Quickly replaceable liquid chromatogram sampling device

Abstract

The utility model discloses a liquid chromatography sampling device capable of being quickly replaced, which relates to the technical field of liquid chromatography and comprises a sampling valve module, a detachable quantitative loop is arranged on the sampling valve module, and the sampling valve module is arranged at the upper end of a panel through a sliding component; according to the sample injection device, under the condition that an instrument shell is not opened, a sample is injected into the sample injection valve through the sample injection window to directly complete sample injection operation of the sample, and the quantitative loop is replaced by pulling the sample injection valve module, and the sample injection valve module slides towards the side end, far away from the instrument shell, of a door plate through a sliding part to achieve disassembly and replacement of the quantitative loop. The operation of liquid chromatograph sample introduction and quantitative loop replacement is greatly simplified, a user can directly perform sample introduction through the sample introduction window without opening an instrument shell, and the operation is convenient and safe. Meanwhile, the quantitative rings with different specifications can be quickly replaced by a user through the sliding component, so that tedious steps in a traditional replacement mode are avoided, and the experiment efficiency and the operation convenience of the instrument are greatly improved.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid injection technology for liquid chromatography instruments, and particularly relates to a liquid chromatography injection device for a liquid chromatography instrument, which is convenient to operate and can quickly replace quantitative loops of different specifications. Background Technique

[0002] Liquid chromatography analysis instruments are widely used in fields such as chemistry, pharmacy, and biology. As a key component for samples to enter the analysis system, the performance and design of its injection device directly affect the accuracy and efficiency of analysis. In traditional liquid chromatography instruments, the liquid quantification device is usually made of a circular stainless-steel pipeline. According to the required quantification volume and the inner diameter of the pipeline, a corresponding length is intercepted and wound into a loop, which is called a quantitative loop. The quantitative loop is tightly connected to the injection six-port valve through a stainless-steel joint and a blade ring. The injection six-port valve is a commonly used injection device in the liquid chromatography system, and it consists of a circular gasket (rotor) and a fixed base (stator). During the injection operation, the sample is injected into the quantitative loop through the injection needle from the injection hole. After the quantitative loop is filled, the excess sample is discharged from the vent hole. The circular gasket (rotor) is rotated to connect the six-port valve to the liquid phase flow path. The mobile phase pumped by the pump flushes the quantitative loop and pushes the sample into the liquid chromatography analysis column for analysis or preparative purification.

[0003] In the prior art, for example, CN218524654U discloses an adjustable volume quantification device for a liquid chromatography instrument, and its specification appendix Figure 1 displays a common injection device, which includes an injection six-port valve and a fixed quantitative loop. During the injection process, the sample is injected into the quantitative loop through the injection hole. When the quantitative loop is filled, the excess sample is discharged from the vent hole. When the six-port valve is connected to the liquid phase flow path, the mobile phase pumped by the pump flushes the quantitative loop and pushes the sample into the liquid chromatography analysis column for analysis.

[0004] However, such prior art liquid chromatography instrument injection devices still have the following deficiencies:

[0005] 1. Operational complexity and error-proneness: In existing liquid chromatography instruments, the injection six-port valve is usually installed on the instrument panel, inside the instrument, or on a special bracket. When performing manual injection, the user needs to open the instrument door to manually inject the sample, and then pull out the injection needle and close the instrument door after the injection is completed. This operation method has an obvious defect: if the user forgets to pull out the injection needle and closes the door, it may cause the injection needle to bend or break, thereby affecting subsequent experiments. In addition, the injection six-port valve installed on the bracket is not stable enough, and the injection valve needs to be held by hand during manual injection, increasing the operation difficulty and the risk of misoperation.

[0006] 2. Difficult to adjust the injection volume: During the experiment, if it is necessary to change the injection volume, it is usually necessary to replace the quantitative loop of different specifications. In the existing liquid chromatography instrument, this replacement process requires disassembling the instrument housing to access the built-in quantitative loop and injection valve. For a liquid chromatography instrument with a modular stacked design, this process is quite cumbersome, requiring the removal of system pipelines and the movement of stacked instruments, which is time-consuming and laborious, seriously affecting the experimental efficiency and operation convenience.

