Biological reaction bag with adjustable paddle position

Abstract

The utility model discloses a biological reaction bag with adjustable paddle position, which comprises an accommodating bag for accommodating substances and a stirring shaft at least partially arranged in the accommodating bag, at least one end of the stirring shaft is movably fixed with the accommodating bag, one end of the stirring shaft is connected with a driving mechanism, a plurality of stirring paddles are arranged on the stirring shaft, and the stirring paddles are connected with the accommodating bag. The plurality of stirring paddles comprise at least one movable stirring paddle; and the movable stirring paddle can move along the axial direction of the stirring shaft. According to the biological reaction bag with the position-adjustable paddles, the structure of the movable stirring paddle is arranged, so that the relative position between the movable stirring paddle and the stirring shaft is adjustable, and the position of the movable stirring paddle can be adjusted according to actual conditions, so that the optimal stirring effect is expected to be realized.

Description

Technical Field

[0001] The utility model relates to a biological reaction bag, in particular to a biological reaction bag with adjustable paddle position. Background Art

[0002] A stirring shaft for stirring is usually provided in a biological reaction bag. However, in the existing biological reaction bag, the position of the paddle on the stirring shaft is usually fixed, that is, it is impossible to adjust the position of the paddle according to the actual situation of the culture medium in the reaction bag (such as the liquid level height, viscosity, etc.). In the actual use process, for culture media with different liquid levels and different viscosities, the optimal stirring position of the paddle is not the same. Therefore, it is necessary to design a biological reaction bag with adjustable paddle position.

[0003] In the prior art, there is a reaction kettle with adjustable height of stirring blades disclosed in a Chinese patent with the publication number CN218359221U, including a reaction kettle body. A positioning column is vertically provided at the center of the inner wall of the top of the reaction kettle body. The bottom of the positioning column is slidably connected with a cross-shaped movable column. A cross-shaped connection groove for slidably connecting with the cross-shaped movable column is opened at the bottom of the positioning column. The end of the cross-shaped connection groove communicates with the outside. A plurality of stirring elements are arranged outside the cross-shaped movable column at equal intervals. Each stirring element includes a sleeve. A plurality of stirring blades distributed in a ring shape are arranged on the outer wall of the sleeve. The sleeve is detachably connected with the cross-shaped movable column through a fastening bolt. A plurality of threaded grooves are opened on the outer wall of the cross-shaped movable column at equal intervals.

[0004] For the reaction kettle with adjustable height of stirring blades disclosed in the above patent, the stirring blades are arranged on the cross-shaped movable column movably connected to the bottom of the reaction kettle body, and the position of the stirring paddle is adjusted by driving the relative movement between the cross-shaped movable column and the cross-shaped movable groove. However, this structure requires the end of the cross-shaped movable groove connecting the cross-shaped movable column to communicate with the outside, and the biological reaction bag usually requires sterility. Therefore, this structure cannot be applied to the biological reaction bag. In addition, under this structure, the adjustment of the position of the stirring paddle entirely depends on the experience of the operator, and manual adjustment is required every time new reaction substances are loaded, which is not convenient to use. Summary of the Utility Model

[0005] In order to solve the problems existing in the prior art, the utility model discloses a biological reaction bag with adjustable paddle position.

[0006] A bioreaction bag with adjustable blade position, comprising a containing bag for containing substances and a stirring shaft at least partially disposed within the containing bag. At least one end of the stirring shaft is movably fixed to the containing bag, and one end of the stirring shaft is connected to a driving mechanism. A plurality of stirring blades are provided on the stirring shaft, and the plurality of stirring blades include at least one movable stirring blade, which can move along the axial direction of the stirring shaft;

[0007] When the stirring shaft stirs the substances in the containing bag, the substances in the containing bag exert a thrust on the movable stirring blade. The magnitude of the thrust is controlled by controlling the rotational speed of the stirring shaft, and the direction of the thrust is controlled by controlling the rotational direction of the stirring shaft.

[0008] Specifically, generally speaking, the substances in the containing bag are culture substances in a fluid state. Therefore, during use, the movable stirring blade is subjected to four forces: the gravity of the movable stirring blade itself, the buoyancy force of the movable stirring blade in the culture substances, the thrust given by the culture substances to the movable stirring blade, and the frictional force between the movable stirring blade and the stirring shaft. When these four forces are in a balanced state, the relative position between the movable stirring blade and the stirring shaft can be maintained stable. When the four forces are unbalanced, the movable stirring blade will move along the axial direction of the stirring shaft. Therefore, by controlling the rotational speed of the stirring shaft, the balance state of the movable stirring blade can be controlled, and thus the relative position between the movable stirring blade and the stirring shaft can be changed; the purpose of adjusting the position of the movable stirring blade in the containing bag under sterile conditions is achieved.

