Suspension circulating filling system
Through the circulation system of buffer tank, filling bottle and mixing bottle, combined with power source and agitator, the problem of poor uniformity of the medicine liquid during suspension filling is solved, and the continuous flow and uniformity of the medicine liquid during filling is achieved.
Patent Information
- Application Number
- CN202422581102.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-25
- Publication Date
- 2025-08-05
- Estimated Expiration
- 2034-10-25
AI Technical Summary
In the prior art, during the filling process of suspension, the long-term stay of the medicine liquid in the filling bottle leads to particle deposition, resulting in poor dose uniformity.
A circulating system is adopted that connects the buffer tank, filling bottle and mixing bottle in turn to provide power through the liquid discharge and hydraulic power source to continuously flow the suspension, combine with agitator to prevent particles from precipitating, and a filling pipe is set up on the filling bottle to achieve uniform filling.
Effectively prevent the suspension from deposition in the filling bottle, improve the uniformity of the dose of the medicine liquid, and ensure the uniformity of the medicine liquid filled to the target product.
Smart Images
Figure CN223188909U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the technical field of drug filling, and specifically relates to a suspension circulating filling system. Background Art
[0002] Suspension-type medicaments generally contain insoluble drug particles dispersed in a liquid, forming a non-uniform dispersion liquid medicament. There are basic requirements for suspensions: the suspended particles should be fine and uniform, sink slowly, and the speed should not affect the correct measurement of the dose; therefore, during the filling process of suspensions, the residence time cannot exceed the time for the particles to sink. If the residence time is too long, the particles in the suspension will precipitate, resulting in non-uniform dose in the filled liquid medicine.
[0003] In the related art, the filling method is to use a pump to extract the liquid medicine into the filling bottle, and then use the filling bottle to fill the liquid medicine into the target product. The filling flow rate is less than the flow rate of the pump extracting the liquid medicine into the filling bottle, resulting in a large amount of liquid medicine in the filling bottle not being filled for a long time and causing particle deposition. Eventually, the dose uniformity of the filled liquid medicine is poor. Utility Model Content
[0004] The embodiments of this application provide a suspension circulating filling system to improve the problem of poor dose uniformity of the filled liquid medicine.
[0005] The embodiments of this application provide a suspension circulating filling system, including:
[0006] A buffer tank, the top of the buffer tank is provided with a circulating liquid inlet, and the bottom is provided with a circulating liquid outlet;
[0007] A filling bottle, the filling bottle is provided with a filling liquid inlet and includes a filling cavity communicated with the filling liquid inlet. The filling bottle is provided with a filling pipeline, the filling pipeline is communicated with the filling cavity, the filling bottle is further provided with a circulating liquid infusion port, the filling liquid inlet is communicated with the circulating liquid outlet through an outlet pipeline, and an outlet power source is provided on the outlet pipeline;
[0008] A mixing bottle, the mixing bottle is provided with a mixing liquid inlet and a mixing liquid outlet, the mixing liquid inlet is communicated with the circulating liquid infusion port, the mixing liquid outlet is communicated with the circulating liquid inlet through an inlet pipeline, and an inlet power source is provided on the inlet pipeline.
[0009] In some embodiments of this application, the number of the filling liquid inlets is at least two, and the number of the filling pipelines is multiple.
[0010] In some embodiments of this application, the caliber of the filling liquid inlet is larger than the caliber of the filling pipeline, and the caliber of the circulating liquid outlet is larger than the caliber of the filling pipeline.
[0011] In some embodiments of the present application, a first air pressure regulating pipe is provided on the filling bottle, the first air pressure regulating pipe is connected to the filling chamber, and the end of the first air pressure regulating pipe facing away from the filling bottle is connected to a first air pressure regulator.
[0012] In some embodiments of the present application, the volume of the mixing bottle gradually decreases from the mixing liquid inlet toward the mixing liquid outlet.
[0013] In some embodiments of the present application, the mixing bottle is conical in shape.
[0014] In some embodiments of the present application, the mixing bottle is connected to a second air pressure regulating pipe, and an end of the second air pressure regulating pipe facing away from the mixing bottle is connected to a second air pressure regulator.
