Blood cell redness quantitative analyzer
Through the blood cell redness quantization analyzer, the combination of spectrophotometer and driving source is used to solve the problem of inconsistency in red blood cell judgment in thin-layer liquid-based cytology examination, and the accurate evaluation and automated determination of red blood cell concentration are achieved, and the production quality and efficiency are improved.
Patent Information
- Application Number
- CN202421737949.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-22
- Publication Date
- 2025-07-01
- Estimated Expiration
- 2034-07-22
AI Technical Summary
In the prior art, the blood cell component judgment of the specimen in thin-layer liquid-based cytology examination relies on artificial subjective judgment, resulting in inconsistent results, and photosensitive devices are difficult to accurately capture the blood cell conditions inside the specimen, limiting the application of automation technology.
The blood cell redness quantization analyzer is used to emit light at a specific wavelength through a spectrophotometer, measure the absorbance of red blood cells in the specimen bottle, combine the driving source to adjust the light angle, avoid the label of the specimen bottle, and achieve accurate assessment of red blood cell concentration.
It realizes accurate assessment of red blood cell content, improves the consistency of production quality and measurement efficiency, reduces the differences in manual judgments, and supports automated analysis.
Smart Images
Figure CN223051175U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the technical field of blood cell determination, and specifically to a blood cell redness quantification analyzer. Background Art
[0002] In thin-layer liquid-based cytology examinations, some TCT specimens contain a relatively large amount of blood cell components due to the characteristics of the sample nature. If these specimens are directly prepared into slides, the presence of blood cells will interfere with and affect subsequent microscopic cytological diagnoses. Therefore, special treatment is usually required before slide preparation to dissolve or destroy red blood cells to reduce their interference with cytological examinations. This pretreatment is a common operating step in thin-layer liquid-based cytology examinations.
[0003] Currently, it usually relies on the operator's naked-eye subjective judgment of the specimens. For specimens that are clearly blood-free or have a heavy blood content, the operator can easily make a judgment. However, for specimens with a certain degree of bloodiness, relying on subjective factors such as personal experience and eyesight, it is very easy to have judgment differences, affecting the consistency of the examination results and resulting in unstable slide preparation quality;
[0004] In addition, when using a photosensitive device to determine the specimens, since the specimen bottle body is almost transparent, but there are many randomly pasted labels on the bottle body, and the bottle cap is opaque, the light emitted by the photosensitive device is difficult to pass through completely. Therefore, the photosensitive device faces difficulties in attempting to automatically determine the bloodiness degree of the specimens and cannot accurately capture and analyze the actual situation inside the specimens, thus limiting the application effect of automation technology in this field.
[0005] Therefore, it is necessary to provide a blood cell redness quantification analyzer to solve the above problems.
[0006] It should be noted that the above information disclosed in this background art section is only used to understand the background art of the concept of this application, and therefore, it may include information that does not constitute the prior art. Utility Model Content
[0007] Based on the above problems existing in the prior art, the problem to be solved by this application is: to provide a blood cell redness quantification analyzer. By moving the specimen bottle to one side of the spectrophotometer, the spectrophotometer emits light. Red blood cells in the specimen bottle can strongly absorb specific wavelengths within the visible light band. By measuring the absorbance of the sample at these specific wavelengths, the concentration of red blood cells in the sample can be deduced, and then the content of red blood cells in the specimen can be evaluated. In addition, by setting a driving source, the irradiation angle of the light emitted by the spectrophotometer relative to the specimen bottle on the clamping ring can be adjusted, so that the light emitted by the spectrophotometer can avoid the labels on the specimen bottle body and obtain accurate absorbance measurement data.
[0008] The technical solution adopted by this application to solve its technical problems is as follows: A blood cell redness quantification analyzer, comprising: a base and a clamping mechanism. A spectrocolorimeter is installed on the base, and a rotating disk is rotatably connected to the base. An installation groove is provided on the rotating disk. A driving component for driving the rotation of the rotating disk is further installed inside the base. The clamping mechanism includes a connecting ring disposed in the installation groove. An accommodating space for placing a specimen bottle is provided inside the connecting ring. A clamping ring is provided inside the connecting ring for clamping the specimen bottle; wherein, the clamping ring and the spectrocolorimeter can rotate relative to each other.
