Sampling and quantitative detection integrated device

Abstract

The utility model relates to the technical field of medical instruments for in vitro diagnosis, in particular to an integrated device for sampling and quantitative detection, which comprises a sampling cap (1), a sampling rod (2) and a sampling tube (4), one side of the sampling tube (4) is provided with a liquid storage cavity (411), the other side of the sampling tube (4) is provided with a detection cavity (410), the detection cavity (410) is communicated with a chromatographic liquid flow channel cavity (413), and the sampling cap (1) is provided with a liquid outlet (412). A valve element assembly (6) is arranged in the liquid storage cavity (411) and comprises a pressing part and a connecting part which are sequentially arranged along the axis of the liquid storage cavity, and the connecting part is provided with a first sealing part and a second sealing part; the sampling rod slides along the axis of the liquid storage cavity (411) and pushes the valve element assembly (6) to slide from the first position to the second position along the axis. The quantitative liquid storage cavity at the lower part of the liquid storage cavity determines to quantitatively output chromatography mixed liquid required to react by the test strip, so that the chromatography influence of excessive liquid on the test strip is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of in vitro diagnostic medical devices, and particularly relates to an integrated device for sampling and quantitative detection, which is used for sampling and detecting samples such as feces. Background Art

[0002] At present, the overall structural form of fecal sampling and detection devices is partly split sampling (the storage tube and the detection tube are independently and separately arranged); and partly the storage tube and the detection tube are designed with a side-by-side structure. For the chromatographic strip running process, in most sampling devices, after the bottom of the storage tube is punctured by the end of the sampling rod, most of the sample mixture will flow into the cavity for reaction chromatography with the test strip for contact reaction. However, due to process limitations, the test strip itself has a limited absorption capacity for the sample volume and cannot quantitatively output the chromatographic mixture required for the reaction of the test strip. The excessive liquid will affect the chromatographic reaction process and easily cause the user to obtain ineffective test results, resulting in test failures. Since the integrated device is usually disposable, once an ineffective test result cannot be obtained, it is necessary to replace the device and retest. This will not only cause waste of test products and materials, but also waste the time and energy of the tester due to the fact that fecal samples cannot be collected at any time. Summary of the Utility Model

[0003] The purpose of the utility model is to overcome the defects of the prior art and propose an integrated device for sampling and quantitative detection.

[0004] The utility model proposes an integrated device for sampling and quantitative detection, which comprises a sampling cap 1, a sampling rod 2 and a sampling tube 4. A storage cavity 411 is arranged on one side of the sampling tube 4, and a detection cavity 410 is arranged on the other side. The detection cavity 410 is communicated with a chromatographic liquid flow channel cavity 413. A valve core assembly 6 is arranged inside the storage cavity 411. The valve core assembly 6 comprises a pressing part and a connecting part which are sequentially arranged along the axis of the storage cavity. The connecting part has a first sealing part and a second sealing part;

[0005] The sampling rod slides along the axis of the storage cavity 411, and the valve core assembly 6 is pushed to slide from a first position to a second position along the axis;

[0006] In the first position, the second sealing part of the valve core assembly 6 is hermetically connected to the bottom cavity opening of the storage cavity 411,

[0007] In the second position, the first sealing part of the valve core assembly 6 is hermetically connected to the bottom cavity opening of the storage cavity 411;

[0008] When the valve core assembly 6 is located between the first position and the second position, the storage cavity 411 is communicated with the chromatographic liquid flow channel cavity 413.

[0009] Preferably, the valve core assembly 6 is located below the sampling rod 2. The space between the valve core assembly 6 and the bottom orifice of the liquid storage chamber 411 is a quantitative liquid storage chamber 412, which is used to control the flow rate of the liquid in the liquid storage chamber 411 and quantitatively extract liquid.

[0010] Preferably, the cross-sectional area of the quantitative liquid storage chamber 412 is smaller than that of the liquid storage chamber 411. A stepped structure 9 is provided between the quantitative liquid storage chamber 412 and the liquid storage chamber 411 for installing the valve core assembly 6. The valve core retaining piece 611 is in clearance fit with the surface of the stepped structure 9. The stepped structure 9 is provided with a clearance in the axial direction. The quantitative liquid storage chamber 412 and the liquid storage chamber 411 are communicated through the clearance of the stepped structure 9.

[0011] Preferably, when the height of the valve core assembly 6 is 13.3 - 14.0 mm, the quantitative liquid in the quantitative liquid storage chamber is 50 μL - 450 μL.

[0012] Preferably, the inner part of the bottom orifice of the liquid storage chamber 411 is stepped, and the lower part of the orifice of the liquid storage chamber 411 is respectively sealed in cooperation with the first sealing part and the second sealing part.

