Crystallization device convenient to collect and used for producing norfloxacin intermediate

Abstract

The utility model provides a convenient-to-collect crystallization device for producing norfloxacin intermediates, which belongs to the technical field of norfloxacin production and comprises a crystallization box, a reaction cylinder arranged in the crystallization box, a discharge pipe arranged at the bottom end of the reaction cylinder, a separation box arranged at the bottom of the discharge pipe and a water seepage plate arranged in the separation box. The upper side of the water seepage plate is provided with a crystallization cavity, the bottom side of the water seepage plate is provided with a solution cavity, the rear side of the solution cavity is communicated with a connecting pipeline, the rear end of the crystallization box is provided with an infusion pump connected with the connecting pipeline, and a water outlet of the infusion pump is connected with a circulating pipeline. The continuous cooling condensation operation is facilitated, and the production efficiency of norfloxacin is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of norfloxacin production, in particular to a crystallization device used for producing norfloxacin intermediates and convenient for collection. Background Art

[0002] Norfloxacin, also known as fluphenazine, is a third-generation quinolone antibacterial drug that inhibits the action of DNA gyrase in pathogenic bacteria in the digestive tract, hinders bacterial DNA replication, and has an inhibitory effect on bacteria. It is a commonly used drug for treating enteritis and dysentery. However, this drug has a delaying effect on bone formation in minors and will affect development. Therefore, it is prohibited for minors to take it. A crystallization device is required in the production and processing of norfloxacin. Some existing crystallization devices used in the production of norfloxacin intermediates that are easy to collect condense the solution into crystals in a crystallization kettle and then discharge them for collection. It is not possible to perform continuous cooling and condensation operations by separating the solution from the crystals. The crystallization efficiency is relatively slow, which affects the production efficiency of norfloxacin. Utility Model Content

[0003] In view of this, the utility model provides a crystallization device for producing norfloxacin intermediates that is easy to collect, can realize the separation operation of solution and crystals, is conducive to continuous cooling and condensation operations, and improves the production efficiency of norfloxacin.

[0004] In order to solve the above technical problems, the utility model provides a crystallization device for producing norfloxacin intermediates that is easy to collect, including a crystallization box, a reaction cylinder is arranged inside the crystallization box, a discharge pipe is arranged at the bottom end of the reaction cylinder, a separation box is arranged at the bottom of the discharge pipe, a water seepage plate is arranged inside the separation box, a crystallization cavity is opened on the upper side of the water seepage plate, a solution cavity is opened on the bottom side of the water seepage plate, a connecting pipe is connected to the rear side of the solution cavity, a liquid pump connected to the connecting pipe is arranged at the rear end of the crystallization box, and a circulation pipe is connected to the water outlet of the liquid pump. The solution will penetrate downward into the solution cavity through the water seepage plate in the separation box, thereby realizing the separation operation of the solution and the crystals. The staff can use the liquid pump to extract the solution in the solution cavity through the connecting pipe and re-flow it into the reaction cylinder through the circulation pipe.

[0005] A liquid inlet pipe is provided at the upper end of the crystallization box. When performing the crystallization operation of norfloxacin solution, the staff can inject the solution into the reaction cylinder through the liquid inlet pipe. A control valve is provided on the surface of the discharge pipe. The staff can open the control valve, and the crystals at the bottom of the reaction cylinder will fall into the separation box through the discharge pipe along with the uncondensed solution.

[0006] A cooling chamber is provided inside the crystallization box, which is located on the outside of the reaction cylinder. A cold water inlet is provided on the upper part of the crystallization box, and a cold water outlet is provided on the bottom of the crystallization box. The staff can use the cold water inlet to flow cold water into the cooling chamber to cool the solution in the reaction cylinder so that the solution gradually condenses into crystals. The used cooling water can be discharged through the cold water outlet to realize circulating cooling operation.

[0007] A door is hinged on the outer side of the separation box through a hinge, and a handle is provided on the surface of the door. The staff can open the door through the handle and take out the crystals in the crystallization chamber.

[0008] A rotating motor is provided at the upper end of the crystallization box, and a rotating shaft is fixedly connected to the output rod of the rotating motor. A stirring rack is provided on the surface of the rotating shaft, and a spiral blade is provided at the bottom of the rotating shaft. The staff can start the rotating motor to make the rotating shaft drive the stirring rack to rotate, and scrape off the crystals attached to the inner wall of the reaction cylinder. The spiral blade facilitates the discharge of the crystals and avoids the crystals from accumulating into blocks and clogging the discharge pipe.