[0009] Preferably, the movable stirring blade is movably connected to the stirring shaft through a sliding coupling member. The sliding coupling member includes a first sliding coupling member provided on the stirring shaft and a second sliding coupling member provided on the movable stirring blade; the first sliding coupling member is provided on the stirring shaft and extends along the axial direction of the stirring shaft. The axial dimension of the first sliding coupling member is smaller than the axial dimension of the stirring shaft, and the first sliding coupling member is movably connected to the second sliding coupling member.

[0010] Specifically, the first sliding coupling member can be a slide rail, and the second sliding coupling member can be a slider. The structures of the slider and the slide rail make the movement of the movable stirring blade on the stirring shaft smoother.

[0011] Preferably, at least one end of the first sliding coupling member is provided with an elastic member.

[0012] Specifically, an elastic member is provided at the upper end and / or the lower end of the first sliding coupling member. The elastic force of the elastic member enables a greater adjustment space for the rotational speed of the stirring shaft.

[0013] Preferably, the stirring shaft has a variable axial dimension.

[0014] Specifically, the stirring shaft with variable axial dimension can not only be applicable to accommodation spaces of more dimensions, but also make the stirring shaft easier to transport, that is, the stirring shaft is in the state with the minimum axial dimension during transportation.

[0015] Preferably, the stirring shaft includes a first part and a second part, and the first part and the second part are movably connected; the second part is a hollow cylindrical structure, and the first part is sleeved inside the second part;

[0016] The stirring shaft is also provided with a stop structure, and the stop structure is used to prevent the first part and the second part from separating, and the stop structure is used to transmit power.

[0017] Specifically, the structure in which the first part and the second part are sleeved is very convenient for adjusting the axial dimension of the stirring shaft, and the position where the stop structure is located determines the maximum axial dimension of the stirring shaft;

[0018] In addition, the stop structure is: a structure in which a protruding stop member provided on the inner wall of the second part cooperates with a groove provided on the outer wall of the first part, and a structure in which a spherical plunger protruding from the inner wall of the second part cooperates with an arc-shaped groove provided on the outer wall of the first part.

[0019] Preferably, a plurality of air inlet holes and exhaust holes are further provided on the accommodation bag, the air inlet holes are connected to a gas source, and the exhaust holes are connected to an exhaust device.

[0020] Preferably, at least one liquid discharge hole and at least one liquid replenishment hole are provided on the accommodation bag.

[0021] Specifically, the liquid in the accommodation bag is discharged through the liquid discharge hole, so the liquid discharge hole is usually arranged at a lower position of the accommodation bag. When liquid discharge is not required, the liquid discharge hole is not communicated with the inside and outside of the accommodation bag;

[0022] The liquid to be supplemented enters the accommodation bag through the liquid replenishment hole, so the liquid replenishment hole is usually arranged at a higher position of the accommodation bag. When liquid replenishment is not required, the liquid discharge hole is not communicated with the inside and outside of the accommodation bag.

[0023] Preferably, it further includes at least one sensor for monitoring parameters inside the accommodation bag, and the sensor is one or several of the following sensors: pH sensor, dissolved carbon dioxide sensor, dissolved oxygen sensor, liquid level sensor.

[0024] Specifically, various parameters of the culture substance in the accommodation bag can be detected in real time by using the sensor, which is convenient for the operator to obtain the parameters more quickly and intuitively, and is more conducive to the progress of the culture.

[0025] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0026] By setting the structure of the movable stirring paddle, the relative position between the movable stirring paddle and the stirring shaft can be adjusted, and the position of the movable stirring paddle can be adjusted according to the actual situation to achieve the best stirring effect. At the same time, the movable stirring paddle is set to a structure whose position can be adjusted by the thrust generated by the material to be stirred, and the magnitude of the thrust can be controlled by adjusting the rotation speed of the movable stirring paddle. That is, by adjusting the rotation speed of the movable stirring paddle, the relative position between the movable stirring paddle and the stirring shaft can be adjusted, achieving the purpose of adjusting the position of the movable stirring paddle in the containing bag under sterile conditions. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 FIG. is an overall schematic diagram of a bioreaction bag with adjustable paddle position provided by the present utility model;

[0028] Figure 2 FIG. is a schematic diagram of a first embodiment of the movable stirring paddle of the bioreaction bag with adjustable paddle position provided by the present utility model;

[0029] Figure 3 FIG. is a schematic diagram of a second embodiment of the movable stirring paddle of the bioreaction bag with adjustable paddle position provided by the present utility model;

[0030] Figure 4 FIG. is a schematic diagram of a third embodiment of the movable stirring paddle of the bioreaction bag with adjustable paddle position provided by the present utility model;

[0031] Figure 5 FIG. is a schematic diagram of a fourth embodiment of the movable stirring paddle of the bioreaction bag with adjustable paddle position provided by the present utility model. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0032] The present utility model will be further described below with reference to the accompanying drawings and specific embodiments.