[0013] Preferably, the pressing part is the valve core retaining piece 611, and the cross-sectional area of the valve core retaining piece 611 is smaller than that of the liquid storage chamber 411.

[0014] Preferably, the first sealing part is the first sealing ring 612, the second sealing part is the second sealing ring 613, and the first sealing ring and the second sealing ring are in interference fit with the bottom orifice of the liquid storage chamber 411.

[0015] Preferably, the first sealing part, the second sealing part and the bottom orifice of the liquid storage chamber are respectively provided with a matching groove structure, and the sealing is realized by using a transition groove fit.

[0016] Preferably, an upper sealing sleeve 3 is installed on the sampling rod 2 for sealing the liquid storage chamber 411; the sampling rod limiting boss 211 and the sampling rod sliding column 212 form a limiting fit with the corresponding slots of the sampling tube 4 for completing the installation and pressing-down operation process of the sampling rod 2; the sampling rod limiting disc 213 corresponds to the inner wall shape of the liquid storage chamber 411 and is in clearance fit.

[0017] Preferably, a test strip 8 is arranged in the detection chamber 410, and it is installed on the test strip fixing plate 5.

[0018] Compared with the prior art, the advantages of the present utility model are as follows:

[0019] 1) The liquid storage chamber and the detection chamber of the present utility model share a large cavity, so the integrity is better; the integrated device has a simple structure and is convenient to install.

[0020] 2) The quantitative liquid storage cavity at the lower part of the liquid storage cavity of the present utility model determines the chromatographic mixed liquid required for the quantitative output test strip, reducing the chromatographic influence of excessive liquid on the test strip. Description of the Drawings

[0021] Figure 1 It is a schematic cross-sectional view of an embodiment of the integrated fecal sampling and quantitative detection device of the present utility model;

[0022] Figure 2 It is a schematic view of an embodiment of the sampling rod assembly of the present utility model;

[0023] Figure 3 It is a schematic view of an embodiment of the relative position relationship between the sampling rod and the sampling tube in the detection device of the present utility model;

[0024] Figure 4 It is a schematic view of an embodiment of the valve core assembly in the detection device of the present utility model;

[0025] Figure 5 It is a schematic view of the stepped structure between the liquid storage cavity and the quantitative liquid storage cavity in the detection device of the present utility model;

[0026] Reference Signs:

[0027] 1 - Sampling cap; 2 - Sampling rod, 211 - Sampling rod limiting boss, 212 - Sampling rod sliding column, 213 - Sampling rod limiting disk, 214 - Sampling head, 215 - First indication mark; 3 - Upper sealing sleeve; 4 - Sampling tube, 410 - Detection cavity, 411 - Liquid storage cavity, 412 - Quantitative liquid storage cavity, 413 - Chromatographic liquid flow channel cavity, 414 - Second indication mark, 415 - Vent hole; 5 - Test strip fixing plate; 6 - Valve core assembly, 611 - Valve core upper retaining piece, 612 - First sealing ring, 613 - Second sealing ring; 7 - Sampling tube base; 8 - Test strip; 9 - Stepped structure. Detailed Embodiment

[0028] The technical solution of the present utility model will be described in detail below in conjunction with the embodiments and the drawings.

[0029] The present utility model provides an integrated device for sampling and quantitative detection, which includes a sampling cap 1, a sampling rod 2 and a sampling tube 4, as Figure 1 shown;

[0030] As Figure 2As shown in the figure, an upper sealing sleeve 3 is installed on the sampling rod 2 to seal the upper part of the liquid storage cavity 411. The limiting boss 211 and the sliding column 212 of the sampling rod form a limiting fit with the corresponding slots of the sampling tube 4 to complete the installation and pressing-down operation process of the sampling rod 2. The limiting disc 213 of the sampling rod corresponds to the inner wall shape of the liquid storage cavity 411 and has a clearance fit, which is more conducive to aligning the central axes of the sampling rod 2 and the sampling tube 4 and preventing the lower section of the sampling rod 2 from being eccentric during installation and use, thus affecting the pressing-down valve core assembly 6. The sampling head 214 at the end of the sampling rod is a spiral or other grooved structure convenient for collecting fecal samples; a limiting structure can be added or not added at the end of the sampling rod.

[0031] The internal cavity of the sampling tube of the sampling device is divided into a liquid storage cavity 411, a detection cavity 410, and a chromatographic liquid flow channel cavity 413. The liquid storage cavity 411 is provided on one side of the sampling tube, and the detection cavity 410 is provided on the other side. A valve core assembly 6 is arranged inside the liquid storage cavity 411. The valve core assembly 6 is located below the sampling rod 2. The space between the valve core assembly 6 and the bottom orifice of the liquid storage cavity 411 is a quantitative liquid storage cavity 412, which is used to control the flow rate of the liquid in the liquid storage cavity and quantitatively take the liquid. The valve core assembly 6 includes a pressing part and a connecting part arranged in sequence along the axis of the liquid storage cavity 411. The connecting part has a first sealing part and a second sealing part.

