Biopharmaceutical stirring device convenient to clean

Abstract

The utility model discloses a biopharmaceutical stirring device convenient to clean, and relates to the technical field of pharmaceutical equipment. The biopharmaceutical stirring device convenient to clean comprises a mixing barrel, a stirring mechanism and an anti-precipitation mechanism. The stirring mechanism comprises a first rotary driver, a main shaft and a plurality of stirring blades. And each stirring blade is connected to the side direction of the main shaft. The first rotary driver is connected with one end of the spindle. The precipitation prevention mechanism comprises a second rotary driver, a secondary shaft and a disturbance part. The secondary shaft is fixed to the output end of the second rotary driver. And the disturbance piece is mounted on the secondary shaft. The secondary shaft is parallel to the inner bottom surface of the mixing barrel. The disturbance part is positioned at the inner bottom of the mixing barrel. Due to the fact that the secondary shaft is parallel to the inner bottom face of the mixing barrel, the stirring direction is perpendicular to the inner bottom face of the mixing barrel, and the disturbance piece is located at the inner bottom of the mixing barrel, chemicals at the bottom of the mixing barrel can be easily taken up through rotation of the secondary shaft, and the chemicals at the bottom are sufficiently disturbed to be sufficiently mixed with chemicals on the upper middle layer. And the bottom of the mixing barrel is not easy to remain.

Description

Technical Field

[0001] The present application relates to the technical field of pharmaceutical equipment, and in particular to a stirring device for biopharmaceuticals that is easy to clean. Background Art

[0002] Biopharmaceutical mixing can fully mix different raw materials or ingredients, which is crucial to ensure the uniformity and final quality of the drug. At the same time, stirring helps to accelerate the molecular diffusion and chemical reactions in the material, thereby improving production efficiency. Therefore, stirring is crucial in biopharmaceuticals. It not only affects the stability of the production process, but is also directly related to the quality of the drug.

[0003] The Chinese utility model patent with announcement number CN212017667U discloses a biopharmaceutical stirring device that is easy to clean. The setting of the biopharmaceutical stirring device that is easy to clean includes a lower tank body, the bottom of the lower tank body is fixedly connected to a motor, the output end of the motor passes through the interior of the lower tank body and is fixedly connected to a stirring rod, and both sides of the stirring rod are fixedly connected to stirring blades. The lower tank body, motor, stirring rod, stirring blade, discharge pipe, hinge, upper tank body, hopper, shell, sliding rod, sliding ring, pressure rod, lifting plate, transmission rod, guide rod, vertical plate, guide ring, inclined hole plate, movable plate, clamping rod, spring, connecting rod and clamping groove are used in coordination, which solves the problem that most of the existing stirring devices are of integrated design and the stirring devices cannot be disassembled for cleaning. The biopharmaceutical stirring device that is easy to clean has the advantage of being easy to clean, is convenient for users to clean the stirring device, saves users a lot of time, and improves the working efficiency of the stirring device.

[0004] However, during the use of the above easy-to-clean biopharmaceutical stirring device, since the stirring direction is parallel to the bottom surface of the tank body, the medicine will precipitate at the bottom during the stirring process, resulting in the medicine at the bottom not being able to fully blend with other medicines. At the same time, after the equipment is used, a lot of residues will remain at the bottom of the equipment. Utility Model Content

[0005] The present application provides a biopharmaceutical stirring device that is easy to clean to solve the problems raised in the above background technology. To this end, the present application adopts the following technical solution.

[0006] A stirring device for biopharmaceuticals which is easy to clean comprises a mixing barrel, a stirring mechanism and an anti-sedimentation mechanism.

[0007] The stirring mechanism comprises a first rotary driver, a main shaft and a plurality of stirring blades. Each stirring blade is connected to the side of the main shaft. The first rotary driver is connected to one end of the main shaft.

[0008] The anti-settling mechanism includes a second rotary driver, a secondary shaft, and a disturbing member. The second rotary driver is installed outside the mixing barrel. The secondary shaft is fixed to the output end of the second rotary driver. The disturbing member is installed on the secondary shaft. The secondary shaft is parallel to the inner bottom surface of the mixing barrel. The disturbing member is located at the inner bottom of the mixing barrel.

