Vessel model device and assembly for manufacturing the same

Abstract

The utility model provides a blood vessel model device and an assembly for manufacturing the blood vessel model device, and relates to the technical field of medical test instruments. The blood vessel model device comprises a first mold, a second mold and a hydrogel body, the first mold is provided with a first end and a second end which are oppositely arranged, a cavity penetrating through the first end and the second end is formed in the first mold, the cavity is filled with the hydrogel body, and a simulated blood vessel channel is formed in the hydrogel body in a penetrating mode; the second mold is arranged at the second end so as to limit the hydrogel in the cavity. An assembly for manufacturing the blood vessel model device comprises the first mold, the second mold and a third mold, the third mold serves as a channel template and is inserted before the hydrogel in the cavity is solidified, and a simulated blood vessel channel can be formed by removing the hydrogel after the hydrogel is solidified. The blood vessel model device is simple in structure, the manufacturing method is simple, the simulated blood vessel channel is formed in the hydrogel, and the blood vessel model device can be effectively applied to in-vitro testing of the performance of the embolism microspheres.

Description

Technical Field

[0001] This application relates to the technical field of medical testing instruments. Specifically, it relates to a vascular model device and components for manufacturing the vascular model device. Background Art

[0002] Microspheres refer to spheres with a particle size in the micrometer range. In recent years, microspheres have often been used in the embolization treatment of tumors. By embolizing to block the blood flow in the blood supply arteries of tumors, tumor cells cannot obtain sufficient nutrients and thus necrosis occurs. Microspheres can be classified into degradable microspheres and non-degradable microspheres according to their types. Before clinical application, it is necessary to evaluate the embolization performance of microspheres using in vitro models. Especially for degradable microspheres, they will be decomposed by enzymes in the blood after embolizing blood vessels for a certain period of time and the blood flow will resume. Therefore, it is crucial to evaluate the embolization performance of microspheres after degradation in the blood.

[0003] For non-degradable microspheres, there are currently some models that can be used to simulate embolization in vitro, but these models still have obvious disadvantages. For example, using ordinary plastic capillary tubes to simulate blood vessels for embolization, since the tube wall itself cannot permeate liquids, it cannot simulate the permeability of tissues near the embolization site, and the liquid exchange is not sufficient, affecting the degradation efficiency of microspheres. At the same time, the rigid tube wall cannot simulate the elasticity existing in the blood vessels themselves. Models using hydrogel 3D printing technology can appropriately improve the above problems, but due to printing accuracy issues, they cannot well simulate the diameter and shape of thinner blood vessels, and there is also the problem of high cost. Similarly, some models made from animal tissue organs after decellularization also have problems such as non-reusability and excessive time consumption. For degradable microspheres, there is currently no good in vitro model for evaluating the embolization performance of degradable microspheres after degradation. Summary of the Utility Model

[0004] To solve the above technical problems, the purpose of this application is to provide a vascular model device and components for manufacturing the vascular model device, which are used for in vitro testing of the performance of embolized microspheres in blood vessels.

[0005] In a first aspect, an embodiment of this application provides a vascular model device, including a first mold, a second mold, and a hydrogel body. The first mold has a first end and a second end arranged oppositely, and a cavity penetrating the first end and the second end is provided inside the first mold. The hydrogel body is arranged inside the cavity, and a simulated blood vessel channel is penetrated inside the hydrogel body. The second mold is arranged at the second end of the first mold to confine the hydrogel body inside the cavity.

[0006] In the vascular model device provided in this application, by using the first mold as a carrier to load the hydrogel body and using the second mold to confine the hydrogel body in the cavity, a simulated blood vessel channel is formed in the hydrogel body, which can more realistically simulate the elasticity of the blood vessel itself. Moreover, since the hydrogel has a certain permeability, it can more approximately simulate the liquid exchange situation during the embolization of microspheres in the body, so that it can be effectively applied to simulate the embolization process of degradable microspheres in vitro.

[0007] In a possible implementation manner, the first mold is made of a transparent material.

[0008] By setting the first mold to be made of a transparent material, such as transparent plastic, during the evaluation and testing process, the embolization situation of the microspheres can be directly observed through the transparent side wall. Once the degradation of the microspheres causes changes in the position and degree of embolization, it can be directly observed and the feedback can be recorded.

[0009] In a possible implementation manner, along the direction from the first end to the second end of the first mold, the diameter of the simulated blood vessel channel gradually decreases.

