Portable semen detector

Abstract

The utility model discloses a portable semen detector and relates to the field of semen detectors. The device comprises a device body, the device body comprises a bottom box, a slot is formed in one side of the bottom box, a micro-flow control chip is arranged in the slot, a cover plate is arranged at the top of the bottom box, a focusing mechanism is arranged on one side in the bottom box, a lens mechanism is arranged in an open hole, and the lens mechanism is arranged in the open hole. According to the utility model, the scheme of micro-fluidic chip and combined lens imaging is adopted, the aberration of the combined lens is improved compared with that of a spherical lens, a better imaging effect can be provided, and in order to further improve the definition of image imaging, the focusing module is additionally arranged on the microscopic device, so that the imaging efficiency is improved. By adjusting the focusing condition of the instrument, the device can shoot a high-quality sperm image by using a smart phone on the premise of low cost control, thereby lowering the threshold for detection and evaluation of male fertility.

Description

Technical Field

[0001] The utility model relates to the field of semen detectors, in particular to a portable semen detector. Background Technique

[0002] The quality of male sperm is related to fertility problems. Usually, patients need to collect semen by themselves at a medical institution and hand it over to a professional doctor for semen examination. This process is time-consuming and costly. It is an ideal way to be able to conduct semen examination at home without the need for hospital diagnosis. However, manual detection based on a microscope and a computer-aided semen analysis (CASA) system are the current clinical standard methods. The former requires trained operators to observe and count, while the latter relies on a microscope image analysis system. With the gradual miniaturization and multi-functionality of electronic devices, integrating biomedical devices into a POCT diagnostic device has become an achievable approach. The idea of constructing a portable microscope based on a smart phone and applying it to semen examination has also become a reality.

[0003] Existing miniaturized semen analysis microscopy devices can be mainly divided into several components: small optical elements. This part can use a spherical lens or a hemispherical lens with a small effective focal length and a high magnification factor alone, and the same effect can also be achieved by combining multiple groups of lenses; a sample carrier platform. This part has an important impact on the accurate measurement of the concentration and vitality of semen samples. Usually, a structure of two glass slides adhered together is selected. After the semen sample is dropped, it penetrates into the cavity due to capillary action; an LED lamp, a device that provides light source, and the imaging device either relies on a mobile phone camera or a built-in imaging system in the system. Currently, common products of this type usually adopt an observation component with a spherical lens and a sample loading method of adhering upper and lower glass slides. Although such a combination has a low cost, it sacrifices certain imaging performance and measurement accuracy. Content of the Utility Model

[0004] Based on this, the purpose of the utility model is to provide a portable semen detector to solve the technical problem of poor imaging performance and measurement accuracy of existing semen detectors.

[0005] To achieve the above purpose, the utility model provides the following technical solution: a portable semen detector, including a device main body, the device main body includes a bottom box, a slot is opened on one side of the bottom box, a microfluidic control chip is arranged inside the slot, a cover plate is arranged on the top of the bottom box, a focusing mechanism is arranged on one side inside the bottom box, the focusing mechanism includes a focusing knob, a gear set is arranged on one side of the focusing knob, a bracket is arranged on the top of the gear set, an opening is opened on the surface of the cover plate, a lens mechanism is arranged inside the opening, and an LED mechanism is arranged below the lens mechanism.

[0006] By adopting the above technical solution, the combined lens has improved aberration compared with the spherical lens, so it can provide a better imaging effect. To further improve the image clarity, a focusing mechanism is installed on the microscopic device to optimize the image quality by adjusting the focusing of the instrument.

[0007] Further, fixed columns are fixedly arranged on the inner wall of the bottom box, and the fixed columns are used to limit the position of the focusing mechanism.

[0008] By adopting the above technical solution, the fixed columns fixedly arranged on the inner wall of the bottom box play a stable supporting role for the focusing mechanism, limit the position of the focusing mechanism, so that it will not move or shake randomly during operation, thus ensuring the accuracy and precision of focusing.

[0009] Further, the lens mechanism includes two convex lenses and a transparent plastic housing, and the convex lenses are lenses that can couple lasers.