[0009] Further, the clamping ring is fixedly connected to the inner side wall of the connecting ring, and the spectrocolorimeter is rotatably connected to the base.
[0010] Further, the clamping ring is rotatably connected to the inner side wall of the connecting ring, and the spectrocolorimeter is fixedly connected to the base.
[0011] Further, a driving source is further included, and the driving source is used to drive the rotation of the clamping ring. The driving source includes a second motor, and the output end of the second motor is in transmission connection with the clamping ring.
[0012] Further, a third gear and an external gear ring are further included. The third gear is connected to the output end of the second motor. The external gear ring is installed on the outer side wall of the clamping ring, and the external gear ring is meshed with the third gear.
[0013] Further, a plurality of flexible strips for clamping the specimen bottle are installed on the inner side wall of the clamping ring.
[0014] Further, the base and the rotating disk are rotatably connected through a rotating shaft. The driving component includes a first motor installed inside the base. A second gear is installed at the output end of the first motor. A first gear meshed with the second gear is installed on the outer side wall of the rotating shaft.
[0015] Further, a slider is installed on the outer side wall of the connecting ring. A chute is provided on the inner side wall of the installation groove, and the slider is slidably connected to the chute; a spring is installed on the outer side wall of the slider, and the end of the spring away from the slider is connected to the inner wall of the chute.
[0016] Further, a connecting rod is installed on the outer side wall of the connecting ring. The connecting rod penetrates through the rotating disk and is slidably connected to the rotating disk. A roller is rotatably connected to the end of the connecting rod away from the connecting ring. An arc-shaped plate is installed on the outer side of the rotating disk, and a plurality of arc-shaped blocks are installed on the inner side wall of the arc-shaped plate at equal intervals.
[0017] The beneficial effects of the present application are as follows: A hematocyte redness quantification analyzer provided by the present application moves a specimen bottle to one side of a spectrocolorimeter. The spectrocolorimeter emits light. Red blood cells in the specimen bottle can strongly absorb specific wavelengths within the visible light band. By measuring the absorbance of the sample at these specific wavelengths, the concentration of red blood cells in the sample can be deduced, and then the content of red blood cells in the specimen can be evaluated. In addition, a driving source is provided to adjust the irradiation angle of the light emitted by the spectrocolorimeter relative to the specimen bottle on the clamping ring, so that the light emitted by the spectrocolorimeter can avoid the label on the bottle body of the specimen bottle, and accurate absorbance measurement data can be obtained.
[0018] In addition to the objectives, features, and advantages described above, the present application has other objectives, features, and advantages. The following will refer to the drawings to further elaborate on the present application in detail. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] The schematic diagrams in the specification forming a part of the present application are used to provide a further understanding of the present application. The schematic embodiments of the present application and their descriptions are used to explain the present application and do not constitute an improper limitation to the present application.
[0020] In the drawings:
[0021] Figure 1 is a schematic diagram of the overall structure;
[0022] Figure 2 is a schematic diagram of the sectional structure;
[0023] Figure 3 is an exploded schematic diagram of the rotating disk;
[0024] Figure 4 is a schematic diagram of the clamping mechanism and the driving source;
[0025] Figure 5 is a sectional schematic diagram of the clamping mechanism and the driving source.
[0026] Among them, the reference numerals in the drawings are as follows:
[0027] 1, base; 2, spectrocolorimeter; 3, chute; 4, rotating disk; 5, arc plate; 6, arc block; 7, installation groove; 8, clamping mechanism; 81, connecting ring; 82, clamping ring; 83, flexible strip; 84, connecting rod; 85, roller; 86, slider; 87, spring; 9, driving component; 91, rotating shaft; 92, first gear; 93, first motor; 94, second gear; 10, driving source; 1001, external gear ring; 1002, second motor; 1003, third gear. DETAILED DESCRIPTION OF THE EMBODIMENTS
[0028] It should be noted that, without conflict, the embodiments in the present application and the features in the embodiments can be combined with each other. The following will describe the present application in detail with reference to the drawings and in combination with the embodiments.
[0029] In order to enable those skilled in the art to better understand the solution of the present application, the following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.
