Emulsifying device for microsphere preparation

Abstract

The utility model relates to the technical field of microsphere preparation, and discloses an emulsifying device for microsphere preparation, which comprises an emulsifying machine body, the emulsifying machine body comprises a reaction kettle, and the bottom of the surface of the reaction kettle is fixedly connected with a heating outer frame. According to the emulsifying device for microsphere preparation, water is injected into an inner cavity of a water tank through a water inlet pipe, then after the water tank is filled with water, a pipe cover is fixedly installed at the top of the water inlet pipe, then a water pump is started, water in the water tank is pumped into the inner cavity of the water inlet pipe through work of the water pump, and then the water is guided through an annular pipe; the inner wall of the reaction kettle is cleaned by spraying water, and then the water is sprayed out through the spray head, so that the effect of cleaning the inner wall of the reaction kettle by spraying water is achieved, and the problem that a large amount of materials remaining in the previous emulsification process are adhered to the interior of the reaction kettle due to the fact that an operator cannot conveniently clean the inner wall of the reaction kettle in the using process of an existing emulsification device can be solved.

Description

Technical Field

[0001] The utility model relates to the technical field of microsphere preparation, and particularly relates to an emulsifying device for microsphere preparation. Background Technique

[0002] Microspheres refer to a particulate dispersion system in which drugs are dispersed or adsorbed in a polymer matrix. The preparation methods of microspheres mainly include three types: emulsification dispersion method, coacervation method, and polymerization method. These methods can select different preparation methods according to the particle size, drug release performance, and clinical administration route of the required microspheres.

[0003] However, during the use of the existing emulsifying device, it is not convenient for operators to clean the inner wall of the reaction kettle, which will cause a large amount of materials remaining from the previous emulsification process to adhere to the inside of the reaction kettle. This will easily cause pollution and corrosion to the next emulsification work, and then affect the preparation effect of microspheres and reduce the use effect of subsequent microspheres. To solve the above problems, we have made improvements and proposed an emulsifying device for microsphere preparation. Content of the Utility Model

[0004] The purpose of the utility model is to provide an emulsifying device for microsphere preparation to solve the problems raised in the above background technique.

[0005] To achieve the above purpose, the utility model provides the following technical solutions:

[0006] An emulsifying device for microsphere preparation, including an emulsifying machine body. The emulsifying machine body includes a reaction kettle. The bottom of the surface of the reaction kettle is fixedly connected with a heating outer frame. A scraper is installed in the inner cavity of the reaction kettle. The surface of the scraper is movably connected to the inner cavity of the reaction kettle. The top of the reaction kettle is fixedly connected with a servo motor I. The output end of the servo motor I penetrates into the inner cavity of the reaction kettle and is fixedly connected with a rotating shaft. The bottom of the rotating shaft is fixedly connected with a sector plate. The front side of the top of the reaction kettle is communicated with a feeding pipe. The bottom of the reaction kettle is communicated with a discharging pipe. A cleaning mechanism is installed on the left side of the heating outer frame;

[0007] The cleaning mechanism includes a water tank. The right side of the water tank is fixedly connected to the left side of the reaction kettle. The top of the water tank is fixedly connected with a water pump. The output end of the water pump is fixedly connected to the inner cavity of the water tank. The output end of the water pump is communicated with a water inlet pipe. The right side of the surface of the water inlet pipe penetrates into the inner cavity of the reaction kettle and is communicated with an annular pipe. The bottom of the annular pipe is communicated with a plurality of spray heads.

[0008] As a further solution of the utility model: a water inlet pipe is communicated with the back side of the top of the water tank, a pipe cover is movably connected to the top of the surface of the water inlet pipe, a support column is fixedly connected to the outer side of the annular pipe, and the outer side of the support column is fixedly connected to the inner cavity of the reaction kettle.