[0007] 3. Limitations of replacing the quantitative loop: For example, the prior art CN207502469U discloses a liquid chromatography instrument, including a liquid storage bottle, a high-pressure pump, an injector, a separation column, and a detector connected in sequence, where the injector is a six-way valve injector. The injector also includes a stator, a rotor, and a quantitative loop, a sample inlet, a sample outlet, a mobile phase inlet, a mobile phase outlet, a quantitative loop inlet, and a quantitative loop outlet. It is characterized in that a detachable syringe head is provided at the sample outlet, reducing the caliber of the sample flow, increasing the resistance of the sample flow, making the force used when injecting the sample easier to control, and achieving the effect of being able to stop injecting in time after the sample is full. However, this design still requires the user to open the instrument for manual operation during the injection process, and fails to solve the problems of quickly replacing the quantitative loop and avoiding manually supporting the injection device. Summary of the Utility Model

[0008] The problems to be solved by the present utility model are that the injection device of the existing liquid chromatography instrument has problems such as complex operation, inconvenient adjustment of the injection volume, easy error in manual operation, and difficulty in replacing the quantitative loop. In order to overcome these deficiencies and improve the experimental efficiency and operation convenience, the present utility model provides a liquid chromatography injection device with a quick replacement type, which simplifies the injection operation, facilitates the replacement of the quantitative loop, avoids user operation errors, and improves the overall experimental efficiency.

[0009] To solve the above problems, the present utility model provides a liquid chromatography injection device with a quick replacement type, including:

[0010] An injection valve module, on which a detachable quantitative loop is provided, and the injection valve module is arranged at the upper end of the panel through a sliding component;

[0011] An injection window, arranged on the instrument housing, corresponding to the injection port of the injection valve module in position, and the injection valve module passes through the injection window and is arranged inside the instrument housing;

[0012] Among them, without opening the instrument housing, the sample is injected into the injection valve through the injection window to directly complete the sample injection operation, and the replacement of the quantitative loop is realized by pulling the injection valve module, and the injection valve module slides away from the door panel side end of the instrument housing through the sliding component to disassemble and replace the quantitative loop.

[0013] Preferably, the sliding member is arranged at the inner end of the instrument housing, and the sliding member is fixed to the panel at its lower end through a fastener.

[0014] Preferably, the sliding member includes a slide rail. The bottom end of the slide rail is fixedly connected to the panel through a fastening bolt. A slider is arranged at the upper end of the slide rail, and the convex portions at the inner edges of both ends of the slider are clamped in the chute of the slide rail.

[0015] Preferably, when the quantitative loop is not replaced, the injection valve module is locked and connected to the screw seat arranged at the inner edge of the injection window through module fixing screws.

[0016] Preferably, the injection valve module is a six-port valve, an eight-port valve or a ten-port valve. The injection valve module is integrated in the pump module, the auto-sampler module, the column oven module or the detector module of the liquid chromatograph, and can flexibly adapt to different application requirements: The injection valve module is designed to be detachable and modular, suitable for different types of injection valves such as six-port valves, eight-port valves or ten-port valves, and can be flexibly adjusted according to actual needs to adapt to different applications of analytical and preparative liquid chromatography. In addition, the injection valve module can be integrated in the pump module, the auto-sampler module, the column oven module or the detector module of the liquid chromatograph, and has good compatibility and flexibility.

[0017] Preferably, the quantitative loop is fixed to the injection valve module through at least two screws.

[0018] Compared with the prior art, the utility model has the following beneficial technical effects:

[0019] 1. Simplify the operation and reduce the risk of misoperation: By arranging an injection window on the instrument housing, the user can directly inject the sample into the injection valve module through this window without opening the instrument housing. This can avoid the risk of the injection needle being bent or damaged due to forgetting to remove the injection needle in the traditional method, and at the same time, there is no need to hold the injection valve by hand, reducing the complexity of the operation and the possibility of misoperation.

