Porous screw

Abstract

The utility model provides a porous screw. The porous screw comprises a screw body and a Piezo agonist. The screw body comprises a threaded shaft section and a pore shaft section, external threads are arranged on the outer wall of the threaded shaft section, and at least one medicine carrying hole body is formed in the outer wall of the pore shaft section; the Piezo agonist is arranged at the medicine carrying hole body of the threaded shaft section and / or the pore shaft section of the screw body, and when the screw body is installed on a human body, the Piezo agonist is used for inhibiting bone resorption of the human body. According to the porous screw provided by the invention, the hole shaft section on the screw body is provided with the medicine carrying hole body, so that the screw body is of a porous structure, and compared with a bone nail of a compact structure in the prior art, the screw body of the porous structure has lower rigidity and can reduce stress shielding, so that bone resorption can be inhibited. In addition, the bone resorption can be further inhibited through the Piezo1 agonist arranged on the screw body.

Description

Technical Field

[0001] The utility model relates to the field of medical devices, in particular to a porous screw. Background Art

[0002] As an indispensable internal fixation device in orthopedic surgery, bone screws have a long development history. As early as in the 19th century, doctors began to try to use various materials to make bone screws to effectively fix fracture sites. With the continuous progress of medical technology, the materials and designs of bone screws have also undergone many reforms.

[0003] However, in the prior art, as the main form of bone screws, metal screws have gradually shown problems. The stiffness of metal screws is usually much higher than that of bone tissue, which leads to the occurrence of stress shielding. When the screw is implanted into the body, due to its high stiffness, it will bear most of the external forces, while the bone tissue will gradually show bone resorption due to the lack of stress stimulation. Bone resorption is a physiological behavior in which the volume and density of bone tissue gradually decrease under a relatively low stress level. This not only affects the healing quality of fractures but also may lead to the occurrence of secondary fractures. Summary of the Utility Model

[0004] In view of this, the purpose of the utility model is to overcome the deficiencies in the prior art and provide a porous screw.

[0005] The utility model provides the following technical solutions:

[0006] An embodiment of the present application provides a porous screw, including a screw body and a Piezo agonist. The screw body includes a threaded shaft section and a porous shaft section. An external thread is provided on the outer wall of the threaded shaft section, and at least one drug-loading hole body is opened on the outer wall of the porous shaft section; the Piezo agonist is arranged at the threaded shaft section of the screw body and / or in the drug-loading hole body of the porous shaft section. When the screw body is installed in the human body, the Piezo agonist is used to inhibit human bone resorption; the first direction is parallel to the axis of the screw body and points from the head end of the screw body to the tail end of the screw body, and the second direction is the reverse of the first direction.

[0007] In one embodiment, one threaded shaft section is provided, one porous shaft section is provided, and the threaded shaft section and the porous shaft section are sequentially distributed along the first direction.

[0008] In one embodiment, one threaded shaft section is provided, one porous shaft section is provided, and the threaded shaft section and the porous shaft section are sequentially distributed along the second direction.

[0009] In one embodiment, one pore shaft section is provided, more than two threaded shaft sections are provided, the threaded shaft sections and the pore shaft section are alternately distributed in sequence along the first direction, and the pore shaft section is located between two of the threaded shaft sections.

[0010] In one embodiment, one threaded shaft section is provided, more than two pore shaft sections are provided, the pore shaft sections and the threaded shaft section are alternately distributed in sequence along the first direction, and the threaded shaft section is located between two of the pore shaft sections.

[0011] In one embodiment, more than two threaded shaft sections are provided, more than two pore shaft sections are provided, the pore shaft sections and the threaded shaft sections are alternately distributed in sequence along the first direction, or the threaded shaft sections and the pore shaft sections are alternately distributed in sequence along the first direction.

[0012] In one embodiment, one threaded shaft section is provided, one pore shaft section is provided, the threaded shaft section and the pore shaft section are sequentially distributed along the circumferential direction of the screw body, and the threaded shaft section and the pore shaft section are connected end to end.