[0009] As a further solution of the utility model: columns are fixedly connected to the four corners of the bottom of the heating outer frame, anti-slip pads are fixedly connected to the bottoms of the columns, the anti-slip pads are arranged in a circular structure, sealing covers are movably connected to the top of the surface of the feeding pipe and the bottom of the surface of the discharging pipe, and a thermometer is fixedly connected to the front side of the inner cavity of the heating outer frame.

[0010] As a further solution of the utility model: a circular frame is installed on the surface of the sector plate, a connecting rod is fixedly connected to the top of the circular frame, a connecting plate is fixedly connected to the top of the connecting rod, an inclined column is fixedly connected to the top of the connecting plate, the inclined column is arranged at an inclined angle, a positioning plate is fixedly connected to the top of the inclined column, and the inner side of the positioning plate is fixedly connected to the surface of the rotating shaft.

[0011] As a further solution of the utility model: a moving mechanism is installed on the left side of the back side of the reaction kettle. The moving mechanism comprises a second servo motor. The output end of the second servo motor penetrates into the inner cavity of the reaction kettle and is fixedly connected to a worm. The front side of the worm is movably connected to the front side of the inner cavity of the reaction kettle. A worm gear is meshed and connected to the left side of the worm. A screw rod is fixedly connected to the bottom of the worm gear. A screw sleeve is meshed and connected to the surface of the screw rod. The surface of the screw sleeve is fixedly connected to the left side of the inner cavity of the scraper.

[0012] As a further solution of the utility model: a guide rod is movably connected to the right side of the inner cavity of the scraper. A fixing plate is fixedly connected to the back side of the second servo motor. The right side of the front side of the fixing plate is fixedly connected to the inner cavity of the reaction kettle.

[0013] As a further solution of the utility model: a top plate is movably connected to the top of the surface of the screw rod. The surface of the top plate is fixedly connected to the inner cavity of the reaction kettle. A support plate is movably connected to the bottom of the screw rod. The surface of the support plate is fixedly connected to the inner cavity of the reaction kettle. The top and the bottom of the guide rod are respectively fixedly connected to the bottom of the top plate and the top of the support plate.

[0014] Compared with the prior art, the beneficial effects of the utility model are:

[0015] 1. The utility model injects water into the inner cavity of the water tank through the water inlet pipe. Then, after the water tank is filled with water, the pipe cap is installed and fixed on the top of the water inlet pipe. Then, the water pump is started. Subsequently, through the operation of the water pump, the water inside the water tank is pumped into the inner cavity of the water inlet pipe, and then the water is guided through the annular pipe and then sprayed out through the nozzle, thereby achieving the effect of spraying and cleaning the inner wall of the reaction kettle. It can solve the problem that in the existing emulsifying device during use, it is not convenient for the operator to clean the inner wall of the reaction kettle, which will cause a large amount of materials remaining from the previous emulsification process to adhere to the inside of the reaction kettle, thus easily causing pollution and corrosion to the next emulsification work, further affecting the preparation effect of the microspheres and reducing the use effect of the subsequent microspheres.

[0016] 2. Through the setting of the water inlet pipe, it is more convenient for the operator to inject water into the inner cavity of the water tank through the water inlet pipe. Through the setting of the pipe cap, it achieves the effect of sealing the water tank in the working state and prevents dust in the air from entering the inner cavity of the water tank. Through the setting of the support column, it realizes the effect of supporting and fixing the annular pipe in the working state. Through the setting of the support column and the anti-slip pad, it realizes the effect of supporting and anti-slip for the heating outer frame and the reaction kettle in the working state. Through the setting of the sealing cover, it achieves the effect of sealing the inner cavity of the reaction kettle in the working state and prevents dust in the air from entering the inner cavity of the reaction kettle, thereby affecting the emulsification work in the inner cavity of the reaction kettle. Description of the Drawings

[0017] Figure 1 It is a schematic structural diagram of an emulsifying device for microsphere preparation;

[0018] Figure 2 It is a rear view of the reaction kettle in an emulsifying device for microsphere preparation;

[0019] Figure 3 It is a sectional view of the reaction kettle in an emulsifying device for microsphere preparation;

[0020] Figure 4 It is a sector plate in an emulsifying device for microsphere preparation;

[0021] Figure 5 It is a schematic structural connection diagram of the nozzle in an emulsifying device for microsphere preparation;

[0022] Figure 6 It is a schematic structural connection diagram of the guide rod in an emulsifying device for microsphere preparation.

