Airflow filtering and drying device for polypeptide synthesis

Abstract

The utility model discloses an airflow filtering and drying device for polypeptide synthesis, which comprises a device body provided with an air inlet and an alkali liquor inlet pipe, and the device body is sequentially provided with a first chamber, a second chamber and a third chamber from bottom to top, the air inlet is communicated with the first cavity, a rotatable brush frame is arranged in the first cavity, a liquid guide disc communicated with an alkali liquor inlet pipe is arranged in the second cavity, a plurality of spray heads are arranged at the bottom of the liquid guide disc, the second cavity is communicated with the third cavity through a first communicating pipe, an exhaust pipe is arranged at the top of the third cavity, and the second cavity is communicated with the third cavity through a second communicating pipe. And the exhaust pipe exhausts the dried airflow. The brush frame is convenient to disassemble and assemble, the dust adsorption effect is improved, the sufficient reaction of alkali liquor and acid gas is improved, and exhausted airflow is dry and free of acid.

Description

Technical Field

[0001] The utility model relates to the technical field of polypeptide solid-phase synthesis, and particularly relates to an air flow filtering and drying device for polypeptide synthesis. Background Art

[0002] Polypeptide is a bioactive substance related to various cell functions in organisms. Its molecular structure is between amino acids and proteins, and it is a compound formed by multiple amino acids combined through peptide bonds in a certain arrangement order. Polypeptide is the general term for bioactive substances related to various cell functions in organisms, and is often applied in fields such as functional analysis, antibody research, especially drug R & D.

[0003] The requirements for reaction conditions in polypeptide solid-phase synthesis are very strict. Before the reaction, the solid-phase carrier needs to be treated to meet the requirements of being dry and acid-free. The traditional ventilation method is to use bottled compressed nitrogen instead of an air stirrer to meet the conditions of being dry and acid-free. There are problems that nitrogen cylinders are heavy and not easy to carry, occupy a large space, and have high production costs; in the existing air flow drying, the removal of dust in the air is not thorough, and in the process of acid removal, the alkali solution is located in the air flow to fully react to achieve the purpose of completely acid-free air flow, thus affecting solid-phase synthesis.

[0004] In view of this, this application is proposed. Summary of the Utility Model

[0005] The purpose of the utility model is to provide an air flow filtering and drying device for polypeptide synthesis. By setting a detachable brush rack in the first chamber, a rotatable liquid guide disk in the second chamber, and multiple filter drying layers in the third chamber, the discharged air flow can be made dry and acid-free, solving the problems existing in the prior art.

[0006] To solve the above technical problems, the utility model adopts the following solutions:

[0007] An air flow filtering and drying device for polypeptide synthesis, including a device body provided with an air inlet and an alkali liquid inlet pipe. The device body is sequentially provided with a first chamber, a second chamber, and a third chamber from bottom to top. The air inlet is communicated with the first chamber, and a rotatable brush rack is arranged inside the first chamber. A liquid guide disk communicated with the alkali liquid inlet pipe is arranged in the second chamber. Multiple spray heads are arranged at the bottom of the liquid guide disk. The second chamber is communicated with the third chamber through a first connecting pipe. An exhaust pipe is arranged at the top of the third chamber, and the exhaust pipe discharges the dried air flow.

[0008] Preferably, a rotating shaft is arranged inside the first chamber. Multiple detachably connected brush racks are arranged on the outer peripheral surface of the rotating shaft. The end of the rotating shaft far from the air inlet is communicated with the output end of a motor, and the motor is located in an assembly rack arranged on the side of the device body.

[0009] Preferably, a plurality of insertion shafts are provided on one side of the brush holder adjacent to the rotating shaft. A slot is provided in the middle of the insertion shaft, and an assembly groove is provided on the outer peripheral surface of the rotating shaft. After elastic deformation, the insertion shaft is located in the assembly groove.

[0010] Preferably, the first chamber is provided with a second connecting pipe communicating with the second chamber. The alkali liquid inlet pipe is in an L shape and the vertical part penetrates through the top center of the liquid guiding disc. A bearing is provided between the alkali liquid inlet pipe and the liquid guiding disc.