[0013] In one embodiment, more than two threaded shaft sections are provided, more than two pore shaft sections are provided, and the threaded shaft sections and the pore shaft sections are alternately distributed in sequence along the circumferential direction of the screw body.

[0014] In one embodiment, a mating block body is fixedly connected to the screw body, and a mating groove is formed on an end face of the mating block body away from the screw body; a tapered block is fixedly connected to the tail of the screw body.

[0015] In one embodiment, an auxiliary feed groove is formed in the threaded shaft section, the auxiliary feed groove has a first inner wall and a second inner wall, the first inner wall and the second inner wall are joined, a plane where the first inner wall is located is inclined with respect to the axis of the screw body, and a plane where the second inner wall is located is parallel to the axis of the screw body.

[0016] In one embodiment, the pore shaft section is a hollow shaft body formed by intertwining a plurality of strip-shaped entities, the plurality of strip-shaped entities are fixedly connected to each other, and there is at least one gap between the strip-shaped entities, and the gap forms the drug-loading hole body.

[0017] The embodiments of the present utility model have the following advantages:

[0018] The porous shaft section on the screw body is provided with a drug-loading hole body, so that the screw body forms a porous structure. Compared with the bone nail with a dense structure in the prior art, the screw body with a porous structure has lower stiffness, can reduce stress shielding, and thus can inhibit bone resorption. And bone resorption can be further inhibited by the Piezo1 agonist provided on the screw body.

[0019] In order to make the above-mentioned objects, features and advantages of the present utility model more obvious and understandable, the following specifically gives preferred embodiments and, in conjunction with the accompanying drawings, makes a detailed description as follows. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the following will briefly introduce the drawings required for use in the embodiments. It should be understood that the following drawings only show some embodiments of the present utility model, and therefore should not be regarded as limiting the scope. For those of ordinary skill in the art, without creative efforts, other related drawings can also be obtained based on these drawings.

[0021] Figure 1 FIG. shows a schematic structural view of one perspective of a porous screw provided by an embodiment of the present application;

[0022] Figure 2 FIG. shows a schematic structural view of two perspectives of another embodiment of a porous screw provided by an embodiment of the present application;

[0023] Figure 3 FIG. shows a schematic structural view of three perspectives of another embodiment of a porous screw provided by an embodiment of the present application;

[0024] Figure 4 FIG. shows a schematic structural view of four perspectives of yet another embodiment of a porous screw provided by an embodiment of the present application;

[0025] Figure 5 FIG. shows a schematic structural view of five perspectives of another embodiment of a porous screw provided by an embodiment of the present application;

[0026] Figure 6 FIG. shows a schematic structural view of six perspectives of another embodiment of a porous screw provided by an embodiment of the present application;

[0027] Figure 7 FIG. shows a schematic structural view of seven perspectives of a strip-shaped entity of one embodiment of a porous screw provided by an embodiment of the present application;

[0028] Figure 8 FIG. shows a schematic structural view of eight perspectives of a strip-shaped entity of another embodiment of a porous screw provided by an embodiment of the present application.

[0029] Description of Main Component Symbols:

[0030] 100 - Screw Body;

[0031] 110 - Threaded Shaft Section; 112 - Auxiliary Feed Groove; 114 - First Inner Wall; 116 - Second Inner Wall;

[0032] 120 - Pore Shaft Section; 122 - Drug - carrying Hole Body; 124 - Strip - shaped Entity;

[0033] 130 - Fitting Block;

[0034] 140 - Tapered Block. Detailed Embodiment

[0035] The embodiments of the present utility model will be described in detail below. The examples of the embodiments are shown in the drawings, where the same or similar reference numerals denote the same or similar elements or elements with the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary and are only used to explain the present utility model and should not be construed as a limitation of the present utility model.