[0033] As Figure 1 shown, the bioreaction bag with adjustable paddle position includes a containing bag 10 for containing substances and a stirring shaft 20 at least partially disposed in the containing bag 10. At least one end of the stirring shaft 20 is movably fixed to the containing bag 10, and one end of the stirring shaft 20 is connected to a driving mechanism. A plurality of stirring paddles 30 are provided on the stirring shaft 20. The plurality of stirring paddles 30 include at least one movable stirring paddle 31, and the movable stirring paddle 31 can move along the axial direction of the stirring shaft 20;

[0034] When the stirring shaft 20 stirs the substances in the containing bag 10, the substances in the containing bag 10 apply a thrust to the movable stirring paddle 31. The magnitude of the thrust is controlled by controlling the rotation speed of the stirring shaft 20, and the direction of the thrust is controlled by controlling the rotation direction of the stirring shaft 20.

[0035] Generally speaking, the substance in the accommodation bag 10 is a culture substance in a fluid state. Therefore, during the use of the movable stirring paddle 31, it is subjected to four forces: the gravity of the movable stirring paddle 31 itself, the buoyancy force of the movable stirring paddle 31 in the culture substance, the thrust force exerted by the culture substance on the movable stirring paddle 31, and the frictional force between the movable stirring paddle 31 and the stirring shaft 20. When these four forces are in a balanced state, the relative position between the movable stirring paddle 31 and the stirring shaft 20 can be kept stable. When the four forces are unbalanced, the movable stirring paddle 31 will move along the axial direction of the stirring shaft 20. Therefore, by controlling the rotation speed of the stirring shaft 20, the balance state of the movable stirring paddle 31 can be controlled, and then the relative position between the movable stirring paddle 31 and the stirring shaft 20 can be changed; the purpose of adjusting the position of the movable stirring paddle 31 in the accommodation bag 10 under sterile conditions is achieved.

[0036] As Figure 2 shown in the first embodiment, the movable stirring paddle 31 and the stirring shaft 20 are movably connected through a sliding coupling member. The sliding coupling member includes a first sliding coupling member 42 provided on the stirring shaft 20 and a second sliding coupling member 41 provided on the movable stirring paddle 31. The first sliding coupling member 42 is provided on the stirring shaft 20 and extends along the axial direction of the stirring shaft 20. The axial dimension of the first sliding coupling member 42 is smaller than the axial dimension of the stirring shaft 20, and the first sliding coupling member 42 is movably connected to the second sliding coupling member 41.

[0037] The first sliding coupling member 42 can be a slide rail, and the second sliding coupling member 41 can be a slider. The structures of the slider and the slide rail make the movement of the movable stirring paddle 31 on the stirring shaft 20 smoother.

[0038] As Figures 3 - 5 shown in the second, third, and fourth embodiments, at least one end of the first sliding coupling member 42 is provided with an elastic member 51.

[0039] The upper end and / or the lower end of the first sliding coupling member 42 is provided with an elastic member 51. The elastic force of the elastic member 51 enables the rotation speed of the stirring shaft 20 to have a larger adjustment space.

[0040] As Figure 1 shown, the stirring shaft 20 has a variable axial dimension.

[0041] The stirring shaft 20 with a variable axial dimension can not only be applicable to accommodation spaces of more sizes, but also make the stirring shaft 20 easier to transport, that is, the stirring shaft 20 is in the state with the smallest axial dimension during the transportation process.

[0042] The stirring shaft 20 includes a first part 21 and a second part 22. The first part 21 and the second part 22 are movably connected; the second part 22 is a hollow cylindrical structure, and the first part 21 is sleeved inside the second part 22.

[0043] The stirring shaft 20 is further provided with a stop structure 23 for preventing the first part 21 from separating from the second part 22 and for transmitting power.

[0044] The structure in which the first part 21 and the second part 22 are sleeved facilitates the adjustment of the axial dimension of the stirring shaft 20. The position where the stop structure 23 is located determines the maximum axial dimension of the stirring shaft 20.

