plurality of washing and filtering devices 2 are provided, and the plurality of washing and filtering devices 2 are arranged in parallel. The first end 211 of each washing and filtering device 2 is communicated with the return port 11, and the second end 212 of each washing and filtering device 2 is communicated with the discharge port 12. By increasing the number of the washing and filtering devices 2, the processing capacity of the microsphere solution can be further improved. That is, the microsphere solution discharged from the discharge port 12 can be divided into multiple paths, and each path of microsphere solution is filtered by a washing and filtering device 2 and then stored in the tank body 1 through the return port 11.

[0036] Optionally, at least two discharge ports 213 are provided, and the at least two discharge ports 213 are arranged at intervals in the axial direction of the cylinder body 21. In specific implementation, the multiple discharge ports 213 can be communicated to the same discharge pipe 107 for discharge. The axial direction of the cylinder body 21 is also the flowing direction of the microsphere solution. Therefore, setting multiple discharge ports 213 also facilitates the impurities filtered out by the filter screen 22 to be discharged out of the cylinder body 21 in time.

[0037] Optionally, the microsphere washing and purification system further includes a return pipe and a first discharge pipe. One end of the return pipe is communicated with the return port 11, and the other end of the return pipe is communicated with the first end 211. One end of the first discharge pipe is communicated with the discharge port 12, and the other end of the first discharge pipe is communicated with the second end 212. In this embodiment, a plurality of washing and filtering devices 2 are provided, then the return pipe includes a return main pipe 101 and a plurality of return sub-pipes 102. One end of the return main pipe 101 is communicated with the return port 11, and the other end of the return main pipe 101 is communicated with the plurality of return sub-pipes 102. One return sub-pipe 102 corresponds to and is communicated with one first end 211. The first discharge pipe includes a first discharge main pipe 103 and a plurality of discharge sub-pipes 104. One end of the first discharge main pipe 103 is communicated with the discharge port 12, and the other end of the first discharge main pipe 103 is communicated with the plurality of discharge sub-pipes 104. One discharge sub-pipe 104 corresponds to and is communicated with one second end 212.

[0038] Optionally, the return pipe has a first reduced-diameter section 1011, and the cross-sectional area of the first reduced-diameter section 1011 gradually increases along the flowing direction of the fluid in the return pipe, that is, the pressure of the fluid in the return pipe decreases after passing through the first reduced-diameter section 1011, so as to avoid the increase of the pressure after the fluids in the plurality of return sub-pipes 102 are mixed and affect the system safety.

[0039] Optionally, the first discharge pipe has a second reduced-diameter section 1031, and the cross-sectional area of the second reduced-diameter section 1031 gradually decreases along the flow direction of the fluid in the first discharge pipe. That is, the pressure of the fluid in the first discharge pipe increases after passing through the second reduced-diameter section 1031, so as to promote the substances such as non-conforming small balls and dichloromethane in the microsphere solution to pass through the filter screen 22 of the washing and filtering device 2 and be discharged outside the cylinder body 21 when the microsphere solution passes through the washing and filtering device 2.

[0040] Optionally, a low-shear pump 106 is provided on the first discharge pipe. The low-shear pump 106 is used to pump the microsphere solution in the tank body 1 into the washing and filtering device 2, and the low-shear pump 106 can effectively prevent the microsphere structure of the microsphere solution from being damaged. The low-shear pump 106 can be a peristaltic pump, a screw pump, etc.

[0041] In addition, the washing and filtering device 2 further includes a sealing chuck 23. Sealing chucks 23 are provided at both the first end 211 and the second end 212 of the cylinder body 21. The first end 211 is hermetically connected to the return pipe through the sealing chuck 23, and the second end 212 is hermetically connected to the first discharge pipe through the sealing chuck 23. The part of the sealing chuck 23 extending into the cylinder body 21 abuts against the filter screen 22. As Figure 4 shown, the sealing chuck 23 is axially penetrated, and one end is a cylinder connection end 231 and the other end is a pipeline connection end 232. The cylinder connection end 231 of one sealing chuck 23 is inserted into the first end 211 of the cylinder body 21, and its pipeline connection end 232 is connected to the return pipe. The cylinder connection end 231 of the other sealing chuck 23 is inserted into the second end 212 of the cylinder body 21, and its pipeline connection end 232 is connected to the first discharge pipe. A sealing ring is also sleeved on the cylinder connection end 231. A stepped surface is provided on the inner wall of the cylinder connection end 231. The filter screen 22 is inserted into the cylinder connection end 231 and abuts against the stepped surface. The cylinder body 21 is sleeved outside the cylinder connection end 231 and presses the sealing ring against the main body of the sealing chuck 23, so as to realize the sealed connection between the cylinder body 21 and the sealing chuck 23.

[0042] Optionally, a sampling port 13 is further provided on the tank body 1, and a sampling valve is provided at the sampling port 13. After the preset time for washing and purifying the microsphere solution in the tank body 1, the sampling valve can be opened to take a sample through the sampling port 13. A small amount of the sampled microsphere solution is filled into a sterile sampling bag, and various indicators of the materials in the sterile sampling bag are detected to see if they meet the requirements. If they meet the requirements, the material is discharged through the discharge port 12. If not, the washing and purifying of the microspheres is continued in a cycle.