[0036] It should be noted that when an element is referred to as being "fixed to" another element, it can be directly on the other element or there can also be an intermediate element. When an element is considered to be "connected" to another element, it can be directly connected to the other element or there may be an intermediate element at the same time. On the contrary, when an element is referred to as being "directly on" another element, there is no intermediate element. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are only for the purpose of illustration.

[0037] In the present utility model, unless otherwise clearly specified and defined, the terms "installed", "connected", "connected to", "fixed" and other terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication of two elements or the interaction relationship between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0038] In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of the present utility model, the meaning of "a plurality" is two or more unless otherwise clearly and specifically defined.

[0039] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field to which this application belongs. The terms used in the description of the template herein are for the purpose of describing specific embodiments only and are not intended to limit the present utility model. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0040] As Figures 1 to 8 shown, an embodiment of the present application provides a porous screw, including a screw body 100 and a Piezo1 agonist.

[0041] The screw body 100 is an internal fixator installed on the human bone. The Piezo1 agonist can inhibit human bone resorption.

[0042] The screw body 100 includes a threaded shaft section 110 and a porous shaft section 120. An external thread is provided on the outer wall of the threaded shaft section 110, and at least one drug-loading hole body 122 is opened on the outer wall of the porous shaft section 120. Exemplarily, the helix angle γ of the above external thread satisfies: 20° ≤ γ ≤ 40°, so that the screw body 100 can self-lock. Exemplarily, the helix angle γ of the external thread = 20°. In another embodiment, the helix angle γ of the external thread = 30°. In another embodiment, the helix angle γ of the external thread = 40°.

[0043] The porous shaft section 120 is provided with the drug-loading hole body 122, so that the screw body 100 forms a porous structure. Compared with the bone nail with a dense structure in the prior art, the screw body 100 with the porous structure provided by the present application has lower stiffness and can reduce stress shielding, thereby being able to inhibit bone resorption.

[0044] Exemplarily, the screw body 100 can be manufactured by 3D printing, or can also be manufactured by other methods, such as machining or die casting. Exemplarily, the screw body 100 is made of one of the following materials: metals, bioceramics, or polymers and other materials with good biocompatibility, sufficient mechanical strength, and characteristics promoting bone ingrowth.

[0045] Exemplarily, the drug-loading hole body 122 is a regular pore or an irregular pore, and the average pore diameter range of the drug-loading hole body 122 is 300μm - 1000μm.

[0046] The Piezo1 agonist is disposed on the outer surface of the threaded shaft section 110 of the screw body 100. When the screw body 100 is implanted into the human body, the Piezo1 agonist is slowly released and can activate Piezo1 expression (Piezo1 is one of the members of the mechanically gated cation channel family, which can generate excitatory electrical signals in response to mechanical stresses such as tensile, extrusion, and shear forces, and is the molecular basis for cells to sense pressure), thereby inhibiting human bone resorption. Exemplarily, the Piezo1 agonist is an inhibitor of bone resorption.

[0047] Exemplarily, the Piezo1 agonist includes, but is not limited to, one of the following: Yoda1, JIDE1, JIDE2, or Dooku1. The Chinese translations of the above compounds are phonetic transcriptions, and their Chinese names are not unique.

[0048] Yoda1 is an agonist used to activate the Piezo1 channel. Activating the Piezo1 channel can affect the behavior and function of cells. There are also some other compounds that can activate the Piezo1 channel, such as JIDE1 and JIDE2. JIDE1 and JIDE2 can also activate the Piezo1 channel, but their potencies and binding affinities are different from those of Yoda1; the EC50 value of JIDE1 is approximately 200 μM, and the EC50 value of JIDE1 is approximately 158 μM. Real-time SPR binding assays show that the Kd values of the two compounds binding to mouse Piezo1 are much weaker, which are 2754 μM and 2770 μM, respectively. In addition, Dooku1 is a compound born from the synthesis and structure-activity relationship analysis of Yoda1 derivatives. Dooku1 is another compound with a similar effect to Yoda1. Exemplarily, gelatin microspheres loaded with the Piezo1 agonist Yoda1 are carried on the outer wall of the threaded shaft section 110 of the screw body 100. In another embodiment, the Piezo1 agonist is disposed at the drug-loading pore body 122 of the pore shaft section 120. In another embodiment, the Piezo1 agonist is disposed at the drug-loading pore body 122 of the threaded shaft section 110 and the pore shaft section 120.