[0020] 2. Improve the injection efficiency: The injection valve module of the utility model is fixed to the upper end of the panel through a sliding member and can move freely through the sliding member. This enables the quantitative loop to be replaced without disassembling the instrument housing or complex operations. The user only needs to simply pull the injection valve module to slide it to the side end away from the instrument housing door panel, and then the quantitative loop can be easily replaced. Compared with the traditional method that requires removing the system pipeline and moving the stacked instruments, the utility model greatly simplifies the replacement process and significantly improves the injection efficiency.

[0021] 3. Convenient replacement of the loop, reducing experimental downtime: This utility model allows users to directly complete the replacement of the loop through a sliding operation without disassembling the instrument housing. This not only reduces the time for replacing the loop but also avoids experimental downtime caused by the need to remove system pipelines or move instrument stacks during the replacement process, further improving the working efficiency of the laboratory and the usability of the instrument.

[0022] 4. Stable structure and reasonable design: This utility model realizes the fixation and movement of the injection valve module through the slide rail and slider structure, making the device highly stable during the injection and replacement processes. The sliding components are fixed to the panel through fasteners, ensuring that the injection device is not easily loosened or detached during operation, improving the overall safety and durability of the device.

[0023] 5. Reducing the operation difficulty for users and enhancing the user experience: By optimizing the structural design of the injection device, this utility model significantly reduces the operation steps and difficulty required by users during injection and maintenance. Without the need to frequently disassemble and assemble the instrument or operate complex mechanical structures, users can more easily perform sample injection and device maintenance, enhancing the user's operation experience and satisfaction.

[0024] In summary, the quick-changeable liquid chromatography injection device provided by this utility model simplifies the operation process, improves the injection efficiency, adapts to different application requirements, reduces experimental downtime, and ensures the stability of the device. Brief Description of the Drawings

[0025] Figure 1 is a schematic structural diagram of the quick-changeable liquid chromatography injection device of this utility model.

[0026] Figure 2 is a schematic structural diagram when the injection valve module is closed.

[0027] Figure 3 is a schematic structural diagram when the injection valve module is opened.

[0028] Figure 4 is a top view schematic diagram when the injection valve module is opened.

[0029] Figure 5 is a side view schematic diagram when the injection valve module is opened.

[0030] In the figure: 1 - injection valve module, 2 - sliding component, 201 - slide rail, 202 - slider, 203 - fastening bolt, 204 - convex part, 205 - chute, 3 - panel, 4 - loop, 5 - instrument housing, 6 - injection window, 7 - module fixing screw, 8 - screw seat, 9 - screw. Detailed Description of the Invention

[0031] The present utility model will be further explained and illustrated below in conjunction with the accompanying drawings and embodiments.

[0032] Referring to Figures 1-5 As shown, a quickly replaceable liquid chromatography injection device includes: an injection valve module 1, on which a detachable quantitative loop 4 is provided, and the injection valve module 1 is arranged at the upper end of a panel 3 through a sliding member 2; an injection window 6, which is arranged on the instrument housing 5 and corresponds to the injection port of the injection valve module 1, and the injection valve module 1 passes through the injection window 6 and is arranged inside the instrument housing 5; wherein, without opening the instrument housing 5, the sample is injected into the injection valve module 1 through the injection window 6 to directly complete the sample injection operation. By providing an injection window on the instrument housing, the user can directly inject the sample into the injection valve module 1 through this window without opening the instrument housing. This can avoid the risk of the injection needle being bent or damaged due to forgetting to remove the injection needle in the traditional method, and at the same time, there is no need to hold the injection valve by hand, reducing the complexity of the operation and the possibility of misoperation; the replacement of the quantitative loop 4 is realized by pulling the injection valve module 1, and the injection valve module 1 slides away from the door panel side end of the instrument housing 5 through the sliding member 2 to realize the disassembly and replacement of the quantitative loop 4. The injection valve module 1 is fixed to the upper end of the panel 3 through the sliding member 2 and can move freely through the sliding member 2, which makes it unnecessary to disassemble the instrument housing or perform complex operations when replacing the quantitative loop 4. The user only needs to simply pull the injection valve module 1 to slide it to the door panel side end away from the instrument housing 5, and then can easily replace the quantitative loop 4. Compared with the traditional method that requires removing the system pipeline and moving the stacked instruments, the present utility model greatly simplifies the replacement process and significantly improves the injection efficiency.

