Chemiluminescence detection magnetic attraction structure

Abstract

The utility model discloses a chemiluminescence detection magnetic attraction structure. The structure comprises a guide bracket, a magnetic attraction substrate, a displacement driving assembly and a permanent magnet. And the magnetic substrate is connected to the guide bracket in a sliding manner along the inclined direction and is driven by the displacement driving assembly. The magnetic attraction base plate is provided with two working positions, namely an avoiding position and a magnetic attraction position. And the avoiding position is positioned obliquely above the magnetic attraction position. The horizontal component in the direction from the avoiding position to the magnetic attraction position is the horizontal displacement direction; one or more permanent magnets are fixed to the side, close to the horizontal displacement direction, of the magnetic attraction base plate. According to the utility model, the magnetic substrate is set to slide along the inclined direction, so that the permanent magnet tightly attached to the detection tube cannot be blocked by the edge of the end part of the reagent strip or the limiting flange at the top of the outer side wall of the reagent strip in the upward resetting process, and the reagent strip is further prevented from being bumped and displaced in the moving process of the magnetic substrate.

Description

Technical Field

[0001] The utility model belongs to the technical field of sample detection, and particularly relates to a chemiluminescence detection magnetic attraction structure. Background Art

[0002] Magnetic adsorption is often used to separate magnetic beads from waste liquid in single-dose chemiluminescence detection. For example, publication number "CN219799478U" discloses a chemiluminescence detector that uses a magnetic adsorption module to adsorb magnetic beads onto the side wall of the tip for magnetic bead separation. The specific process is as follows: first, the magnetic beads and waste liquid are sucked into the TIP tip, and then a permanent magnet is used to cling to the outer wall of the TIP tip to adsorb the magnetic beads. After the adsorption is completed, the waste liquid is spitted out of the TIP tip, thereby achieving the purpose of magnetic bead separation. However, this type of magnetic bead adsorption structure can only be performed after the TIP tip absorbs the waste liquid containing magnetic beads. In the process of the TIP tip absorbing the magnetic bead liquid, there is a residual risk, which increases the possibility of magnetic bead loss. Summary of the Invention

[0003] The purpose of the utility model is to provide a chemiluminescence detection magnetic attraction structure.

[0004] The present invention provides a chemiluminescence detection magnetic structure, which includes a guide bracket, a magnetic substrate, a shift drive assembly and a permanent magnet. The magnetic substrate is slidably connected to the guide bracket along an inclined direction and is driven by the shift drive assembly. The magnetic substrate has two working positions, namely an avoidance position and a magnetic position. The avoidance position is located obliquely above the magnetic position. The horizontal component of the direction from the avoidance position to the magnetic position is the horizontal shift direction; one or more permanent magnets are fixed to the side of the magnetic substrate close to the horizontal shift direction.

[0005] Preferably, the sliding direction of the magnetic substrate is 30° to 60° with the horizontal plane.

[0006] Preferably, the side of the magnetic attraction substrate is provided with a plurality of permanent magnets arranged in sequence along the horizontal direction.

[0007] Preferably, a groove structure is provided on the outer surface of the permanent magnet.

[0008] Preferably, the groove structure is arc-shaped.

[0009] Preferably, when the magnetic substrate is in the avoidance position, the bottom surface of the magnetic substrate and the permanent magnet is higher than the moving path in the chemiluminescence detection instrument. When the magnetic substrate is in the magnetic attraction position, the permanent magnet on the magnetic substrate is aligned with the detection tube in the chemiluminescence detection instrument.

[0010] Preferably, the device further includes a limit detection component. The limit detection component includes a limit sensor and a contact piece. The limit sensor matches the position of the contact piece; when the magnetic substrate is detected to be in the avoidance position, the contact piece triggers the limit sensor.

[0011] Preferably, the magnetic substrate is connected to the guide bracket via a guide rail and a slider. The guide rail is fixed to the guide bracket; the slider is slidably connected to the guide rail. The top surface of the magnetic substrate and the slider are fixed via a connecting rod.