[0023] In the figure: 1. Emulsifying machine body; 101. Reaction kettle; 102. Heating outer frame; 103. Servo motor I; 104. Thermometer; 105. Support pillar; 106. Anti-slip mat; 107. Rotating shaft; 108. Scraper; 109. Discharge pipe; 110. Feed pipe; 111. Sealing cover; 112. Positioning plate; 113. Inclined column; 114. Connecting rod; 115. Circular frame; 116. Sector plate; 117. Connecting plate; 2. Cleaning mechanism; 201. Water tank; 202. Water pump; 203. Water inlet pipe; 204. Pipe cover; 205. Water inlet pipe; 206. Annular pipe; 207. Nozzle; 208. Support column; 3. Moving mechanism; 301. Servo motor II; 302. Worm; 303. Worm gear; 304. Nut bushing; 305. Screw; 306. Support plate; 307. Guide rod; 308. Top plate; 309. Fixed plate. Detailed implementation mode

[0024] To make the purpose, technical solutions and advantages of the embodiments of the present utility model clearer, the technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are part of the embodiments of the present utility model, rather than all of them. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative work belong to the scope of protection of the present utility model.

[0025] Embodiment

[0026] Please refer to Figure 1 、 2 Figures 3, 4, 5 and 6, an emulsifying device for microsphere preparation, including an emulsifying machine body 1, the emulsifying machine body 1 includes a reaction kettle 101, the bottom of the surface of the reaction kettle 101 is fixedly connected with a heating outer frame 102, a scraper 108 is installed in the inner cavity of the reaction kettle 101, the surface of the scraper 108 is movably connected to the inner cavity of the reaction kettle 101, the top of the reaction kettle 101 is fixedly connected with a servo motor I 103, the output end of the servo motor I 103 penetrates into the inner cavity of the reaction kettle 101 and is fixedly connected with a rotating shaft 107, the bottom of the rotating shaft 107 is fixedly connected with a sector plate 116, the front side of the top of the reaction kettle 101 is communicated with a feed pipe 110, the bottom of the reaction kettle 101 is communicated with a discharge pipe 109, and a cleaning mechanism 2 is installed on the left side of the heating outer frame 102;

[0027] The cleaning mechanism 2 includes a water tank 201. The right side of the water tank 201 is fixedly connected to the left side of the reaction kettle 101. A water pump 202 is fixedly connected to the top of the water tank 201. The output end of the water pump 202 is fixedly connected to the inner cavity of the water tank 201. The output end of the water pump 202 is communicated with a water inlet pipe 203. The right side of the surface of the water inlet pipe 203 penetrates into the inner cavity of the reaction kettle 101 and is communicated with an annular pipe 206. The bottom of the annular pipe 206 is communicated with a spray head 207. The number of the spray heads 207 is multiple.