[0011] Preferably, an annular block is provided on the outer periphery of the liquid guiding disc. The annular block is provided with a plurality of teeth, and an assembly block meshing with the annular block is provided on the inner wall of the second chamber.

[0012] Preferably, a first bevel gear is provided at the output end of the motor. A transmission rod is further included. A second bevel gear meshing with the first bevel gear is provided at the bottom end of the transmission rod. A gear is provided at the top end of the transmission rod. The gear passes through a through groove of the device body and partially meshes with the annular block.

[0013] Preferably, the transmission rod is located inside the placement box.

[0014] Preferably, an activated carbon filter layer, a quicklime layer, and a color-changing silica gel desiccant layer are sequentially provided in the third chamber from bottom to top.

[0015] Preferably, a plurality of universal wheels are provided at the bottom of the device body, and a dust exhaust pipe communicating with the first chamber is opened.

[0016] The beneficial effects of the present utility model are as follows:

[0017] By providing a detachable brush holder connected to the rotating shaft and disassembling and assembling in a manner that the insertion shaft is elastically deformed and located in the assembly groove, the disassembly and assembly are convenient, and the dust in the air is fully adsorbed, improving the dust adsorption effect.

[0018] The output end of the motor is driven by the first bevel gear and the second bevel gear, so that the gear at the top end of the rotating rod meshes with and rotates with the annular block, thereby making the alkali liquid sprayed through the nozzle rotate and spray out, improving the full reaction of the alkali liquid with the acidic gas. Then, the gas after the reaction enters the third chamber through the first connecting pipe, and the steps of secondary filtration and drying of dust are sequentially carried out, so that the filtered and dried air flow is discharged to the solid-phase synthesis device through the exhaust pipe for the solid-phase synthesis reaction of polypeptides, making the solid-phase carrier reach the conditions of being dry and acid-free, and the effect of filtering and drying the air flow is good. Description of the Drawings

[0019] Figure 1 is a schematic structural diagram of the present utility model;

[0020] Figure 2 of the present utility model Figure 1Schematic diagram of the partial enlarged structure of circle A;

[0021] Figure 3 This is a schematic diagram of the assembly structure of the annular plate and the gear of the present utility model.

[0022] Reference numerals: 1 - device body, 10 - air inlet, 11 - lye inlet pipe, 12 - universal wheel, 13 - dust exhaust port, 14 - placement box, 2 - first chamber, 20 - rotating shaft, 200 - assembly groove, 21 - brush holder, 210 - inserting shaft, 2100 - slot, 22 - second connecting pipe, 3 - second chamber, 30 - liquid guiding disc, 31 - spray head, 32 - annular block, 33 - assembly block, 34 - bearing, 35 - through slot, 4 - first connecting pipe, 5 - third chamber, 50 - activated carbon filter layer, 51 - quicklime layer, 52 - discolored silica gel desiccant layer, 6 - exhaust pipe, 7 - motor, 70 - output end, 71 - first bevel gear, 72 - second bevel gear, 73 - transmission rod, 74 - gear. Detailed implementation manners

[0023] The following will further elaborate on the present utility model in detail in conjunction with the embodiments and the accompanying drawings, but the implementation manners of the present utility model are not limited thereto.

[0024] In the description of the present utility model, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "longitudinal", "lateral", "horizontal", "inner", "outer", "front", "rear", "top", "bottom", etc. is based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the product of this utility model is usually placed during use. It is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation to the present utility model.

[0025] In the description of the present utility model, it should also be noted that unless otherwise clearly specified and defined, the terms "set", "provided with", "installed", "connected", "connected to" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0026] Embodiment

[0027] An embodiment of the present utility model is an air flow filtering and drying device for polypeptide synthesis, which includes a device body 1 provided with an air inlet 10 and an alkali liquid inlet pipe 11. The device body 1 is sequentially provided with a first chamber 2, a second chamber 3 and a third chamber 5 from bottom to top. The air inlet 10 is communicated with the first chamber 2, and a rotatable brush holder 21 is arranged inside the first chamber 2. A liquid guide tray 30 communicated with the alkali liquid inlet pipe 11 is arranged inside the second chamber 3, and a plurality of nozzles 31 are arranged at the bottom of the liquid guide tray 30. The second chamber 3 is communicated with the third chamber 5 through a first connecting pipe 4, and an exhaust pipe 6 is arranged at the top of the third chamber 5. The exhaust pipe 6 discharges the dried air flow.