[0009] Install the stirring mechanism into the mixing barrel such that the stirring mechanism is arranged at intervals above the anti-settling mechanism, and each stirring blade faces the inner side wall of the mixing barrel.

[0010] By adopting the above technical solution, the stirring mechanism can fully stir the medicine in the mixing barrel. At the same time, since the secondary shaft is parallel to the inner bottom surface of the mixing barrel and the stirring direction is perpendicular to the inner bottom surface of the mixing barrel, and since the disturbing member is located at the inner bottom of the mixing barrel, by rotating the secondary shaft, it is easy to lift the medicine at the bottom of the mixing barrel, so that the medicine at the bottom is fully disturbed and mixed with the medicine in the middle and upper layers. It is not easy to leave medicine residues at the bottom of the mixing barrel.

[0011] A preferred structure of the stirring device for biopharmaceuticals that is easy to clean is that the disturbing member is a spiral coil. The spiral coil is wound around the secondary shaft.

[0012] By adopting the above technical solution, the spiral coil has a simple structure and low cost, and can fully lift the medicine at the bottom of the mixing barrel.

[0013] A preferred structure of the stirring device for biopharmaceuticals that is easy to clean is that the closest distance between the spiral coil and the inner bottom surface of the mixing barrel is 1 - 3 cm.

[0014] By adopting the above technical solution, the spiral coil disturbs the bottom medicine at a close distance and has a large power to lift the bottom medicine, so that the medicine is fully mixed.

[0015] A preferred structure of the stirring device for biopharmaceuticals that is easy to clean is that the stirring blade includes a fixing block and a strip plate. The fixing block is fixed to the outer wall surface of the main shaft. The strip plate is fixed to the fixing block. The strip plate is perpendicular to the main shaft.

[0016] By adopting the above technical solution, the strip plate can fully disturb the solution in the barrel and fully stir the medicine.

[0017] A preferred structure of the stirring device for biopharmaceuticals that is easy to clean is that the stirring device for biopharmaceuticals further includes a flushing mechanism. The flushing mechanism includes a telescopic driver, a branch pipe, a moving member, a plurality of spray heads, an inner through pipe, and an outer ring pipe.

[0018] The inner through pipe has a hollow cylindrical joint and a main pipe. One end of the main pipe communicates with the joint. The main shaft is divided into an upper shaft and a lower shaft. The upper shaft is connected to the end face of the joint, and the side wall of the main pipe is connected to the lower shaft. The side ring wall of the joint has an inner through hole. The inner ring wall of the outer ring pipe has an outer through hole. The outer ring pipe surrounds the outer periphery of the joint, so that the outer through hole communicates with the inner through hole, and a sealed connection is made on the peripheral sides of the outer through hole and the inner through hole. The outer ring pipe has a water inlet.

[0019] The telescopic driver is fixed to the upper shaft, the outer ring pipe, the main pipe or the lower shaft. The output end of the telescopic driver is connected to the moving member. The moving member has a hollow cavity. The plurality of nozzles are installed on the moving member, and each nozzle communicates with the cavity. The outlet of each nozzle faces the inner wall of the mixing barrel. One end of the branch pipe communicates with the cavity of the moving member, and the other end communicates with the main pipe.

[0020] An axial chute is formed on the surface of the lower shaft. The chute avoids the stirring blades. The moving member is embedded in the chute. The telescopic direction of the telescopic driver is axial, and it can drive the moving member to move back and forth along the chute.

[0021] By adopting the above technical solution, the water inlet of the outer ring pipe can be connected to a high-pressure water source, such as a water pipe, so that water can enter the outer ring pipe, then enter the inner through pipe, then flow to the branch pipe and the moving member, and finally be sprayed out from the nozzles and sprayed onto the inner wall of the mixing barrel. While the water is flowing, the upper shaft is driven to rotate by the first rotary driver, the inner through pipe and the lower shaft rotate simultaneously, the outer ring pipe remains stationary, the water flow between the outer ring pipe and the inner through pipe continues, and the direction of the water flow finally sprayed out from the nozzles changes in real time, and it can be sprayed 360° onto the ring wall of the mixing barrel to fully clean the barrel wall at this height. At the same time, the telescopic driver can drive the moving member to move back and forth along the chute, so that the plurality of nozzles on the moving member move up and down accordingly, that is, the barrel walls at various heights can be cleaned.

