Preparation wet-process high-speed shearing, stirring and mixing device

Abstract

The utility model relates to the technical field of preparation of solid preparations, and discloses a preparation wet-process high-speed shearing, stirring and mixing device which comprises a stirring tank, a cover body is fixedly mounted at the top end of the stirring tank, and a smashing mechanism for pretreating and refining solid added materials is arranged at the rear end of the top of the cover body. When the preparation wet-process high-speed shearing, stirring and mixing device is used, the speed reducing motor can be controlled to start to drive the rotating drum to rotate; auxiliary pre-smashing and refining treatment can be carried out on some blocky raw materials contained in powdery raw materials through a plurality of groups of rotating movable cutters and a plurality of groups of fixed cutters, and the refined powdery raw materials can be rapidly and uniformly mixed after being guided into the device, so that the quality of raw materials used for preparing solid preparations is improved; the problem that powdery raw materials for solid preparation preparation are inconvenient to pretreat and refine is solved.

Description

Technical Field

[0001] The utility model relates to the technical field of solid preparation preparation, in particular to a preparation wet method high-speed shearing stirring and mixing device. Background Art

[0002] Solid preparations refer to preparations in which drugs are in solid form, including powders, granules, tablets, capsules, etc. These dosage forms account for a large proportion of pharmaceutical preparations, usually about 70%.

[0003] In the preparation of solid dosage forms, powder mixing is often a critical operation in the production process, as the mixing of product components determines product quality. Furthermore, the majority of products sold on the market are solid dosage forms, such as tablets and capsules. Therefore, the pharmaceutical industry is particularly concerned about the uniformity of powder mixing. Mixing, the process of homogenizing two or more components, is an essential step in the solid dosage process. Some processes even require multiple mixing steps, such as premixing before granulation or final mixing before tableting. Mixing processes are used throughout the entire solid dosage form process. Typically, formulations require the mixing of several or even dozens of materials to achieve the desired material properties. To ensure uniform mixing of powder materials during the powder mixing process, a wet high-speed shear mixing device is used. This device utilizes high-speed rotating blades or paddles to impart intense shear and impact to the powder materials, achieving uniform mixing.

[0004] However, when the wet high-speed shear stirring mixing device for preparations is used to mix materials used in the preparation of solid preparations, during the process of introducing the powder materials to be prepared into the internal mixing process of the device, the powder raw materials will contain some agglomerated block materials. When introduced into the interior of the device, the mixing speed of the large block powders is slow and it is difficult to obtain uniform mixing, which is insufficient and inconvenient for pre-processing and refining the powder raw materials used in the preparation of solid preparations.

[0005] Now, a new type of wet high-speed shear stirring mixing device for preparation is proposed to solve the above-mentioned shortcomings. Utility Model Content

[0006] The purpose of the utility model is to provide a wet high-speed shear stirring and mixing device for preparations, so as to solve the problem in the above background technology that it is inconvenient to pre-treat and refine powdered raw materials for the preparation of solid preparations.

[0007] To achieve the above-mentioned object, the present invention provides the following technical solution: a high-speed shear stirring and mixing device for a preparation by wet method, comprising a stirring tank, a cover body being fixedly mounted on the top of the stirring tank, and a crushing mechanism for pre-processing and refining solid additive materials being provided at the rear end of the top of the cover body;

[0008] The crushing mechanism includes a feed port, a rotating drum, a movable knife, a reduction motor and a fixed knife. The feed port is fixedly installed at the rear end of the top of the cover body, and the bottom end inside the feed port is movably connected with the rotating drum. The two sides of the rotating drum respectively penetrate the interior of both sides of the feed port. The reduction motor is fixedly installed at the bottom end of the right side of the feed port. The top, bottom and both ends of the rotating drum are respectively fixed with movable knives, and the two ends inside the feed port are respectively fixed with fixed knives.

[0009] Preferably, the bottom end of the feed port passes through the interior of the cover and is communicated with the interior of the stirring tank.

[0010] Preferably, the output shaft of the reduction motor is fixedly connected to the right side of the rotating drum, and the movable knives are fixed in multiple groups at equal intervals on the top and bottom and both ends of the rotating drum, and the fixed knives are fixed in multiple groups at equal intervals on both ends inside the feed port, and the movable knives and fixed knives are staggered inside the feed port.