[0028] The back side of the top of the water tank 201 is communicated with a water inlet pipe 205. The top of the surface of the water inlet pipe 205 is movably connected with a pipe cover 204. The outer side of the annular pipe 206 is fixedly connected with a support column 208. The outer side of the support column 208 is fixedly connected to the inner cavity of the reaction kettle 101. Through the arrangement of the water inlet pipe 205, it is more convenient for the operator to inject water into the inner cavity of the water tank 201 through the water inlet pipe 205. Through the arrangement of the pipe cover 204, the function of sealing the water tank 201 in the working state is achieved, and dust in the air is prevented from entering the inner cavity of the water tank 201. Through the arrangement of the support column 208, the effect of supporting and fixing the annular pipe 206 in the working state is realized. The four corners of the bottom of the heating outer frame 102 are fixedly connected with support columns 105. The bottom of the support columns 105 is fixedly connected with anti-slip pads 106. The anti-slip pads 106 are arranged in a circular structure. The top of the surface of the feeding pipe 110 and the bottom of the surface of the discharging pipe 109 are both movably connected with sealing covers 111. A thermometer 104 is fixedly connected to the front side of the inner cavity of the heating outer frame 102. Through the arrangement of the support columns 105 and the anti-slip pads 106, the effect of supporting and anti-slip of the heating outer frame 102 and the reaction kettle 101 in the working state is realized. Through the arrangement of the sealing covers 111, the function of sealing the inner cavity of the reaction kettle 101 in the working state is achieved, and dust in the air is prevented from entering the inner cavity of the reaction kettle 101, thereby affecting the emulsification work in the inner cavity of the reaction kettle 101.

[0029] A circular frame 115 is mounted on the surface of the sector plate 116. A connecting rod 114 is fixedly connected to the top of the circular frame 115. A connecting plate 117 is fixedly connected to the top of the connecting rod 114. An inclined column 113 is fixedly connected to the top of the connecting plate 117. The inclined column 113 is arranged at an inclined angle. A positioning plate 112 is fixedly connected to the top of the inclined column 113. The inner side of the positioning plate 112 is fixedly connected to the surface of the rotating shaft 107. By starting the first servo motor 103, the rotation of the rotating shaft 107 is driven by the operation of the first servo motor 103. Subsequently, the sector plate 116 is driven to rotate. Then, the positioning plate 112 is driven to rotate by the rotation of the rotating shaft 107. Subsequently, the inclined column 113 is driven to rotate. Then, the connecting plate 117 is driven to rotate. Subsequently, the connecting rod 114 is driven to move. Then, the circular frame 115 is driven to rotate, thereby achieving the effect of high-shear mixing and emulsification. A guide rod 307 is movably connected to the right side of the inner cavity of the scraper 108. A fixing plate 309 is fixedly connected to the back side of the second servo motor 301. The right side of the front side of the fixing plate 309 is fixedly connected to the inner cavity of the reaction kettle 101. By providing the guide rod 307, the effect of guiding the scraper 108 in a moving state is achieved. By providing the fixing plate 309, the function of supporting and fixing the second servo motor 301 in a working state is achieved, avoiding the phenomenon that the second servo motor 301 shakes and drops during the working process. The top of the surface of the screw rod 305 is movably connected to a top plate 308. The surface of the top plate 308 is fixedly connected to the inner cavity of the reaction kettle 101. The bottom of the screw rod 305 is movably connected to a support plate 306. The surface of the support plate 306 is fixedly connected to the inner cavity of the reaction kettle 101. The top and bottom of the guide rod 307 are respectively fixedly connected to the bottom of the top plate 308 and the top of the support plate 306. By providing the top plate 308 and the support plate 306, the function of supporting the screw rod 305 and the guide rod 307 in a working state is achieved, thereby ensuring the stability of the screw rod 305 and the guide rod 307 during operation.