[0022] A preferred structure of the stirring device for biopharmaceuticals that is convenient for cleaning is that the bottom end of the chute away from the telescopic driver is closed.

[0023] By adopting the above technical solution, the moving member is not easily slid out of the chute downward.

[0024] A preferred structure of the stirring device for biopharmaceuticals that is convenient for cleaning is that the stirring device for biopharmaceuticals includes three telescopic drivers, three branch pipes and three moving members. A plurality of nozzles are arranged on each moving member.

[0025] The interior of the lower shaft has a cavity. The branch pipe is accommodated in the cavity. The main pipe is communicated with each branch pipe. Three axial chutes are opened on the surface of the lower shaft, and each chute is provided with a moving member.

[0026] By adopting the above technical solution, the three rows of nozzles spray water synchronously, and the inner wall of the mixing barrel is efficiently cleaned.

[0027] A preferred structure of the stirring device for biopharmaceuticals that is easy to clean is that the main shaft is perpendicular to the secondary shaft.

[0028] By adopting the above technical solution, the main shaft rotates horizontally, which can fully mix the liquid medicine, and the secondary shaft rotates vertically, which is beneficial to lifting the medicine at the bottom.

[0029] In summary, the stirring device for biopharmaceuticals that is easy to clean in this application has the following beneficial effects: The stirring mechanism can fully stir the medicine in the mixing barrel. At the same time, since the secondary shaft is parallel to the inner bottom surface of the mixing barrel and the stirring direction is perpendicular to the inner bottom surface of the mixing barrel, and since the disturbing member is located at the inner bottom of the mixing barrel, through the rotation of the secondary shaft, it is easy to lift the medicine at the bottom of the mixing barrel, so that the medicine at the bottom is fully disturbed and fully mixed with the medicine in the middle and upper layers. There is not easy to be residual medicine at the bottom of the mixing barrel. Description of the Drawings

[0030] Figure 1 It is an overall structure diagram of the stirring device for biopharmaceuticals that is easy to clean.

[0031] Figure 2 It is a schematic structural diagram of the anti-precipitation mechanism installed at the inner bottom of the mixing barrel in the stirring device for biopharmaceuticals that is easy to clean.

[0032] Figure 3 For Figure 1 The structural diagram of the stirring mechanism and the flushing mechanism in

[0033] Figure 4 It is a partial view of the flushing mechanism.

[0034] Figure 5 It is a schematic structural diagram of the outer ring pipe sleeved outside the joint and communicated with each other, the joint communicating downward with the main pipe, and the joint being fixedly connected upward to the upper shaft.

[0035] Reference numerals: 1, mixing barrel; 2, stirring mechanism; 3, anti-precipitation mechanism; 21, first rotary driver; 22, main shaft; 23, stirring blades; 231, fixing block; 232, strip plate; 31, second rotary driver; 32, secondary shaft; 33, disturbing member; 5, support frame; 4, flushing mechanism; 41, telescopic driver; 42, branch pipe; 43, moving member; 44, nozzle; 2221, chute; 45, inner through pipe; 46, outer ring pipe; 451, joint; 452, main pipe; 221, upper shaft; 222, lower shaft; 4511, inner through hole; 461, outer through hole; 47, sealing ring; 462, water inlet. Detailed implementation manners

[0036] Next, the technical solutions in the embodiments will be clearly and completely described in conjunction with the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the following embodiments, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the scope of protection of this application.

[0037] Reference Figure 1 and Figure 2 , a stirring device for biopharmaceuticals that is easy to clean, including a mixing barrel 1, a stirring mechanism 2, and an anti-precipitation mechanism 3.

