Auxiliary shaping device for acellular matrix membrane material

Abstract

The utility model relates to the technical field of biomedical material processing equipment, and discloses an auxiliary shaping device for an acellular matrix membrane material, which comprises a shaping mold, and the shaping mold mainly comprises a shaping template and a base; the shaping template is provided with an upper cavity with a downward opening, the top surface of the shaping template is provided with an inward concave shaping cavity, and the top surface of the shaping template is provided with a plurality of adsorption through holes; an upper cavity is formed in the upper portion of the base, a lower cavity corresponding to the upper cavity is formed in the upper portion of the base, the shaping template is detachably connected with the base in a sealed mode, the upper cavity and the lower cavity jointly form a negative pressure cavity, and an air hole connector communicated with the negative pressure cavity is arranged on the side face of the shaping template or the side face of the base and used for being connected with a negative pressure source. According to the utility model, the shaping template with the shaping cavity is designed, and the diaphragm is shaped in a negative pressure adsorption manner, so that the acellular matrix diaphragm can be prefabricated into a shape matched with various wound surfaces, the fitting degree of the diaphragm and the wound surfaces is greatly improved, and the problem that the traditional plane diaphragm is difficult to fit is effectively solved.

Description

Technical Field

[0001] The utility model relates to the technical field of biomedical material processing equipment, and particularly relates to an auxiliary shaping device for acellular matrix membrane materials. Background Art

[0002] As an important biomedical material, the cell matrix has been widely used in the fields of tissue repair, regenerative medicine, etc. due to its good biocompatibility, low immunogenicity and other characteristics. For example, in surgeries such as skin repair, cartilage regeneration, corneal transplantation, etc., the acellular matrix membrane material plays a key role.

[0003] At present, most acellular matrix membrane materials are in a flat sheet shape. For example, Chinese invention patent CN103272273B discloses a mold for preparing acellular small intestinal submucosa matrix material, which consists of a bottom plate, a pressing frame and a pressing net. The bottom plate is a square plate, the pressing frame is a hollow square frame, and the pressing net is a square frame with a square structure or a net structure inside. Before entering the freeze-drying step after completing steps such as acellularization, the material is laid flat on the bottom plate, and multiple layers can be stacked. Then, the pressing frame is placed on the material, fixed with stainless steel screws, and then the pressing net is placed, and finally all are put into a freeze-dryer for the freeze-drying step. The membrane sheet made by the above patent is in a flat sheet shape, and the flat sheet-shaped acellular matrix membrane sheet has obvious limitations in practical applications. Taking corneal surgery as an example, the cornea has a special curved surface shape, and it is difficult for the flat sheet-shaped acellular matrix membrane material to fit well with the corneal wound surface and be sutured, which not only increases the difficulty of the surgical operation, but also may affect the surgical effect and the postoperative recovery of the patient. To improve this situation, pre-shaping the acellular matrix membrane sheet so that it can better fit the wound surface is of great significance for improving the convenience of surgical operation and the treatment effect. Therefore, there is an urgent need to develop an efficient and practical auxiliary shaping device. Summary of the Utility Model

[0004] To solve the above deficiencies in the prior art, the utility model provides an auxiliary shaping device for acellular matrix membrane materials, which can effectively shape different types of acellular matrix membrane sheets, pre-make them into shapes matching various wound surface shapes, greatly improve the fitting degree between the membrane sheet and the wound surface, and meet the requirements of different surgical scenarios.

[0005] To achieve the above technical purpose, the technical solution adopted by the utility model is:

[0006] An auxiliary shaping device for acellular matrix membrane materials, comprising a shaping mold, which mainly includes a shaping template and a base; the shaping template is provided with an upper chamber with a downward opening, the top surface of the shaping template is provided with an inwardly concave shaping cavity, and a number of adsorption through-holes are opened on the top surface of the shaping template; the upper part of the base is provided with a lower chamber corresponding to the upper chamber, the shaping template and the base are detachably and sealingly connected, and the upper chamber and the lower chamber together form a negative pressure chamber, and an air hole joint communicating with the negative pressure chamber is arranged on the side surface of the shaping template or the base, and the air hole joint is used to connect a negative pressure source.

[0007] As a preferred technical solution, a mutually adapted stop groove and stop are provided on the facing surfaces of the base and the shaping template.

[0008] As a preferred technical solution, the shaping mold further includes a sealing gasket, and the sealing gasket is located between the shaping template and the base.

[0009] As a preferred technical solution, the base, the sealing gasket and the shaping template are connected by screws. The base is provided with a through base screw hole, the sealing gasket is provided with a through sealing gasket screw hole, and the shaping template is provided with a threaded template screw hole. The screw passes through the base, the sealing gasket and the shaping template from bottom to top for connection.

