Separation and purification device for extracting active substances of marine organisms

Abstract

The utility model discloses a separation and purification device for extracting marine bioactive substances, which belongs to the technical field of extraction devices and comprises an extraction box, a driving motor I is fixedly connected to the left side of the extraction box, and a rotating rod is fixedly connected to the right end of an output shaft of the driving motor I; the right end of the rotating rod extends to the right side of the extraction box and is fixedly connected with a rotating disc; when the crushed marine organisms and the organic solution are both located in the extraction box, a plurality of stirring rods are controlled by a driving motor I to rotate so as to fully mix the marine organism raw materials and the extraction solvent, so that active substances can be effectively dissolved into the solvent from the biological raw materials; the fine filter screen and the coarse filter screen can be driven to transversely move in a staggered manner, so that the problems that the filter holes of the fine filter screen and the coarse filter screen are blocked by impurities when the fine filter screen and the coarse filter screen are used for filtering the extracting solution, the filtering effect of the extracting solution is reduced, and the separation and purification quality is influenced can be prevented.

Description

Technical Field

[0001] The utility model relates to the technical field of extraction devices, in particular to a separation and purification device for extracting marine bioactive substances. Background Technique

[0002] Marine bioactive substances have various types, including but not limited to proteins, polypeptides, polysaccharides, alkaloids, terpene compounds, etc. These substances may be rare in terrestrial organisms or have different structural and functional characteristics. For example, marine polysaccharides have unique chemical structures and biological activities, such as alginate, carrageenan, etc. They have broad application prospects in the fields of food, medicine, cosmetics, etc. Many marine bioactive substances also have medicinal effects such as antibacterial, antiviral, antitumor, and anti-inflammatory, and are a potential treasure trove for developing new drugs;

[0003] When the existing separation and purification device for marine bioactive substances purifies marine organisms, when large marine biological fragments are mixed with the extraction solvent, the filter plate is easily blocked, thereby reducing the extraction quality. At the same time, during the use of traditional extraction devices, the crushing effect on marine organisms is poor, resulting in a large consumption of marine organisms, a slow extraction speed of bioactive substances, and low work efficiency. Content of the Utility Model

[0004] Purpose of the utility model: The purpose of the utility model is to solve the problem that when the separation and purification device purifies marine organisms, the filter plate is easily blocked when large marine biological fragments are mixed with the extraction solvent; another purpose of the utility model is to solve the problem that during the use of traditional extraction devices, the crushing effect on marine organisms is poor, resulting in a large consumption of marine organisms and a slow extraction speed of bioactive substances.

[0005] Technical solution: A separation and purification device for extracting marine bioactive substances, including an extraction tank, a driving motor 1 is fixedly connected to the left side of the extraction tank, the right end of the output shaft of the driving motor 1 is fixedly connected to a rotating rod, the right end of the rotating rod extends to the right side of the extraction tank and is fixedly connected to a rotating disc, and a plurality of stirring rods are fixedly connected to the outer side wall of the rotating rod and located inside the extraction tank;

[0006] On the right side of the extraction box and below the rotating disc, there is a fixed connection with an extrusion box. Inside the extrusion box, there is a piston plate I slidingly connected. On the upper surface of the piston plate I, there is a fixed connection with an extrusion rod. The top end of the extrusion rod extends above the extrusion box. On the upper part of the outer side wall of the rotating disc, there is a fixed connection with a convex block. Inside the extraction box, there are symmetrically fixed connections with sliding boxes. Inside both sliding boxes, there is a piston plate II slidingly connected. On the opposite sides of the two piston plate IIs, there is a common fixed connection with a coarse filter screen. There is an air transmission round hole opened between the left side inside the extrusion box and the inside of the sliding box located on the right side inside the extraction box. Between the lower surface of the piston plate I and the lower surface inside the extrusion box, there are multiple springs fixedly connected.

[0007] Furthermore, the lower surface of the extraction box is fixedly connected with a mounting base plate.

[0008] Furthermore, inside the extraction box and below both sliding boxes, there are ventilation chambers opened. Inside both ventilation chambers, there is a piston plate III slidingly connected. On the opposite sides of the two piston plate IIIs, there is a common fixed connection with a fine filter screen. There is an air transmission groove opened between the sliding box located on the left side of the extraction box and the ventilation chamber.