[0030] Please refer to Figure 2 and 6, An emulsifying device for microsphere preparation. A moving mechanism 3 is installed on the left side of the back of the reaction kettle 101. The moving mechanism 3 includes a second servo motor 301. The output end of the second servo motor 301 penetrates into the inner cavity of the reaction kettle 101 and is fixedly connected to a worm 302. The front side of the worm 302 is movably connected to the front side of the inner cavity of the reaction kettle 101. A worm gear 303 is meshed and connected to the left side of the worm 302. A screw rod 305 is fixedly connected to the bottom of the worm gear 303. A screw sleeve 304 is meshed and connected to the surface of the screw rod 305. The surface of the screw sleeve 304 is fixedly connected to the left side of the inner cavity of the scraper 108. By starting the second servo motor 301, the worm 302 is driven to rotate through the operation of the second servo motor 301, and then the worm gear 303 is driven to rotate, and then the screw rod 305 is driven to rotate. Subsequently, the screw sleeve 304 is driven to move under the action of meshing, and then the scraper 108 is moved up and down. Subsequently, the scraper 108 scrapes and cleans the inner wall of the reaction kettle 101. At the same time, the movement of the scraper 108 drives the scraper 108 to slide on the surface of the guide rod 307, thereby achieving the function of guiding the scraper 108 in a moving state.

[0031] The working principle of the present utility model is as follows: First, hold by hand and pour water into the inner cavity of the water tank 201 through the water inlet pipe 205. Then, hold by hand and place the pipe cap 204 on the top of the water inlet pipe 205. Then, start the first servo motor 103. Through the operation of the first servo motor 103, drive the rotating shaft 107 to rotate. Subsequently, drive the sector plate 116 to rotate. Then, through the rotation of the rotating shaft 107, drive the positioning plate 112 to rotate. Subsequently, drive the inclined column 113 to rotate. Then, drive the connecting plate 117 to rotate. Subsequently, drive the connecting rod 114 to move. Then, drive the circular frame 115 to rotate, thereby achieving the effect of high-shear mixing and emulsification. Secondly, hold by hand and install the sealing cover 111 at the bottom of the discharge pipe 109. Subsequently, the operator pours the material into the inner cavity of the reaction kettle 101 through the feeding pipe 110. Then, hold by hand and install and fix the sealing cover 111 on the top of the feeding pipe 110. Subsequently, shear, mix and emulsify the material through the sector plate 116 and the circular frame 115. Then, hold by hand and remove the sealing cover 111 from the bottom of the discharge pipe 109, thereby achieving the function of discharging materials for the scraper 108. Finally, after the discharging is completed, start the second servo motor 301. Through the operation of the second servo motor 301, drive the worm 302 to rotate. Subsequently, drive the worm gear 303 to rotate. Then, drive the screw rod 305 to rotate. Subsequently, drive the nut sleeve 304 to move under the meshing action. Then, make the scraper 108 move up and down. Subsequently, make the scraper 108 scrape and clean the inner wall of the reaction kettle 101. At the same time, drive the scraper 108 to slide on the surface of the guide rod 307 through the movement of the scraper 108, thereby achieving the function of guiding the scraper 108 in the moving state. Then, start the water pump 202. Subsequently, through the operation of the water pump 202, the water inside the water tank 201 is pumped into the inner cavity of the water inlet pipe 203. Then, make the water flow through the annular pipe 206 and then be sprayed out through the nozzle 207, thereby achieving the function of spraying water and scraping and cleaning the inner wall of the reaction kettle 101 through the scraper 108 and the nozzle 207.

[0032] The above-mentioned is only the preferred specific embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present utility model, according to the technical solution of the present utility model and its inventive concept, makes equivalent substitutions or changes, and all should be covered within the protection scope of the present utility model.