[0012] Preferably, the shift drive assembly includes a magnetic shift motor and a first screw. The magnetic shift motor is fixed to a guide bracket; the first screw is rotatably connected to the guide bracket. The output shaft of the magnetic shift motor is fixed to the end of the first screw; the first screw and a nut fixed to the magnetic base plate form a screw pair.

[0013] Preferably, the shift drive assembly adopts a belt transmission structure driven by a motor.

[0014] The beneficial effects of the utility model are:

[0015] 1. The chemiluminescence detection magnetic structure provided by the present invention matches the position of the reagent strip, and the magnetic beads in the detection tube are adsorbed on the inner wall of the detection tube by approaching the detection tube on the reagent strip, thereby separating the magnetic beads from the reaction waste liquid or cleaning waste liquid of the chemiluminescence detection while retaining the magnetic beads in the detection tube.

[0016] 2. The utility model sets the magnetic substrate to slide in an inclined direction, so that the permanent magnet that is tightly fitted to the detection tube will not be blocked by the edge of the end of the reagent strip or the limiting flange on the top of the outer wall of the reagent strip during the upward reset process, thereby preventing the reagent strip from being bumped and displaced during the movement of the magnetic substrate.

[0017] 3. The utility model provides a groove structure on the outer surface of the permanent magnet to increase the magnetic attraction force on the magnetic beads in the detection tube of chemiluminescence detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a structural diagram of the utility model;

[0019] Figure 2 This is a schematic diagram of the working state of the utility model;

[0020] Figure numerals: 1. Guide bracket; 2. Magnetic substrate; 3. Shift drive assembly; 3-1 Magnetic shift motor; 3-2. First screw rod; 4. Permanent magnet; 5. Limit detection assembly; 5-1. Limit sensor; 5-2. Contact piece; 6. Reagent strip; 7. Detection tube; 8 Guide rail; 9. Slider. DETAILED DESCRIPTION

[0021] The present invention will be further described below with reference to the accompanying drawings.

[0022] Example 1

[0023] A chemiluminescence detection magnetic structure is installed inside a chemiluminescence detection instrument and is used to apply or cancel a magnetic field to the inside of a detection tube at the end of a reagent strip, so that the magnetic beads inside the detection tube are adsorbed on the side wall of the detection tube, making it easy to use a suction head to absorb waste liquid in the tube without affecting the magnetic beads in the detection tube.

[0024] like Figure 1 and Figure 2 As shown, the chemiluminescence detection magnetic structure includes a guide bracket 1, a magnetic substrate 2, a displacement drive assembly 3, a permanent magnet 4, and a limit detection assembly 5. A guide rail 8 is fixed to the guide bracket 1; a slider 9 is slidably connected to the guide rail 8. The top surface of the magnetic substrate 2 and the slider 9 are fixed together by a connecting rod. The axis of the guide rail 8 forms a 60° angle with the horizontal plane, allowing the magnetic substrate 2 to slide tiltably.

[0025] The slider 9 is driven to slide back and forth by the shift drive assembly 3. The shift drive assembly 3 includes a magnetic shift motor 3-1 and a first screw 3-2. The magnetic shift motor 3-1 is fixed to the guide bracket 1 via a motor base; the first screw 3-2 is rotatably connected to the guide bracket 1. The output shaft of the magnetic shift motor 3-1 is fixed to the end of the first screw 3-2. The first screw 3-2 forms a screw pair with a nut fixed to the magnetic base 2.

[0026] The magnetic substrate 2 has two operating positions: a retractable position and a magnetic attraction position. The retractable position is located diagonally above the magnetic attraction position. The horizontal component of the sliding direction of the magnetic substrate 2 from the retractable position to the magnetic attraction position is used as the horizontal displacement direction. One or more permanent magnets 4 are fixed to the side of the magnetic substrate 2 closest to the horizontal displacement direction.