[0028] Referring to Figure 1 , the present utility model mainly performs dust removal, acid removal and drying treatment by partitioning the inside of the device body 1 to ensure that the finally discharged air flow reaches the purpose of being dry and acid-free. Thus, the first chamber 2 mainly adsorbs the dust in the incoming air, avoiding the direct entry of the dust in the air into the third chamber 5, which may cause excessive blocking pressure on the filtering and drying layer in the third chamber 5 and prevent the air flow from being thoroughly dried. The gas after dust adsorption enters the second chamber 3, and the alkaline liquid enters the second chamber 3 through the alkali liquid inlet pipe 11 and uniformly contacts the gas, and reacts with the acidic gas in the gas to neutralize the acidic gas in the gas. Then, after removing the acidic gas in the gas, it is transferred to the third chamber 5 through the first connecting pipe 4 for adsorption and drying. Thus, the dried air flow participates in the solid-phase reaction of polypeptides, improving the reaction effect of the solid-phase reaction.

[0029] In some preferred embodiments, a rotating shaft 20 is arranged inside the first chamber 2, and a plurality of brush holders 21 detachably connected are arranged on the outer peripheral surface of the rotating shaft 20. The end of the rotating shaft 20 far from the air inlet 10 is communicated with the output end 70 of a motor 7, and the motor 7 is located in an assembly frame arranged on the side surface of the device body 1. A plurality of insertion shafts 210 are arranged on the side of the brush holder 21 adjacent to the rotating shaft 20, a slot hole 2100 is arranged in the middle of the insertion shaft 210, and an assembly groove 200 is arranged on the outer peripheral surface of the rotating shaft 20. After elastic deformation, the insertion shaft 210 is located in the assembly groove 200.

[0030] Specifically, the brush holder 21 mainly rotates with the rotation shaft 20 driven by the motor 7, so that the tiny dust contained in the air entering the first chamber 2 is completely adsorbed, reducing the amount of tiny dust entering the second chamber 3 and the third chamber 5. At the same time, the brush holder 21 is detachably connected to the rotation shaft 20. The specific connection method is that the insertion shaft 210 elastically deforms under the pressure of the hand to reduce the diameter of the insertion end and then enters the assembly groove 200 for clamping, so as to lock the position of the brush holder 21 on the rotation shaft 20, realizing convenient disassembly and assembly, and timely cleaning the dust adsorbed on the brush in the brush holder 21, thereby improving the adsorption effect when used again. A door body that can be opened and closed is provided in the first chamber 2. When disassembling and assembling the brush holder 21, the door body can be opened or closed.

[0031] It should be noted that, referring to Figure 2 , the insertion shaft 210 is made of a material that can elastically deform. Ensure that after the insertion shaft 210 is subjected to force, it is extruded into the circumferential groove hole 2100 on the outer periphery, so as to reduce the diameter when inserting into the assembly groove 200. At the same time, a limiting block (not marked in the figure) is provided at the top of the insertion shaft 210 to limit the movement of the insertion shaft 210 in the assembly groove 200, so as to ensure that the brush holder 21 is in a connected state during rotation. When disassembling and cleaning, only need to reduce the diameter of the insertion shaft 210 by applying force and then take it out.

[0032] In some preferred embodiments, the first chamber 2 is provided with a second communication pipe 22 communicating with the second chamber 3. The alkali liquid inlet pipe 11 is in an L shape and the vertical part penetrates through the center of the top of the liquid guide plate 30. A bearing 34 is provided between the alkali liquid inlet pipe 11 and the liquid guide plate 30. An annular block 32 is provided on the outer periphery of the liquid guide plate 30. The annular block 32 is provided with a plurality of teeth. An assembly block 33 meshing with the annular block 32 is provided on the inner wall of the second chamber 3.