[0033] The sliding member 2 is arranged at the inner end of the instrument housing 5, and the sliding member 2 is fixed to the panel 3 at its lower end through a fastener.

[0034] The sliding member 2 includes a slide rail 201, the bottom end of the slide rail 201 is fixedly connected to the panel 3 through a fastening bolt 203, the upper end of the slide rail 201 is provided with a slider 202, and the convex parts 204 at the inner edges of both ends of the slider 202 are clamped in the chute 205 of the slide rail 201. The fixing and movement of the injection valve module are realized through the slide rail 201 and the slider structure 202, so that the device has high stability during the injection and replacement processes. The sliding member is fixed to the panel through a fastener, ensuring that the injection device is not easily loosened or detached during operation, and improving the overall safety and durability of the device.

[0035] When the quantitative loop 4 is not replaced, the injection valve module 1 is locked and connected to the screw seat 8 arranged at the inner edge of the injection window 6 through a module fixing screw 7.

[0036] The injection valve module 1 is a six-port valve, an eight-port valve, or a ten-port valve. The injection valve module 1 is integrated into the pump module, the auto-sampler module, the column oven module, or the detector module of the liquid chromatography instrument, flexibly adapting to different application requirements: The injection valve module is designed to be detachable and modular, suitable for different types of injection valves such as six-port valves, eight-port valves, or ten-port valves, and can be flexibly adjusted according to actual needs to adapt to different applications of analytical and preparative liquid chromatography. In addition, the injection valve module can be integrated into the pump module, the auto-sampler module, the column oven module, or the detector module of the liquid chromatography instrument, having good compatibility and flexibility.

[0037] The quantitative loop 4 is fixed to the injection valve module 1 by at least two screws 9.

[0038] To facilitate the understanding of the above technical solution of the present invention, the above technical solution of the present invention will be described in detail below through specific usage methods.

[0039] The working process of the present invention mainly includes injection operation and replacement of the quantitative loop, and the specific steps are as follows:

[0040] Injection operation: When it is necessary to inject a sample into the liquid chromatography instrument, the user does not need to open the instrument housing 5, but inserts the injection needle into the injection hole of the injection valve module 1 through the injection window 6. Since the injection window 6 directly corresponds to the injection port of the injection valve module 1, the sample can be smoothly injected into the quantitative loop 4 through the injection window 6.

[0041] After the injection needle is inserted, the user injects the sample to be analyzed into the quantitative loop 4 through the injection needle. After the quantitative loop is filled, the excess sample will be discharged through the vent hole to ensure the accuracy of the sample volume in the quantitative loop.

[0042] After the sample injection is completed, the user can pull out the injection needle. At this time, the injection valve flushes the quantitative loop with the mobile phase delivered by the pump and pushes the sample into the liquid analysis column to complete the injection and analysis of the sample.

[0043] 2. Replacement of the quantitative loop: When it is necessary to replace the quantitative loop 4 to adjust the injection volume, the user can achieve the rapid replacement of the quantitative loop through the sliding member 2 without disassembling the instrument housing or complex operations.

[0044] First, the user loosens the module fixing screw 7 that fixes the injection valve module 1 and the inner edge of the injection window 6, and then slides the injection valve module 1 out of its original position by a certain distance through the sliding structure of the slide rail 201 and the slider 202. When sliding, the convex part 204 of the slider is clamped in the chute 205 of the slide rail to ensure smooth and stable sliding.

[0045] After the injection valve module 1 is pulled out to the appropriate position, the user can use a tool to remove the two screws 9 fixed on the quantitative loop, so as to disassemble the quantitative loop 4 from the injection valve module 1.