[0032] Preferably, as Figure 4As shown, the pressing part is the valve core baffle 611, and the cross-sectional area of the valve core baffle is smaller than the cross-sectional area of the liquid storage cavity 411; the first sealing part is the first sealing ring 612, and the second sealing part is the second sealing ring 613. The sealing ring is in interference connection with the bottom orifice of the liquid storage cavity 411. The first sealing ring 612 and the second sealing ring 613 are installed on the valve core assembly 6. When the valve core assembly 6 is not pressed in the liquid storage cavity 411, the second sealing ring 613 cooperates with the bottom orifice at the lower end of the liquid storage cavity 411 to form a lower seal, and the original buffer solution without samples or the sample mixture after sampling is temporarily stored between the sampling rod limiting disc 213 and the quantitative liquid storage cavity 412; when the valve core assembly 6 is pressed downward by force and is in the pressed state, the first sealing ring 612 cooperates with the bottom orifice at the lower end of the liquid storage cavity 411 to form a lower seal again, so as to ensure that the sample mixture in the quantitative liquid storage cavity 412 smoothly enters the chromatographic liquid flow channel cavity 413 and ensure that the sample mixture outside the quantitative liquid storage cavity 412 no longer flows out. The valve core baffle 611 has a certain area and corresponds to the internal shape of the quantitative liquid storage cavity 412 so that the sampling head 214 can contact and press down the valve core and has a clearance fit with the quantitative liquid storage cavity 412. The cross-sectional area of the quantitative liquid storage cavity 412 is smaller than the cross-sectional area of the liquid storage cavity 411. A stepped structure 9 is provided between the quantitative liquid storage cavity 412 and the liquid storage cavity 411 to facilitate the installation of the valve core assembly 6. The valve core baffle 611 has a clearance fit with the surface of the stepped structure 9, and the stepped structure is provided with a clearance along the axial direction. The quantitative liquid storage cavity 412 and the liquid storage cavity 411 are communicated through the clearance of the stepped structure 9.

[0033] To quantitatively control the liquid, different valve core assemblies can be switched according to the detection requirements to meet the quantitative detection. Preferably, when the diameter of the quantitative liquid storage cavity 412 is 9 mm and the heights of the valve core assemblies 6 are 13.3 mm, 13.8 mm, and 14.0 mm respectively, the measured quantitative liquids are 100 ± 50 μL, 200 ± 50 μL, and 400 ± 50 μL. The lower part of the liquid storage cavity determines the surrounding structure of the quantitatively output sample mixture, including the valve core assembly and the stepped structure at the lower part of the liquid storage cavity. By installing different valve core assemblies, 100 ± 50 uL, 200 ± 50 uL, and 400 ± 50 uL can be quantitatively output.

[0034] The test strip 8 is installed on the test strip fixing plate 5 and placed in the detection cavity 410. Different numbers of test reagent strips (such as single test, double test, triple test, etc.) can be installed in the detection cavity 410. For different numbers of test reagent strips, most of the structures are shared, and only the valve core and the sampling rod need to be replaced to complete the replacement, saving the development cost. The upper end of the sampling tube 4 is designed with a vent hole 415 to keep the air pressure inside and outside the tube body detection cavity 410 consistent so that the pressing action can be smoothly performed and the chromatographic strip running process can be completed.

[0035] Preferably, the first sealing portion, the second sealing portion and the bottom opening of the liquid storage cavity are respectively provided with a matching slot structure, and the transition slot is used for cooperation to achieve sealing.

[0036] The working principle of the present utility model is as follows:

[0037] During use, first remove the sampling cap 1, then pull out the sampling rod 2 from the sampling tube 4, so that the sampling head 214 contacts and collects the fecal sample, and then insert the sampling rod 2 back into the sampling tube 4. After shaking the device to fully mix the sample and the buffer solution, place the device on a horizontal tabletop. Rotate the sampling rod 2 so that the first indication mark 215 at its upper end aligns with the second indication mark 414 of the sampling tube. As Figure 3 shown, press the end of the sampling rod 2. During the process that the connected sampling rod sliding column 212 moves down a certain distance along the inner slideway of the tube body, the end of the sampling rod 2 presses down the valve core assembly 6 downward. The quantitative sample mixture in the quantitative liquid storage cavity 412 enters the chromatographic liquid flow channel cavity 413 and contacts the bottom of the test strip 8 in the test cavity 410 and starts the chromatographic running process. After reading the result within the specified time, one detection is completed.

