Stirrer for microcarrier

Abstract

The utility model relates to the technical field of stirrers, in particular to a stirrer for a microcarrier, which is characterized in that an adjusting knob is arranged outside a main disc body, one end of the adjusting knob is provided with a threaded rod piece I, and one end of the threaded rod piece I is connected with an eccentric cylinder. Through the adjusting design of the stirring blade component group, the stirring amplitude can be adjusted according to the characteristics of different cells, so that the cells are prevented from being damaged.

Description

Technical Field

[0001] The utility model relates to the technical field of stirrers, in particular to a stirrer for microcarriers. Background Technique

[0002] In the process of microcarrier cell culture in biotransformation engineering, a stirrer is a commonly used device for uniformly stirring and mixing the culture. There are mainly two purposes for stirring in the cell culture process: one is to maintain the uniformity of the culture medium to ensure the uniform distribution of nutrients and oxygen, and the other is to avoid cell aggregation to prevent cells from lacking oxygen or nutrients due to local high density. However, the design of the stirrer blades used in the prior art will cause damage to fragile cells at higher rotation speeds, and the length of the driving rod of the current stirrer cannot be adjusted. When facing stirrer containers of different sizes, it is impossible to adaptively adjust the depth of the stirrer container, reducing the practicability of the stirrer. Content of the Utility Model

[0003] In order to overcome the above technical problems, the purpose of the utility model is to provide a stirrer for microcarriers to solve the problem that the current microcarrier stirrer is prone to damage fragile cells as mentioned in the above background technique.

[0004] To achieve the above purpose, the utility model provides the following technical solution:

[0005] A stirrer for microcarriers, comprising: a stirring blade component group, the stirring blade component group includes a main disk body, an adjusting knob is arranged outside the main disk body, one end of the adjusting knob is provided with a first threaded rod member, one end of the first threaded rod member is connected with an eccentric cylinder, a blade connecting rod is in contact with the side surface of the eccentric cylinder, and one end of the blade connecting rod is connected with a stirring blade; a driving rod component group is arranged at the top of the stirring blade component group, and the driving rod component group is used to drive the stirring blade component group to rotate and stir.

[0006] Preferably: the adjusting knob, the first threaded rod member, the eccentric cylinder, the blade connecting rod and the stirring blade are provided with four groups, and the four groups of adjusting knobs, first threaded rod members, eccentric cylinders, blade connecting rods and stirring blades are evenly distributed on the main disk body, one end of the first threaded rod member is connected with the adjusting knob, and the other end of the first threaded rod member is connected with the eccentric cylinder.

[0007] Preferably: the first threaded rod member is connected with the main disk body through threads, the main disk body is provided with a groove at the position corresponding to the eccentric cylinder, and the axis of the eccentric cylinder is different from the axis of the first threaded rod member.

[0008] Preferably: the side surface of the eccentric cylinder is in contact with one end of the blade connecting rod, and the other end of the blade connecting rod is connected with the stirring blade.

[0009] Preferably, the driving rod component group includes an outer sleeve rod, an anti-slip contact ring is arranged inside the outer sleeve rod, a second threaded rod member is arranged on one side of the anti-slip contact ring, a collar member is arranged outside the second threaded rod member, an upper end ring cylinder is arranged at one end of the collar member, and a lead screw member is arranged inside the collar member.

[0010] Preferably, an annular groove is arranged at one end of the outer sleeve rod corresponding to the second threaded rod member, and the outer sleeve rod and the second threaded rod member are in contact through the annular groove.

[0011] Preferably, the bottom of the anti-slip contact ring is in contact with the outer sleeve rod, the collar member is connected to the lead screw member through a nut pair, the upper end ring cylinder is connected to the outer sleeve rod through a bearing, the upper end ring cylinder is connected to the collar member, and the upper end ring cylinder is in sliding contact with the lead screw member.

[0012] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0013] 1. The stirrer for microcarriers is provided with a stirring blade component group and a driving rod component group. In the prior art, the blade design of the stirrer will cause damage to fragile cells at higher rotation speeds. In the designed stirring blade component group, the angle between the blade connecting rod of the component and the stirring blade of the component can be controlled to adjust the angle of contact with the medium when the stirrer is working. Through this adjustment, the stirring amplitude can be adjusted according to the characteristics of different cells to avoid damaging the cells;

[0014] 2. The stirrer for microcarriers is provided with a stirring blade component group and a driving rod component group. At present, the length of the driving rod of the stirrer cannot be adjusted. When facing stirring containers of different sizes, the depth of the stirring container cannot be adjusted adaptively, reducing the practicability of the stirrer. In the designed driving rod component group, the length of the driving rod composed of the outer sleeve rod and the lead screw member can be adjusted, and then it can be adjusted and adapted according to the depth size of the used stirring container, improving the practicability of the device. Description of the Drawings