[0030] Embodiment 1:
[0031] As Figures 1-5 shown, the present application provides a blood cell redness quantification analyzer, including: a base 1 and a clamping mechanism 8. A spectrocolorimeter 2 is installed on the base 1, and a rotating disk 4 is rotatably connected to the base 1. Installation grooves 7 are provided on the rotating disk 4, and the number of the installation grooves 7 is two. A driving component 9 for driving the rotating disk 4 to rotate is further installed inside the base 1. The clamping mechanism 8 includes a connecting ring 81 disposed in the installation groove 7. The number of the clamping mechanisms 8 is two, which are respectively located in the two installation grooves 7. A receiving space for placing a specimen bottle is provided inside the connecting ring 81, and a clamping ring 82 is provided inside the connecting ring 81 for clamping the specimen bottle; wherein, the clamping ring 82 and the spectrocolorimeter 2 can rotate relative to each other.
[0032] This solution is used to measure red blood cells in TCT specimens during thin-layer liquid-based cytology examination, replacing the subjective judgment of specimens by operators with the naked eye, achieving the purpose of judging redness, accurately reflecting the content of red blood cells in the specimens, and being more conducive to the quality control of liquid-based preparations.
[0033] Specifically, the specimen bottle that is difficult to judge with the naked eye is placed in the clamping ring 82 and fixed. Subsequently, the driving component 9 is used to control the rotating disk 4 to rotate by 180°, so that the specimen bottle is located on one side of the spectrocolorimeter 2. The spectrocolorimeter 2 emits light, and the red blood cells in the specimen bottle can strongly absorb specific wavelengths within the visible light band. By measuring the absorbance of the sample at these specific wavelengths, the concentration of red blood cells in the sample can be deduced, and then the content of red blood cells in the specimen can be evaluated, and further the purpose of judging redness can be achieved;
[0034] Among them, a double-station design is adopted. During the measurement of red blood cells in a single specimen bottle, loading and unloading operations can be performed, reducing the downtime and improving the measurement efficiency;
[0035] In addition, since many labels are randomly attached to the body of the specimen bottle, the driving source 10 can adjust the irradiation angle of the light emitted by the spectrophotometer 2 relative to the specimen bottle on the clamping ring 82, so that the light emitted by the spectrophotometer 2 can avoid the labels on the body of the specimen bottle, pass through the specimen bottle smoothly, irradiate the red blood cells in the sample liquid, and obtain accurate absorbance measurement data.
[0036] It should be noted that an external interface is provided on the spectrophotometer 2, and the external interface is connected to an external display terminal by a wire, so that the content of red blood cells in the specimen can be fed back on the display terminal, achieving the purpose of visualizing the measurement results.
[0037] In this embodiment, a clamping ring 82 is rotatably connected to the inner side wall of the connecting ring 81, and the spectrophotometer 2 is fixedly connected to the base 1.
[0038] As Figures 4-5 shown, it further includes a driving source 10. The driving source 10 is used to drive the rotation of the clamping ring 82. The driving source 10 includes a second motor 1002. The second motor 1002 can be fixed to the outer side wall of the connecting ring 81 by bolts. The output end of the second motor 1002 is in transmission connection with the clamping ring 82. The driving source 10 further includes a third gear 1003 and an external gear ring 1001. The third gear 1003 is connected to the output end of the second motor 1002, the third gear 1003 is fixedly connected to the output end of the second motor 1002, the external gear ring 1001 is installed on the outer side wall of the clamping ring 82, the external gear ring 1001 is fixed to the outer side wall of the clamping ring 82 by welding, and the external gear ring 1001 is meshed with the third gear 1003.
[0039] In this embodiment, the rotation of the third gear 1003 can be controlled by the provided second motor 1002. Under the meshing connection of the third gear 1003 and the external gear ring 1001, the clamping ring 82 can be driven to rotate, thereby driving the specimen bottle inside the clamping ring 82 to rotate, and the position of the spectrophotometer 2 remains unchanged, so as to adjust the irradiation angle of the light emitted by the spectrophotometer 2 relative to the specimen bottle on the clamping ring 82.
[0040] As Figures 4-5 shown, a plurality of flexible strips 83 for clamping the specimen bottle are installed on the inner side wall of the clamping ring 82.
[0041] In this embodiment, the specimen bottle can be fixed in the clamping ring 82 by using the flexible strips 83.