[0010] The gradually decreasing diameter of the simulated blood vessel passage facilitates the formation of embolization by microspheres and is applicable to testing embolization microspheres of various sizes. In actual use, the shape and diameter of the simulated blood vessel channel can be arbitrarily adjusted according to the diameter and shape of the blood vessel to be simulated.

[0011] In a possible implementation manner, a mounting groove is formed by inward depression on the surface of the second end of the first mold. The mounting groove communicates with the cavity, and the shape of the mounting groove matches the outer shape of the second mold. The second mold is detachably arranged in the mounting groove.

[0012] By setting the shape of the mounting groove to match that of the second mold, the mounting reliability and the operability of technicians can be improved.

[0013] In a possible implementation manner, a first opening is provided at the first end of the first mold, a second opening is provided at the second end, a through hole is provided through the second mold, and the simulated blood vessel channel communicates with the first opening, the second opening, and the through hole; the first opening is used to inject the microspheres to be tested and the test liquid into the simulated blood vessel channel, and the second opening and the through hole are used to discharge the waste liquid generated after the test.

[0014] In a possible implementation manner, the vascular model device further includes a liquid storage chamber, a liquid inlet pipe, a waste liquid collection chamber, and a liquid outlet pipe. The liquid storage chamber is used to store the test liquid, the liquid inlet pipe communicates with the first opening and the liquid storage chamber, and the liquid outlet pipe communicates with the second opening and the waste liquid collection chamber.

[0015] In a possible implementation, the blood vessel simulation device further includes a liquid inlet pipe, a liquid inlet pump, a waste liquid collection chamber, and a liquid outlet pipe. The liquid inlet pipe, the first opening, the second opening, the liquid outlet pipe, the waste liquid collection chamber, the liquid inlet pump, and the liquid inlet pipe are sequentially connected to form a circulation path. A filter membrane is provided between the waste liquid collection chamber and the liquid inlet pipe.

[0016] By setting a filter membrane between the liquid inlet pump and the waste liquid collection chamber to form a circulation path, the simulated test liquid can be circulated in the blood vessel model device to simulate the blood flow in a living body, thereby increasing the reliability of the test.

[0017] In a second aspect, an embodiment of the present application further provides a component for manufacturing a blood vessel model device, including a first mold, a second mold, and a third mold. The first mold has a first end and a second end arranged opposite to each other, and a cavity penetrating through the first end and the second end is provided inside the first mold. The cavity is used for filling a hydrogel body formed after the hydrogel is cured. The second mold is arranged at the second end of the first mold to confine the hydrogel body in the cavity. The third mold is used to be inserted into the cavity and removed after the hydrogel is cured, so as to form a simulated blood vessel channel in the hydrogel body.

[0018] The component for manufacturing the blood vessel model device provided in the present application only includes the first mold, the second mold, and the third mold. Using the third mold as a channel template, after filling the cavity of the first mold with hydrogel and curing it, the blood vessel model device can be manufactured. It only relies on the hydrogel to be cured and formed in the pre-set cavity, without using 3D printing technology. The overall component is simple and the cost is low. Moreover, the hydrogel has a low cost and high repeatability, and is more suitable for multiple and batch screening during the product R & D process. In addition, the formula of the hydrogel body can be adjusted according to the elastic modulus of different human organs, so as to better simulate the resistance brought by different organs.

[0019] In a possible implementation, the third mold includes an end portion and a column core connected to one end of the end portion. The diameter of the column core gradually decreases from one end close to the end portion towards the end away from the end portion.

[0020] In a possible implementation, the diameter of the column core gradually decreases from 1 - 2 mm to 0.1 - 0.2 mm.

[0021] In the present application, by controlling the shape and size of the third mold, the shape and size of the simulated blood vessel channel can be correspondingly controlled. Therefore, the shape and size of any blood vessel to be simulated can be simply obtained. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] To more clearly illustrate the technical solutions of the embodiments of the present application, the accompanying drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and should not be regarded as limiting the scope. For those of ordinary skill in the art, without creative efforts, other related drawings can also be obtained based on these drawings.