[0038] Reference Figure 3 , the stirring mechanism 2 includes a first rotary driver 21, a main shaft 22, and a plurality of stirring blades 23. For example, there are three stirring blades 23 in each layer, the included angle between adjacent stirring blades 23 in each layer is 120°, and a total of five layers of stirring blades 23 are provided. Each of the stirring blades 23 is connected to the side of the main shaft 22. The first rotary driver 21 can be a motor.

[0039] The first rotary driver 21 is connected to the upper end of the main shaft 22.

[0040] An optional structure of the stirring blade 23 is that the stirring blade 23 includes a fixing block 231 and a strip plate 232. The fixing block 231 is fixed to the outer wall of the main shaft 22, the strip plate 232 is fixed to the fixing block 231, the strip plate 232 is perpendicular to the main shaft 22, and the strip plate 232 can fully disturb the solution in the barrel and fully stir the medicine.

[0041] Reference Figure 2, the anti-settling mechanism 3 includes a second rotary driver 31, a secondary shaft 32, and a disturbing member 33. The second rotary driver 31 can be a motor. The second rotary driver 31 is installed outside the mixing barrel 1. The secondary shaft 32 is fixed to the output end of the second rotary driver 31. The disturbing member 33 is installed on the secondary shaft 32. The secondary shaft 32 is parallel to the inner bottom surface of the mixing barrel 1. The inner bottom surface of the mixing barrel 1 is a plane. When the mixing barrel 1 is placed on a horizontal ground or horizontally placed on a support frame 5, the inner bottom surface of the mixing barrel 1 is in a horizontal position. The disturbing member 33 is located at the inner bottom of the mixing barrel 1. The disturbing member 33 can be a spiral coil, and the spiral coil is wound and fixed on the secondary shaft 32. The spiral coil has a simple structure and low cost, and can fully lift the medicament at the bottom of the mixing barrel 1. The closest distance between the spiral coil and the inner bottom surface of the mixing barrel 1 is 1-3 cm. The spiral coil disturbs the bottom medicament at a close distance, and has a large power to lift the bottom medicament, so that the medicament is fully mixed.

[0042] Preferably, the main shaft 22 is perpendicular to the secondary shaft 32. The mixing barrel 1 is placed on a horizontal ground or horizontally placed on the support frame 5. The main shaft 22 rotates horizontally, which can fully mix the liquid medicine. The secondary shaft 32 rotates vertically, which is beneficial to lifting the medicament at the bottom.

[0043] Install the stirring mechanism 2 into the mixing barrel 1 so that the stirring mechanism 2 is arranged at intervals above the anti-settling mechanism 3, and each stirring blade 23 faces the inner side wall of the mixing barrel 1. The stirring mechanism 2 can be hoisted above the mixing barrel 1, the first rotary driver 21 is fixed, and the main shaft 22 extends into the mixing barrel 1.

[0044] For the above-mentioned stirring device for biopharmaceuticals, the stirring mechanism 2 can fully stir the medicines in the mixing barrel 1. At the same time, since the secondary shaft 32 is parallel to the inner bottom surface of the mixing barrel 1 and the stirring direction is perpendicular to the inner bottom surface of the mixing barrel 1, and since the disturbing member 33 is located at the inner bottom of the mixing barrel 1, by rotating the secondary shaft 32, it is easy to lift the medicament at the bottom of the mixing barrel 1, so that the bottom medicament is fully disturbed and fully mixed with the medicament in the middle and upper layers. There is not easy to remain medicament at the bottom of the mixing barrel 1.

[0045] Reference Figure 3 and Figure 4 , the stirring device for biopharmaceuticals can also include a flushing mechanism 4. The flushing mechanism 4 includes a telescopic driver 41, a branch pipe 42, a moving member 43, a plurality of spray heads 44, an inner through pipe 45, and an outer ring pipe 46.

[0046] As Figure 4 , the inner through pipe 45 has a hollow cylindrical joint 451 and a main pipe 452. One end of the main pipe 452 communicates with the joint 451.

[0047] AsFigure 3 The main shaft 22 is divided into an upper shaft 221 and a lower shaft 222.