[0042] As Figure 2As shown, the base 1 is rotatably connected to the rotating disk 4 through a rotating shaft 91. The bottom of the rotating shaft 91 is rotatably connected to the base 1, and the top of the rotating shaft 91 is fixedly connected to the rotating disk 4. The driving assembly 9 includes a first motor 93 installed in the base 1. The first motor 93 is fixed to the top of the base 1 by bolts. A second gear 94 is installed at the output end of the first motor 93, and the output end of the first motor 93 is fixedly connected to the second gear 94. A first gear 92 meshing with the second gear 94 is installed on the outer side wall of the rotating shaft 91, and the first gear 92 is fixed to the outer side wall of the rotating shaft 91 by welding.
[0043] In this embodiment, by setting the first motor 93, the second gear 94 can be controlled to rotate. Under the meshing connection of the second gear 94 and the first gear 92, the rotating shaft 91 is controlled to rotate, thereby driving the rotating disk 4 to rotate.
[0044] It should be noted that when the spectrocolorimeter 2 irradiates the specimen bottle on the clamping ring 82, the rotating shaft 91 in this solution can block between two specimen bottles, preventing the light emitted by the spectrocolorimeter 2 from irradiating on another specimen bottle, and improving the accuracy of measurement data.
[0045] As Figures 2-4 shown, a slider 86 is installed on the outer side wall of the connecting ring 81. The slider 86 is fixed to the outer side wall of the connecting ring 81 by welding. A sliding groove 3 is opened on the inner side wall of the installation groove 7, and the slider 86 is slidably connected to the sliding groove 3; a spring 87 is installed on the outer side wall of the slider 86, and one end of the spring 87 away from the slider 86 is connected to the inner wall of the sliding groove 3. A connecting rod 84 is installed on the outer side wall of the connecting ring 81. The connecting rod 84 is fixed to the outer side wall of the connecting ring 81 by welding. The connecting rod 84 passes through the rotating disk 4 and is slidably connected to the rotating disk 4. A roller 85 is rotatably connected to one end of the connecting rod 84 away from the connecting ring 81. An arc-shaped plate 5 is installed on the outer side of the rotating disk 4. The arc-shaped plate 5 can be fixed to the top of the base 1 by bolts. A plurality of arc-shaped blocks 6 are installed on the inner side wall of the arc-shaped plate 5 at equal intervals.
[0046] In this embodiment, the specimen bottle to be judged is placed on the clamping ring 82. The driving assembly 9 is used to control the rotating disk 4 to rotate 180°. At this time, when the roller 85 at the end of the connecting rod 84 is squeezed by the arc-shaped block 6, the slider 86 on the outer side wall of the connecting ring 81 slides in the sliding groove 3, and at the same time, the spring 87 is compressed. When the roller 85 moves between two adjacent arc-shaped blocks 6, under the elastic force of the spring 87, the clamping mechanism 8 is reset. As the rotating disk 4 continues to rotate, the clamping mechanism 8 drives the specimen bottle to vibrate continuously, ensuring that the contents of the specimen bottle are easily and fully mixed, preventing red blood cell precipitation, and improving the accuracy of the measurement result.
[0047] Embodiment Two:
[0048] A clamping ring 82 is fixedly connected to the inner side wall of the connecting ring 81. The spectrocolorimeter 2 is rotatably connected to the base 1. An annular slide rail or an annular electric slide rail is provided on the base 1. The slide rail and the clamping ring 82 above are coaxially arranged. It can be pushed manually or electrically to make the spectrocolorimeter 2 slide on the annular slide rail, so that the spectrocolorimeter 2 rotates relative to the clamping ring 82. Since many labels are randomly attached to the bottle body of the specimen bottle, the driving source 10 provided can adjust the irradiation angle of the light emitted by the spectrocolorimeter 2 relative to the specimen bottle on the clamping ring 82, so that the light emitted by the spectrocolorimeter 2 can avoid the labels on the bottle body of the specimen bottle and pass through the specimen bottle smoothly.