[0015] In some embodiments of the present application, the liquid inlet power source and the liquid outlet power source are both peristaltic pumps.
[0016] In some embodiments of the present application, the filling bottle, the mixing bottle, the liquid inlet pipe, and the liquid outlet pipe are all transparent.
[0017] In some embodiments of the present application, a first agitator and a second agitator are provided in the buffer tank, the first agitator is located in the lower half of the interior of the buffer tank, and the second agitator is located inside the buffer tank and above the first agitator.
[0018] It can be seen that the embodiment of the present application realizes the filling and circulation of the suspension by connecting the buffer tank, the filling bottle and the mixing bottle in sequence, effectively preventing the suspension from being stored in a container, such as the filling bottle, for too long and causing particle precipitation, which is beneficial to improving the dosage uniformity of the liquid medicine filled into the target product. In detail, first, the buffer tank and the filling bottle are connected by the liquid outlet pipe, the mixing bottle and the buffer tank are connected by the liquid inlet pipe, and the filling bottle and the mixing bottle are connected by the mixing liquid inlet and the circulation infusion port, so that the buffer tank, the filling bottle and the mixing bottle form a circulation connection passage; then, the liquid outlet power source and the liquid inlet power source are used to provide power for the flow of the suspension, so that the suspension is always in a state of motion, effectively preventing the precipitation of particles in the suspension; and a filling pipe is provided on the filling bottle so that the filling pipe can be connected to the filling needle, thereby playing the role of discharging the suspension into the filling needle. In general, the present invention can achieve the delivery of the suspension to the filling needle while also maintaining the continuous circulation of the suspension, effectively preventing the sedimentation of the suspension, thereby improving the uniformity of the drug dosage in the suspension. Furthermore, when the mixing bottle receives the suspension from the filling bottle, it can also mix the suspension, further reducing the occurrence of particle sedimentation. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] To more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those skilled in the art, without creative efforts, other drawings can be obtained based on these drawings.
[0020] Figure 1 It is a schematic structural diagram of a suspension liquid circulation filling system provided by an embodiment of the present utility model;
[0021] Figure 2 It is a schematic structural diagram of a filling bottle in a suspension liquid circulation filling system provided by an embodiment of the present utility model;
[0022] Figure 3 It is a schematic structural diagram of a mixing bottle in a suspension liquid circulation filling system provided by an embodiment of the present utility model.
[0023] Explanation of the reference numerals:
[0024] 1. Buffer tank; 11. Circulation inlet; 12. Circulation outlet; 13. First stirrer; 14. Second stirrer; 2. Filling bottle; 21. Filling inlet; 22. Filling cavity; 23. Filling pipeline; 24. Circulation infusion port; 3. Mixing bottle; 31. Mixing inlet; 32. Mixing outlet; 4. Inlet pipeline; 5. Outlet pipeline; 6. Inlet power source; 7. Outlet power source; 8. First air pressure regulator; 9. Second air pressure regulator. Specific embodiments
[0025] The following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some embodiments of the present application, rather than all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative efforts belong to the scope protected by the present application.
[0026] In the description of the present application, it should be understood that the terms "first" and "second" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include one or more features. In the description of the present application, "multiple" means two or more, unless otherwise specifically defined.
[0027] Please refer to Figures 1 to 3 , an embodiment of the present application provides a suspension liquid circulation filling system, including a buffer tank 1, a filling bottle 2 and a mixing bottle 3.
[0028] Among them, a circulating liquid inlet 11 is provided at the top of the buffer tank 1, and a circulating liquid outlet 12 is provided at the bottom. The filling bottle 2 is provided with a filling liquid inlet 21 and includes a filling cavity 22 communicated with the filling liquid inlet 21. The filling bottle 2 is provided with a filling pipeline 23, and the filling pipeline 23 is communicated with the filling cavity 22. The filling bottle 2 is further provided with a circulating liquid infusion port 24. The filling liquid inlet 21 is communicated with the circulating liquid outlet 12 through a liquid outlet pipeline 5, and a liquid outlet power source 7 is provided on the liquid outlet pipeline 5. The mixing bottle 3 is provided with a mixing liquid inlet 31 and a mixing liquid outlet 32. The mixing liquid inlet 31 is communicated with the circulating liquid infusion port 24, and the mixing liquid outlet 32 is communicated with the circulating liquid inlet 11 through a liquid inlet pipeline 4, and a liquid inlet power source 6 is provided on the liquid inlet pipeline 4.