[0011] Preferably, an outer tube is fixed to the bottom end of the cover body, and an inner tube is provided on the inner side of the outer tube, the top end of the inner tube is fixedly connected to the bottom end of the cover body, nozzles are fixed to the bottom ends of the outer tube and the inner tube respectively, a connecting tube is fixed between the outer tube and the inner tube, a water pump is installed and fixed to the bottom end of the right side of the mixing tank, and a water pipe is installed and fixed to the output end of the water pump, a water pumping pipe is fixed to the input end of the water pump, and the top end of the water pipe passes through the interior of the right side of the mixing tank and is fixedly connected to the right side of the outer tube.

[0012] Preferably, the outer tube is connected to the interior of the inner tube through a connecting tube, and a plurality of nozzles are fixed in a circular manner at equal intervals at the bottom ends of the outer tube and the inner tube.

[0013] Preferably, a fixing tube is fixed to the right side of the front end of the top of the cover body, and the bottom end of the fixing tube passes through the interior of the cover body and is connected to the interior of the mixing tank, a connecting plate is fixed to the top end of the outside of the fixing tube, a mounting plate is provided at the top end of the connecting plate, and a mounting bolt is provided at the top end of the mounting plate, a viewing plate is fixed to the inside of the mounting plate, and a threaded hole is opened inside the top end of the connecting plate to cooperate with the mounting bolt.

[0014] Preferably, the mounting bolts are arranged in five groups at equal intervals in a ring shape on the top of the mounting plate, and the bottom ends of the mounting bolts pass through the interior of the mounting plate.

[0015] Preferably, legs are fixed on both sides and both ends of the bottom of the mixing tank, a mixing shaft is provided inside the mixing tank, and the top end of the mixing shaft passes through the interior of the cover body, a mounting bracket is fixed at the middle position of the top end of the cover body, and a reducer is fixed on the top end of the mounting bracket, and a driving motor 2 is fixed on the left side of the reducer, and a rotating shaft is vertically movably connected on both sides of the bottom end of the cover body, and blades are fixed on the top and bottom ends of the outside of the rotating shaft, the top end of the rotating shaft passes through the interior of the cover body, and a driving motor 1 is fixed on both sides of the top end of the cover body, a discharge pipe is fixed on the bottom end of the mixing tank, and a valve is fixed on the bottom end of the discharge pipe, and a liquid adding pipe is fixed at the front end of the top of the cover body.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows: the wet high-speed shear stirring and mixing device for preparation of solid preparations not only facilitates the pretreatment and refinement of powdered raw materials used in the preparation of solid preparations, facilitates auxiliary cleaning of the inner wall of the mixing device, but also facilitates the inspection of the mixing state of the solid preparation raw materials inside the device;

[0017] (1) The device is provided with a stirring tank, a cover, a feed port, a rotating drum, a movable blade, a reduction motor and a fixed blade. When the device is used, the reduction motor can be controlled to start driving the rotating drum to rotate, and then the solid powder raw material is introduced into the feed port. The plurality of rotating movable blades and the plurality of fixed blades can be used to perform auxiliary pre-crushing and refining treatment on some block raw materials contained in the powder raw material. After the powder raw material after the refining treatment is introduced into the interior of the device, it can be quickly and evenly mixed, thereby improving the quality of the raw materials used in the preparation of solid preparations;

[0018] (2) The device is provided with a mixing tank, an outer tube, a cover, an inner tube, a water pipe, a water pump, a water extraction pipe, a connecting pipe and a nozzle. After the device is used, the prepared mixture is discharged from the discharge pipe, and then the water extraction pipe can be connected to an external water supply source. By controlling the start of the water pump, the external water source can be drawn in by the water extraction pipe and introduced into the interior of the outer tube and the inner tube through the water extraction pipe and the connecting pipe. Finally, the water can be sprayed on the inner wall of the mixing tank by multiple groups of nozzles, and the residue on the inner wall of the device can be auxiliaryly rinsed and cleaned;

[0019] (3) By providing a cover body, a mounting plate, a viewing plate, a mounting bolt, a fixing pipe and a connecting plate, when the device is used to mix and process the raw materials for preparing solid preparations, a viewing plate is fixed in the mounting plate installed on the top of the cover body. The material mixing state inside the stirring tank can be directly viewed through the viewing plate, which is convenient for real-time inspection and understanding of the material mixing processing state inside the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the front cross-sectional structure of the utility model;

[0021] Figure 2 This is a schematic diagram of the front view structure of the movable knife of the utility model;

[0022] Figure 3 This is a schematic diagram of the top view of the feed port of the utility model;

[0023] Figure 4 This is a schematic diagram of an enlarged partial cross-section of the mounting plate of the present invention;

[0024] Figure 5 This is a schematic diagram of the enlarged structure of the outer tube of the utility model from a top view.