[0033] Referring to Figure 3 , the liquid guide plate 30 transfers the alkali liquid in the alkali liquid inlet pipe 11 to the nozzle 31. The nozzles 31 are evenly arranged at the bottom of the liquid guide plate 30. Under the rotation of the liquid guide plate 30, the alkali liquid in the nozzles 31 is evenly sprayed in all directions, and reacts fully with the acidic gas in the air. The rotation of the liquid guide plate 30 in the second chamber 3 is mainly achieved by the engagement of the annular block 32 with a plurality of teeth on the outside and the assembly block 33 with teeth inside the second chamber 3, applying a rotational force to the liquid guide plate 30, so that the annular block 32 rotates on the assembly block 33, realizing the rotational spraying of the alkali liquid.

[0034] The rotational force applied to the liquid guide tray 30 is mainly achieved through the engagement of the gear 74 of the rotating rod with the annular block 32. The output end 70 of the motor 7 is provided with a first bevel gear 71, and further includes a transmission rod 73. The bottom end of the transmission rod 73 is provided with a second bevel gear 72 that engages with the first bevel gear 71. The top end of the transmission rod 73 is provided with a gear 74, and the gear 74 passes through the through groove 35 of the device body 1 and partially engages with the annular block 32.

[0035] Specifically, the first bevel gear 71 provided at the output end 70 of the motor 7 engages with the second bevel gear 72 of the rotating rod, thereby providing a rotational force in the horizontal direction for the rotating rod. This rotational force is transmitted to the annular block 32 through the gear 74, so that the annular block 32 rotates within the assembly block 33. During the rotation process, due to the provision of the bearing 34, the vertical end of the alkali liquid inlet pipe 11 always remains in a fixed position, preventing the rotation of the alkali liquid inlet pipe 11 when the liquid guide tray 30 rotates.

[0036] In some preferred embodiments, the transmission rod 73 is located inside the placement box 14. This is conducive to the rational utilization of the space inside the placement box 14, and the placement box 14 is a sealed structure.

[0037] In some preferred embodiments, an activated carbon filter layer 50, a quicklime layer 51, and a color-changing silica gel desiccant layer 52 are sequentially provided in the third chamber 5 from bottom to top. The gas after being fully neutralized by the alkali liquid enters the third chamber 5 through the first connecting pipe 4, and undergoes secondary dust filtration and drying steps in sequence, so that the filtered and dried air flows out through the exhaust pipe 6 and is used for the solid-phase synthesis reaction of polypeptides in the solid-phase synthesis device, enabling the solid-phase carrier to reach the conditions of being dry and acid-free.

[0038] In some preferred embodiments, the bottom of the device body 1 is provided with a plurality of universal wheels 12 and a dust discharge pipe communicating with the first chamber 2 is provided. The dust discharge pipe is provided with a valve, which can be used to collect and process the dust existing at the bottom of the first chamber 2.

[0039] The working principle of the present utility model is as follows: When in use, first open the door body of the first chamber 2, elastically deform the insertion shaft 210 under force and install it in the assembly groove 200, and then close the door body. Air enters the first chamber 2 through the air inlet 10. Under the action of an external controller, the motor 7 is started. The motor 7 drives the rotating shaft 20 to rotate, so that the brush holder 21 rotates to adsorb dust in the air. The air enters the second chamber 3 through the second connecting pipe 22. The alkali liquid enters the liquid guide tray 30 and is sprayed out through the nozzle 31. The motor 7 is driven by the first bevel gear 71 and the second bevel gear 72, so that the gear 74 at the top of the rotating rod meshes with and rotates with the annular block 32, so that the alkali liquid passing through the nozzle 31 is sprayed out in a rotating manner, improving the full reaction of the alkali liquid with the acidic gas. Then the reacted gas enters the third chamber 5 through the first connecting pipe 4, and the secondary filtration and drying steps of dust are carried out in sequence, so that the filtered and dried air flow is discharged into the solid-phase synthesis device through the exhaust pipe 6 for the solid-phase synthesis reaction of polypeptides, so that the solid-phase carrier reaches the conditions of being dry and acid-free. The effect of filtering and drying the air flow is good.