[0048] Such as Figure 5 The upper shaft 221 is connected to the end face of the joint 451, and the side wall of the main pipe 452 is connected to the lower shaft 222. The side ring wall of the joint 451 has an inner through hole 4511. The inner ring wall of the outer ring pipe 46 has an outer through hole 461. The outer ring pipe 46 is wrapped around the outer periphery of the joint 451, so that the outer through hole 461 communicates with the inner through hole 4511, and a sealing connection is made through a sealing ring 47 on the peripheral sides of the outer through hole 461 and the inner through hole 4511. The outer ring pipe 46 has a water inlet 462.

[0049] The telescopic driver 41 is fixed to the upper shaft 221, the outer ring pipe 46, the main pipe 452 or the lower shaft 222. For example, the telescopic driver 41 is laterally fixed to the main pipe 452.

[0050] The output end of the telescopic driver 41 is connected downward to the moving member 43. The moving member 43 has a hollow cavity. The moving member 43 can be a square plate-shaped hollow box. The telescopic driver 41 can be a lead screw motor, a cylinder, etc. The plurality of nozzles 44 are installed on the moving member 43, and each nozzle 44 communicates with the cavity. The outlet of each nozzle 44 faces the inner wall of the mixing barrel 1. One end of the branch pipe 42 communicates with the cavity of the moving member 43, and the other end communicates with the main pipe 452. The branch pipe 42 is a flexible water pipe, which can be bent but can maintain water flow.

[0051] An axial chute 2221 is formed on the surface of the lower shaft 222. Since it is axial, the chute 2221 is strip-shaped. The chute 2221 avoids the stirring blade 23. The moving member 43 is embedded in the chute 2221. The telescopic direction of the telescopic driver 41 is axial, and it can drive the moving member 43 to move back and forth along the chute 2221.

[0052] For the flushing mechanism 4 with the above structure, the water inlet 462 of the outer ring pipe 46 can be connected to a high-pressure water source, such as a water pipe, so that water can enter the outer ring pipe 46, then enter the inner through pipe 45, and then flow to the branch pipes 42 and the moving member, and finally spray out from the nozzle 44 and spray onto the inner wall of the mixing barrel 1. While the water is flowing, the upper shaft 221 is driven to rotate by the first rotation driver 21, and the inner through pipe 45 and the lower shaft 222 rotate simultaneously, while the outer ring pipe 46 remains stationary. The water flow between the outer ring pipe 46 and the inner through pipe 45 continues, and finally the direction of the water flow sprayed out from the nozzle 44 changes in real time and can spray 360° onto the inner wall of the mixing barrel 1 to fully clean the barrel wall at this height. At the same time, the telescopic driver 41 can drive the moving member 43 to move back and forth along the chute 2221, so that the multiple nozzles on the moving member move up and down accordingly, that is, the barrel walls at various heights can be cleaned.

[0053] Preferably, the bottom end of the chute 2221 away from the telescopic driver 41 is closed, so that the moving member is not easily slipped out of the chute 2221 downward.

[0054] In order to improve the flushing efficiency and enable the flushing mechanism 4 to achieve self-balancing, it is provided that the biopharmaceutical stirring device includes three telescopic drivers 41, three branch pipes 42 and three moving members 43. The inside of the lower shaft 222 has a cavity. The branch pipes 42 are accommodated in the cavity. The main pipe 452 communicates with each branch pipe 42. Three axial chutes 2221 are opened on the surface of the lower shaft 222, and each chute 2221 communicates with the cavity. Each chute 2221 is provided with a moving member 43. The three rows of nozzles 44 spray water synchronously to efficiently clean the inner wall of the mixing barrel 1.

[0055] Although the present application has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A stirring device for biopharmaceuticals that is convenient for cleaning, characterized in that, It includes a mixing barrel (1), a stirring mechanism (2) and a sediment prevention mechanism (3); The stirring mechanism (2) includes a first rotary driver (21), a main shaft (22) and a plurality of stirring blades (23); each of the stirring blades (23) is connected to the lateral side of the main shaft (22); the first rotary driver (21) is connected to one end of the main shaft (22); The sediment prevention mechanism (3) includes a second rotary driver (31), a secondary shaft (32) and a disturbing member (33); the second rotary driver (31) is installed outside the mixing barrel (1); The secondary shaft (32) is fixed to the output end of the second rotary driver (31); the disturbing member (33) is installed on the secondary shaft (32); the secondary shaft (32) is parallel to the inner bottom surface of the mixing barrel (1); the disturbing member (33) is located at the inner bottom of the mixing barrel (1); The stirring mechanism (2) is installed in the mixing barrel (1) such that the stirring mechanism (2) is spaced above the sediment prevention mechanism (3), and each of the stirring blades (23) faces the inner side wall of the mixing barrel (1).