Claims

1. An emulsifying device for preparing microspheres, comprising an emulsifying machine body (1), characterized in that: The emulsifying machine body (1) comprises a reactor (101), the bottom of the surface of the reactor (101) is fixedly connected to a heating outer frame (102), the inner cavity of the reactor (101) is installed with a scraper (108), the surface of the scraper (108) is movably connected to the inner cavity of the reactor (101), the top of the reactor (101) is fixedly connected to a servo motor (103), the output end of the servo motor (103) passes through the inner cavity of the reactor (101) and is fixedly connected to a rotating shaft (107), the bottom of the rotating shaft (107) is fixedly connected to a fan-shaped plate (116), the front side of the top of the reactor (101) is connected to a material inlet pipe (110), the bottom of the reactor (101) is connected to a material outlet pipe (109), and the left side of the heating outer frame (102) is installed with a cleaning mechanism (2); The cleaning mechanism (2) comprises a water tank (201), the right side of the water tank (201) is fixedly connected to the left side of the reaction kettle (101), the top of the water tank (201) is fixedly connected to a water pump (202), the output end of the water pump (202) is fixedly connected to the inner cavity of the water tank (201), the output end of the water pump (202) is connected to a water inlet pipe (203), the right side of the surface of the water inlet pipe (203) penetrates into the inner cavity of the reaction kettle (101) and is connected to an annular pipe (206), the bottom of the annular pipe (206) is connected to a nozzle (207), and the number of the nozzles (207) is multiple.

2. An emulsifying device for preparing microspheres according to claim 1, characterized in that: The back side of the top of the water tank (201) is connected to a water inlet pipe (205), the top of the surface of the water inlet pipe (205) is movably connected to a pipe cover (204), the outer side of the annular tube (206) is fixedly connected to a support column (208), and the outer side of the support column (208) is fixedly connected to the inner cavity of the reaction kettle (101).

3. An emulsifying device for preparing microspheres according to claim 1, characterized in that: The four corners of the bottom of the heating outer frame (102) are fixedly connected to pillars (105), the bottom of the pillars (105) is fixedly connected to an anti-skid pad (106), and the anti-skid pad (106) is arranged in a circular structure. The top of the surface of the feed pipe (110) and the bottom of the surface of the discharge pipe (109) are movably connected to a sealing cover (111), and the front side of the inner cavity of the heating outer frame (102) is fixedly connected to a temperature gauge (104).

4. An emulsifying device for preparing microspheres according to claim 1, characterized in that: A circular frame (115) is installed on the surface of the fan-shaped plate (116); the top of the circular frame (115) is fixedly connected to a connecting rod (114); the top of the connecting rod (114) is fixedly connected to a connecting plate (117); the top of the connecting plate (117) is fixedly connected to an inclined column (113); the inclined column (113) is arranged at an inclined angle; the top of the inclined column (113) is fixedly connected to a positioning plate (112); the inner side of the positioning plate (112) is fixedly connected to the surface of the rotating shaft (107).

5. An emulsifying device for preparing microspheres according to claim 1, characterized in that: A moving mechanism (3) is installed on the left side of the back side of the reactor (101), and the moving mechanism (3) includes a servo motor 2 (301). The output end of the servo motor 2 (301) penetrates the inner cavity of the reactor (101) and is fixedly connected to a worm (302). The front side of the worm (302) is movably connected to the front side of the inner cavity of the reactor (101). The left side of the worm (302) is meshedly connected to a worm wheel (303). The bottom of the worm wheel (303) is fixedly connected to a screw (305). The surface of the screw (305) is meshedly connected to a screw sleeve (304). The surface of the screw sleeve (304) is fixedly connected to the left side of the inner cavity of the scraper (108).

6. An emulsifying device for preparing microspheres according to claim 5, characterized in that: The right side of the inner cavity of the scraper (108) is movably connected to a guide rod (307), the back side of the servo motor 2 (301) is fixedly connected to a fixing plate (309), and the right side of the front side of the fixing plate (309) is fixedly connected to the inner cavity of the reaction kettle (101).

7. An emulsifying device for preparing microspheres according to claim 6, characterized in that: The top of the surface of the screw rod (305) is movably connected to a top plate (308), and the surface of the top plate (308) is fixedly connected to the inner cavity of the reaction kettle (101). The bottom of the screw rod (305) is movably connected to a support plate (306), and the surface of the support plate (306) is fixedly connected to the inner cavity of the reaction kettle (101). The top and bottom of the guide rod (307) are fixedly connected to the bottom of the top plate (308) and the top of the support plate (306), respectively.

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