[0029] The technical solution provided by this application realizes the filling and circulation of the suspension by using the buffer tank 1, the filling bottle 2 and the mixing bottle 3 connected end to end in sequence, effectively avoiding the particle precipitation caused by the suspension being in a certain container, such as the filling bottle 2, for too long, which is beneficial to improving the dosage uniformity of the liquid medicine filled into the target product. Specifically, first, the buffer tank 1 and the filling bottle 2 are connected through the liquid outlet pipeline 5, the mixing bottle 3 and the buffer tank 1 are connected through the liquid inlet pipeline 4, and the filling bottle 2 and the mixing bottle 3 are also connected through the mixing liquid inlet 31 and the circulating liquid infusion port 24, so that a circulating connection path is formed among the buffer tank 1, the filling bottle 2 and the mixing bottle 3; then, the liquid outlet power source 7 and the liquid inlet power source 6 are used to provide power for the flow of the suspension, so that the suspension is always in a moving state, effectively preventing the particles in the suspension from depositing; the filling pipeline 23 is also provided on the filling bottle 2, so that the filling pipeline 23 can be connected to the filling needle, playing a role in discharging the suspension into the filling needle. Generally speaking, this application can not only realize the input of the suspension into the filling needle, but also continuously maintain the circulating flow of the suspension, effectively preventing the deposition of the suspension, thereby improving the uniformity of the drug dosage in the suspension. And when the mixing bottle 3 receives the suspension from the filling bottle 2, the mixing bottle 3 can also play a role in mixing the suspension, further reducing the situation of particle deposition.
[0030] In some embodiments, both the liquid inlet power source 6 and the liquid outlet power source 7 adopt peristaltic pumps. For the liquid inlet pipeline 4 and the liquid outlet pipeline 5, silica gel tubes are both adopted, and by adjusting the rotation speed of the peristaltic pump, the flow rate of the suspension in the liquid inlet pipeline 4 and the liquid outlet pipeline 5 can be adjusted. Since the peristaltic pump is an existing device, it will not be elaborated here.
[0031] In some embodiments, the filling bottle 2, the mixing bottle 3, the liquid inlet pipeline 4 and the liquid outlet pipeline 5 are all transparent, which is beneficial for the staff to observe the flow path of the suspension and is also beneficial for troubleshooting the filling bottle 2, the mixing bottle 3, the liquid inlet pipeline 4 and the liquid outlet pipeline 5.
[0032] In some embodiments, a first stirrer 13 and a second stirrer 14 are provided inside the buffer tank 1. The first stirrer 13 is located in the lower half region inside the buffer tank 1, which is beneficial to avoid the precipitation of medicament particles to the bottom of the buffer tank 1. The second stirrer 14 is located inside the buffer tank 1 and above the first stirrer 13, and specifically can be arranged at the middle position inside the buffer tank 1, so that the second stirrer 14 can stir the suspension in the buffer tank 1 as comprehensively as possible. For the first stirrer 13 and the second stirrer 14, their structures are the same, and the structure of a motor and a stirring blade can be adopted. For example, the output end of the motor is fixedly connected to the stirring blade. When the motor is started, the stirring blade rotates synchronously under the driving force of the output end of the motor to realize the stirring of the suspension.
[0033] Moreover, for the stirring directions of the two stirrers or the rotation directions of the stirring blades, they can be opposite or the same. In this embodiment, the directions of the two stirrers for stirring the suspension are substantially the same, so as to avoid the cancellation of the stirring forces between the two stirrers and greatly reduce the stirring effect.