[0015] Figure 1 is a schematic diagram of the overall structure of the present utility model;

[0016] Figure 2 is a schematic diagram of the overall sectional structure of the present utility model;

[0017] Figure 3 is of the present utility model Figure 2 structural schematic diagram at A;

[0018] Figure 4 is of the present utility model Figure 2 structural schematic diagram at B;

[0019] Figure 5 The structural schematic diagram of the driving rod component group part of the present utility model;

[0020] Figure 6 The structural schematic diagram of the first threaded rod part and the eccentric cylinder part of the present utility model.

[0021] In the figure: 01, stirring blade component group; 11, main disk body; 12, adjusting knob; 13, first threaded rod part; 14, eccentric cylinder; 15, blade connecting rod; 16, stirring blade; 02, driving rod component group; 21, outer sleeve rod; 22, anti-slip contact ring; 23, second threaded rod part; 24, collar part; 25, upper end ring cylinder; 26, lead screw part. Specific embodiments

[0022] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0023] Please refer to Figures 1-6 , an embodiment provided by the present utility model: A stirrer for microcarriers, comprising: a stirring blade component group 01, the stirring blade component group 01 includes a main disk body 11, an adjusting knob 12 is arranged outside the main disk body 11, a first threaded rod part 13 is arranged at one end of the adjusting knob 12, an eccentric cylinder 14 is connected to one end of the first threaded rod part 13, a blade connecting rod 15 is in contact with the side surface of the eccentric cylinder 14, and a stirring blade 16 is connected to one end of the blade connecting rod 15; a driving rod component group 02 is arranged at the top of the stirring blade component group 01, and the driving rod component group 02 is used to drive the stirring blade component group 01 to rotate and stir.

[0024] Four groups of adjusting knobs 12, first threaded rod parts 13, eccentric cylinders 14, blade connecting rods 15 and stirring blades 16 are provided, and the four groups of adjusting knobs 12, first threaded rod parts 13, eccentric cylinders 14, blade connecting rods 15 and stirring blades 16 are evenly distributed on the main disk body 11. One end of the first threaded rod part 13 is connected to the adjusting knob 12, and the other end of the first threaded rod part 13 is connected to the eccentric cylinder 14.

[0025] The first threaded rod part 13 is connected to the main disk body 11 by threads, the main disk body 11 is provided with a groove at the position corresponding to the eccentric cylinder 14, and the axis line of the eccentric cylinder 14 is different from the axis line of the first threaded rod part 13.

[0026] The side surface of the eccentric cylinder 14 contacts one end of the blade connecting rod 15, and the other end of the blade connecting rod 15 is connected to the stirring blade 16.

[0027] The drive rod component group 02 includes an outer sleeve rod 21. Inside the outer sleeve rod 21, an anti-slip contact ring 22 is provided. On one side of the anti-slip contact ring 22, a second threaded rod member 23 is provided. Outside the second threaded rod member 23, a collar member 24 is provided. At one end of the collar member 24, an upper end ring cylinder 25 is provided. Inside the collar member 24, a lead screw member 26 is provided.

[0028] At one end of the outer sleeve rod 21, an annular groove is provided at a position corresponding to the second threaded rod member 23, and the outer sleeve rod 21 contacts the second threaded rod member 23 through the annular groove.

[0029] The bottom of the anti-slip contact ring 22 contacts the outer sleeve rod 21. The collar member 24 is connected to the lead screw member 26 through a nut pair. The upper end ring cylinder 25 is connected to the outer sleeve rod 21 through a bearing. The upper end ring cylinder 25 is connected to the collar member 24. The upper end ring cylinder 25 is in sliding contact with the lead screw member 26. One end of the outer sleeve rod 21 away from the collar member 24 is connected to the working end of the stirrer drive motor. One end of the lead screw member 26 away from the outer sleeve rod 21 is connected to the main disk body 11.