[0023] Figure 1 Schematic structural diagram of a blood vessel model device provided by an embodiment of the present application;

[0024] Figure 2 Schematic split structural diagram of a first mold and a second mold provided by an embodiment of the present application;

[0025] Figure 3 Top view of a first mold provided by an embodiment of the present application;

[0026] Figure 4 Schematic structural diagram of the blood vessel model device during use provided by an embodiment of the present application;

[0027] Figure 5 Schematic structural diagram of a blood vessel model device provided by another embodiment of the present application;

[0028] Figure 6 Schematic structural diagram of a blood vessel model device provided by another embodiment of the present application;

[0029] Figure 7 Schematic structural diagram of a third mold provided by an embodiment of the present application;

[0030] Figure 8 Schematic structural diagram of the forming process of the blood vessel model device provided by an embodiment of the present application;

[0031] Icon: 1 - First mold; 101 - First end; 102 - Second end; 11 - First opening; 112 - First convex nozzle; 12 - Second opening; 122 - Installation groove; 14 - Cavity; 2 - Second mold; 21 - Through hole; 22 - Groove; 23 - Second convex nozzle; 3 - Hydrogel body; 32 - Simulated blood vessel channel; 4 - Third mold; 41 - End; 42 - Column core; 5 - Liquid storage chamber; 52 - Liquid inlet pipe; 54 - Liquid inlet pump; 6 - Waste liquid collection chamber; 62 - Liquid outlet pipe; 7 - Connecting pipe; 72 - Filter membrane; 200 - Microspheres to be measured; A - Height direction; W - Width; L - Length; H1, H2 - Heights. Detailed implementation manners

[0032] To make the objectives, technical solutions, and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present application.

[0033] In the description of the present utility model, it should be noted that if terms such as "upper", "lower", "inner", "outer", etc. are used to indicate the orientation or positional relationship, it is based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the product of the present utility model is usually placed during use. It is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present utility model.

[0034] In addition, if terms such as "first", "second", etc. are only used for distinguishing descriptions, they should not be construed as indicating or implying relative importance.

[0035] Please refer to Figure 1 , Figure 1 is a schematic structural diagram of the vascular model device provided by an embodiment of the present application. The vascular model device provided by this embodiment includes a first mold 1, a second mold 2, and a hydrogel body 3 disposed in the first mold 1. The first mold 1 has a first end 101 and a second end 102 disposed opposite to each other. A cavity 14 is provided in the first mold 1 and penetrates through the first end 101 and the second end 102. The second mold 2 is disposed at the second end 102 of the first mold 1 to confine the hydrogel body 3 within the cavity 14. The hydrogel body 3 is disposed within the cavity 14, and a simulated blood vessel channel 32 is provided through the hydrogel body 3.

[0036] Among them, the cavity 14 extends vertically along the direction from the first end 101 to the second end 102 (i.e., the height direction A of the first mold 1). The simulated blood vessel channel 32 is a vertical passage extending along the height direction A of the first mold 1, and the diameter of the simulated blood vessel channel 32 gradually decreases along the height direction A so that the microspheres to be measured can smoothly form embolisms. Specifically, the diameter of the simulated blood vessel channel 32 can gradually decrease from 1 - 2 mm to 0.1 - 0.2 mm.

[0037] It can be understood that in actual applications, the shape and size of the simulated blood vessel channel 32 can be correspondingly adjusted according to the shape and size of the blood vessels to be simulated. The simulated blood vessel channel 32 can be any other shape. For example, it can be a dendritic structure (not shown), that is, a multi-stage branching structure, which specifically includes a main channel and a plurality of branch channels communicating with the main channel. Thus, it can be applied to study the embolization behavior of embolizing microspheres at the crossing blood vessels in the human body or in the blood vessel network.

[0038] Please refer to Figure 1 , Figure 2 and Figure 3 , among which, Figure 2 is a schematic diagram of the split structure of the first mold 1 and the second mold 2 provided by this embodiment, Figure 3The top view of the first mold 1 provided in this embodiment. The first mold 1 provided in this application includes a first opening 11 provided at the first end 101 and a second opening 12 provided at the second end 102. A cavity 14 communicates with the first opening 11 and the second opening 12, and the simulated blood vessel channel 32 also communicates with the first opening 11 and the second opening 12. The second mold 2 is clamped at the second opening 12 of the first mold 1 to prevent the hydrogel body 3 from falling off from the cavity 14.

[0039] Wherein, the second mold 2 is provided with a through hole 21 penetrating therethrough. The through hole 21 communicates with the second opening 12, and the diameter of the through hole 21 is smaller than the diameter of the second opening 12. Thus, the microspheres to be tested can be injected through the first opening 11 and the simulated test liquid can be introduced, and the waste liquid after the test can be discharged through the second opening 12 and the through hole 21.