[0043] Optionally, the microsphere washing and purification system further includes a second discharge pipe 105, which is connected to the discharge port 12. When the discharge requirement is met, the material can be discharged through the second discharge pipe 105. In this embodiment, the second discharge pipe 105 is connected to the discharge port 12 through a first discharge pipe. A first valve 108 is provided on the first discharge pipe, and a second valve 109 is provided on the second discharge pipe 105. When washing and purifying the microspheres are required, the second valve 109 is closed and the first valve 108 is opened to enable the microsphere solution to flow from the discharge port 12 to the washing and filtering device 2. When discharging is required, the first valve 108 is closed and the second valve 109 is opened to enable the microsphere solution to flow from the discharge port 12 to the second discharge pipe 105.

[0044] In this embodiment, a magnetic stirrer 17 is further provided in the tank body 1. The magnetic stirrer 17 is used to prevent the microsphere solution from precipitating in the tank body 1. A pressure gauge 19, a pressure transmitter 18 and a temperature sensor 112 are further provided on the tank body 1. The pressure gauge 19 is for the staff to view the pressure in the tank body 1, and the pressure transmitter 18 is used to feedback the pressure in the tank body 1 to the controller in real time. The temperature sensor 112 is used to feedback the temperature in the tank body 1 to the controller in real time, so that the staff can remotely control the pressure and temperature in the tank body 1 by using the controller. A rupture disk 110 is further provided on the tank body 1. When the pressure in the tank body 1 exceeds the preset rupture pressure of the rupture disk 110, the rupture disk 110 will rupture or fall off, quickly releasing the pressure in the tank body 1 to prevent the tank body 1 from rupturing or exploding due to excessive pressure. An exhaust port 16 is further provided on the tank body 1, which can exhaust the inside of the tank body 1 as required to avoid excessive pressure in the tank body 1. A sight glass with a light 111 is further provided on the tank body 1 for the staff to view the materials in the tank body 1. A feeding port 14 and a cleaning port 15 are further provided at the top of the tank body 1. Materials can be replenished into the tank body 1 through the feeding port 14, and a spray ball can be provided through the cleaning port 15. The spray ball can rotate under pressure and spray the cleaning liquid at a high speed to every corner in the tank body 1 to ensure a comprehensive cleaning of the inside of the tank body 1.

[0045] The above embodiments only illustrate the basic principles and characteristics of the present invention. The present invention is not limited by the above embodiments. Without departing from the spirit and scope of the present invention, there are various changes and modifications to the present invention, and these changes and modifications all fall within the scope of the present invention claimed. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.

Claims

1. Microsphere washing and purification system, characterized in that: include: A tank body (1), the tank body (1) is used to contain the microsphere solution, and the tank body (1) is provided with a return port (11) and a discharge port (12); The filter washing device (2) comprises a cylinder (21) and a filter screen (22), wherein the filter screen (22) is inserted into the cylinder (21), the axial direction of the cylinder (21) is arranged at an angle with a horizontal plane, the two axial ends of the cylinder (21) are connected, the first end (211) of the cylinder (21) is connected to the return port (11), the second end (212) of the cylinder (21) is connected to the discharge port (12), and the side wall of the cylinder (21) is also provided with a discharge port (213).

2. The microsphere washing and purification system according to claim 1, characterized in that: A plurality of the filter washing devices (2) are provided, and the plurality of the filter washing devices (2) are arranged in parallel, the first end (211) of each of the filter washing devices (2) is connected to the return port (11), and the second end (212) of each of the filter washing devices (2) is connected to the discharge port (12).

3. The microsphere washing and purification system according to claim 1, characterized in that: At least two discharge ports (213) are provided, and at least two discharge ports (213) are spaced apart in the axial direction of the cylinder (21).

4. The microsphere washing and purification system according to claim 1, characterized in that: The microsphere washing and purification system also includes a return pipe and a first discharge pipe, one end of the return pipe is connected to the return port (11), the other end of the return pipe is connected to the first end (211), one end of the first discharge pipe is connected to the discharge port (12), and the other end of the first discharge pipe is connected to the second end (212).

5. The microsphere washing and purification system according to claim 4, characterized in that: The return pipe has a first diameter-changing section (1011), and the cross-sectional area of ​​the first diameter-changing section (1011) gradually increases along the flow direction of the fluid in the return pipe.

6. The microsphere washing and purification system according to claim 4, characterized in that: The first discharge pipe has a second diameter-changing section (1031), and the cross-sectional area of ​​the second diameter-changing section (1031) gradually decreases along the flow direction of the fluid in the first discharge pipe.

7. The microsphere washing and purification system according to claim 4, characterized in that: The filter washing device (2) further comprises a sealing chuck (23), the first end (211) and the second end (212) are both provided with the sealing chuck (23), the first end (211) is sealedly connected to the return pipe via the sealing chuck (23), the second end (212) is sealedly connected to the first discharge pipe via the sealing chuck (23), and the portion of the sealing chuck (23) extending into the cylinder (21) abuts against the filter screen (22).

8. The microsphere washing and purification system according to claim 4, characterized in that: The first discharge pipe is provided with a low shear pump (106).

9. The microsphere washing and purification system according to claim 1, characterized in that: The microsphere washing and purification system further comprises a second discharge pipe (105), wherein the second discharge pipe (105) is connected to the discharge port (12).

10. The microsphere washing and purification system according to claim 1, characterized in that: The tank body (1) is also provided with a sampling port (13), and a sampling valve is provided on the sampling port (13).

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