Liquid filtering device

Abstract

The utility model discloses a liquid filtering device, which solves the problems of complex core replacement, low filtering efficiency and the like in the sterile filtering process of the existing single-core filter, and adopts the main scheme that the liquid filtering device comprises a filter in which a replaceable multi-core filter core is arranged and is used for filtering a liquid culture medium; the two steel wire lining hoses are correspondingly arranged on the two sides of the filter, one end of each steel wire lining hose is communicated with the filter, and the other end of each steel wire lining hose is communicated with an external liquid preparation system pipeline; the filter and the steel wire lining hose are fixed through a stainless steel hoop, the filter and the external liquid preparation system pipeline are fixed through a stainless steel hoop, the multi-core filter can be used according to the variety requirement in the production process, so that the production efficiency and quality are guaranteed, and replacement is flexible.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid dispensing, and particularly relates to a liquid filtering device. Background Art

[0002] The liquid dispensing process system is the last process step before liquid filling or sub-packaging, and the quality of its GMP workshop design plays a key role in the final quality. How to avoid contamination and cross-contamination in production and how to consider its clean design have always been the key concerns of GMP.

[0003] The liquid dispensing process system, whether it is a chemical synthesis drug or a biological fermentation drug, mainly consists of the following equipment or units: a container for preparing or storing drugs, a temperature control unit (TCU) of the tank configured according to the characteristics of the drugs, an activated carbon adsorption unit, an ultrafiltration unit, a filtration unit, a conveying unit, etc. equipped according to the production process requirements of the drugs, and a stirring and mixing unit, a pH adjustment, a sampling and analysis unit, a CIP / SIP unit, etc. equipped according to the quality control requirements in the drug production process.

[0004] The key points of upstream bioburden control and virus safety management are how to prevent microorganisms such as bacteria, mycoplasma, and viruses from entering the cell culture process. Aseptic filtration is a common operation for removing microorganisms from cell culture media and preventing contamination of bioreactors. Media filtration is a simple bioreactor and upstream process protection solution.

[0005] When actually filtering from the dispensing tank to the filling tank, different varieties can only use a single-core filter for aseptic filtration, and the filter needs to be replaced midway to meet the filtration requirements. It is found that at least the following technical problems exist:

[0006] 1. Product quality problems:

[0007] 1.1. Replacing the filter element midway during the product will increase the risk of contamination;

[0008] 1.2. According to the manufacturer's suggestion, when the single-core filter element filters 400L - 500L each time, there is a risk of rupture of the filter element, resulting in product contamination.

[0009] 2. Production process-related problems:

[0010] 2.1. Replacing the filter element midway during single-batch filtration results in low production efficiency, and the physical and chemical stability properties of the culture medium may be affected due to the extended filtration time;

[0011] 2.2. The single-core filter has low flexibility and is difficult to meet the different filtration conditions of different products;

[0012] 2.3. The steps of replacing the filter element of the single-core filter are cumbersome, increasing the input of workshop personnel and time. Summary of the Utility Model

[0013] In view of the deficiencies of the prior art, the present utility model provides a liquid filtering device with a replaceable flexible connection, which is composed of a filter, a steel wire inner-lined hose, and a stainless steel clamp. The steel wire inner-lined hose is connected to the liquid distribution system pipeline, so as to solve the problems that the single-core filter has low filtering efficiency and the filter element needs to be replaced during the production process, reduce the pollution risk, ensure the product quality, and improve the production efficiency.

[0014] To achieve the above objectives, the present utility model is realized through the following technical solutions:

[0015] A liquid filtering device, characterized in that it includes:

[0016] A filter, with a replaceable multi-core filter element inside, used for filtering liquid medium;

[0017] Two steel wire inner-lined hoses, which are correspondingly arranged on both sides of the filter. One end of each steel wire inner-lined hose is connected to the filter, and the other end is connected to the external liquid distribution system pipeline;

[0018] Both between the filter and the steel wire inner-lined hose, and between the filter and the external liquid distribution system pipeline are fixed by stainless steel clamps.

[0019] Furthermore, the filter further includes a sleeve, the bottom of the sleeve is supported and fixed by a triangular base, and the bottom of the sleeve is also connected with a feed pipe and a discharge pipe, and the steel wire inner-lined hoses are respectively correspondingly connected to the feed pipe and the discharge pipe.

[0020] Furthermore, each stainless steel clamp fixing place is locked and fixed by a flange and a gasket. The steel wire inner-lined hose includes a feed-end steel wire inner-lined hose and a discharge-end steel wire inner-lined hose.