[0034] In some embodiments, please refer to Figure 1 and Figure 2 , the number of filling inlets 21 is at least two, and the two filling inlets 21 are arranged at intervals along the length direction of the filling bottle 2. The number of filling pipes 23 is multiple, and the multiple filling pipes 23 are arranged at intervals along the length direction of the filling bottle 2, and the filling pipes 23 are arranged opposite to the filling inlets 21. The number of filling pipes 23 is set to be multiple, and the number of filling inlets 21 is two, mainly to be able to increase the filling flow rate as much as possible and avoid a large amount of medicament deposition due to too small filling flow rate. Of course, the number of filling inlets 21 can also be three, four, five, etc., without limitation, as long as the number of filling pipes 23 is more than the number of filling inlets 21. Of course, in some embodiments, the number of filling inlets 21 can also be equal to the number of filling pipes 23, or the number of filling inlets 21 is more than the number of filling pipes 23, without limitation. In this embodiment, it is preferred that the number of filling inlets 21 is less than the number of filling pipes 23, which is beneficial to increasing the filling flow rate, reducing the deposition of medicament particles, and also improving the filling efficiency.
[0035] Furthermore, the diameter of the filling inlet 21 is larger than the diameter of the filling pipe 23, so that when the filling pipe 23 fills the liquid medicine into the filling needle, the filling power can be increased due to the reduction of the diameter. And the problem of insufficient flow rate caused by the smaller diameter of the filling pipe 23 is compensated by increasing the number of filling pipes 23. The diameter of the circulating outlet 12 is larger than the diameter of the filling pipe 23, which is beneficial to increasing the flow velocity and flow rate of the suspension in the filling bottle 2 and reducing the deposition of particles.
[0036] In some embodiments, a first air pressure regulating pipe is provided on the filling bottle 2. The first air pressure regulating pipe is connected to the filling chamber 22, and the end of the first air pressure regulating pipe facing away from the filling bottle 2 is connected to a first air pressure regulator 8. By using the first air pressure regulator 8 to regulate the air pressure in the filling bottle 2, the air in the filling bottle 2 can be emptied as much as possible, and the flow of the suspension in the filling bottle 2 can be facilitated.
[0037] In some embodiments, see Figure 1 and Figure 3 The volume of the mixing bottle 3 gradually decreases from the mixing inlet 31 toward the mixing outlet 32. This allows unfilled suspension to flow from the mixing inlet 31 into the mixing bottle 3 for subsequent circulation. As the volume of the mixing bottle 3 gradually decreases, the suspension can collide and mix within the mixing bottle 3, resulting in more uniform mixing of the pharmaceutical agents in the suspension and increasing the flow rate of the suspension out of the mixing bottle 3.
[0038] Furthermore, the mixing bottle 3 is tapered, which can not only increase the flow rate of the suspension, but also improve the mixing uniformity of the suspension.
[0039] In some embodiments, the mixing bottle 3 is connected to a second air pressure regulating pipe, and the end of the second air pressure regulating pipe facing away from the mixing bottle 3 is connected to a second air pressure regulator 9. Similar to the first air pressure regulator 8, the second air pressure regulator 9 is mainly used to empty the air in the mixing bottle 3 and assist the flow of the suspension in the mixing bottle 3.
[0040] It should be noted that the first air pressure regulator 8 and the second air pressure regulator 9 may be the same device, such as a hollow silicone sleeve that can release and suck air by squeezing and releasing.
[0041] In summary, the technical solution provided in this application mainly realizes the filling and circulation of the suspension by connecting the buffer tank 1, the filling bottle 2 and the mixing bottle 3 in sequence end to end, effectively avoiding the suspension from being contained in a certain container, such as the filling bottle 2, for too long and causing particle precipitation, which is beneficial to improving the dosage uniformity of the liquid medicine filled into the target product.
[0042] The basic concepts have been described above. It will be apparent to those skilled in the art that the detailed disclosure above is merely illustrative and does not limit the present application. Although not explicitly stated herein, those skilled in the art may make various modifications, improvements, and amendments to the present application. Such modifications, improvements, and amendments are suggested in the present application and remain within the spirit and scope of the exemplary embodiments of the present application.