[0010] As a preferred technical solution, the base and the shaping template are connected by snap fasteners.

[0011] As a preferred technical solution, a base positioning pin is designed on the base, and template positioning pin holes and sealing gasket positioning pin holes are respectively designed on the shaping template and the sealing gasket.

[0012] As a preferred technical solution, a vacuum pump is further included, and the air hole joint of the shaping mold is connected to the vacuum pump through a pipeline.

[0013] As a preferred technical solution, a pressure regulating valve is arranged on the pipeline.

[0014] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0015] The auxiliary shaping device for acellular matrix membrane materials of the present utility model: by designing a shaping template with shaping cavities of different shapes, the acellular matrix membrane sheet can be pre-shaped into a shape matching various wound surfaces, greatly improving the fitting degree between the membrane sheet and the wound surface. Especially for wound surfaces with complex shapes, such as the cornea, etc., it effectively solves the problem of difficult fitting of traditional flat membrane sheets; the shaped membrane sheet is easier to suture with the wound surface during the operation, reducing the difficulty of the operation, shortening the operation time, and reducing the surgical risk and pain of the patient.

[0016] The auxiliary shaping device for acellular matrix membrane materials of the present utility model: shapes the membrane by means of negative pressure adsorption. The buffering effect of the negative pressure chamber for accommodating gas can minimize the impact even if there are small fluctuations during the pressure adjustment process, ensuring the shaping quality of the membrane. It can also cooperate with a pressure regulating valve to achieve precise control of the pressure, ensuring that membranes of different materials and thicknesses can obtain good and stable shaping effects, improving the applicability and reliability of the product.

[0017] The auxiliary shaping device for acellular matrix membrane materials of the present utility model: The shaping mold adopts a detachable connection method, which is convenient for cleaning and replacing the mold. At the same time, the whole device has a simple structure and a clear operation process, making it easy for medical staff to master and use. Description of the Drawings

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present application and should not be regarded as limiting the scope. For those of ordinary skill in the art, other relevant drawings can be obtained based on these drawings without creative efforts.

[0019] Figure 1 It is an overall schematic diagram of the shaping mold in the present utility model;

[0020] Figure 2 It is a bottom view of the shaping template in the present utility model;

[0021] Figure 3 It is an overall schematic diagram of the auxiliary shaping device in the present utility model.

[0022] Reference numerals: 1 - vacuum pump, 2 - pressure regulating valve, 3 - shaping mold, 4 - pipeline, 5 - membrane, 31 - shaping template, 32 - sealing gasket, 33 - base, 34 - negative pressure chamber, 35 - screw, 311 - template positioning pin hole, 312 - template screw hole, 313 - adsorption through hole, 314 - shaping cavity, 321 - sealing gasket positioning pin hole, 322 - sealing gasket screw hole, 331 - base positioning pin, 332 - base screw hole, 333 - air hole joint. Detailed Embodiments

[0023] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the following will clearly and completely describe the technical solutions in the embodiments of this application with reference to the accompanying drawings in the embodiments of this application. Obviously, the described embodiments are some, but not all, of the embodiments of this application. Components of the embodiments of this application usually described and illustrated in the accompanying drawings here can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of this application provided in the drawings is not intended to limit the scope of the claimed application, but merely represents selected embodiments of this application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of this application without creative efforts fall within the scope of protection of this application.

[0024] An auxiliary shaping device for acellular matrix membrane materials, as Figures 1-3 shown, includes a shaping mold 3, which includes a shaping template 31 and a base 33.

[0025] The shaping template 31 is provided with an upper chamber with a downward opening. The top surface of the shaping template 31 is provided with an inwardly recessed shaping cavity 314. The shaping cavity 314 can be designed with different shapes according to the shaping requirements of the membrane sheet to meet the fitting requirements of different wound surfaces. For example, the template for corneal surgery can be designed as a curved surface shape matching the corneal morphology. A number of adsorption through-holes 313 are opened on the top surface of the shaping template 31, and these adsorption through-holes 313 can ensure the passage of gas; the upper part of the base 33 is provided with a lower chamber corresponding to the upper chamber. The shaping template 31 and the base 33 are detachably and sealedly connected. The upper chamber and the lower chamber together form a negative pressure chamber 34. An air hole joint 333 communicating with the negative pressure chamber 34 is provided on the side surface of the shaping template 31 or the base 33; by connecting a negative pressure source through the air hole joint 333, the adsorption shaping of the membrane sheet 5 placed on the surface of the shaping template 31 can be realized under the action of negative pressure. There is a negative pressure chamber 34 between the shaping template 31 and the base 33. The negative pressure chamber 34 has the function of accommodating gas and playing a buffering role. During the formation and adjustment of negative pressure, the gas in the negative pressure chamber 34 can buffer the change in the pressure received by the membrane sheet 5, avoiding damage to the membrane sheet 5 due to sudden pressure changes.