[0049] Exemplarily, the preparation process of gelatin microspheres is as follows: ① Add 2.5 g of type A gelatin and 100 ml of deionized water into a clean beaker, and place it on a magnetic heating stirrer to stir evenly; ② Inject 100 ml of acetone into the solution, let it stand at 4 °C in the refrigerator for 10 min, discard the supernatant, retain the lower gelatinous precipitate, and add 100 ml of deionized water again, and place it on a magnetic heating stirrer to stir evenly; during the stirring process, gradually dropwise add hydrochloric acid (0.4 mol) to adjust the pH of the solution to 2.5; ③ Pour the above solution into a round-bottom flask, and use a constant pressure dropping funnel to gradually dropwise add acetone; stop dropping when the solution becomes milky and turbid, and place it in an ice-water bath for condensation; after condensation, dropwise add 800 μl of 25% glutaraldehyde to the solution to crosslink and solidify the gelatin microspheres; ④ Centrifuge the crosslinked and solidified gelatin microsphere solution to remove the supernatant, add an acetone dispersion solution, and disperse the gelatin microsphere precipitate again under ultrasonic emulsification; repeat the above steps 3 times to purify the gelatin microspheres; use a rotary evaporation and condensation device to perform rotary evaporation on the purified gelatin microsphere solution; ⑤ Place the rotary evaporated solution in a petri dish, gradually dropwise add sodium hydroxide (0.4 mol) to adjust the pH of the solution to about 7.4; cover it with plastic wrap and puncture dense small holes, then place it in a -80 °C refrigerator for pre-freezing, and then perform negative pressure freeze-drying to obtain gelatin microspheres; after sub-packaging, sterilize. It can be understood that gelatin microspheres can also be prepared by other methods, and the above process cannot be regarded as a limitation on the protection scope of this application.

[0050] Exemplarily, the process of loading Yoda1 onto gelatin microspheres is as follows: ① Measure an appropriate amount of PBS, add Yoda1, and use a pipette to blow and mix evenly to prepare Yoda1 solutions with different concentrations (1 μmol / L, 10 μmol / L, 50 μmol / L, 100 μmol / L, 500 μmol / L); ② Respectively measure 30 ml of Yoda1 solutions with different concentrations and 30 mg of gelatin microsphere dry powder and place them in a centrifuge tube, and under ultrasonic emulsification, fully mix the Yoda1 solution and the gelatin microspheres; ③ Dispense the above solution into centrifuge tubes and place them in a refrigerator shaker for incubation to allow Yoda1 to fully bind to the gelatin microspheres to obtain Yoda1 gelatin sustained-release microspheres with different concentrations. It can be understood that Yoda1-loaded gelatin microspheres can also be prepared by other methods, and the above process cannot be regarded as a limitation on the protection scope of this application.

[0051] Exemplarily, the composite of porous screws and sustained-release Yoda1 gelatin microspheres: ① Put the porous screws and Yoda1 gelatin sustained-release microspheres with different concentrations into a centrifuge tube, use a pipette to gently blow the air bubbles in the pores of the screws to make the two fully contact, and place them in a 4 °C refrigerator shaker for incubation for 12 h; ② Take out the screws in the centrifuge tube and place them in 24-well plates respectively, pre-freeze them in a -80 °C refrigerator for 10 h, and then perform negative pressure freeze-drying to obtain porous screws with sustained-release Yoda1.

[0052] The first direction is parallel to the axis of the screw body 100 and points from the head end of the screw body 100 to the tail end of the screw body 100, and the second direction is the reverse of the first direction. Exemplarily, after the screw body 100 is installed on the human body, the head of the screw body 100 is close to the outer wall of the bone, the tail of the screw body 100 is far from the outer wall of the bone, and the tail of the screw body 100 is deeper into the bone than the head of the screw body 100.