[0025] In the figure: 1. Support leg; 2. Mixing tank; 3. Blade; 4. Rotating shaft; 5. Mixing shaft; 6. Outer tube; 7. Cover; 8. Driving motor 1; 9. Mounting frame; 10. Driving motor 2; 11. Reducer; 12. Feed inlet; 13. Inner tube; 14. Water pipe; 15. Water pump; 16. Suction pipe; 17. Discharge pipe; 18. Valve; 19. Rotating drum; 20. Movable blade; 21. Reducer motor; 22. Fixed blade; 23. Liquid adding pipe; 24. Mounting plate; 25. Viewing plate; 26. Mounting bolt; 27. Fixed tube; 28. Connecting plate; 29. Connecting tube; 30. Sprinkler. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0027] See also Figure 1-5 The utility model provides an embodiment: a high-speed shear stirring and mixing device for wet preparation, comprising a stirring tank 2, a cover 7 being fixedly mounted on the top of the stirring tank 2, and a crushing mechanism for pre-processing and refining solid additives is provided at the rear end of the top of the cover 7;

[0028] The crushing mechanism includes a feed port 12, a rotating drum 19, a movable knife 20, a reduction motor 21 and a fixed knife 22. The feed port 12 is fixedly mounted on the rear end of the top of the cover body 7, and the bottom end of the feed port 12 is movably connected to the rotating drum 19. The two sides of the rotating drum 19 respectively pass through the interior of the two sides of the feed port 12. The reduction motor 21 is fixedly mounted on the bottom end of the right side of the feed port 12. The top, bottom and both ends of the rotating drum 19 are respectively fixed with movable knives 20. The two ends of the feed port 12 are respectively fixed with fixed knives 22. The bottom end of the feed port 12 passes through the interior of the cover body 7 and is connected to the interior of the mixing tank 2.

[0029] The output shaft of the reduction motor 21 is fixedly connected to the right side of the drum 19. Multiple groups of movable knives 20 are fixed at equal intervals on the top, bottom and both ends of the drum 19. Multiple groups of fixed knives 22 are fixed at equal intervals on both ends of the feed port 12. The movable knives 20 and the fixed knives 22 are staggered inside the feed port 12.

[0030] Specifically, if Figure 1-Figure 3 As shown, the reduction motor 21 can be controlled to start driving the drum 19 to rotate, and then the solid powdered raw materials are introduced into the feed port 12. The multiple groups of rotating movable knives 20 and the multiple groups of fixed knives 22 can be used to assist in pre-crushing and refining some block raw materials contained in the powdered raw materials. After the refined powdered raw materials are introduced into the interior of the device, they can be quickly and evenly mixed.

[0031] An outer tube 6 is fixed to the bottom end of the cover body 7, and an inner tube 13 is provided on the inner side of the outer tube 6. The top end of the inner tube 13 is fixedly connected to the bottom end of the cover body 7. Sprinklers 30 are respectively fixed to the bottom ends of the outer tube 6 and the inner tube 13. A connecting pipe 29 is fixed between the outer tube 6 and the inner tube 13. A water pump 15 is installed and fixed to the bottom end of the right side of the mixing tank 2, and a water pipe 14 is installed and fixed to the output end of the water pump 15. A water pumping pipe 16 is fixed to the input end of the water pump 15. The top end of the water pipe 14 passes through the interior of the right side of the mixing tank 2 and is fixedly connected to the right side of the outer tube 6. The outer tube 6 is communicated with the interior of the inner tube 13 through the connecting pipe 29. A plurality of groups of sprinklers 30 are fixed in a ring at equal intervals at the bottom ends of the outer tube 6 and the inner tube 13;

[0032] Specifically, if Figure 1 and Figure 5 As shown, after the prepared mixture is discharged from the discharge pipe 17, the water pumping pipe 16 can be connected to an external water supply source. By controlling the water pump 15 to start, the external water source can be drawn in by the water pumping pipe 16 and introduced into the interior of the outer tube 6 and the inner tube 13 through the water supply pipe 14 and the connecting pipe 29. Finally, it can be sprayed on the inner wall of the mixing tank 2 by multiple groups of nozzles 30, which can assist in flushing and cleaning the residue on the inner wall of the device.