[0010] By adopting the above technical solution, the two convex lenses adopted by the lens mechanism can provide a high magnification, so that the morphology and movement state of sperm can be seen more clearly when observing semen samples.

[0011] Further, the gear set is composed of two spur gears meshing with each other. The bracket is used to place the sample. A fixing member is arranged at the bottom of the gear set, and the fixing member is used for the installation connection of the gear set and the bottom box.

[0012] By adopting the above technical solution, this structure can ensure the smoothness and precision during the focusing process. When the user rotates the focusing knob, the gear set can smoothly transmit the rotational force to achieve fine adjustment of the focal length, thereby improving the clarity of observation.

[0013] Further, the LED mechanism includes a battery, a circuit group, an LED lamp and a plastic housing, and the LED lamp is a green light source.

[0014] By adopting the above technical solution, the green light source LED lamp in the LED mechanism can provide light suitable for observing sperm motility, making sperm more clearly visible under the microscope. The green light source helps to enhance the contrast of the sperm image, enabling the observer to more accurately judge the number, morphology and motility of sperm.

[0015] Further, the microfluidic control chip includes a PMMA layer and a glass slide layer, and a microfluidic bubble sphere is arranged on one side of the top of the PMMA layer.

[0016] By adopting the above technical solution, the PMMA layer and the glass slide layer in the microfluidic control chip jointly form a stable sample loading platform. This structure can not only ensure the uniform distribution of semen samples, but also facilitate the observation and analysis under the microscope.

[0017] Furthermore, a double-sided adhesive layer is provided between the PMMA layer and the glass slide layer.

[0018] By adopting the above technical solution, setting a double-sided adhesive layer between the PMMA layer and the glass slide layer can firmly bond these two layers together, forming a stable sample-bearing platform. This bonding method ensures the stability of the sample during microscopic observation, prevents the displacement or damage of the sample, and thus improves the accuracy of detection.

[0019] Furthermore, the bottom box is detachably connected to the cover plate through engagement holes and connecting columns.

[0020] By adopting the above technical solution, it provides great convenience for users, making the assembly, disassembly, cleaning, and maintenance of the microscope simple and easy, reducing the usage difficulty and maintenance cost.

[0021] In summary, the main beneficial effects of the present utility model are as follows:

[0022] The present utility model adopts a microfluidic chip and a combined lens imaging solution to design a microscopic device for instant detection of semen motility and concentration: the detection work on the microfluidic chip can be realized at the micron scale of semen, only requiring a small amount of sample and being able to improve the stability of the detection result; compared with the spherical lens, the combined lens has improved aberration and can provide a better imaging effect. In order to further improve the clarity of the image, a focusing module is installed on the microscopic device, and the focusing of the instrument can be adjusted. On the premise of controlling the low cost, the above solution enhances the accuracy of semen quality detection, and high-quality sperm images can be taken using a smartphone, reducing the threshold for the detection and evaluation of male fertility. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 is a three-dimensional structural schematic diagram of the present utility model;

[0024] Figure 2 is a cross-sectional structural schematic diagram of the present utility model;

[0025] Figure 3 is a structural schematic diagram of the bottom box of the present utility model;

[0026] Figure 4 is a bottom view structural schematic diagram of the cover plate of the present utility model;

[0027] Figure 5 is a structural schematic diagram of the microfluidic control chip of the present utility model;

[0028] Figure 6 is a structural schematic diagram of the focusing mechanism of the present utility model.

[0029] In the figure: 1. Device main body; 11. Bottom box; 12. Cover plate; 13. Slot; 14. Engagement hole; 15. Fixed column; 16. Opening; 2. Lens mechanism; 3. Focus adjustment mechanism; 31. Focus adjustment knob; 32. Gear set; 33. Bracket; 34. Fixing member; 4. LED mechanism; 5. Microfluidic control chip; 51. Microfluidic bubble sphere; 52. PMMA layer; 53. Double-sided adhesive layer; 54. Slide layer. Specific implementation mode

[0030] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. The embodiments described below by referring to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as a limitation to the present invention.