[0049] Working principle:
[0050] The specimen bottle that is difficult to judge with the naked eye is placed in the clamping ring 82, and the specimen bottle is fixed by using the flexible strip 83. Then, the driving assembly 9 is used to control the rotary disk 4 to rotate 180°, so that the specimen bottle is located on one side of the spectrocolorimeter 2. At this time, another specimen bottle to be measured is placed on the idle work station. The spectrocolorimeter 2 emits light. The red blood cells in the specimen bottle can strongly absorb specific wavelengths within the visible light band. By measuring the absorbance of the sample at these specific wavelengths, the concentration of red blood cells in the sample can be deduced, and then the content of red blood cells in the specimen can be evaluated. The driving source 10 provided can adjust the irradiation angle of the light emitted by the spectrocolorimeter 2 relative to the specimen bottle on the clamping ring 82, so that the light emitted by the spectrocolorimeter 2 can avoid the labels on the bottle body of the specimen bottle and pass through the specimen bottle smoothly. After the measurement is completed, the driving assembly 9 can be used again to control the rotary disk 4 to rotate 180°, take out the measured specimen bottle, and re-place the specimen bottle to be measured. During the process of taking and placing the specimen bottle, the measurement work of the spectrocolorimeter 2 is not stopped, and the downtime is reduced, thereby improving the measurement efficiency.
[0051] The above are only the preferred embodiments of the present application and are not used to limit the present application. For those skilled in the art, various changes and modifications can be made to the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims
1. A blood cell red cell quantitative analyzer, characterized in that: include: A base (1), wherein a spectrophotometer (2) is mounted on the base (1), and a rotating disk (4) is rotatably connected to the base (1), a mounting groove (7) is provided on the rotating disk (4), and a driving component (9) for driving the rotating disk (4) to rotate is also mounted inside the base (1); A clamping mechanism (8), the clamping mechanism (8) comprising a connecting ring (81) arranged in the mounting groove (7), a receiving space for placing a specimen bottle in the connecting ring (81), a clamping ring (82) arranged in the connecting ring (81), and the clamping ring (82) used for clamping the specimen bottle; The clamping ring (82) and the spectrophotometer (2) are relatively rotatable.
2. A blood cell red cell quantitative analyzer according to claim 1, characterized in that: The clamping ring (82) is fixedly connected to the inner side wall of the connecting ring (81), and the spectrophotometer (2) is rotatably connected to the base (1).
3. A blood cell red cell quantitative analyzer according to claim 1, characterized in that: The inner side wall of the connecting ring (81) is rotatably connected to the clamping ring (82), and the spectrophotometer (2) is fixedly connected to the base (1).
4. A blood cell red cell quantitative analyzer according to claim 3, characterized in that: It also includes a driving source (10), the driving source (10) is used to drive the rotation of the clamping ring (82), the driving source (10) includes a second motor (1002), and the output end of the second motor (1002) is transmission-connected to the clamping ring (82).
5. A blood cell red cell quantitative analyzer according to claim 4, characterized in that: It also includes a third gear (1003) and an outer gear ring (1001), wherein the third gear (1003) is connected to the output end of the second motor (1002), and the outer gear ring (1001) is installed on the outer side wall of the clamping ring (82), and the outer gear ring (1001) is meshingly connected with the third gear (1003).
6. A blood cell red cell quantitative analyzer according to claim 5, characterized in that: The inner side wall of the clamping ring (82) is provided with a plurality of flexible strips (83) for clamping the specimen bottle.
7. A blood cell red cell quantitative analyzer according to claim 1, characterized in that: The base (1) and the rotating disk (4) are rotatably connected via a rotating shaft (91); the driving assembly (9) comprises a first motor (93) installed in the base (1); a second gear (94) is installed at the output end of the first motor (93); and a first gear (92) meshingly connected with the second gear (94) is installed on the outer wall of the rotating shaft (91).
8. A blood cell red cell quantitative analyzer according to claim 7, characterized in that: A slider (86) is installed on the outer wall of the connecting ring (81), a slide groove (3) is opened on the inner wall of the installation groove (7), and the slider (86) is slidably connected to the slide groove (3); a spring (87) is installed on the outer wall of the slider (86), and one end of the spring (87) away from the slider (86) is connected to the inner wall of the slide groove (3).
9. A blood cell red cell quantitative analyzer according to claim 7, characterized in that: A connecting rod (84) is installed on the outer wall of the connecting ring (81), and the connecting rod (84) passes through the rotating disk (4) and is slidably connected to the rotating disk (4). One end of the connecting rod (84) away from the connecting ring (81) is rotatably connected to a roller (85). An arc plate (5) is installed on the outer side of the rotating disk (4), and a plurality of arc blocks (6) distributed at equal distances are installed on the inner wall of the arc plate (5).