[0043] Meanwhile, this application uses specific terms to describe the embodiments of this application. For example, "one embodiment", "an embodiment", and / or "some embodiments" mean a certain feature, structure, or characteristic related to at least one embodiment of this application. Therefore, it should be emphasized and noted that the "one embodiment" or "an embodiment" or "an alternative embodiment" mentioned twice or more at different positions in this specification does not necessarily refer to the same embodiment. In addition, certain features, structures, or characteristics in one or more embodiments of this application can be appropriately combined.
[0044] Similarly, it should be noted that, in order to simplify the presentation of this application disclosure and thus help the understanding of one or more application embodiments, in the previous description of the embodiments of this application, sometimes multiple features are grouped into one embodiment, drawing, or description thereof. However, this disclosure method does not mean that the features required by the subject matter of this application are more than those mentioned in the claims. In fact, the features of the embodiments are less than all the features of the single embodiments disclosed above.
[0045] For each patent, patent application, patent application publication, and other materials cited in this application, such as articles, books, specifications, publications, documents, etc., their entire contents are hereby incorporated into this application by reference, except for the application history documents that are inconsistent with or conflict with the content of this application, and also except for the documents that limit the broadest scope of the claims of this application (currently or subsequently attached to this application). It should be noted that if there are inconsistencies or conflicts between the descriptions, definitions, and / or uses of terms in the attached materials of this application and the content of this application, the descriptions, definitions, and / or uses of terms in this application shall prevail.
[0046] The above are only the preferred embodiments of this application and are not used to limit this application. For those skilled in the art, this application can have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of this application shall be included within the protection scope of this application.
Claims
1. A suspension circulation filling system, characterized in that: include: A buffer tank, wherein the top of the buffer tank is provided with a circulating liquid inlet, and the bottom of the buffer tank is provided with a circulating liquid outlet; A filling bottle, wherein the filling bottle is provided with a filling liquid inlet and includes a filling cavity connected to the filling liquid inlet, the filling bottle is provided with a filling pipe, the filling pipe is connected to the filling cavity, the filling bottle is further provided with a circulation infusion port, the filling liquid inlet is connected to the circulation liquid outlet via a liquid outlet pipe, and the liquid outlet pipe is provided with a liquid outlet power source; A mixing bottle is provided with a mixing liquid inlet and a mixing liquid outlet, wherein the mixing liquid inlet is connected to the circulating infusion port, and the mixing liquid outlet is connected to the circulating liquid inlet through a liquid inlet pipe, and the liquid inlet pipe is provided with a liquid inlet power source.
2. The suspension circulation filling system according to claim 1, characterized in that: The number of the filling liquid inlets is at least two, and the number of the filling pipes is multiple.
3. The suspension circulation filling system according to claim 2, characterized in that: The diameter of the filling liquid inlet is larger than the diameter of the filling pipe, and the diameter of the circulation liquid outlet is larger than the diameter of the filling pipe.
4. The suspension circulation filling system according to claim 1, characterized in that: The filling bottle is provided with a first air pressure regulating pipe, the first air pressure regulating pipe is communicated with the filling cavity, and one end of the first air pressure regulating pipe away from the filling bottle is communicated with a first air pressure regulator.
5. The suspension circulation filling system according to claim 1, characterized in that: The volume of the mixing bottle gradually decreases from the mixing liquid inlet toward the mixing liquid outlet.
6. The suspension circulation filling system according to claim 5, characterized in that: The mixing bottle is in a cone shape.
7. The suspension circulation filling system according to claim 5, characterized in that: The mixing bottle is connected to a second air pressure regulating pipe, and one end of the second air pressure regulating pipe facing away from the mixing bottle is connected to a second air pressure regulator.
8. The suspension circulation filling system according to any one of claims 1 to 7, characterized in that: The liquid inlet power source and the liquid outlet power source are both peristaltic pumps.
9. The suspension circulation filling system according to any one of claims 1 to 7, characterized in that: The filling bottle, the mixing bottle, the liquid inlet pipe, and the liquid outlet pipe are all transparent.
10. The suspension circulation filling system according to any one of claims 1 to 7, characterized in that: A first agitator and a second agitator are provided in the buffer tank. The first agitator is located in the lower half of the interior of the buffer tank, and the second agitator is located inside the buffer tank and above the first agitator.