[0031] Next, the embodiments of the present invention will be described according to the overall structure of the present invention.

[0032] Portable semen detector, such as Figures 1-6 As shown, it includes a device main body 1. The device main body 1 includes a bottom box 11. A slot 13 is opened on one side of the bottom box 11. A microfluidic control chip 5 is arranged inside the slot 13. A cover plate 12 is arranged on the top of the bottom box 11. A focus adjustment mechanism 3 is arranged on one side inside the bottom box 11. The focus adjustment mechanism 3 includes a focus adjustment knob 31. A gear set 32 is arranged on one side of the focus adjustment knob 31. A bracket 33 is arranged on the top of the gear set 32. An opening 16 is opened on the surface of the cover plate 12. A lens mechanism 2 is arranged inside the opening 16. An LED mechanism 4 is arranged below the lens mechanism 2. The combined lens has improved aberration compared with the spherical lens, so it can provide a better imaging effect. In order to further improve the image clarity, a focus adjustment mechanism 3 is installed on the microscopic device to optimize the image quality by adjusting the focusing of the instrument. At the same time, on the premise of keeping the cost low, the accuracy of semen quality detection is significantly improved through the above scheme. With the help of a smart phone, users can easily take high-quality sperm images, which not only reduces the threshold of male fertility detection and evaluation, but also brings a more convenient and efficient health examination experience to the general public.

[0033] Refer to Figure 3, a fixing column 15 is fixedly arranged on the inner wall of the bottom box 11. The fixing column 15 is used to limit the position of the focusing mechanism 3. The fixing column 15 fixedly arranged on the inner wall of the bottom box 11 plays a stable supporting role for the focusing mechanism 3, limits the position of the focusing mechanism 3, so that it will not move or shake randomly during operation, thus ensuring the accuracy and precision of focusing. At the same time, the fixing column 15 can also effectively prevent the focusing mechanism 3 from shifting due to external forces, further enhancing the stability and reliability of the microscope. It not only improves the clarity of the image during semen detection, but also provides a better user experience. It is an important functional component in the microscope device.

[0034] Refer to Figure 1 , Figure 2 , Figure 4 , the lens mechanism 2 includes two convex lenses and a transparent plastic housing. The convex lenses are lenses that can couple lasers. The two convex lenses adopted by the lens mechanism 2 can provide a relatively high magnification, enabling the morphology and movement state of sperm to be seen more clearly when observing a semen sample. At the same time, these convex lenses can couple lasers, which means they can focus and transmit light more effectively, improving the resolution and contrast of imaging, making the observed image more vivid and rich in details, greatly enhancing the accuracy and reliability of semen detection, helping users to evaluate sperm quality more precisely, and providing strong technical support for the detection and evaluation of male fertility.

[0035] Refer to Figure 6 , the gear set 32 is composed of two spur gears meshing with each other. The bracket 33 is used to place the sample. A fixing part 34 is arranged at the bottom of the gear set 32. The fixing part 34 is used for the installation and connection of the gear set 32 and the bottom box 11. This structure can ensure the smoothness and precision during the focusing process. When the user rotates the focusing knob 31, the gear set 32 can smoothly transmit the rotational force to achieve fine adjustment of the focal length, thereby improving the clarity of observation. At the same time, the fixing part 34 arranged at the bottom of the gear set 32 ensures the firm connection between the gear set 32 and the bottom box 11, preventing misalignment or loosening caused by movement or vibration during use, further ensuring the stability of focusing and the accuracy of observation, making the entire focusing mechanism 3 more reliable, and providing high-quality imaging support for semen detection.

[0036] Refer to Figure 2, the LED mechanism 4 includes a battery, a circuit group, an LED lamp, and a plastic housing. The LED lamp is a green light source. The green light source LED lamp in the LED mechanism 4 can provide light suitable for observing sperm motility, making sperm more clearly visible under a microscope. The green light source helps enhance the contrast of sperm images, enabling the observer to more accurately judge the quantity, morphology, and motility of sperm. At the same time, the LED mechanism 4 includes a battery, a circuit group, and a plastic housing, making the entire LED lamp mechanism more compact and portable, facilitating users to perform semen tests anytime and anywhere. The green light source can also effectively avoid color difference interference, improve the imaging quality, and provide more accurate results for semen tests.