[0045] In addition, the stop structure 23 is a structure in which a protruding stop member provided on the inner wall of the second part 22 cooperates with a groove provided on the outer wall of the first part 21, or a structure in which a spherical plunger protruding from the inner wall of the second part 22 cooperates with an arc-shaped groove provided on the outer wall of the first part 21.

[0046] The accommodating bag 10 is further provided with a plurality of air inlet holes 71 and air outlet holes 72. The air inlet holes 71 are connected to an air source, and the air outlet holes 72 are connected to an exhaust device.

[0047] The accommodating bag 10 is provided with at least one liquid discharge hole and at least one liquid replenishment hole.

[0048] The liquid in the accommodating bag 10 is discharged through the liquid discharge hole. Therefore, the liquid discharge hole is usually arranged at a lower position of the accommodating bag 10. When the liquid does not need to be discharged, the liquid discharge hole is not communicated with the inside and outside of the accommodating bag.

[0049] The liquid to be supplemented enters the accommodating bag 10 through the liquid replenishment hole. Therefore, the liquid replenishment hole is usually arranged at an upper position of the accommodating bag 10. When the liquid does not need to be replenished, the liquid discharge hole is not communicated with the inside and outside of the accommodating bag 10.

[0050] It further includes at least one sensor for monitoring the parameters inside the accommodating bag 10. The sensor is one or several of the following sensors: pH sensor, dissolved carbon dioxide sensor, dissolved oxygen sensor, liquid level sensor.

[0051] Specifically, the sensor can be used to detect various parameters of the culture substance inside the accommodating bag 10 in real time, facilitating the operator to obtain the parameters more quickly and intuitively, and being more conducive to the progress of the culture.

Claims

1. A bioreactor bag with adjustable blade position, comprising a containing bag for containing a substance and a stirring shaft at least partially disposed in the containing bag, wherein at least one end of the stirring shaft is movably fixed to the containing bag, and one end of the stirring shaft is connected to a driving mechanism, characterized in that: The stirring shaft is provided with a plurality of stirring paddles, the plurality of stirring paddles including at least one movable stirring paddle, and the movable stirring paddle can move along the axial direction of the stirring shaft.

2. The bioreactor bag with adjustable paddle position according to claim 1, characterized in that: When the stirring shaft stirs the material in the bag, the material in the bag gives thrust to the movable stirring paddle. The magnitude of the thrust is controlled by controlling the rotation speed of the stirring shaft, and the direction of the thrust is controlled by controlling the rotation direction of the stirring shaft.

3. The bioreactor bag with adjustable paddle position according to claim 1, characterized in that: The movable stirring paddle is movably connected to the stirring shaft via a sliding coupling.

4. The bioreactor bag with adjustable paddle position according to claim 3, characterized in that: The sliding coupling member comprises a first sliding coupling member arranged on the stirring shaft, and a second sliding coupling member arranged on the movable stirring paddle; The first sliding coupling member extends along the axial direction of the stirring shaft, the axial dimension of the first sliding coupling member is smaller than the axial dimension of the stirring shaft, and the first sliding coupling member is movably connected to the second sliding coupling member.

5. The bioreactor bag with adjustable paddle position according to claim 3, characterized in that: An elastic member is disposed at at least one end of the first sliding coupling member.

6. The bioreactor bag with adjustable paddle position according to claim 1, characterized in that: The stirring shaft has a variable axial dimension; the stirring shaft comprises a first part and a second part, the first part and the second part are movably connected; the second part is a hollow cylindrical structure, and the first part is sleeved inside the second part; The stirring shaft is also provided with a stop structure, which is used to prevent the first part from separating from the second part, and the stop structure is used to transmit power.

7. The bioreactor bag with adjustable paddle position according to claim 1, characterized in that: The containing bag is also provided with a plurality of air inlet holes and air outlet holes. The air inlet holes are connected to an air source, and the air outlet holes are connected to an exhaust device.

8. The bioreactor bag with adjustable paddle position according to claim 1, characterized in that: The containing bag is provided with at least one liquid drain hole and at least one liquid replenishing port.

9. The bioreactor bag with adjustable paddle position according to claim 1, characterized in that: Also included is at least one sensor for monitoring a parameter within the containment bag.

10. The bioreactor bag with adjustable paddle position according to claim 9, characterized in that: The sensor is one or more of the following sensors: a pH sensor, a dissolved carbon dioxide sensor, a dissolved oxygen sensor, and a liquid level sensor.

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