[0040] Specifically, the first mold 1 can be made of a transparent material, such as transparent plastic, polymethyl methacrylate (PMMA), polycarbonate (PC), polypropylene (PP), polystyrene (PS), etc. Thus, during the evaluation test, the embolization situation of the microspheres to be tested can be directly observed through the transparent side wall. Once the degradation of the microspheres to be tested causes changes in the position and degree of embolization, it can be directly observed and recorded for feedback. The shape of the first mold 1 can be a cube, a cuboid, a cylinder or any other three-dimensional shape. In this embodiment, the first mold 1 is generally in the shape of a cuboid, its width W can be 80 mm, its length L can be 80 mm, and the height H1 of the first mold 1 can be 400 mm. The diameter of the first opening 11 can be 15 mm, and the diameter of the second opening 12 can be 35 mm.

[0041] Since the small blood vessels in the body are more affected by the squeezing action of the surrounding tissues, in the embodiment of this application, the diameter of the simulated blood vessel channel 32 gradually decreases along the height direction A, and the diameter of the cavity 14 gradually increases along the height direction A, so as to more accurately simulate the state of the thinner blood vessel ends in the body being squeezed by the surrounding tissues. It can be understood that in other embodiments, the cavity 14 can be of any shape. In this embodiment, the center lines of the first opening 11, the cavity 14, the second opening 12, and the simulated blood vessel channel 32 are collinear.

[0042] In addition, a mounting groove 122 is recessed inward on the surface of the second end 102 of the first mold 1. The mounting groove 122 communicates with the cavity 14, and the shape of the mounting groove 122 matches the outer shape of the second mold 2. The second mold 2 is clamped in the mounting groove 122. Among them, the size (such as diameter or width) of the mounting groove 122 can be slightly smaller than the size of the second mold 2, so as to improve the clamping force between the second mold 2 and the mounting groove 122, and thus improve the sealing performance of the second mold 2. In this embodiment, the second mold 2 is generally square, and the shape of the corresponding mounting groove 122 is also generally square.

[0043] In this embodiment, the surface of the second mold 2 facing the cavity 14 may also be recessed inward to form a groove 22, and the groove 22 communicates with the through hole 21 and the cavity 14, thereby relatively extending the length of the simulated blood vessel channel 32.

[0044] Please refer to Figure 4 , Figure 4 which is a schematic structural diagram of the blood vessel model device provided in this embodiment when in use. When the blood vessel model device provided in this application is in use, the test microspheres 200 can be injected from the first opening 11 of the first mold 1. After the embolization of the test microspheres 200 in the simulated blood vessel channel 32 is formed, a degradation test solution for simulating blood is introduced from the first opening 11, and the waste liquid after the test is discharged from the second opening 12. In the embodiment of this application, the simulated blood vessel channel 32 is parallel to the height direction A of the first mold 1, so that the liquid flow direction is the height direction A of the first mold 1.

[0045] Among them, the degradation test solution for simulating blood can be a phosphate buffer solution with a pH of 7.4 or 0.9% normal saline, or other commercial blood simulation solutions.

[0046] In this embodiment, the blood vessel model device is applied to in vitro simulate the embolization process of degradable microspheres in blood vessels. However, it should be noted that the blood vessel model device in this application can be applied to simulate the embolization of both degradable microspheres and non-degradable microspheres. The test microspheres 200 can be degradable embolization microspheres such as polyvinyl alcohol (PVA) microspheres, sodium alginate microspheres, gelatin microspheres, and polylactic acid microspheres, or non-degradable embolization microspheres such as polystyrene (PS) microspheres, polymethyl methacrylate (PMMA) microspheres, and silicon dioxide (SiO2).

[0047] Please refer to Figure 5 , Figure 5 which is a schematic structural diagram of the blood vessel model device provided in another embodiment of this application. The blood vessel model device may further include a liquid storage chamber 5 and a waste liquid collection chamber 6. The liquid storage chamber 5 can be used to store the test solution, and is connected to the first opening 11 through a liquid inlet pipe 52 to communicate with the simulated blood vessel channel 32. A liquid inlet pump 54 may also be provided on the liquid inlet pipe 52 to adjust the liquid inlet speed and liquid inlet volume. The waste liquid collection chamber 6 is used to collect the waste liquid after the test, and is communicated with the through hole 21 of the second mold 2 and the second opening 12 through a liquid outlet pipe 62 to communicate with the simulated blood vessel channel 32.