[0009] Furthermore, on the upper surface of the mounting base plate and on the right side of the extraction box, there are two side plates fixedly connected. On the opposite sides of the two side plates, there is a common fixed connection with a chromatography column. On the lower surface of the chromatography column, there is an integrally formed liquid discharge port. Inside the chromatography column, there is an ion exchange resin filled. On the upper surface of the chromatography column, there is a detachable connection with a drainage pipe. The end of the drainage pipe far from the chromatography column extends below the inside of the extraction box. On the outer side wall of the drainage pipe and on the right side of the extraction box, there is a pressure pump fixedly connected.

[0010] Furthermore, there is a through-type pressure relief hole opened on the right side inside the ventilation chamber located on the right side of the extraction box.

[0011] Further, a crushing box is arranged above the extraction box. A feeding pipe is fixedly connected to the lower surface of the crushing box. A second driving motor is fixedly connected to the front surface of the crushing box. The rear end of the output shaft of the second driving motor extends into the crushing box and is fixedly connected to a rotating column. A plurality of crushing blades are fixedly connected to the outer side wall of the rotating column. A feeding port is integrally formed on the upper surface of the crushing box. Sliding cavities are integrally formed on the left and right sides inside the crushing box. Piston plates IV are slidably connected to the interiors of the two sliding cavities. Sealing baffles are fixedly connected to the opposite sides of the two piston plates IV. The opposite sides of the two sealing baffles are in contact with each other. An air box is fixedly connected to the right side of the extraction box and above the rotating disc. A piston plate V is slidably connected to the interior of the air box. A push rod is rotatably connected to the lower surface of the piston plate V through a rotating shaft. A through horizontal groove is formed on the lower surface inside the air box. The lower left side of the push rod passes through the horizontal groove and is rotatably connected to the upper right side of the rotating disc through a rotating shaft. Two air conveying hoses are symmetrically arranged on the upper surface of the air box. The left ends of the two air conveying hoses are respectively communicated with the interiors of the two sliding cavities.

[0012] Further, a plurality of support columns are fixedly connected between the upper surface of the extraction box and the lower surface of the crushing box.

[0013] Further, a sealed maintenance door is rotatably connected to the front surface of the extraction box through a hinge.

[0014] Beneficial effects:

[0015] When both the crushed marine organisms and the organic solution are inside the extraction box, the first driving motor is used to control the rotation of a plurality of stirring rods to fully mix the marine biological raw materials and the extraction solvent, so as to ensure that the active substances can be effectively dissolved from the biological raw materials into the solvent. At the same time, it will also drive the fine filter screen and the coarse filter screen to move horizontally in a staggered manner, which can prevent impurities from blocking the filter holes of the fine filter screen and the coarse filter screen when filtering the extraction liquid, thereby reducing the filtering effect of the extraction liquid and affecting the quality of separation and purification.

[0016] The second driving motor is used to drive a plurality of crushing blades to rotate simultaneously. Due to the blocking of the two sealing baffles, the fragments are blocked inside the crushing box, which can ensure that the marine organisms put into the crushing box can be fully crushed. At the same time, the first driving motor is used to drive the rotating disc to rotate, so that when the marine organisms are crushed to a certain extent, the two sealing baffles can be controlled to open intermittently, and the crushed marine organisms and the organic solution can be conveyed into the extraction box, thereby increasing the extraction efficiency and quality. Description of the drawings

[0017] Figure 1 is the overall structural schematic diagram of the present utility model;

[0018] Figure 2 It is a schematic diagram of the front sectional structure of the crushing box of the present utility model;

[0019] Figure 3 It is a schematic diagram of the front sectional structure of the extraction box, air box and extrusion box of the present utility model;

[0020] Figure 4 It is a schematic diagram of the front sectional structure of the chromatography column of the present utility model;

[0021] Figure 5 It is of the present utility model Figure 1 The enlarged structure diagram at position A;

[0022] Figure 6 It is of the present utility model Figure 3 The enlarged structure diagram at position B.