[0037] Refer to Figure 1 , Figure 3 , Figure 5 , the microfluidic control chip 5 includes a PMMA layer 52 and a glass slide layer 54. On one side of the top of the PMMA layer 52, there is a microfluidic bubble sphere 51. The PMMA layer 52 and the glass slide layer 54 in the microfluidic control chip 5 jointly form a stable sample loading platform. This structure can not only ensure the uniform distribution of semen samples but also facilitate observation and analysis under a microscope. At the same time, the microfluidic bubble sphere 51 set on one side of the top of the PMMA layer 52 can conveniently and quickly aspirate semen samples, greatly simplifying the sample loading steps and improving the detection efficiency. The setting of this microfluidic control chip is both practical and efficient, providing great convenience for semen tests and helping to improve the accuracy and reliability of detection.

[0038] Refer to Figure 1 , Figure 3 , Figure 5 , a double-sided adhesive layer 53 is provided between the PMMA layer 52 and the glass slide layer 54. Setting the double-sided adhesive layer 53 between the PMMA layer 52 and the glass slide layer 54 can firmly bond these two layers together to form a stable sample loading platform. This bonding method ensures the stability of the sample during microscope observation, prevents the displacement or damage of the sample, thereby improving the detection accuracy. At the same time, the use of the double-sided adhesive layer 53 also simplifies the assembly process of the microfluidic control chip 5, reduces the production cost and manufacturing difficulty. The double-sided adhesive layer 53 also has good sealing performance, which can prevent sample leakage and ensure the safety and reliability of detection. The double-sided adhesive layer 53 plays a key connection and fixing role in the microfluidic control chip 5.

[0039] Refer to Figure 3 , Figure 4, the bottom box 11 is detachably connected to the cover plate 12 through the engagement holes 14 and the connecting columns, which provides great convenience for users, makes the assembly, disassembly, cleaning and maintenance of the microscope simple and easy, reduces the usage difficulty and maintenance cost. At the same time, the detachable structure also means that when needed, users can easily upgrade or replace parts of the microscope, thus extending the service life of the microscope and improving its adaptability. This structure also helps to reduce the storage space, facilitate carrying and transportation, and meet the usage needs of users in different scenarios.

[0040] The implementation principle of the present utility model is as follows:

[0041] I. The microscopic device for immediate semen examination, the device main body 1 includes: a bottom box 11; a cover plate 12; a slot 13, an engagement hole 14, a fixing column 15. The whole device is made by 3D printing with PLA material. The bottom box 11 houses the focusing module and the LED lamp. The surface of the cover plate 12 can place a smart phone. To adapt to various mobile phone cameras, no other structures are added. The opening 16 part thereof adapts to the lens combination. The slot 13 is specially designed for placing the microfluidic chip. The engagement hole 14 mainly facilitates the mutual fitting of the bottom box 11 and the cover plate 12 for easy assembly. The fixing column 15 can fix the position of the focusing module, facilitating the installation of the focusing module and ensuring that the field of view does not shake easily during sample detection.

[0042] II. The lens mechanism 2 includes: two convex lenses and a plastic housing for assembling the two lenses. The convex lenses selected are lenses that can couple lasers, with a small focal length and a large numerical aperture, which can provide a high magnification and resolution. The selected lenses are glass aspherical lenses, divided into an objective lens and an eyepiece. The objective lens is selected with a numerical aperture greater than 0.25, and there is no such requirement for the eyepiece. The combined magnification of the two is between 200 - 400 times.