[0030] Working principle: During use, when adjusting the angle of the stirring blade 16, by controlling the rotation of the adjustment knob 12, the rotation of the adjustment knob 12 drives the first threaded rod member 13 to rotate. While the first threaded rod member 13 rotates and moves up and down through the thread, it drives the eccentric cylinder 14 to rotate. Since the axes of the first threaded rod member 13 and the eccentric cylinder 14 are different, the eccentric cylinder 14 will release the contact with one end of the blade connecting rod 15. At this time, the blade connecting rod 15 and the stirring blade 16 can be controlled to adjust the angle, and thus the angle of contact with the medium during stirring can be changed, achieving the effect of adjusting the stirring amplitude according to different cell conditions. After adjusting to the appropriate angle, by controlling the reverse rotation of the adjustment knob 12, the eccentric cylinder 14 is made to contact one end of the blade connecting rod 15 again. After the eccentric cylinder 14 contacts the blade connecting rod 15, the eccentric cylinder 14 will squeeze one end of the blade connecting rod 15 to lock the position of the blade connecting rod 15. In the designed drive rod component group 02, by rotating the second threaded rod member 23, the second threaded rod member 23 moves up and down through the thread of the collar member 24, so that the anti-slip contact ring 22 releases the contact with the outer sleeve rod 21. At this time, the collar member 24 can be controlled to rotate. The collar member 24 will drive the lead screw member 26 to move up and down through the nut pair, and thus the lead screw member 26 extends or retracts. When the collar member 24 rotates, the second threaded rod member 23 will slide in the arc-shaped groove of the outer sleeve rod 21. When the lead screw member 26 is adjusted to the appropriate position, control the second threaded rod member 23 to reverse rotate, so that the bottom of the anti-slip contact ring 22 contacts the outer sleeve rod 21, and through the friction effect, the position between the lead screw member 26 and the outer sleeve rod 21 is locked.

[0031] For those skilled in the art, it is obvious that the present utility model is not limited to the details of the above-described exemplary embodiments, and the present utility model can be implemented in other specific forms without departing from the spirit or basic characteristics of the present utility model. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present utility model is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be embraced within the present utility model. Any reference signs in the claims should not be construed as limiting the claims involved.

Claims

1. A stirrer for microcarriers, characterized in that, Comprising: A stirring blade component group (01), the stirring blade component group (01) includes a main disk body (11), an adjusting knob (12) is arranged outside the main disk body (11), one end of the adjusting knob (12) is provided with a first threaded rod member (13), one end of the first threaded rod member (13) is connected with an eccentric cylinder (14), the side surface of the eccentric cylinder (14) contacts with a blade connecting rod (15), and one end of the blade connecting rod (15) is connected with a stirring blade (16); At the top of the stirring blade component group (01), there is a driving rod component group (02), and the driving rod component group (02) is used to drive the stirring blade component group (01) to rotate and stir.

2. The stirrer for microcarriers according to claim 1, characterized in that: There are four groups of the adjusting knob (12), the first threaded rod member (13), the eccentric cylinder (14), the blade connecting rod (15) and the stirring blade (16), and the four groups of the adjusting knob (12), the first threaded rod member (13), the eccentric cylinder (14), the blade connecting rod (15) and the stirring blade (16) are evenly distributed on the main disk body (11). One end of the first threaded rod member (13) is connected with the adjusting knob (12), and the other end of the first threaded rod member (13) is connected with the eccentric cylinder (14).

3. The stirrer for microcarriers according to claim 1, characterized in that: The first threaded rod member (13) is connected with the main disk body (11) by threads. The main disk body (11) is provided with a groove at the position corresponding to the eccentric cylinder (14), and the axis line of the eccentric cylinder (14) is different from the axis line of the first threaded rod member (13).

4. The stirrer for microcarriers according to claim 1, characterized in that: The side surface of the eccentric cylinder (14) contacts with one end of the blade connecting rod (15), and the other end of the blade connecting rod (15) is connected with the stirring blade (16).

5. A stirrer for microcarriers according to claim 1, characterized in that: The driving rod component group (02) includes an outer sleeve rod (21), an anti-slip contact ring (22) is arranged inside the outer sleeve rod (21), one side of the anti-slip contact ring (22) is provided with a second threaded rod member (23), a collar member (24) is arranged outside the second threaded rod member (23), one end of the collar member (24) is provided with an upper end ring cylinder (25), and a lead screw member (26) is arranged inside the collar member (24).

6. The stirrer for microcarriers according to claim 5, characterized in that: One end of the outer sleeve rod (21) is provided with an annular groove at the position corresponding to the second threaded rod member (23), and the outer sleeve rod (21) contacts with the second threaded rod member (23) through the annular groove.

7. A stirrer for microcarriers according to claim 5, characterized in that: The bottom of the anti-slip contact ring (22) contacts with the outer sleeve rod (21). The collar member (24) is connected with the lead screw member (26) by a nut pair. The upper end ring cylinder (25) is connected with the outer sleeve rod (21) through a bearing. The upper end ring cylinder (25) is connected with the collar member (24), and the upper end ring cylinder (25) is in sliding contact with the lead screw member (26).

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