[0023] In the figure: 1. Extraction box; 2. Driving motor I; 3. Rotating rod; 4. Rotating disc; 5. Stirring rod; 6. Extrusion box; 7. Piston plate I; 8. Extrusion rod; 9. Convex block; 10. Sliding box; 11. Piston plate II; 12. Coarse filter screen; 13. Air transmission round hole; 14. Spring; 15. Installation base plate; 16. Air exchange cavity; 17. Piston plate III; 18. Fine filter screen; 19. Air transmission groove; 20. Side plate; 21. Chromatography column; 22. Drainage port; 23. Ion exchange resin; 24. Drainage pipe; 25. Pressure pump; 26. Pressure relief hole; 27. Crushing box; 28. Feeding pipe; 29. Driving motor II; 30. Rotating column; 31. Crushing blade; 32. Feeding port; 33. Sliding cavity; 34. Piston plate IV; 35. Sealing baffle; 36. Air box; 37. Piston plate V; 38. Pushing rod; 39. Horizontal groove; 40. Air transmission hose; 41. Support column; 42. Sealed maintenance door. Detailed implementation mode

[0024] To make the technical solution of the present utility model clearer, the following further describes the present utility model in detail with reference to the accompanying drawings and specific embodiments.

[0025] Embodiment 1

[0026] As Figure 1 shown, the lower surface of the extraction box 1 is fixedly connected with an installation base plate 15;

[0027] The installation base plate 15 provides a solid bottom support for the extraction box 1, thus ensuring the stability of the entire extraction process.

[0028] As Figure 3 , Figure 5 and Figure 6As shown in the figure, a separation and purification device for extracting marine bioactive substances is provided, including an extraction tank 1. A driving motor 1 is fixedly connected to the left side of the extraction tank 1. The right end of the output shaft of the driving motor 1 is fixedly connected to a rotating rod 3. The right end of the rotating rod 3 extends to the right side of the extraction tank 1 and is fixedly connected to a rotating disk 4. A plurality of stirring rods 5 are fixedly connected to the outer side wall of the rotating rod 3 and inside the extraction tank 1. A pressing tank 6 is fixedly connected to the right side of the extraction tank 1 and below the rotating disk 4. A piston plate 7 is slidably connected inside the pressing tank 6. The upper surface of the piston plate 7 is fixedly connected to a pressing rod 8. The top end of the pressing rod 8 extends above the pressing tank 6. A convex block 9 is fixedly connected to the upper part of the outer side wall of the rotating disk 4. Two sliding boxes 10 are symmetrically and fixedly connected inside the extraction tank 1. A piston plate 11 is slidably connected inside each of the two sliding boxes 10. A coarse filter screen 12 is fixedly connected to the opposite sides of the two piston plates 11. An air delivery round hole 13 is formed between the left side inside the pressing tank 6 and the inside of the sliding box 10 located on the right side inside the extraction tank 1. A plurality of springs 14 are fixedly connected between the lower surface of the piston plate 7 and the lower surface inside the pressing tank 6;

[0029] After the extraction solvent and the crushed marine organisms enter the inside of the extraction tank 1, by starting the provided driving motor 1 to drive the rotation of the rotating rod 3, the rotation of the rotating rod 3 drives the simultaneous rotation of the plurality of stirring rods 5 on the outer side. Thus, the marine biological raw materials and the extraction solvent can be fully mixed by the plurality of stirring rods 5 to ensure that the active substances can be effectively dissolved from the biological raw materials into the solvent. At the same time, the rotation of the rotating rod 3 drives the rotation of the outer rotating disk 4. When the convex block 9 rotates to contact the top end of the pressing rod 8, the convex block 9 exerts a downward pressure on the pressing rod 8. Then, the pressing rod 8 drives the piston plate 7 to move downward. During the continuous rotation of the rotating disk 4, the convex block 9 gradually separates from the pressing rod 8. At this time, the piston plate 7 moves upward under the elastic force of the spring 14 and returns to the initial position. With the continuous rotation of the rotating disk 4, the convex block 9 periodically contacts and separates from the pressing rod 8, thereby changing the air pressure inside the pressing tank 6. The air pressure inside the pressing tank 6 is conveyed to the inside of the sliding box 10 on the right through the provided air delivery round hole 13. Thus, while the coarse filter screen 12 is filtering, it can be controlled to slide horizontally repeatedly inside the two sliding boxes 10, preventing the filter holes above the coarse filter screen 12 from being blocked by larger particle impurities and improving the efficiency and quality of subsequent separation and purification.