[0038] The sampling device of the present utility model can quantitatively output the required reaction chromatographic solution, and has the characteristics of simple structure, convenient installation, convenient operation and good stability. The structure has good versatility and can meet different detection requirements.

[0039] The content not detailedly described in the present utility model can all adopt the conventional technical knowledge in the field.

[0040] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present utility model and not to limit them. Although the present utility model has been described in detail with reference to the embodiments, those of ordinary skill in the art should understand that any modification or equivalent replacement of the technical solutions of the present utility model does not depart from the spirit and scope of the technical solutions of the present utility model, and they should all be covered within the scope of the claims of the present utility model.

Claims

1. An integrated device for sampling and quantitative detection, which comprises a sampling cap (1), a sampling rod (2) and a sampling tube (4). A liquid storage cavity (411) is provided on one side of the sampling tube (4), and a detection cavity (410) is provided on the other side. The detection cavity (410) is communicated with a chromatographic liquid flow channel cavity (413). It is characterized in that, A valve core assembly (6) is arranged inside the liquid storage cavity (411). The valve core assembly (6) includes a pressing part and a connecting part arranged in sequence along the axis of the liquid storage cavity. The connecting part has a first sealing part and a second sealing part; The sampling rod slides along the axis of the liquid storage cavity (411), and the valve core assembly (6) is pushed to slide from the first position to the second position along the axis; In the first position, the second sealing part of the valve core assembly (6) is sealingly connected to the bottom cavity opening of the liquid storage cavity (411), In the second position, the first sealing part of the valve core assembly (6) is sealingly connected to the bottom cavity opening of the liquid storage cavity (411); When the valve core assembly (6) is located between the first position and the second position, the liquid storage cavity (411) is communicated with the chromatographic liquid flow channel cavity (413).

2. The integrated device for sampling and quantitative detection according to claim 1, wherein The valve core assembly (6) is located below the sampling rod (2). The space between the valve core assembly (6) and the bottom cavity opening of the liquid storage cavity (411) is a quantitative liquid storage cavity (412), which is used to control the flow rate of the liquid in the liquid storage cavity (411) and quantitatively take liquid.

3. The integrated device for sampling and quantitative detection according to claim 2, characterized in that, The cross-sectional area of the quantitative liquid storage cavity (412) is smaller than the cross-sectional area of the liquid storage cavity (411). A stepped structure (9) is arranged between the quantitative liquid storage cavity (412) and the liquid storage cavity (411) for installing the valve core assembly (6). The valve core retaining piece (611) is in clearance fit with the surface of the stepped structure (9). The stepped structure (9) is provided with a gap in the axial direction. The quantitative liquid storage cavity (412) and the liquid storage cavity (411) are communicated through the gap of the stepped structure (9).

4. The integrated device for sampling and quantitative detection according to claim 1, wherein, When the height of the valve core assembly (6) is 13.3 - 14.0 mm, the quantitative liquid in the quantitative liquid storage cavity is 50 μL - 450 μL.

5. The integrated device for sampling and quantitative detection according to claim 1, wherein The inner part of the bottom cavity opening of the liquid storage cavity (411) is stepped, and the lower part of the cavity opening of the liquid storage cavity (411) is respectively in sealing fit with the first sealing part and the second sealing part.

6. The integrated device for sampling and quantitative detection according to claim 1, characterized in that, The pressing part is a valve core retaining piece (611), and the cross-sectional area of the valve core retaining piece (611) is smaller than the cross-sectional area of the liquid storage cavity (411).

7. The integrated device for sampling and quantitative detection according to claim 1, wherein, The first sealing part is a first sealing ring (612), and the second sealing part is a second sealing ring (613). The first sealing ring and the second sealing ring are in interference fit with the bottom cavity opening of the liquid storage cavity (411).

8. The integrated device for sampling and quantitative detection according to claim 1, characterized in that The first sealing part, the second sealing part and the bottom cavity opening of the liquid storage are respectively provided with a matching clamping groove structure, and the sealing is realized by using a transition clamping groove fit.

9. The integrated device for sampling and quantitative detection according to claim 1, characterized in that An upper sealing sleeve (3) is installed on the sampling rod (2) for sealing the liquid storage cavity (411); The sampling rod limit boss (211) and the sampling rod sliding column (212) form a limit fit with the corresponding slot holes of the sampling tube (4) to complete the installation and pressing-down operation process of the sampling rod (2); The sampling rod limit disc (213) corresponds to the inner wall shape of the liquid storage cavity (411) and is in clearance fit.

10. The integrated device for sampling and quantitative detection according to claim 1, characterized in that, A test strip (8) is arranged in the detection cavity (410), and it is installed on the test strip fixing plate (5).

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