Solvent evaporation and recovery device for producing atorvastatin calcium intermediate M4

Abstract

The utility model discloses a solvent evaporation and recovery device for producing atorvastatin calcium intermediates M4, which comprises a plurality of exhaust pipelines on production equipment, each exhaust pipeline is provided with a fire-retardant single exhalation valve, the exhalation end of each fire-retardant single exhalation valve is connected with one end of an air inlet pipe through a flange, and the other end of the air inlet pipe is connected with the other end of the fire-retardant single exhalation valve. The other end of each air inlet pipe is correspondingly inserted into the bottom of a cooling area of a water cooler, a circulating cooling water pipe is arranged in the water cooler, a plurality of baffle plates are arranged in the cooling area in a crossed mode, the bottom of the water cooler is connected with a liquid inlet of a collecting tank through a flow guide pipe, and air outlet pipes are arranged at the tops of the cooling areas of the water cooler. The top of each gas outlet pipe is connected with a waste gas pipeline, and the waste gas pipeline flows to the gas inlet end of the burn-back furnace. According to the technical scheme, different solvent steam discharged by multiple pieces of production equipment can be collected and uniformly cooled and separated through the cooler, so that the solvent steam discharged by the breather valve is effectively recycled, the use waste of the solvent is avoided, and the cost is saved.

Description

Technical Field:

[0001] The utility model relates to the technical field of pharmaceutical processing, and specifically relates to a solvent evaporation recovery device for the production of atorvastatin calcium intermediate M4. Background Art:

[0002] Atorvastatin calcium is a kind of lipid-lowering drug. Atorvastatin M4 is an important intermediate (main ring) for the production of this kind of drug atorvastatin calcium (trade name Lipitor). Its market capacity is closely related to the market capacity of lipid-lowering drugs. This product is used in large quantities in the pharmaceutical field. Large enterprises use more than medium and small enterprises, and it can maintain a certain scale of use for a long time.

[0003] Generally, the production of atorvastatin M4 mostly uses a variety of solvents. The production of atorvastatin M4 needs to be completed through multiple processes. Each process uses different production equipment (including reaction kettles, storage tanks, drying equipment, rectification equipment, etc.) according to different solvents. During the production process, each production equipment will generate solvent vapor and discharge it into its respective exhaust pipe. Usually, a breather valve is installed on the exhaust pipe to ensure the stability of the air pressure in the pipe. However, the problem is that the solvent vapor discharged through the breather valve is not effectively recycled and is basically discharged into the air, resulting in waste of resources. Content of the Utility Model:

[0004] The purpose of the utility model is to provide a solvent evaporation recovery device for the production of atorvastatin calcium intermediate M4 to solve the problems put forward in the above background art.

[0005] The utility model is implemented by the following technical solutions:

[0006] A solvent evaporation recovery device for the production of atorvastatin calcium intermediate M4 includes exhaust pipes on multiple production equipment. A fireproof single breather valve is installed on each exhaust pipe. The exhalation end of each fireproof single breather valve is connected to one end of an inlet pipe through a flange. The other end of each inlet pipe is respectively inserted into the bottom of the cooling area of a water cooler. A circulating cooling water pipe is arranged in the water cooler. A plurality of baffle plates are cross-arranged in the cooling area. The bottom of the water cooler is connected to the liquid inlet of a collection tank through a diversion pipe. An outlet pipe is arranged at the top of each cooling area of the water cooler. The tops of the outlet pipes are all connected to an exhaust gas pipe, and the exhaust gas pipe flows to the intake end of a backfire furnace.

[0007] Preferably, the circulating cooling water pipe runs through all the cooling areas.

[0008] Preferably, there are multiple cooling areas, including a methanol cooling area, a toluene cooling area, a dichloromethane cooling area, and an isopropanol cooling area.

[0009] Preferably, the upper surface of the baffle plate slopes downward toward the middle position of the cooling zone.