2. The stirring device for biopharmaceuticals that is convenient for cleaning according to claim 1, wherein, The disturbing member (33) is a spiral coil; the spiral coil is wound around the secondary shaft (32).

3. The stirring device for biopharmaceuticals that is convenient for cleaning according to claim 2, wherein, The closest distance between the spiral coil and the inner bottom surface of the mixing barrel (1) is 1 to 3 cm.

4. The stirring device for biopharmaceuticals that is convenient for cleaning according to claim 1, wherein The stirring blade (23) includes a fixing block (231) and a strip plate (232); the fixing block (231) is fixed to the outer wall surface of the main shaft (22); the strip plate (232) is fixed to the fixing block (231); the strip plate (232) is perpendicular to the main shaft (22).

5. The stirring device for biopharmaceuticals that is convenient for cleaning according to claim 1, wherein The stirring device for biopharmaceuticals further includes a flushing mechanism (4); the flushing mechanism (4) includes a telescopic driver (41), a branch pipe (42), a moving member (43), a plurality of spray heads (44), an inner through pipe (45), an outer ring pipe (46); The inner through pipe (45) has a hollow cylindrical joint (451) and a main pipe (452); one end of the main pipe (452) communicates with the joint (451); the main shaft (22) is divided into an upper shaft (221) and a lower shaft (222); the upper shaft (221) is connected to the end face of the joint (451), and the side wall of the main pipe (452) is connected to the lower shaft (222); the side ring wall of the joint (451) has an inner through hole (4511); the inner ring wall of the outer ring pipe (46) has an outer through hole (461); the outer ring pipe (46) is wrapped around the outer periphery of the joint (451) such that the outer through hole (461) communicates with the inner through hole (4511), and a sealed connection is made on the peripheral sides of the outer through hole (461) and the inner through hole (4511); the outer ring pipe (46) has a water inlet (462); The telescopic driver (41) is fixed to the upper shaft (221), the outer ring pipe (46), the main pipe (452) or the lower shaft (222); the output end of the telescopic driver (41) is connected to the moving member (43); the moving member (43) has a hollow cavity; the plurality of nozzles (44) are installed on the moving member (43), and each nozzle (44) communicates with the cavity; the outlet of each nozzle (44) faces the inner wall of the mixing barrel (1); one end of the branch pipe (42) communicates with the cavity of the moving member (43), and the other end communicates with the main pipe (452). An axial chute (2221) is formed on the surface of the lower shaft (222); the chute (2221) avoids the stirring blade (23); the moving member (43) is embedded in the chute (2221); the telescopic direction of the telescopic driver (41) is axial, and can drive the moving member (43) to move back and forth along the chute (2221).

6. The stirring device for biopharmaceuticals that is convenient for cleaning according to claim 5, wherein, The bottom end of the chute (2221) away from the telescopic driver (41) is closed.

7. The stirring device for biopharmaceuticals that is convenient for cleaning according to claim 5, characterized in that, The stirring device for biopharmaceuticals includes three telescopic drivers (41), three branch pipes (42) and three moving members (43); a plurality of nozzles (44) are arranged on each moving member (43). The interior of the lower shaft (222) has a cavity; the branch pipe (42) is accommodated in the cavity; the main pipe (452) communicates with each branch pipe (42); three axial chutes (2221) are formed on the surface of the lower shaft (222), and each chute (2221) is provided with a moving member (43).

8. The stirring device for biopharmaceuticals that is easy to clean according to claim 1, wherein, The main shaft (22) is perpendicular to the secondary shaft (32).

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