[0040] The above is only a preferred embodiment of the present utility model, and does not impose any form of limitation on the present utility model. Based on the technical essence of the present utility model, any simple modification, equivalent replacement and improvement made to the above embodiments within the spirit and principle of the present utility model still fall within the protection scope of the technical solution of the present utility model.

Claims

1. An airflow filtration and drying device for polypeptide synthesis, characterized in that: The invention comprises a device body (1) provided with an air inlet (10) and an alkali liquid inlet pipe (11), wherein the device body (1) is provided with a first chamber (2), a second chamber (3) and a third chamber (5) in sequence from bottom to top, the air inlet (10) is connected to the first chamber (2) and a rotatable brush holder (21) is provided inside the first chamber (2), a liquid guide plate (30) connected to the alkali liquid inlet pipe (11) is provided inside the second chamber (3), a plurality of nozzles (31) are provided at the bottom of the liquid guide plate (30), the second chamber (3) is connected to the third chamber (5) through a connecting pipe (4), and an exhaust pipe (6) is provided at the top of the third chamber (5), and the exhaust pipe (6) discharges the airflow after drying.

2. The airflow filtration and drying device for peptide synthesis according to claim 1, characterized in that: A rotating shaft (20) is provided inside the first chamber (2), and a plurality of detachably connected brush holders (21) are provided on the outer peripheral surface of the rotating shaft (20). The end of the rotating shaft (20) away from the air inlet (10) is connected to the output end (70) of the motor (7), and the motor (7) is located in an assembly frame arranged on the side of the device body (1).

3. The airflow filtration and drying device for peptide synthesis according to claim 2, characterized in that: A plurality of insertion shafts (210) are provided on one side of the brush holder (21) adjacent to the rotating shaft (20); a slot hole (2100) is provided in the middle of the insertion shaft (210); an assembly groove (200) is provided on the outer peripheral surface of the rotating shaft (20); and the insertion shaft (210) is located in the assembly groove (200) after elastic deformation.

4. The airflow filtration and drying device for peptide synthesis according to claim 2, characterized in that: The first chamber (2) is provided with a second connecting pipe (22) communicating with the second chamber (3); the alkali liquid inlet pipe (11) is L-shaped and its vertical portion passes through the top center of the liquid guide plate (30); and a bearing (34) is provided between the alkali liquid inlet pipe (11) and the liquid guide plate (30).

5. The airflow filtration and drying device for peptide synthesis according to claim 2, characterized in that: An annular block (32) is provided on the outer periphery of the liquid guide plate (30), the annular block (32) is provided with a plurality of teeth, and an inner wall of the second chamber (3) is provided with an assembly block (33) meshing with the annular block (32).

6. The airflow filtration and drying device for peptide synthesis according to claim 5, characterized in that: The output end (70) of the motor (7) is provided with a bevel gear 1 (71), and also includes a transmission rod (73), the bottom end of the transmission rod (73) is provided with a bevel gear 2 (72) meshing with the bevel gear 1 (71), and the top end of the transmission rod (73) is provided with a gear (74), and the gear (74) passes through the through slot (35) of the device body (1) and is partially meshed with the annular block (32).

7. The airflow filtration and drying device for peptide synthesis according to claim 6, characterized in that: The transmission rod (73) is located inside the placement box (14).

8. The airflow filtration and drying device for peptide synthesis according to claim 6, characterized in that: The third chamber (5) is provided with an activated carbon filter layer (50), a quicklime layer (51) and a color-changing silica gel desiccant layer (52) in sequence from bottom to top.

9. The airflow filtration and drying device for peptide synthesis according to claim 6, characterized in that: The bottom of the device body (1) is provided with a plurality of universal wheels (12) and a dust exhaust pipe connected to the first chamber (2) is provided.

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