[0053] As Figure 1 or Figure 5 shown, in one embodiment, one threaded shaft section 110 is provided and one porous shaft section 120 is provided, and the threaded shaft section 110 and the porous shaft section 120 are sequentially distributed in the second direction.

[0054] Exemplarily, the ratio of the width H1 of the threaded shaft section 110 in the first direction to the width H2 of the porous shaft section 120 in the first direction is B, where B = H1 / H2 > 0, that is, in this embodiment, the sizes of H1 and H2 are not limited, as long as they are not zero. Exemplarily, B = 1, that is, H1 = H2. As Figure 1 shown, in another embodiment, B = 2 / 3 and 3H1 = 2H2. In another embodiment, B = 3 / 5 and 5H1 = 3H2. In yet another embodiment, B = 2 and H1 = 2H2.

[0055] Exemplarily, assuming that the ratio of the width of the threaded shaft section 110 to the width of the porous shaft section 120 is 1:1, if one threaded shaft section is provided and two porous shaft sections are provided, and the two porous shaft sections are adjacent, and the porous shaft section and the threaded shaft section are sequentially arranged in the first direction, that is, the porous shaft section, the porous shaft section, and the threaded shaft section are sequentially arranged, then the two porous shaft sections can be regarded as a combined porous shaft section with a width twice that of the threaded shaft section. Therefore, it can be regarded as one porous shaft section and one threaded shaft section are provided, where B = 1 / 3 and the width H2 of the porous shaft section = 2 (the width H1 of the threaded shaft section 110).

[0056] As Figure 2 shown, in one embodiment, one threaded shaft section 110 is provided and one porous shaft section 120 is provided, and the threaded shaft section 110 and the porous shaft section 120 are sequentially distributed in the first direction. During use, a hole can be drilled in advance at the location where the porous screw is to be installed, and then the porous screw is installed into the hole. The external thread of the threaded shaft section 110 abuts against the inner wall of the hole to prevent the porous screw from coming out.

[0057] Exemplarily, the ratio of the width H1 of the threaded shaft section 110 in the first direction to the width H2 of the porous shaft section 120 in the first direction is B, where B = H1 / H2 > 0, that is, the sizes of H1 and H2 are not limited, as long as they are not zero. Exemplarily, B = 1, that is, H1 = H2. As Figure 1As shown, in another embodiment, B = 2 / 3 and 3H1 = 2H2. In another embodiment, B = 3 / 5 and 5H1 = 3H2. In yet another embodiment, B = 2 and H1 = 2H2.

[0058] As Figure 3 As shown, in one embodiment, one pore shaft section 120 is provided, and two or more threaded shaft sections 110 are provided. The threaded shaft sections 110 and the pore shaft section 120 are alternately distributed in sequence along the first direction, and the pore shaft section 120 is located between two threaded shaft sections 110. Exemplarily, in this embodiment, the widths of the pore shaft section 120 and the two threaded shaft sections 110 in the first direction are not limited. Providing two threaded shaft sections 110 can improve the anti-disengagement ability of the porous screw.

[0059] In one embodiment, one threaded shaft section 110 is provided, and two or more pore shaft sections 120 are provided. The pore shaft sections 120 and the threaded shaft section 110 are alternately distributed in sequence along the first direction, and the threaded shaft section 110 is located between two pore shaft sections 120.

[0060] In one embodiment, two or more threaded shaft sections 110 are provided, and two or more pore shaft sections 120 are provided. The pore shaft sections 120 and the threaded shaft sections 110 are alternately distributed in sequence along the first direction.