[0048] By providing independent liquid storage chamber 5 and waste liquid collection chamber 6, it is convenient for technicians to adjust the liquid inlet volume and liquid inlet speed, and to test the relevant data of the waste liquid in the waste liquid collection chamber 6 at any time.

[0049] In some embodiments, a first protruding nozzle 112 is formed by protruding outward from the surface of the first end 101 of the first mold 1, which facilitates the connection of the liquid inlet pipe 52. Similarly, a second protruding nozzle 23 is formed by protruding outward from the surface of the side of the second mold 2 facing away from the first mold 1, which facilitates the connection of the liquid outlet pipe 62.

[0050] In some embodiments, the vascular model device of the present embodiment can also be used to simulate and test the drug release performance of drug-loaded microspheres. By measuring the drug concentration in the waste liquid collection chamber 6, the drug release rate per unit time in the environment of the simulated blood vessel can be obtained.

[0051] Please refer to Figure 6 , Figure 6 which is a schematic structural diagram of the vascular model device provided by another embodiment of the present application. The difference from the structure of the above-mentioned vascular model device is that: the vascular model device does not include the liquid storage chamber 5. A connecting pipe 7 is connected between the waste liquid collection chamber 6 and the liquid inlet pump 54, and a filter membrane 72 is provided at the connecting pipe 7. Thus, the liquid inlet pump 54, the liquid inlet pipe 52, the first opening 11, the simulated blood vessel channel 32, the second opening 12, the through hole 23, the liquid outlet pipe 62, the waste liquid collection chamber 6 and the connecting pipe 7 are sequentially connected to form a circulation path.

[0052] By forming a circulation path by setting a filter membrane 72 between the liquid inlet pump 54 and the waste liquid collection chamber 6, the simulated test liquid can be circulated in the vascular model device, simulating the blood flow in the living body and increasing the reliability of the test.

[0053] In the embodiments of the present application, the hydrogel body 3 is loaded with the first mold 1 as a carrier, and the hydrogel body 3 is restricted in the cavity 14 by the second mold 2. By forming a simulated blood vessel channel 32 in the hydrogel body 3, the hydrogel body 3 can be directly cured in the cavity 14 by the hydrogel. The tube wall material of the simulated blood vessel channel 32 is the hydrogel body 3, which can more realistically simulate the elasticity of the blood vessel itself. And because the hydrogel has a certain permeability, it can more approximately simulate the liquid exchange situation when the microspheres are embolized in the body. Thus, it can be effectively applied to simulate the embolization process of degradable microspheres.

[0054] Please also refer to Figure 1 , Figure 7 , Figure 8 , the embodiments of the present application also provide a component for manufacturing the above-mentioned vascular model device. The component includes a first mold 1, a second mold 2 and a third mold 4. Figure 7 which is a schematic structural diagram of the third mold provided for this embodiment. Figure 8 which is a schematic structural diagram of the forming process of the vascular model device provided for this embodiment.

[0055] In this component, for the specific structures of the first mold 1 and the second mold 2, reference may be made to the above description and will not be elaborated here. The third mold 4 may include an end portion 42 and a core 44 having one end connected to the end portion 42. The third mold 4 serves as a channel template for forming the simulated blood vessel channel 32.

[0056] Among them, the end portion 41 of the third mold 4 facilitates the operation by technicians holding it, and the core 42 is used to simulate the shape and size of the blood vessel to form the subsequent simulated blood vessel channel 32. In some embodiments, the diameter of the core 42 may gradually decrease from one end close to the end portion 41 towards the end away from the end portion 41. The diameter of the end portion 41 is larger than the diameter of the first opening 11, and the diameter of the core 42 is smaller than the diameter of the first opening 11. In the embodiments of the present application, the overall height H2 of the third mold 4 is approximately 430 mm, and the diameter of the core 42 gradually changes from 2 mm to 0.2 mm.

[0057] It can be understood that in practical applications, the shape and size of the third mold 4 are not limited, and the shape and size of the third mold 4 can be arbitrarily adjusted according to the shape and size of the blood vessel to be simulated.

[0058] In the embodiments of the present application, the following method can be adopted for this component to manufacture the blood vessel model device:

[0059] Seal the second opening 12 of the second mold 1 with the second mold 2, pour hydrogel from the first opening 11, insert the third mold 4 into the cavity 14 before the hydrogel starts to solidify, then continue to add hydrogel. After the hydrogel cures, a hydrogel body 3 is formed. Remove the third mold 4, and thus the simulated blood vessel channel 32 is formed, and the blood vessel model device is obtained.