[0010] Advantages of the present utility model: It can collect different solvent vapors discharged from multiple production devices at the same time, and perform unified cooling and separation through a cooler, so that the solvent vapors discharged from the breather valve can be effectively recycled, avoiding waste of solvent use and saving costs. Description of the drawings:

[0011] Figure 1 is a schematic structural diagram of the present utility model;

[0012] Figure 2 is Figure 1 a cross-sectional view at A in

[0013] Figure 3 is Figure 2 a top view of

[0014] In the figure: 1. Exhaust pipe, 2. Flame arrestor single breathing valve, 3. Inlet pipe, 4. Water cooler, 4.1 Methanol cooling zone, 4.2 Toluene cooling zone, 4.3 Dichloromethane cooling zone, 4.4 Isopropanol cooling zone, 5. Circulating cooling water pipe, 6. Baffle plate, 7. Diversion pipe, 8. Collection tank, 9. Outlet pipe, 10. Exhaust gas pipe. Specific embodiments:

[0015] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0016] Please refer to Figures 1-3 , the present utility model provides a technical solution for a solvent evaporation recovery device for the production of atorvastatin calcium intermediate M4:

[0017] A solvent evaporation and recovery device for the production of atorvastatin calcium intermediate M4, comprising exhaust pipes 1 on multiple production devices. A fire prevention single check valve 2 is installed on each exhaust pipe 1. The exhalation end of each fire prevention single check valve 2 and one end of the intake pipe 3 are connected by a flange. The other end of each intake pipe 3 is respectively inserted into the bottom of the cooling area of the water cooler 4. A circulating cooling water pipe 5 is arranged in the water cooler 4, and the circulating cooling water pipe 5 penetrates through all cooling areas. There are multiple cooling areas, including a methanol cooling area 4.1, a toluene cooling area 4.2, a dichloromethane cooling area 4.3, an isopropanol cooling area 4.4, etc. A plurality of baffle plates 6 are arranged crosswise in the cooling area. The upper surface of the baffle plate 6 slopes downward towards the middle position of the cooling area, facilitating the downward flow of the condensed solvent liquid. The bottom of the water cooler 4 is connected to the liquid inlet of the collection tank 8 through a diversion pipe 7. An air outlet pipe 9 is arranged at the top of each cooling area of the water cooler 4, and the top of each air outlet pipe 9 is connected to the exhaust gas pipe 10. The exhaust gas pipe 10 flows towards the intake end of the afterburner furnace.

[0018] The working principle is as follows: The solvent vapor exhaled from the fire prevention single check valve 2 on the exhaust pipe 1 of different solvents can be respectively introduced into the corresponding cooling areas in the water cooler 4 through the intake pipe 3. After the solvent vapor enters the cooling area, under the action of the circulating cooling water pipe 5, it is cooled to form a liquid, which is collected into the collection tank 8 through the diversion pipe 7 for recovery. At the same time, the uncondensed gas that is not cooled in each cooling area is uniformly collected through the air outlet pipe 9 at the top of its respective cooling area and flows into the exhaust gas pipe 10. Finally, the uncondensed gas is discharged into the afterburner furnace along the exhaust gas pipe 10 for fuel recovery and utilization.

[0019] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A solvent evaporation and recovery device for the production of atorvastatin calcium intermediate M4, comprising exhaust pipes (1) on a plurality of production equipment, each of the exhaust pipes (1) being equipped with a flame-blocking single-call valve (2), characterized in that: The exhalation end of each fire-blocking single-call valve (2) and one end of the air inlet pipe (3) are connected by a flange, and the other end of each air inlet pipe (3) is respectively inserted into the bottom of the cooling zone of the water cooler (4). A circulating cooling water pipe (5) is arranged in the water cooler (4), and a plurality of baffles (6) are cross-arranged in the cooling zone. The bottom of the water cooler (4) is connected to the liquid inlet of the collecting tank (8) through a guide pipe (7). The top of each cooling zone of the water cooler (4) is provided with an air outlet pipe (9), and the top of each air outlet pipe (9) is connected to the exhaust gas pipe (10), and the exhaust gas pipe (10) flows to the air inlet end of the reburning furnace.

2. The solvent evaporation recovery device for producing atorvastatin calcium intermediate M4 according to claim 1, characterized in that: The circulating cooling water pipe (5) runs through all cooling zones.

3. The solvent evaporation recovery device for producing atorvastatin calcium intermediate M4 according to claim 1, characterized in that: The cooling zones are provided in plurality, including a methanol cooling zone (4.1), a toluene cooling zone (4.2), a dichloromethane cooling zone (4.3) and an isopropanol cooling zone (4.4).

4. The solvent evaporation recovery device for producing atorvastatin calcium intermediate M4 according to claim 1, characterized in that: The upper surface of the baffle (6) is inclined downward toward the middle position of the cooling zone.

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