[0061] Exemplarily, two threaded shaft sections 110 are provided and two pore shaft sections 120 are provided. The pore shaft sections 120 and the threaded shaft sections 110 are alternately distributed in sequence along the first direction. For example, the two threaded shaft sections 110 are respectively named the first threaded shaft section and the second threaded shaft section, and the two pore shaft sections 120 are respectively named the first pore shaft section and the second pore shaft section. Then the arrangement order of the two threaded shaft sections 110 and the two pore shaft sections 120 along the first direction is: the first pore shaft section, the first threaded shaft section, the second pore shaft section, and the second threaded shaft section. In another embodiment, three threaded shaft sections 110 are provided and three pore shaft sections 120 are provided. The pore shaft sections 120 and the threaded shaft sections 110 are alternately distributed in sequence along the first direction.

[0062] In one embodiment, two or more threaded shaft sections 110 are provided, and two or more pore shaft sections 120 are provided. The threaded shaft sections 110 and the pore shaft sections 120 are alternately distributed in sequence along the first direction.

[0063] Exemplarily, two threaded shaft sections 110 are provided and two pore shaft sections 120 are provided. The threaded shaft sections 110 and the pore shaft sections 120 are alternately distributed in sequence along the first direction. In another embodiment, three threaded shaft sections 110 are provided and three pore shaft sections 120 are provided. The threaded shaft sections 110 and the pore shaft sections 120 are alternately distributed in sequence along the first direction.

[0064] As Figure 6As shown, in one embodiment, one threaded shaft section 110 is provided, and one porous shaft section 120 is provided. The threaded shaft section 110 and the porous shaft section 120 are sequentially distributed along the circumferential direction of the screw body 100, and the threaded shaft section 110 and the porous shaft section 120 are connected end to end.

[0065] Exemplarily, the width of the porous shaft section 120 in the circumferential direction of the screw body 100 is W1, and the width of the threaded shaft section 110 in the circumferential direction of the screw body 100 is W2, where W1 + W2 = the circumference of the screw body 100. Exemplarily, W1 / W2 = K, where K > 0, that is, in this embodiment, W1 and W2 are not limited. Exemplarily, K = 1, W1 = W2. In another embodiment, K = 1 / 4, 4W1 = W2. In another embodiment, K = 2, W1 = 2W2.

[0066] In one embodiment, two or more threaded shaft sections 110 are provided, and two or more porous shaft sections 120 are provided. The threaded shaft sections 110 and the porous shaft sections 120 are alternately distributed in sequence along the circumferential direction of the screw body 100. Exemplarily, two threaded shaft sections 110 are provided, and two porous shaft sections 120 are provided. The threaded shaft sections 110 and the porous shaft sections 120 are alternately distributed in sequence along the circumferential direction of the screw body 100. For convenience of description, the two threaded shaft sections 110 are respectively named threaded shaft section 110 one and threaded shaft section 110 two, and the two porous shaft sections 120 are respectively named porous shaft section 120 one and porous shaft section 120 two. In the rotation direction of the screw body 100, the threaded shaft section 110 one, the porous shaft section 120 one, the threaded shaft section 110 two, and the porous shaft section 120 two are alternately distributed in sequence. In another embodiment, three threaded shaft sections 110 are provided, and three porous shaft sections 120 are provided. The threaded shaft sections 110 and the porous shaft sections 120 are alternately distributed in sequence along the circumferential direction of the screw body 100.

[0067] As Figure 1 or Figure 5 As shown, in one embodiment, the head end of the screw body 100 is fixedly connected with a mating block 130 by means of welding, gluing, bolt connection, snap connection or integral molding, etc. A mating groove is formed on the end surface of the mating block 130 away from the screw body 100; the tail of the screw body 100 is fixedly connected with a tapered block 140 by means of welding, gluing, bolt connection, snap connection or integral molding, etc. The tapered block 140 is beneficial to the installation of the screw body 100.