[0060] Among them, the hydrogel can be selected from one of gelatin, sodium alginate, agar, active peptide, collagen, heparin, chondroitin sulfate, hyaluronic acid, mucopolysaccharide, glycoprotein, matrix gel, dextran, chitosan, polyethylene glycol diacrylate, or fibrinogen. The curing method of the hydrogel can be any method such as photocuring, thermal curing, or chemical crosslinking curing.

[0061] In the present application, the component for manufacturing the blood vessel model device only includes the first mold 1, the second mold 2, and the third mold 4. There is no need to use 3D printing technology. By relying on the curing after pouring hydrogel, the simulated blood vessel channel 32 can be obtained. The component has a simple structure, convenient operation, and low cost. Moreover, the hydrogel has a low cost and high repeatability, and is more suitable for multiple and batch screening during product research and development. In addition, by using the component in the present application, the elastic modulus of different human organs can be matched by adjusting the formula of the hydrogel, and the resistance brought by different organs can be better simulated. Thus, a blood vessel model device suitable for simulation tests of multiple different organs can be prepared.

[0062] The above are only the preferred embodiments of the present application and are not intended to limit the present application. For those skilled in the art, the present application may have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included within the protection scope of the present application.

Claims

1. A blood vessel model device, characterized in that: include: A first mold, wherein the first mold has a first end and a second end that are oppositely disposed, and a cavity that passes through the first end and the second end is provided in the first mold; A hydrogel body, wherein the hydrogel body is filled in the cavity, and a simulated blood vessel channel is penetrated through the hydrogel body; A second mold is disposed at the second end to confine the hydrogel body in the cavity.

2. The blood vessel model device according to claim 1, characterized in that: The first mold is made of transparent material.

3. The blood vessel model device according to claim 1, characterized in that: Along the direction from the first end to the second end, the diameter of the simulated blood vessel channel gradually decreases.

4. The blood vessel model device according to claim 1, characterized in that: The second end surface of the first mold is inwardly recessed to form a mounting groove, the mounting groove is connected to the cavity, the shape of the mounting groove matches the outer shape of the second mold, and the second mold is detachably disposed in the mounting groove.

5. The blood vessel model device according to any one of claims 1 to 4, characterized in that: The first end of the first mold is provided with a first opening, the second end is provided with a second opening, the second mold is penetrated by a through hole, and the simulated vascular channel connects the first opening, the second opening and the through hole; the first opening is used to inject the microspheres to be tested and the test liquid into the simulated vascular channel, and the second opening and the through hole are used to discharge the waste liquid generated after the test.

6. The blood vessel model device according to claim 5, characterized in that: The blood vessel model device also includes a liquid storage chamber, a liquid inlet pipe, a waste liquid collection chamber and a liquid outlet pipe. The liquid storage chamber is used to store the test liquid. The liquid inlet pipe connects the first opening and the liquid storage chamber. The liquid outlet pipe connects the second opening and the waste liquid collection chamber.

7. The blood vessel model device according to claim 5, characterized in that: The blood vessel model device further comprises a liquid inlet pipe, a liquid inlet pump, a waste liquid collection chamber and a liquid outlet pipe, wherein the liquid inlet pipe, the first opening, the second opening, the liquid outlet pipe, the waste liquid collection chamber, the liquid inlet pump and the liquid inlet pipe are sequentially connected to form a circulation path; A filter membrane is provided between the waste liquid collection chamber and the liquid inlet pump.

8. A component for manufacturing a blood vessel model device, characterized in that: include: A first mold, wherein the first mold has a first end and a second end that are oppositely disposed, and a cavity that passes through the first end and the second end is provided in the first mold, and the cavity is used to fill a hydrogel body formed after the hydrogel is cured; a second mold, the second mold being disposed at the second end of the first mold to confine the hydrogel body in the cavity; A third mold is used to be inserted into the cavity and removed after the hydrogel is solidified to form a simulated blood vessel channel in the hydrogel body.

9. The assembly according to claim 8, characterized in that The third mold includes an end portion and a column core whose one end is connected to the end portion, and a diameter of the column core gradually decreases from an end close to the end portion toward an end far away from the end portion.

10. The assembly according to claim 9, characterized in that The diameter of the column core gradually decreases from 1 to 2 mm to 0.1 to 0.2 mm.

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