[0026] In one embodiment, mutually adapted stop grooves and stop mouths are provided on the facing surfaces of the base 33 and the shaping template 31 to achieve sealing between the two. In another preferred embodiment, a sealing gasket 32 is further included. The sealing gasket 32 is located between the shaping template 31 and the base 33 and plays a sealing role to prevent the gas in the negative pressure chamber 34 from leaking during the formation of negative pressure, ensuring that a stable negative pressure environment can be formed inside the device.

[0027] Preferably, the base 33, the gasket 32 and the shaping template 31 are connected by screws 35. The base 33 is provided with a through base screw hole 332, the gasket 32 is provided with a through gasket screw hole 322, and the shaping template 31 is provided with a threaded template screw hole 312. The screw 35 passes through the base 33, the gasket 32 and the shaping template 31 from the bottom for connection. This connection method is convenient for disassembly and assembly, and facilitates the cleaning, replacement and maintenance of the mold. Of course, the base 33 and the shaping template 31 can also be connected by a snap connection method.

[0028] Further, for facilitating assembly and positioning, a base positioning pin 331 is designed on the base 33, and template positioning pin holes 311 and gasket positioning pin holes 321 are respectively designed on the shaping template 31 and the gasket 32. The base positioning pin 331 passes through the gasket positioning pin hole 321 and is inserted into the template positioning pin hole 311 to achieve assembly positioning.

[0029] Preferably, a vacuum pump 1 is further included. The air hole joint 333 of the shaping mold 3 is connected to the vacuum pump 1 through a pipeline 4, and a pressure regulating valve 2 is arranged on the pipeline 4. The vacuum pump 1 serves as a power source and can provide negative pressure, while the pressure regulating valve 2 can adjust the magnitude of the negative pressure to adapt to the shaping requirements of acellular matrix membranes 5 with different materials and thicknesses. At the same time, the pressure regulating valve 2 cooperates with the buffering effect of the negative pressure chamber 34 to more precisely control the pressure received by the membrane 5 and ensure the shaping effect.

[0030] The working principle of the auxiliary shaping device of the present utility model is as follows:

[0031] During use, first, the shaping template 31, the gasket 32 and the base 33 are positioned through the base positioning pin 331, the template positioning pin hole 311 and the gasket positioning pin hole 321, and the shaping template 31 and the base 33 are fixedly connected by screws 35 to ensure that the gasket 32 plays a good sealing role. Then, the membrane 5 is placed on the upper surface of the shaping template 31, and the negative pressure vacuum pump 1 is turned on to form negative pressure inside the negative pressure chamber 34. Since the shaping template 31 is provided with adsorption through holes 313, the membrane 5 will be adsorbed on the shaping template 31 under the action of negative pressure and start to be shaped according to the shape of the shaping cavity 314 of the shaping template.

[0032] During the formation and change of negative pressure, the gas contained in the negative pressure chamber 34 plays a buffering role. When the negative pressure rises or falls rapidly, the gas in the negative pressure chamber 34 can absorb the impact brought by the pressure change, preventing the diaphragm 5 from being deformed or damaged by excessive pressure instantaneously. At the same time, the operator can adjust the magnitude of the negative pressure according to the specific situation of the diaphragm 5 through the pressure regulating valve 2. The pressure regulating valve 2 controls the inflow and outflow of gas, and the buffering of the gas in the negative pressure chamber 34 makes the pressure change more stable. The two work together to ensure that the diaphragm 5 can be stably shaped and will not be damaged due to excessive pressure or too rapid pressure change. After the diaphragm 5 is shaped under specific processes (temperature, time, etc.), the vacuum pump 1 is turned off, and the shaped diaphragm 5 is taken out.

[0033] The following are specific experimental examples:

[0034] Experimental Example 1: Shaping of the corneal acellular matrix diaphragm

[0035] Preparation work: Select a shaping template 31 that matches the shape of the cornea, place the gasket 32 between the shaping template 31 and the base 33, and achieve accurate positioning and combination through the base positioning pin 331, the template positioning pin hole 311, and the gasket positioning pin hole 321, and then fix and connect the three with screws 35. After that, connect the vacuum pump 1, the pressure regulating valve 2, and the air hole joint 333 in sequence with the pipeline 4.

[0036] Place the diaphragm: Place the corneal acellular matrix diaphragm to be shaped flat on the surface of the shaping template 31.

[0037] Start the equipment: Start the vacuum pump 1, adjust the pressure regulating valve 2 to an appropriate negative pressure value (for example, -20 kPa), so that the corneal acellular matrix diaphragm is adsorbed on the surface of the shaping template 31 under the action of negative pressure. During the formation of negative pressure, the gas in the negative pressure chamber 34 between the shaping template 31 and the base 33 plays a buffering role, preventing the corneal acellular matrix diaphragm from being damaged due to rapid pressure change; maintain this negative pressure state at room temperature for 180 minutes to fully shape the corneal acellular matrix diaphragm.