[0043] III. The focusing mechanism 3 includes: a focusing knob 31, a gear set 32, a bracket 33, a bottom connection fixing part 34. When in use, rotate the focusing knob 31 to drive the inner gear part to rotate; the base gear cooperates with the focusing knob and rotates together, causing the screw part on its upper part to rotate; the lower part of the bracket 33 is engraved with screw threads on the inner side and can be sleeved on the screw part above the base gear. As the base gear rotates, the top bracket 33 restricted from rotating by the fixing column 15 and the bottom box 11 moves up and down, and the sample is placed above the bracket 33, thereby being able to adjust the focal length; the bottom connection fixing part 34 is connected to the gear set 32, and the two are separated by the bottom of the bottom box 11, and the middle part is glued or fixed with screws. Its function is on the one hand to fix the position of the gear set, and on the other hand, not being connected to the gear set 32 is more convenient for later processing and assembly.

[0044] IV. LED mechanism 4: It includes a battery, a circuit group, an LED lamp and a plastic shell. The LED lamp uses a green light source suitable for observing sperm motility. In addition, the monochromatic light source can avoid the interference of lens chromatic aberration, which is beneficial for imaging.

[0045] V. The microfluidic control chip 5 includes: a microfluidic bubble sphere 51, which is made of ABS material and can provide negative pressure to suck in the semen sample; the PMMA layer 52 and the glass slide layer 54 are jointly fixed by the double-sided adhesive layer 53. Among them, the double-sided adhesive layer 53 selects a double-sided adhesive material with a thickness of 10 microns, and the microfluidic channel is cut by laser cutting; the PMMA layer 52 and the microfluidic bubble sphere 51 are glued together as a whole; the glass slide layer 54 is made of glass and is adhesively bonded to the PMMA layer 52 as a bearing platform for the semen sample.

[0046] Parts not involved in the present utility model are the same as or can be implemented by the prior art, and will not be elaborated here.

[0047] Although the embodiments of the present utility model have been shown and described, the specific embodiments are only explanations of the present utility model, and they are not limitations to the utility model. The specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. After reading this specification, those skilled in the art can make modifications, substitutions and variations that do not contribute creatively to the embodiments according to needs, but as long as they are within the scope of the claims of the present utility model, they are protected by the patent law.

Claims

1. A portable semen detector, characterized in that: The device comprises a device body (1), wherein the device body (1) comprises a bottom box (11), a slot (13) is provided on one side of the bottom box (11), a microfluidic control chip (5) is arranged inside the slot (13), a cover plate (12) is arranged on the top of the bottom box (11), a focusing mechanism (3) is arranged on one side of the bottom box (11), the focusing mechanism (3) comprises a focusing knob (31), a gear set (32) is arranged on one side of the focusing knob (31), a bracket (33) is arranged on the top of the gear set (32), an opening (16) is provided on the surface of the cover plate (12), a lens mechanism (2) is arranged inside the opening (16), and an LED mechanism (4) is arranged below the lens mechanism (2).

2. The portable semen detector according to claim 1, characterized in that: A fixing column (15) is fixedly provided on the inner wall of the bottom box (11), and the fixing column (15) is used to limit the position of the focusing mechanism (3).

3. The portable semen detector according to claim 1, characterized in that: The lens mechanism (2) comprises two convex lenses and a transparent plastic shell, and the convex lenses are lenses that can couple lasers.

4. The portable semen detector according to claim 1, characterized in that: The gear set (32) is composed of two meshing spur gears. The bracket (33) is used to place the sample. A fixing member (34) is provided at the bottom of the gear set (32). The fixing member (34) is used for installing and connecting the gear set (32) and the bottom box (11).

5. The portable semen detector according to claim 1, characterized in that: The LED mechanism (4) comprises a battery, a circuit group, an LED lamp and a plastic shell, and the LED lamp is a green light source.

6. The portable semen detector according to claim 1, characterized in that: The microfluidic control chip (5) comprises a PMMA layer (52) and a glass slide layer (54), and a microfluidic bubble ball (51) is arranged on one side of the top of the PMMA layer (52).

7. The portable semen detector according to claim 6, characterized in that: A double-sided adhesive layer (53) is provided between the PMMA layer (52) and the glass slide layer (54).

8. The portable semen detector according to claim 1, characterized in that: The base box (11) is in a detachable connection structure with the cover plate (12) via a joint hole (14) and a connection column.

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