[0009] Support legs are provided at the four corners of the bottom of the crystallization box.

[0010] In summary, compared with the prior art, this application has at least one of the following beneficial technical effects:

[0011] 1. When the utility model is used, the separation operation of solution and crystallization can be realized, which is conducive to continuous cooling and condensation operation and improves the production efficiency of norfloxacin.

[0012] 2. When the utility model is used, the staff can open the control valve, and the crystals at the bottom of the reaction cylinder will fall into the separation box through the discharge pipe along with the uncondensed solution.

[0013] 3. When the utility model is used, the staff can use the cold water inlet to flow cold water into the cooling chamber to cool the solution in the reaction cylinder, so that the solution gradually condenses into crystals. The used cooling water can be discharged through the cold water outlet to achieve a circulating cooling operation.

[0014] 4. When the utility model is used, the staff can start the rotating motor so that the rotating shaft drives the stirring frame to rotate, and the crystals attached to the inner wall of the reaction cylinder are scraped off. The spiral blades facilitate the discharge of the crystals and avoid the crystals from accumulating into blocks and clogging the discharge pipe. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a structural diagram of the utility model;

[0016] Figure 2 It is a schematic structural diagram of the front side section of the present invention;

[0017] Figure 3 It is a schematic structural diagram of the right side cross-section of the present invention;

[0018] Figure 4 It is a structural schematic diagram of the right side of the utility model.

[0019] Explanation of the accompanying reference numerals: 100, crystallization box; 200, reaction cylinder; 301, liquid inlet pipe; 302, discharge pipe; 303, control valve; 401, separation box; 402, water seepage plate; 403, crystallization chamber; 404, solution chamber; 405, connecting pipe; 406, liquid pump; 407, circulation pipe; 501, cooling chamber; 502, cold water inlet; 503, cold water outlet; 600, box door; 701, rotating motor; 702, rotating shaft; 703, stirring frame; 704, spiral blade; 800, supporting leg. DETAILED DESCRIPTION

[0020] In order to make the purpose, technical solutions and advantages of the embodiment of the present invention clearer, the following will be combined with the appended drawings of the embodiment of the present invention. Figure 1-4 , clearly and completely describing the technical solutions of the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field fall within the scope of protection of the present invention.

[0021] According to one embodiment of the present invention, Figure 2 and Figure 3As shown: This embodiment provides a crystallization device for producing norfloxacin intermediates that is easy to collect, including a crystallization box 100, a reaction cylinder 200 is provided inside the crystallization box 100, a discharge pipe 302 is provided at the bottom of the reaction cylinder 200, a separation box 401 is provided at the bottom of the discharge pipe 302, a water seepage plate 402 is provided inside the separation box 401, a crystallization cavity 403 is provided on the upper side of the water seepage plate 402, a solution cavity 404 is provided on the bottom side of the water seepage plate 402, a connecting pipe 405 is connected to the rear side of the solution cavity 404, a liquid pump 406 connected to the connecting pipe 405 is provided at the rear end of the crystallization box 100, a flow pipe 407 is connected to the water outlet of the liquid pump 406, and a liquid inlet pipe 301 is provided at the upper end of the crystallization box 100. When performing the crystallization operation of the norfloxacin solution, the staff can pass through the liquid inlet pipe 301. 01 The solution is injected into the reaction cylinder 200. A control valve 303 is provided on the surface of the discharge pipe 302. The staff can open the control valve 303. The crystals at the bottom of the reaction cylinder 200 will fall into the separation box 401 through the discharge pipe 302 along with the condensed solution. Then the control valve 303 is closed. The solution will penetrate downward into the solution cavity 404 through the seepage plate 402 in the separation box 401 to realize the separation of the solution and the crystals. The staff can use the liquid pump 406 to extract the solution in the solution cavity 404 through the connecting pipe 405, and re-flow it into the reaction cylinder 200 through the circulation pipe 407. The outer surface of the separation box 401 is hinged with a box door 600 by a hinge. The surface of the box door 600 is provided with a handle. The staff can open the box door 600 through the handle to take out the crystals in the crystallization cavity 403.