[0038] Take out the diaphragm: Turn off the vacuum pump 1, remove the screws 35, and carefully take out the shaped corneal acellular matrix diaphragm for subsequent sterilization, packaging and other preparation processes.

[0039] Experimental Example 2: Shaping of the skin acellular matrix diaphragm

[0040] Select a suitable template: According to the shape and requirements of the skin wound surface, select a shaping template 31 of the corresponding shape, install the gasket 32 and the base 33 in the same way as above, and fix and connect them. After that, connect the vacuum pump 1, the pressure regulating valve 2, and the air hole joint 333 in sequence with the pipeline 4 as above.

[0041] Diaphragm Placement: Place the acellular dermal matrix diaphragm on the surface of the shaping template 31, ensuring that the acellular dermal matrix diaphragm is flat.

[0042] Equipment Operation: Turn on the vacuum pump 1 and adjust the negative pressure to -50 kPa through the pressure regulating valve 2 to make the acellular dermal matrix diaphragm adsorbed on the surface of the shaping template 31. The gas in the negative pressure chamber 34 between the shaping template 31 and the base 33 buffers the pressure change to ensure the stable shaping of the acellular dermal matrix diaphragm. Keep it at -25 °C for 24 hours to complete the shaping of the acellular dermal matrix diaphragm.

[0043] Shaping Completion: Turn off the equipment, take out the shaped acellular dermal matrix diaphragm for subsequent sterilization, packaging and other preparation processes.

[0044] As can be seen from the above experimental examples, the acellular matrix membrane material auxiliary shaping device of the present utility model can effectively realize the shaping of different types of acellular matrix diaphragms, meet the needs of different surgical scenarios, and at the same time use the buffering function of the negative pressure chamber between the shaping template and the base to better protect the diaphragm and improve the shaping effect.

[0045] Certainly, the present utility model may have many other embodiments. Without departing from the spirit and essence of the present utility model, those skilled in the art can make various corresponding changes and deformations according to the present utility model, but these corresponding changes and deformations should all fall within the protection scope of the appended claims of the present utility model.

Claims

1. An auxiliary shaping device for acellular matrix membrane materials, characterized in that: It includes a shaping mold (3), and the shaping mold (3) mainly includes a shaping template (31) and a base (33); the shaping template (31) is provided with an upper chamber with a downward opening, the top surface of the shaping template (31) is provided with a recessed shaping cavity (314), and a number of adsorption through-holes (313) are opened on the top surface of the shaping template (31); the upper part of the base (33) is provided with a lower chamber corresponding to the upper chamber, the shaping template (31) is detachably and sealingly connected to the base (33), and the upper chamber and the lower chamber together form a negative pressure chamber (34). An air hole connector (333) communicating with the negative pressure chamber (34) is arranged on the side surface of the shaping template (31) or the base (33), and the air hole connector (333) is used for connecting a negative pressure source.

2. The auxiliary shaping device for acellular matrix membrane materials according to claim 1, wherein: On the opposite surfaces of the base (33) and the shaping template (31), there are mutually adapted stop grooves and stop lips.

3. The auxiliary shaping device for acellular matrix membrane materials according to claim 1, characterized in that: The shaping mold (3) further includes a gasket (32), and the gasket (32) is located between the shaping template (31) and the base (33).

4. The auxiliary shaping device for acellular matrix membrane materials according to claim 3, wherein: The base (33), the gasket (32) and the shaping template (31) are connected by screws (35). The base (33) is provided with a through base screw hole (332), the gasket (32) is provided with a through gasket screw hole (322), and the shaping template (31) is provided with a threaded template screw hole (312). The screw (35) passes through the base (33), the gasket (32) and the shaping template (31) in sequence from the bottom upwards for connection.

5. The auxiliary shaping device for acellular matrix membrane materials according to claim 3, wherein: The base (33) and the shaping template (31) are connected by snap fasteners.

6. The auxiliary shaping device for acellular matrix membrane materials according to claim 4 or 5, characterized in that: A base positioning pin (331) is designed on the base (33), and template positioning pin holes (311) and gasket positioning pin holes (321) are respectively designed on the shaping template (31) and the gasket (32).

7. The auxiliary shaping device for acellular matrix membrane materials according to claim 1, wherein: It further includes a vacuum pump (1), and the air hole connector (333) of the shaping mold (3) is connected to the vacuum pump (1) through a pipeline (4).

8. The auxiliary shaping device for acellular matrix membrane materials according to claim 7, wherein: A pressure regulating valve (2) is arranged on the pipeline (4).

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