[0027] The vertical distance between the two positions of the magnetic substrate 2 satisfies the following conditions:

[0028] When the magnetic substrate 2 is in the avoidance position, the bottom surfaces of the magnetic substrate 2 and the permanent magnet 4 are higher than the moving path in the chemiluminescence detection instrument, thereby preventing the magnetic substrate 2 and the permanent magnet 4 from blocking the reciprocating movement of the reagent strip 6 that needs to be performed during the reaction.

[0029] When the magnetic substrate 2 is in the magnetic attraction position, the permanent magnet 4 on the substrate 2 aligns with the detection tube 7 at the end of the reagent strip 6 in the chemiluminescence detection instrument. When the detection tube 7 moves to the designated aspiration position in the chemiluminescence detection instrument (i.e., below the pipette tip), the outer wall of the detection tube 7 contacts the permanent magnet 4. The magnetic beads in the detection tube 7 are attracted to the inner wall by the permanent magnet 4, preventing the beads from being aspirated by the pipette.

[0030] In some embodiments, a plurality of permanent magnets 4 are arranged in sequence along the horizontal direction on the side of the magnetic attraction substrate 2. Each permanent magnet 4 is used to provide magnetic attraction to a plurality of reagent strips 6 arranged in sequence in a multi-channel chemiluminescence detection instrument.

[0031] In some embodiments, a groove structure is provided on the outer surface of the permanent magnet 4; the groove structure matches the shape of the outer wall of the detection tube 7, allowing the permanent magnet 4 to fit tightly against the outer wall of the detection tube 7, thereby increasing the magnetic attraction force on the magnetic beads in the detection tube 7. Furthermore, the groove structure on the permanent magnet 4 is arc-shaped.

[0032] The limit detection assembly 5 is used to limit the magnetic substrate 2 to its avoidance position. It includes a limit sensor 5-1 and a contact 5-2. The limit sensor 5-1 is fixed to the guide bracket 1; the contact 5-2 is fixed to the slider 9. The positions of the limit sensor 5-1 and the contact 5-2 match. When the contact 5-2 triggers the limit sensor 5-1, the magnetic substrate 2 enters the avoidance position. In this embodiment, the limit sensor 5-1 is a U-shaped infrared sensor.

[0033] The chemiluminescence detection magnetic structure provided in this embodiment is used when it is necessary to perform magnetic bead separation on the liquid containing magnetic beads in the detection tube 7. The working principle thereof is as follows:

[0034] The chemiluminescence detection instrument moves the test tube 7 of the reagent strip 6 to the designated aspiration position. The magnetic displacement motor 3-1 drives the magnetic base plate 2 to move obliquely downward from the avoidance position to the magnetic attraction position, so that the permanent magnet 4 contacts the outer wall of the test tube 7, causing the magnetic beads to be attracted to the inner wall of the test tube 7. The liquid in the test tube 7 is then aspirated using a suction tip, and the magnetic beads remain in the test tube 7 during this process.

[0035] After completing the magnetic bead separation, the magnetic displacement motor 3-1 drives the magnetic substrate 2 to move obliquely upward from the magnetic position to the avoidance position; since the magnetic substrate 2 has a horizontal displacement component away from the detection tube 7 while moving upward, it can closely fit the permanent magnet 4 of the detection tube 7 and the end edge 6-1 of the reagent strip 6 or the limiting flange on the top of the outer wall of the detection tube 7 to block the movement of the permanent magnet 4, thereby preventing the reagent strip 6 from being bumped and displaced during the movement of the magnetic substrate 2.

[0036] When the magnetic substrate 2 moves to the avoidance position, the positions of the magnetic substrate 2 and the permanent magnet 4 are higher than the reagent strip 6, so the movement of the permanent magnet 4 during the reaction and cleaning process will not be affected by the magnetic structure.