[0021] Furthermore, after each stainless steel clamp is locked, the material flow direction of the internal pipeline is that the liquid distribution system pipeline enters the feed-end steel wire inner-lined hose, passes through the feed pipe and the filter, then enters the discharge-end steel wire inner-lined hose from the discharge pipe, and finally flows to the liquid distribution system pipeline.

[0022] Furthermore, the gasket is made of polytetrafluoroethylene.

[0023] Furthermore, the filter element in the filter includes single-core, three-core, and five-core filter elements.

[0024] Furthermore, the steel wire inner-lined hose is made of stainless steel braided hose, its inner diameter is the same as that of the external liquid distribution system pipeline, and its outer diameter is the same as that of the feed pipe and the discharge pipe of the filter.

[0025] Compared with the prior art, the beneficial effects of the present utility model include:

[0026] 1. By adopting a multi-core filter, there is no need to replace the filter element during the process, reducing the pollution risk and thus ensuring product quality. At the same time, the multi-core filter reduces the risk of rupture, ensuring stable product quality;

[0027] 2. The overall flexibility of the equipment is high. According to the feedback of the manufacturer's experimental results, the multi-core filter meets the filtration requirements of all liquid products of our company (endotoxin < 0.25 EU / ml), and the workshop can select a suitable multi-core filter element according to the variety;

[0028] 3. There is no need to replace the filter element during single-batch production, improving production efficiency; there is no need to replace the filter element in the multi-core filter during the process, reducing personnel input and time input. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] The above description is only an overview of the technical solution of the present utility model. In order to understand the technical means of the present utility model more clearly and implement it according to the content of the description, the following describes in detail with reference to the preferred embodiments of the present utility model and the accompanying drawings.

[0030] Figure 1 The upper part is the overall structure diagram before transformation, and the lower part is the overall structure diagram of the filtration device of the present utility model.

[0031] Reference numerals: 1, single-core filter; 2, feed pipeline of the liquid preparation system; 3, discharge pipeline of the liquid preparation system; 4, multi-core filter; 6, discharge pipe; 7, feed pipe; 8, stainless steel clamp; 9, steel wire inner lining hose at the discharge end; 10, steel wire inner lining hose at the feed end. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0032] It is easy to understand that according to the technical solution of the present utility model, without changing the essential spirit of the present utility model, those of ordinary skill in the art can propose various structural ways and implementation ways that can be mutually replaced. Therefore, the following detailed embodiments and the accompanying drawings are only exemplary descriptions of the technical solution of the present utility model, and should not be regarded as all of the present utility model or as a limitation or restriction on the technical solution of the present utility model.

[0033] The following is further described with reference to the drawings in the specification Figure 1 for further illustration.

[0034] In this embodiment, a liquid filtration device solves the problems in the prior art that only a single-core filter can be used, resulting in low filtration efficiency and possible introduction of pollution risks. The device consists of a filter, a steel wire-lined hose, and a stainless steel clamp 8, which are connected through the pipeline of the liquid preparation system. The inlet and outlet pipes 6 of the filter are connected to the pipeline of the liquid preparation system by the inlet-end steel wire-lined hose 10, and a suitable multi-core filter element is selected and installed in the filter. The compressed air inlet pressure of the liquid preparation tank is adjusted so that the liquid medium enters the multi-core filter 4 through the pipeline for filtration and finally enters the canning tank.

[0035] Regarding the specific structure of the device, a liquid filtration device includes:

[0036] A filter with a replaceable multi-core filter element inside for filtering the liquid medium;

[0037] Steel wire-lined hoses, including two, which are correspondingly arranged on both sides of the filter. One end of each steel wire-lined hose is connected to the filter, and the other end is connected to the external liquid preparation system pipeline;

[0038] Both between the filter and the steel wire-lined hose and between the filter and the external liquid preparation system pipeline are fixed by the stainless steel clamp 8.

[0039] Furthermore, the filter further includes a sleeve, the bottom of the sleeve is supported and fixed by a triangular base, the bottom of the sleeve is also connected with a feed pipe 7 and a discharge pipe 6, and the steel wire-lined hoses are respectively correspondingly connected to the feed pipe 7 and the discharge pipe 6. Each fixing position of the stainless steel clamp 8 is locked and fixed through a flange and a gasket. The steel wire-lined hose includes an inlet-end steel wire-lined hose 10 and an outlet-end steel wire-lined hose 9.