[0030] As Figure 3 and Figure 6 As shown in the figure, ventilation cavities 16 are formed below the two sliding boxes 10 inside the extraction tank 1. A piston plate 17 is slidably connected inside each of the two ventilation cavities 16. A fine filter screen 18 is fixedly connected to the opposite sides of the two piston plates 17. An air delivery groove 19 is formed between the sliding box 10 on the left side of the extraction tank 1 and the ventilation cavity 16;

[0031] When the coarse filter screen 12 moves to the left, the piston plate two 11 inside the sliding box 10 on the left side slides to the left, and the air pressure generated by the sliding of the piston plate two 11 can be conveyed through the arranged air delivery groove 19 to the inside of the air exchange cavity 16 below, so as to push the fine filter screens 18 inside the two air exchange cavities 16 to laterally move out of alignment while effectively removing impurities of smaller particles and improving the purity of the extract, which can prevent the filter holes of the fine filter screen 18 from being blocked by impurities and further improve the extraction efficiency and quality.

[0032] As Figure 6 shown, a through-type pressure relief hole 26 starts on the right side inside the air exchange cavity 16 located on the right side of the extraction box 1;

[0033] When the fine filter screens 18 repeatedly move laterally inside the two air exchange cavities 16, the piston plate three 17 on the right side is pushed to slide to the right by the piston plate three 17 on the left side, and the air pressure generated by the sliding of the piston plate three 17 can be discharged to the outside through the pressure relief hole 26, ensuring the smooth movement of the fine filter screens 18 and improving the filtering quality of the fine filter screens 18.

[0034] As Figure 1 shown, the front surface of the extraction box 1 is rotatably connected with a sealed maintenance door 42 through a hinge;

[0035] After the device is used up, the inside of the device such as the fine filter screen 18 and the coarse filter screen 12 can be cleaned by opening the sealed maintenance door 42 without dismantling the whole device, which increases the practicability of the device. At the same time, when the device is in use, the sealing of the sealed maintenance door 42 can prevent the original liquid from penetrating to the outside of the device, increasing the sealing performance of the device.

[0036] As Figure 1 and Figure 2As shown in the figure, a crushing box 27 is arranged above the extraction box 1. A feeding pipe 28 is fixedly connected to the lower surface of the crushing box 27. A second driving motor 29 is fixedly connected to the front surface of the crushing box 27. The rear end of the output shaft of the second driving motor 29 extends into the interior of the crushing box 27 and is fixedly connected to a rotating column 30. A plurality of crushing blades 31 are fixedly connected to the outer side wall of the rotating column 30. A feeding port 32 is integrally formed on the upper surface of the crushing box 27. Sliding cavities 33 are integrally formed on the left and right sides inside the crushing box 27. Piston plates four 34 are slidably connected to the interiors of the two sliding cavities 33. Sealing baffles 35 are fixedly connected to the opposite sides of the two piston plates four 34. The opposite sides of the two sealing baffles 35 are in contact with each other. A gas box 36 is fixedly connected to the right side of the extraction box 1 and above the rotating disc 4. A piston plate five 37 is slidably connected to the interior of the gas box 36. A push rod 38 is rotatably connected to the lower surface of the piston plate five 37 through a rotating shaft. A through horizontal groove 39 is formed on the lower surface inside the gas box 36. The lower left side of the push rod 38 passes through the horizontal groove 39 and is rotatably connected to the upper right side of the rotating disc 4 through a rotating shaft. Two air supply hoses 40 are symmetrically arranged on the upper surface of the gas box 36. The left ends of the two air supply hoses 40 are respectively communicated with the interiors of the two sliding cavities 33;