[0046] After replacing the new quantitative loop 4, the user re-fixes the quantitative loop 4 on the injection valve module 1 through the screws 9, then pushes the injection valve module 1 back to its original position, and re-locks it on the inner edge of the injection window 6 through the module fixing screw 7 to ensure the stability and firmness of the injection valve module.

[0047] 3. Reset of the injection valve module: After the quantitative loop 4 is replaced, the user pushes the injection valve module 1 back to the starting position of the slide rail 201 and ensures that the module fixing screw 7 is tightly connected to the screw seat 8 to ensure the stability of the injection valve module 1. The entire replacement process does not require disassembling the instrument housing, which is simple and fast.

[0048] The utility model greatly simplifies the operations of sample injection and quantitative loop replacement of the liquid chromatograph. The user can directly perform sample injection through the injection window without opening the instrument housing, which is convenient and safe. At the same time, through the sliding components, the user can quickly replace quantitative loops of different specifications, avoiding the cumbersome steps in the traditional replacement method, and greatly improving the experimental efficiency and the operation convenience of the instrument.

[0049] In the description of the present utility model, it should be noted that the orientation or positional relationship indicated by terms such as "upper", "lower", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus cannot be construed as a limitation to the present utility model. Unless otherwise clearly specified and defined, the terms "installation", "connection", and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0050] It should be noted that in the present utility model, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprising", "including" or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements but also includes other elements not expressly listed, or further includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising an..." does not exclude the presence of additional identical elements in the process, method, article or device comprising said element.

[0051] The above are only specific embodiments of the present utility model, enabling those skilled in the art to understand or implement the present utility model. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present utility model. Therefore, the present utility model will not be limited to these embodiments shown herein, but rather will be accorded the widest scope consistent with the principles and novel features described herein.

Claims

1. A quickly replaceable liquid chromatography injection device, comprising: An injection valve module (1) having a detachable quantitative loop (4) thereon. It is characterized in that the injection valve module (1) is arranged at the upper end of a panel (3) through a sliding member (2); An injection window (6) is arranged on an instrument housing (5), and its position corresponds to the injection port of the injection valve module (1), and the injection valve module (1) passes through the injection window (6) and is arranged inside the instrument housing (5); Among them, without opening the instrument housing (5), the sample is injected into the injection valve module (1) through the injection window (6) to directly complete the sample injection operation, and the replacement of the quantitative loop (4) is realized by pulling the injection valve module (1), and the injection valve module (1) slides away from the door panel side end of the instrument housing (5) through the sliding member (2) to disassemble and replace the quantitative loop (4).

2. The quick-changeable liquid chromatography injection device according to claim 1, wherein The sliding member (2) is arranged at the inner end of the instrument housing (5), and the sliding member (2) is fixed to the panel (3) at its lower end through a fastener.

3. The quick-changeable liquid chromatography injection device according to claim 2, wherein, The sliding member (2) includes a slide rail (201), the bottom end of the slide rail (201) is fixedly connected to the panel (3) through a fastening bolt (203), the upper end of the slide rail (201) is provided with a slider (202), and the convex parts (204) at the inner edges of both ends of the slider (202) are clamped in the chute (205) of the slide rail (201).

4. The quick-changeable liquid chromatography injection device according to claim 1 or 3, characterized in that, When the quantitative loop (4) is not replaced, the injection valve module (1) is locked and connected to a screw seat (8) arranged at the inner edge of the injection window (6) through a module fixing screw (7).

5. The quick-changeable liquid chromatography injection device according to claim 1, wherein The injection valve module (1) is a six-way valve or an eight-way valve or a ten-way valve.

6. The quick-changeable liquid chromatography injection device according to claim 5, wherein, The injection valve module (1) is integrated in a pump module or an auto-sampler module or a column oven module or a detector module of a liquid chromatograph.

7. The quick-changeable liquid chromatography injection device according to claim 1, characterized in that, The quantitative loop (4) is fixed to the injection valve module (1) through at least two screws (9).

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