[0040] Through the above structure, after each stainless steel clamp 8 is locked, the material flow direction of the internal pipeline is that the liquid preparation system pipeline enters the inlet-end steel wire-lined hose 10, passes through the feed pipe 7 and the filter, enters the outlet-end steel wire-lined hose 9 from the discharge pipe 6, and finally flows to the liquid preparation system pipeline.

[0041] Regarding the selection and dimensions of each structural component, specifically, in this embodiment, the gasket is made of polytetrafluoroethylene. The filter elements inside the filter include single-core, three-core, and five-core filter elements. The steel wire-lined hose is made of stainless steel braided hose, its inner diameter is the same as that of the external liquid preparation system pipeline, and its outer diameter is the same as that of the feed pipe 7 and the discharge pipe 6 of the filter.

[0042] The gasket is made of polytetrafluoroethylene, which is heat-resistant, acid and alkali-resistant, and corrosion-resistant. Similarly, the pipes of the liquid preparation system and the inlet and outlet pipes 6 for filtration are made of 316 stainless steel. High-grade products of 316 stainless steel are made of 10% nickel, making the stainless steel more durable and corrosion-resistant. The above materials can meet the requirements of aseptic filtration of liquid culture media.

[0043] When making actual structural improvements, considering that it is an improvement to the original pipeline structure, the single-core filter 1 and its inlet and outlet pipes 6 can be disassembled in advance to reserve enough pipes for the liquid preparation system. Then, the multi-core filter 4 is connected to the stainless steel-lined hose with gaskets and stainless steel clamps 8. Next, the stainless steel-lined hose is connected to the liquid preparation system pipeline with gaskets and stainless steel clamps 8. Finally, multi-core filter elements that match the production variety are selected.

[0044] This device consists of a filter, a steel wire-lined hose, and a stainless steel clamp 8, and is sealed with gaskets. During use, the culture solution in the liquid preparation tank is pressurized by compressed air and then transported to the pipes of the liquid preparation system and the steel wire-lined hose and enters the filter. After being filtered by the multi-core filter element, it flows out through the outlet pipe 6, through the steel wire-lined hose, into the liquid preparation system pipeline on the other side, and then into the filling tank.

[0045] The above connection methods can be disassembled section by section after production, and after the liquid preparation system pipeline is cleared, a blind plate is installed on the pipeline and fixed and sealed with a stainless steel clamp 8 to prevent contact and contamination with the outside world.

[0046] Obviously, the above embodiments are only examples for clearly explaining the present invention, and are not limitations on the implementation modes. For those of ordinary skill in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation modes here. And the obvious changes or modifications derived therefrom are still within the protection scope of the present invention.

Claims

1. A liquid filtering device, characterized in that: include: A filter, which contains a replaceable multi-core filter element for filtering liquid culture medium; Steel wire lined hoses, including two and correspondingly arranged on both sides of the filter, one end of each of the steel wire lined hoses is connected to the filter, and the other end is connected to an external liquid distribution system pipeline; The filter and the steel wire lined hose, and the filter and the external liquid distribution system pipeline are fixed by stainless steel clamps.

2. A liquid filtering device according to claim 1, characterized in that: The filter also includes a sleeve, the bottom of the sleeve is fixed by a triangular base support, the bottom of the sleeve is also connected to a feed pipe and a discharge pipe, and the steel wire lined hose is respectively connected to the feed pipe and the discharge pipe.

3. A liquid filtering device according to claim 2, characterized in that: Each of the stainless steel clamp fixing places is locked and fixed by a flange and a gasket, and the steel wire lined hose includes a steel wire lined hose at the feed end and a steel wire lined hose at the discharge end.

4. A liquid filtering device according to claim 3, characterized in that: After each of the stainless steel clamps is locked, the material flow direction of the internal pipeline is from the liquid distribution system pipeline into the wire lined hose at the feed end, through the feed pipe and the filter, from the discharge pipe into the wire lined hose at the discharge end, and finally flows to the liquid distribution system pipeline.

5. A liquid filtering device according to claim 3, characterized in that: The gasket is made of polytetrafluoroethylene.

6. A liquid filtering device according to claim 1, characterized in that: The inner filter element of the filter includes single-core, three-core and five-core filter elements.

7. The liquid filtering device according to claim 1, characterized in that: The wire lined hose is made of a stainless steel braided hose, the inner diameter of which is consistent with the external liquid distribution system pipeline, and the outer diameter is consistent with the filter feed pipe and discharge pipe.

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