[0037] Before the separation and purification of the active substance extraction, large pieces of marine organisms are put into the interior of the crushing box 27 through the feeding port 32. Then, the rotation of the rotating column 30 inside is controlled by the second driving motor 29, so that a plurality of crushing blades 31 on the outer side are driven to rotate simultaneously by the rotating column 30. Due to the blocking of the two sealing baffles 35, the fragments are blocked inside the crushing box 27, which can ensure that the marine organisms put into the crushing box 27 can be fully crushed, making the active substances in the biological cells more likely to be released in the subsequent extraction process. When the marine organisms are crushed to a certain extent, the first driving motor 2 drives the rotating disc 4 to rotate. The reciprocating up and down sliding of the piston plate five 37 inside the gas box 36 is controlled by the rotation of the rotating disc 4 and the driving of the push rod 38. When the air pressure in the lower space of the gas box 36 increases, the gas enters the two sliding cavities 33 through the two air supply hoses 40, which can push the two piston plates four 34 to move to both sides, so that the two sealing baffles 35 are opened, facilitating the crushed material to enter the feeding pipe 28 from the crushing box 27. When the air pressure in the lower space of the gas box 36 decreases, the two sealing baffles 35 can be closed to stop the conveying of the material, thus improving the efficiency of the active substance extraction.

[0038] As Figure 1 shown in the figure, a plurality of support columns 41 are fixedly connected between the upper surface of the extraction box 1 and the lower surface of the crushing box 27;

[0039] The multiple support columns 41 provided can play a role in stably supporting the crushing box 27, preventing the crushing box 27 from shaking severely or even tilting when crushing marine organisms, and improving the stability and safety of the device.

[0040] As Figure 1 and Figure 4 shown, two side plates 20 are fixedly connected to the upper surface of the mounting base plate 15 and on the right side of the extraction tank 1. A chromatography column 21 is fixedly connected to the opposite sides of the two side plates 20. A liquid discharge port 22 is integrally formed on the lower surface of the chromatography column 21. The inside of the chromatography column 21 is filled with ion exchange resin 23. A drainage tube 24 is detachably connected to the upper surface of the chromatography column 21. One end of the drainage tube 24 away from the chromatography column 21 extends to the lower part inside the extraction tank 1. A pressure pump 25 is fixedly connected to the outer wall of the drainage tube 24 and on the right side of the extraction tank 1;

[0041] The fully mixed and filtered organic solution is finally stored below the extraction tank 1. By starting the set pressure pump 25, the organic solution is transported through the drainage tube 24 into the inside of the chromatography column 21. The ion exchange resin 23 inside it is used to separate and purify the marine active substances in the organic solution. According to the different properties of the marine biological active substances, it is necessary to select the appropriate type of ion exchange resin. Cation exchange resin can adsorb positively charged substances, such as some basic proteins or cationic bioactive molecules, while anion exchange resin is used to adsorb negatively charged substances, such as acidic proteins or anionic compounds. Specifically, it can be pre-filled according to the actual situation of specific use. Finally, the liquid that seeps down is discharged through the liquid discharge port 22 provided below, which is convenient for subsequent centralized treatment.

[0042] The above embodiments only represent several implementation manners of the present utility model. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the patent of the present utility model. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present utility model, several deformations and improvements can still be made, and these all belong to the protection scope of the present utility model. Therefore, the protection scope of the patent of the present utility model should be subject to the appended claims.

Claims

1. A separation and purification device for extracting marine bioactive substances, comprising an extraction tank (1), characterized in that: On the left side of the extraction box (1), a first driving motor (2) is fixedly connected. On the right end of the output shaft of the first driving motor (2), a rotating rod (3) is fixedly connected. The right end of the rotating rod (3) extends to the right side of the extraction box (1) and is fixedly connected with a rotating disc (4). On the outer side wall of the rotating rod (3) and inside the extraction box (1), a plurality of stirring rods (5) are fixedly connected. On the right side of the extraction box (1) and below the rotating disc (4), an extrusion box (6) is fixedly connected. Inside the extrusion box (6), a first piston plate (7) is slidably connected. On the upper surface of the first piston plate (7), an extrusion rod (8) is fixedly connected. The top end of the extrusion rod (8) extends above the extrusion box (6). On the upper side of the outer side wall of the rotating disc (4), a convex block (9) is fixedly connected. Inside the extraction box (1), sliding boxes (10) are symmetrically and fixedly connected. Inside both of the sliding boxes (10), a second piston plate (11) is slidably connected. On the opposite sides of the two second piston plates (11), a coarse filter screen (12) is fixedly connected together. Between the left side inside the extrusion box (6) and the inside of the sliding box (10) on the right side inside the extraction box (1), an air delivery round hole (13) is provided. Between the lower surface of the first piston plate (7) and the lower surface inside the extrusion box (6), a plurality of springs (14) are fixedly connected.