[0068] Exemplarily, the mating groove is a cross groove, which can cooperate with a cross screwdriver. The cross screwdriver can abut against and push the inner wall of the mating groove, causing the mating block 130 and the screw body 100 to rotate following the cross screwdriver, and thus causing the screw body 100 to be screwed in or out. In another embodiment, the mating groove is a rectangular groove, which can cooperate with a flat screwdriver. The flat screwdriver can abut against and push the inner wall of the mating groove, causing the mating block 130 and the screw body 100 to rotate following the flat screwdriver, and thus causing the screw body 100 to be screwed in or out. In yet another embodiment, the mating groove is a hexagonal groove body, which can cooperate with an internal hexagonal wrench. The rotation of the internal hexagonal wrench can drive the rotation of the mating block 130 and the screw body 100 by pushing the inner wall of the mating groove, and thus causing the screw body 100 to be screwed in or out.

[0069] Exemplarily, the mating block 130 has a cylindrical structure. In one embodiment, the mating block 130 has a hexagonal block structure, enabling the mating block 130 to cooperate with a wrench, and driving the rotation of the mating block 130 and the screw body 100 through the wrench.

[0070] The mating block 130 is made of one of the following materials: metals, bioceramics, or polymers and other materials with good biocompatibility, sufficient mechanical strength, and the property of promoting bone ingrowth.

[0071] The tapered block 140 is made of one of the following materials: metals, bioceramics, or polymers and other materials with good biocompatibility, sufficient mechanical strength, and the property of promoting bone ingrowth.

[0072] As Figure 4 shown, in one embodiment, the threaded shaft section 110 is provided with an auxiliary feed groove 112. The auxiliary feed groove 112 has a first inner wall 114 and a second inner wall 116. The first inner wall 114 and the second inner wall 116 are connected. The plane of the first inner wall 114 is inclined relative to the axis of the screw body, and the plane of the second inner wall 116 is parallel to the axis of the screw body.

[0073] As Figure 1 shown, the porous shaft section 120 is a hollow shaft body formed by the extension and interweaving of a plurality of strip-shaped entities 124. The plurality of strip-shaped entities 124 are fixedly connected to each other. There is at least one gap between the strip-shaped entities 124, and the gap forms a drug-loading pore body 122. The interweaving of the plurality of strip-shaped entities 124 to form the hollow porous shaft section 120 can increase the surface area of the porous shaft section 120, improve the drug-loading capacity, and can reduce the liquid flow velocity in the drug-loading pore body 122 of the porous shaft section 120 through the mutually interwoven strip-shaped entities 124, reduce the loss of the Piezo1 agonist, extend the sustained-release time of the Piezo1 agonist, and improve the effect of the Piezo1 agonist.

[0074] Exemplarily, the strip-shaped entities 124 are fixedly connected by means such as gluing or integral molding.

[0075] Exemplarily, the above-mentioned strip-shaped entities 124 extend along a straight line; the included angle between the extending direction of a part of the strip-shaped entities 124 and the axis of the screw body 100 is a first preset angle α. The included angle between the extending direction of another part of the strip-shaped entities 124 and the circumferential direction of the screw body 100 is a second preset angle β. The above two parts of strip-shaped entities 124 are intertwined to form the pore shaft section 120 of the grid-shaped hollow shaft structure. Wherein, 0° ≤ first preset angle α ≤ 90°, 0° ≤ second preset angle β ≤ 90°. In one embodiment, as Figure 7 shown, the first preset angle α = 0°, and the second preset angle β = 0°. In another embodiment, as Figure 8 shown, the first preset angle α = 45°, and the second preset angle β = 45°.

[0076] In another embodiment, as Figure 1 shown, multiple strip-shaped entities 124 extend in random directions.

[0077] In another embodiment, the pore shaft section 120 is a solid shaft body, and drug-loading holes 122 are formed by drilling holes in the pore shaft section 120.

[0078] In all the examples shown and described here, any specific value should be construed as merely exemplary and not as a limitation. Therefore, other examples of the exemplary embodiments may have different values.