[0022] According to another embodiment of the present invention, Figure 1 、 Figure 2 and Figure 4 As shown, a cooling chamber 501 is provided inside the crystallization box 100, and the cooling chamber 501 is located outside the reaction cylinder 200. A cold water inlet 502 is provided on the upper part of the crystallization box 100, and a cold water outlet 503 is provided at the bottom of the crystallization box 100. The staff can use the cold water inlet 502 to flow cold water into the cooling chamber 501 to cool the solution in the reaction cylinder 200 so that the solution gradually condenses into crystals. The used cooling water can be discharged through the cold water outlet 503 to realize a circulating cooling operation. The upper end of the crystallization box 100 is provided with a rotary The rotating motor 701 has a rotating shaft 702 fixedly connected to its output rod, a stirring frame 703 is provided on the surface of the rotating shaft 702, and a spiral blade 704 is provided at the bottom of the rotating shaft 702. The staff can start the rotating motor 701 to make the rotating shaft 702 drive the stirring frame 703 to rotate, and scrape off the crystals attached to the inner wall of the reaction cylinder 200. The spiral blade 704 facilitates the discharge of the crystals and avoids the crystals from accumulating into blocks and clogging the discharge pipe 302. Support legs 800 are provided at the four corners of the bottom end of the crystallization box 100.

[0023] The method of use of the present invention is as follows: when performing the crystallization operation of the norfloxacin solution, the staff can inject the solution into the reaction cylinder 200 through the liquid inlet pipe 301, and then the staff can use the cold water inlet 502 to flow cold water into the cooling chamber 501 to cool the solution in the reaction cylinder 200, so that the solution gradually condenses into crystals. The staff can start the rotating motor 701 so that the rotating shaft 702 drives the stirring rack 703 to rotate, and the crystals attached to the inner wall of the reaction cylinder 200 are scraped off. The staff can open the control valve 303, and the crystals at the bottom of the reaction cylinder 200 will fall into the separation box 401 through the discharge pipe 302 along with the uncondensed solution. The spiral blades 704 facilitates the discharge of crystals and avoids the accumulation of crystals into blocks to block the discharge pipe 302. Then the control valve 303 is closed, and the solution will penetrate downward into the solution cavity 404 through the water seepage plate 402 in the separation box 401, realizing the separation operation of the solution and the crystals. The staff can use the liquid pump 406 to extract the solution in the solution cavity 404 through the connecting pipe 405 and re-flow it into the reaction cylinder 200 through the circulation pipe 407. The staff can open the box door 600 by the handle and take out the crystals in the crystallization cavity 403. The utility model can realize the separation operation of the solution and the crystals, which is conducive to continuous cooling and condensation operations and improves the production efficiency of norfloxacin.

[0024] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles described in the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A crystallization device for producing norfloxacin intermediates that is easy to collect, comprising a crystallization box (100), a reaction cylinder (200) disposed inside the crystallization box (100), and a discharge pipe (302) disposed at the bottom end of the reaction cylinder (200), characterized in that: A separation box (401) is provided at the bottom of the discharge pipe (302), a water seepage plate (402) is provided inside the separation box (401), a crystallization cavity (403) is provided on the upper side of the water seepage plate (402), a solution cavity (404) is provided on the bottom side of the water seepage plate (402), the rear side of the solution cavity (404) is connected to a connecting pipe (405), and a liquid pump (406) connected to the connecting pipe (405) is provided at the rear end of the crystallization box (100), and a circulation pipe (407) is connected to the water outlet of the liquid pump (406).

2. A crystallization device for producing a norfloxacin intermediate that is easy to collect as claimed in claim 1, characterized in that: The upper end of the crystallization box (100) is provided with a liquid inlet pipe (301), and the surface of the discharge pipe (302) is provided with a control valve (303).

3. A crystallization device for producing a norfloxacin intermediate that is easy to collect as claimed in claim 1, characterized in that: A cooling chamber (501) is provided inside the crystallization box (100), and the cooling chamber (501) is located outside the reaction cylinder (200). A cold water inlet (502) is provided at the top of the crystallization box (100), and a cold water outlet (503) is provided at the bottom of the crystallization box (100).

4. A crystallization device for producing a norfloxacin intermediate that is easy to collect as claimed in claim 1, characterized in that: A box door (600) is hinged on the outer surface of the separation box (401) via a hinge, and a handle is provided on the surface of the box door (600).

5. A crystallization device for producing a norfloxacin intermediate that is easy to collect as claimed in claim 1, characterized in that: A rotating motor (701) is provided at the upper end of the crystallization box (100), a rotating shaft (702) is fixedly connected to the output rod of the rotating motor (701), a stirring frame (703) is provided on the surface of the rotating shaft (702), and a spiral sheet (704) is provided at the bottom of the rotating shaft (702).

6. A crystallization device for producing a norfloxacin intermediate that is easy to collect as claimed in claim 1, characterized in that: Support legs (800) are provided at the four corners of the bottom end of the crystallization box (100).

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