2. The separation and purification device for extracting marine bioactive substances according to claim 1, characterized in that: On the lower surface of the extraction box (1), a mounting base plate (15) is fixedly connected.

3. The separation and purification device for extracting marine bioactive substances according to claim 1, characterized in that: Inside the extraction box (1) and below both of the sliding boxes (10), ventilation chambers (16) are provided. Inside both of the ventilation chambers (16), a third piston plate (17) is slidably connected. On the opposite sides of the two third piston plates (17), a fine filter screen (18) is fixedly connected together. Between the sliding box (10) on the left side of the extraction box (1) and the ventilation chamber (16), an air delivery groove (19) is provided.

4. The separation and purification device for extracting marine bioactive substances according to claim 2, characterized in that: On the upper surface of the mounting base plate (15) and on the right side of the extraction box (1), two side plates (20) are fixedly connected. On the opposite sides of the two side plates (20), a chromatography column (21) is fixedly connected. On the lower surface of the chromatography column (21), a liquid discharge port (22) is integrally formed. Inside the chromatography column (21), ion exchange resin (23) is filled. On the upper surface of the chromatography column (21), a drainage pipe (24) is detachably connected. The end of the drainage pipe (24) far from the chromatography column (21) extends to the lower part inside the extraction box (1). On the outer side wall of the drainage pipe (24) and on the right side of the extraction box (1), a pressure pump (25) is fixedly connected.

5. The separation and purification device for extracting marine bioactive substances according to claim 3, characterized in that: Inside the ventilation chamber (16) on the right side of the extraction box (1), a through-type pressure relief hole (26) is provided.

6. The separation and purification device for extracting marine bioactive substances according to claim 1, characterized in that: Above the extraction box (1), there is a crushing box (27). The lower surface of the crushing box (27) is fixedly connected to a feeding pipe (28). The front surface of the crushing box (27) is fixedly connected to a second driving motor (29). The rear end of the output shaft of the second driving motor (29) extends into the interior of the crushing box (27) and is fixedly connected to a rotating column (30). A plurality of crushing blades (31) are fixedly connected to the outer side wall of the rotating column (30). The upper surface of the crushing box (27) is integrally formed with a feeding port (32). On the left and right sides inside the crushing box (27), there are sliding cavities (33) integrally formed. A fourth piston plate (34) is slidably connected to the interior of each of the two sliding cavities (33). A sealing baffle (35) is fixedly connected to the opposite side of each of the two fourth piston plates (34). The opposite sides of the two sealing baffles (35) are in contact. On the right side of the extraction box (1) and above the rotating disc (4), there is a gas box (36). A fifth piston plate (37) is slidably connected to the interior of the gas box (36). The lower surface of the fifth piston plate (37) is rotatably connected to a push rod (38) through a rotating shaft. A through horizontal groove (39) is formed on the lower surface inside the gas box (36). The left lower side of the push rod (38) passes through the horizontal groove (39) and is rotatably connected to the upper right side of the rotating disc (4) through a rotating shaft. Two air supply hoses (40) are symmetrically arranged on the upper surface of the gas box (36). The left ends of the two air supply hoses (40) are respectively communicated with the interiors of the two sliding cavities (33).

7. The separation and purification device for extracting marine bioactive substances according to claim 6, characterized in that: A plurality of support columns (41) are fixedly connected between the upper surface of the extraction box (1) and the lower surface of the crushing box (27).

8. The separation and purification device for extracting marine bioactive substances according to claim 1, characterized in that: A sealed inspection door (42) is rotatably connected to the front surface of the extraction box (1) through a hinge.

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