[0033] A fixing tube 27 is fixed to the right side of the front end of the top of the cover body 7, and the bottom end of the fixing tube 27 passes through the interior of the cover body 7 and is connected to the interior of the mixing tank 2. A connecting plate 28 is fixed to the top of the outside of the fixing tube 27. A mounting plate 24 is provided on the top of the connecting plate 28, and a mounting bolt 26 is provided on the top of the mounting plate 24. A viewing plate 25 is fixed to the inside of the mounting plate 24. Threaded holes for fitting with the mounting bolts 26 are provided inside the top of the connecting plate 28. Five groups of mounting bolts 26 are arranged at equal intervals in a ring at the top of the mounting plate 24. The bottom ends of the mounting bolts 26 pass through the interior of the mounting plate 24.

[0034] Specifically, if Figure 1 and Figure 4 As shown, a viewing plate 25 is fixed in the mounting plate 24 installed on the top of the cover body 7, and the mixing state of the materials inside the mixing tank 2 can be directly viewed through the viewing plate 25.

[0035] Legs 1 are fixed on both sides and both ends of the bottom of the mixing tank 2. A stirring shaft 5 is provided inside the mixing tank 2, and the top of the stirring shaft 5 passes through the interior of the cover body 7. A mounting bracket 9 is fixed at the middle position of the top of the cover body 7, and a reducer 11 is fixed to the top of the mounting bracket 9. A driving motor 2 10 is fixed to the left side of the reducer 11. The two sides of the bottom end of the cover body 7 are vertically movably connected with a rotating shaft 4, and the top and bottom ends of the outside of the rotating shaft 4 are respectively fixed with blades 3. The top of the rotating shaft 4 passes through the interior of the cover body 7, and a driving motor 8 is respectively fixed on both sides of the top of the cover body 7. A discharge pipe 17 is fixed to the bottom end of the mixing tank 2, and a valve 18 is fixed to the bottom end of the discharge pipe 17. A liquid adding pipe 23 is fixed to the front end of the top of the cover body 7.

[0036] Working principle: When the high-speed shear stirring and mixing device of the utility model is in use, the reduction motor 21 can be controlled to start driving the drum 19 to rotate, and then the solid powder raw material is introduced through the feed port 12, and the multiple rotating groups of movable knives 20 and the multiple fixed groups of fixed knives 22 can be used to assist in pre-crushing and refining some block raw materials contained in the powder raw material. During the mixing process, after the powder raw material and the liquid raw material are respectively introduced into the interior of the device, the drive motor 1 8 and the drive motor 2 10 can be controlled to start, the drive motor 1 8 can drive the rotating shaft 4 to drive the blade 3 to rotate at high speed to shear and mix the solid powder, and the drive motor 2 10 can drive the stirring shaft 5 to rotate to assist in mixing, so as to prepare the raw materials for solid preparations. High-speed shear stirring and mixing processing. At the same time, when the device is used to mix the raw materials for preparing solid preparations, a viewing plate 25 is fixed in the mounting plate 24 installed on the top of the cover body 7. The viewing plate 25 can be used to directly view the mixing state of the materials inside the stirring tank 2. After the device is used, the prepared mixture is discharged from the discharge pipe 17, and then the water pump 16 can be connected to the external water supply source. By controlling the water pump 15 to start, the water pump 16 can be used to draw in the external water source and introduce it into the outer tube 6 and the inner tube 13 through the water pipe 14 and the connecting pipe 29. Finally, it can be sprayed on the inner wall of the stirring tank 2 by multiple groups of nozzles 30, and the residue on the inner wall of the device can be auxiliary washed and cleaned.

[0037] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the present invention is defined by the appended claims, not the foregoing description, and all variations within the meaning and range of equivalents of the claims are intended to be encompassed within the present invention. Any reference sign in a claim should not be construed as limiting the claim to which it relates.