[0037] The magnetic bead separation in this embodiment can be performed after the reaction is completed or after a round of magnetic bead washing is completed, and can also be performed in other scenarios where magnetic beads need to be separated; multiple magnetic bead separations can be performed in the same detection tube 7, and the magnetic beads remain in the detection tube 7 during the multiple separations without having to be transferred with the pipette tip multiple times, thereby effectively reducing the risk of magnetic bead loss.

[0038] Example 2

[0039] A chemiluminescence detection magnetic structure, the difference between this embodiment and embodiment 1 is that the structure of the displacement drive component 3 is different.

[0040] In this embodiment, the shift drive assembly 3 adopts a belt transmission structure driven by a motor.

[0041] Example 3

[0042] A chemiluminescence detection magnetic structure, the difference between this embodiment and embodiment 1 is that the structure of the displacement drive component 3 is different.

[0043] In this embodiment, the shift drive assembly 3 adopts a gear rack structure driven by a motor.

Claims

1. A chemiluminescence detection magnetic structure, characterized in that: The invention comprises a guide bracket (1), a magnetic base plate (2), a displacement drive assembly (3) and a permanent magnet (4); the magnetic base plate (2) is connected to the guide bracket (1) in a sliding manner along an inclined direction and is driven by the displacement drive assembly (3); the magnetic base plate (2) has two working positions, namely, a avoidance position and a magnetic position; the avoidance position is located obliquely above the magnetic position; the horizontal component of the direction from the avoidance position to the magnetic position is the horizontal displacement direction; one or more permanent magnets (4) are fixed to the side of the magnetic base plate (2) close to the horizontal displacement direction.

2. The chemiluminescence detection magnetic structure according to claim 1, characterized in that: The sliding direction of the magnetic substrate (2) is 30° to 60° with the horizontal plane.

3. The chemiluminescence detection magnetic structure according to claim 1, characterized in that: The side of the magnetic attraction substrate (2) is provided with a plurality of permanent magnets (4) arranged in sequence along the horizontal direction.

4. The chemiluminescence detection magnetic structure according to claim 1, characterized in that: A groove structure is provided on the outer surface of the permanent magnet (4).

5. The chemiluminescence detection magnetic structure according to claim 4, characterized in that: The groove structure is in an arc shape.

6. The chemiluminescence detection magnetic structure according to claim 1, characterized in that: When the magnetic substrate (2) is in the avoidance position, the bottom surfaces of the magnetic substrate (2) and the permanent magnet (4) are higher than the moving path in the chemiluminescence detection instrument; when the magnetic substrate (2) is in the magnetic attraction position, the permanent magnet (4) on the magnetic substrate (2) is aligned with the detection tube (7) in the chemiluminescence detection instrument.

7. The chemiluminescence detection magnetic structure according to claim 1, characterized in that: It also includes a limit detection component (5); the limit detection component (5) includes a limit sensor (5-1) and a contact piece (5-2); the position of the limit sensor (5-1) matches the position of the contact piece (5-2); when the magnetic substrate (2) is detected to be in the avoidance position, the contact piece (5-2) triggers the limit sensor (5-1).

8. The chemiluminescence detection magnetic structure according to claim 1, characterized in that: The magnetic substrate (2) is connected to the guide bracket (1) via a guide rail (8) and a slider (9); the guide rail (8) is fixed on the guide bracket (1); a slider (9) is slidably connected to the guide rail (8); and the top surface of the magnetic substrate (2) and the slider (9) are fixed via a connecting rod.

9. The chemiluminescence detection magnetic structure according to claim 1, characterized in that: The shift drive assembly (3) comprises a magnetic shift motor (3-1) and a first screw rod (3-2); the magnetic shift motor (3-1) is fixed on the guide bracket (1); the first screw rod (3-2) is rotatably connected to the guide bracket (1); the output shaft of the magnetic shift motor (3-1) is fixed to the end of the first screw rod (3-2); the first screw rod (3-2) and a nut fixed on the magnetic base plate (2) form a spiral pair.

10. The chemiluminescence detection magnetic structure according to claim 1, characterized in that: The shift drive assembly (3) adopts a belt transmission structure driven by a motor.

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