[0079] It should be noted that: similar reference numerals and letters denote similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0080] The above-described embodiments merely represent several implementation manners of the present utility model. The description thereof is relatively specific and detailed, but it should not be construed as a limitation to the scope of the present utility model. It should be pointed out that for those of ordinary skill in the art, without departing from the concept of the present utility model, several modifications and improvements can still be made, and these all belong to the protection scope of the present utility model.

Claims

1. A porous screw, characterized in that, Comprising: A screw body (100), the screw body (100) includes a threaded shaft section (110) and a porous shaft section (120), an external thread is provided on the outer wall of the threaded shaft section (110), and at least one drug-carrying hole body (122) is opened on the outer wall of the porous shaft section (120); A Piezo1 agonist, the Piezo1 agonist is arranged at the threaded shaft section (110) of the screw body (100) and / or at the drug-carrying hole body (122) of the porous shaft section (120). When the screw body (100) is installed in the human body, the Piezo1 agonist is used to inhibit human bone resorption; A first direction is parallel to the axis of the screw body (100) and points from the head end of the screw body (100) to the tail end of the screw body (100), and a second direction is the reverse of the first direction.

2. The porous screw according to claim 1, wherein One threaded shaft section (110) is provided, one porous shaft section (120) is provided, and the threaded shaft section (110) and the porous shaft section (120) are sequentially distributed along the first direction.

3. The porous screw according to claim 1, characterized in that, One threaded shaft section (110) is provided, one porous shaft section (120) is provided, and the threaded shaft section (110) and the porous shaft section (120) are sequentially distributed along the second direction.

4. The porous screw according to claim 1, characterized in that One porous shaft section (120) is provided, more than two threaded shaft sections (110) are provided, the threaded shaft sections (110) and the porous shaft section (120) are alternately distributed along the first direction in sequence, and the porous shaft section (120) is located between two threaded shaft sections (110).

5. The porous screw according to claim 1, characterized in that, One threaded shaft section (110) is provided, more than two porous shaft sections (120) are provided, the porous shaft sections (120) and the threaded shaft section (110) are alternately distributed along the first direction in sequence, and the threaded shaft section (110) is located between two porous shaft sections (120).

6. The porous screw according to claim 1, wherein, More than two threaded shaft sections (110) are provided, more than two porous shaft sections (120) are provided, the porous shaft sections (120) and the threaded shaft sections (110) are alternately distributed along the first direction in sequence, or the threaded shaft sections (110) and the porous shaft sections (120) are alternately distributed along the first direction in sequence.

7. The porous screw according to claim 1, wherein One threaded shaft section (110) is provided, one porous shaft section (120) is provided, the threaded shaft section (110) and the porous shaft section (120) are sequentially distributed along the circumferential direction of the screw body (100), and the threaded shaft section (110) and the porous shaft section (120) are connected end to end.

8. The porous screw according to claim 1, characterized in that, More than two threaded shaft sections (110) are provided, more than two porous shaft sections (120) are provided, and the threaded shaft sections (110) and the porous shaft sections (120) are alternately distributed along the circumferential direction of the screw body (100) in sequence.

9. The porous screw according to any one of claims 1 to 8, characterized in that, A fitting block body (130) is fixedly connected to the screw body (100), and a fitting groove is opened on the end face of the fitting block body (130) far from the screw body; a conical block (140) is fixedly connected to the tail of the screw body (100); And / or, the threaded shaft section (110) is provided with an auxiliary feed groove (112), the auxiliary feed groove (112) has a first inner wall (114) and a second inner wall (116), the first inner wall (114) and the second inner wall (116) are connected, a plane where the first inner wall (114) is located is inclined relative to an axis of the screw body (100), and a plane where the second inner wall (116) is located is parallel to the axis of the screw body (100).

10. The porous screw according to claim 9, wherein, The pore shaft section (120) is a hollow shaft body formed by intertwining a plurality of strip-shaped entities (124), the plurality of strip-shaped entities (124) are fixedly connected to each other, and there is at least one gap between the strip-shaped entities (124), and the gap forms the drug-carrying pore body (122).

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