Claims

1. A wet high-speed shear stirring and mixing device for a preparation, comprising a stirring tank (2), characterized in that: A cover (7) is fixedly mounted on the top of the mixing tank (2), and a crushing mechanism for pre-processing and refining solid additive materials is provided at the rear end of the top of the cover (7); The crushing mechanism comprises a feed port (12), a rotating drum (19), a movable knife (20), a reduction motor (21) and a fixed knife (22); the rear end of the top of the cover body (7) is fixedly mounted with the feed port (12), and the bottom end inside the feed port (12) is movably connected with the rotating drum (19); both sides of the rotating drum (19) respectively penetrate the interior of both sides of the feed port (12); the reduction motor (21) is fixedly mounted on the bottom end of the right side of the feed port (12); the top and bottom and both ends of the rotating drum (19) are respectively fixed with movable knives (20); and the two ends inside the feed port (12) are respectively fixed with fixed knives (22).

2. A wet high-speed shear stirring and mixing device for a preparation according to claim 1, characterized in that: The bottom end of the feed port (12) passes through the interior of the cover (7) and is connected to the interior of the stirring tank (2).

3. The wet high-speed shear stirring and mixing device for a preparation according to claim 1, characterized in that: The output shaft of the reduction motor (21) is fixedly connected to the right side of the rotating drum (19), and the movable knives (20) are fixed in groups at equal intervals at the top and bottom and both ends of the rotating drum (19). The fixed knives (22) are fixed in groups at equal intervals at both ends inside the feed port (12), and the movable knives (20) and the fixed knives (22) are staggered inside the feed port (12).

4. A wet high-speed shear stirring and mixing device for a preparation according to claim 1, characterized in that: An outer tube (6) is fixed to the bottom end of the cover (7), and an inner tube (13) is provided on the inner side of the outer tube (6). The top end of the inner tube (13) is fixedly connected to the bottom end of the cover (7). Spray nozzles (30) are fixed to the bottom ends of the outer tube (6) and the inner tube (13), respectively. A connecting tube (29) is fixed between the outer tube (6) and the inner tube (13). A water pump (15) is fixedly installed at the bottom end of the right side of the mixing tank (2), and a water delivery pipe (14) is fixedly installed at the output end of the water pump (15). A water pump (16) is fixedly installed at the input end of the water pump (15). The top end of the water delivery pipe (14) passes through the interior of the right side of the mixing tank (2) and is fixedly connected to the right side of the outer tube (6).

5. A wet high-speed shear stirring and mixing device for a preparation according to claim 4, characterized in that: The outer tube (6) is connected to the interior of the inner tube (13) through a connecting tube (29), and a plurality of nozzles (30) are fixed in an annular manner at equal intervals at the bottom ends of the outer tube (6) and the inner tube (13).

6. A wet high-speed shear stirring and mixing device for a preparation according to claim 1, characterized in that: A fixing tube (27) is fixed to the right side of the front end of the top of the cover body (7), and the bottom end of the fixing tube (27) passes through the interior of the cover body (7) and is connected to the interior of the stirring tank (2). A connecting plate (28) is fixed to the top end of the outside of the fixing tube (27), and a mounting plate (24) is provided at the top end of the connecting plate (28), and a mounting bolt (26) is provided at the top end of the mounting plate (24). A viewing plate (25) is fixed to the inside of the mounting plate (24), and a threaded hole for matching with the mounting bolt (26) is opened inside the top end of the connecting plate (28).

7. A wet high-speed shear stirring and mixing device for a preparation according to claim 6, characterized in that: The mounting bolts (26) are arranged in five groups at equal intervals in a ring shape on the top end of the mounting plate (24), and the bottom ends of the mounting bolts (26) pass through the interior of the mounting plate (24).

8. The wet high-speed shear stirring and mixing device for a preparation according to claim 1, characterized in that: The bottom sides and ends of the mixing tank (2) are respectively fixed with supporting legs (1); the interior of the mixing tank (2) is provided with a mixing shaft (5), and the top end of the mixing shaft (5) passes through the interior of the cover (7); a mounting frame (9) is fixed at the middle position of the top end of the cover (7), and a reducer (11) is fixedly installed on the top end of the mounting frame (9); a driving motor 2 (10) is fixedly installed on the left side of the reducer (11); the two sides of the bottom end of the cover (7) are respectively vertically movably connected with a rotating shaft (4), and the top and bottom ends of the outside of the rotating shaft (4) are respectively fixedly installed with a blade (3); the top end of the rotating shaft (4) passes through the interior of the cover (7); the two sides of the top end of the cover (7) are respectively fixedly installed with a driving motor 1 (8); the bottom end of the mixing tank (2) is fixed with a discharge pipe (17), and the bottom end of the discharge pipe (17) is fixedly installed with a valve (18); the front end of the top of the cover (7) is fixed with a liquid adding pipe (23).

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