Magnetic bead cleaning, liquid injection and uniform mixing device

Abstract

The utility model discloses a magnetic bead cleaning, liquid injection and uniform mixing device, and aims to solve the problems that in the prior art, a magnetic bead cleaning device, a liquid injection device and a uniform mixing device are respectively two parts, so that the whole structure is more complex, meanwhile, the magnetic bead transferring and waiting time is increased, and the magnetic bead cleaning efficiency is reduced. The technical problem is solved through the following technical scheme that the device comprises a liquid suction lifting disc and a liquid injection lifting disc which can move in the vertical direction and are arranged up and down; a gripper uniform mixing assembly is arranged on the liquid injection lifting disc; the gripper uniform mixing assembly comprises a supporting frame, a liquid injection needle arranged at the top end of the supporting frame and a rotating shaft rotationally arranged on the liquid injection lifting disc; the lower end of the rotating shaft is connected with a flexible gripper; a pushing assembly penetrates through the center of the rotating shaft; the liquid injection needle is arranged in the pushing assembly in a penetrating mode, and the bottom of the liquid injection needle is located in the center of the flexible grabbing clamp. The uniform mixing power device drives the rotating shaft to rotate.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, and more specifically, to a magnetic bead cleaning, liquid injection and mixing device. Background Art

[0002] In the field of in vitro diagnosis, the immune complex marker will bind to the magnetic beads after the sample is added, but the bound magnetic beads are still mixed with other unbound markers in the reagent. Therefore, a separation and cleaning device is needed to separate the magnetic beads and clean up the remaining unnecessary substances. The accuracy of the reading can only be guaranteed after thorough cleaning. The cleaning and separation of the magnetic beads requires incubation in advance to allow the marker to fully bind to the magnetic beads, and then multi-stage cleaning is performed on them. After the cleaning is completed, a medium is added to allow it to emit light and read the value. In the prior art, in the entire process mentioned above, many devices and modules are needed, and some modules are relatively large. When they are used in series, the structure is complicated.

[0003] For example, Chinese patent publication number CN110883001B, publication date August 30, 2024, is titled "A magnetic bead cleaning device for an analyzer." Although the device can automatically clean magnetic beads, the mixing component and the injection component are separated during mixing, and the mixing component and the injection component are connected in series, which increases unnecessary transportation and waiting time for the magnetic beads, making the overall structure more complicated and reducing the cleaning efficiency of the magnetic beads, thereby reducing the efficiency of the experiment. Utility Model Content

[0004] The utility model overcomes the problems in the magnetic bead cleaning device in the prior art, in which the liquid injection device and the mixing device are two separate components, making the overall structure more complicated, and also increasing the time for transporting and waiting the magnetic beads, thereby reducing the efficiency of magnetic bead cleaning; and provides a magnetic bead cleaning liquid injection and mixing device, which combines the liquid injection device and the mixing device so that the liquid injection and mixing can be achieved in one set of structures, thereby reducing the magnetic bead transport steps, improving the magnetic bead cleaning efficiency, and thus improving the overall experimental efficiency.

[0005] In order to solve the above technical problems, the utility model adopts the following technical solutions: a magnetic bead cleaning, liquid injection and mixing device, comprising a liquid suction lifting plate and a liquid injection lifting plate, both of which can move in the vertical direction and are arranged on the upper and lower sides;

[0006] A gripper and mixing assembly is provided on the injection lift plate; the gripper and mixing assembly comprises a support frame, an injection needle disposed at the top of the support frame, and a rotating shaft rotatably disposed on the injection lift plate; a flexible gripper is connected to the lower end of the rotating shaft; a pusher assembly is provided through the center of the rotating shaft; the injection needle is provided through the pusher assembly, and the bottom of the injection needle is located at the center of the flexible gripper;

[0007] The mixing power device drives the rotating shaft to rotate.

[0008] The utility model combines a gripper assembly and a mixing assembly, and a mixing power device is used to provide power to the gripper mixing assembly, so that the process of transporting during the injection and mixing process in the prior art can be omitted, thereby improving the cleaning efficiency of the magnetic beads and further improving the efficiency of the experiment.

[0009] Preferably, the pushing assembly includes a pushing shaft, a pushing block arranged at the top of the pushing shaft and a pushing spring for pushing the pushing block to reset; a center hole is provided through the center of the rotating shaft, and the pushing shaft is slidably provided in the center hole; a pushing shaft hole is provided at the center of the pushing shaft, and the injection needle is passed through the pushing shaft hole; the pushing block is located at the bottom of the liquid suction lifting plate.

[0010] In the present application, a liquid suction lifting plate is used to realize the function of ejecting the reaction cup from the flexible clamping claw, eliminating the installation of other ejection force devices, making the overall structure more compact.

[0011] Preferably, the mixing power device includes a rotating synchronous wheel coaxially connected to the rotating shaft and a mixing drive device; an output synchronous wheel is provided on the output shaft of the mixing drive device, and the output synchronous wheel and the rotating synchronous wheel are connected via a synchronous belt transmission.

[0012] Through a mixing synchronous belt, it is possible to drive multiple rotating synchronous wheels to rotate. In addition, a tensioning wheel is provided to tension the mixing synchronous belt.

[0013] Preferably, a bracket through-hole is provided at the top of the support frame, a nut column is provided in the bracket through-hole, and the injection needle is provided in the nut column through the nut; an injection spring is provided in the nut column, and the injection spring abuts between the nut and the injection needle.

[0014] The injection spring can buffer the injection needle, thereby preventing the injection needle or the reaction cup from being damaged when the injection needle contacts the reaction cup.

[0015] Preferably, a rotating shaft fixing hole is provided on the liquid injection lifting plate, and flange bearings are provided at both ends of the rotating shaft fixing hole; the rotating shaft is provided in the flange bearings.

[0016] The flange bearing fixes the rotating shaft, thereby allowing the rotating shaft to rotate freely relative to the rotating shaft fixing hole.

[0017] Preferably, the push spring is sleeved on the periphery of the push shaft.

[0018] This allows the push spring to move more stably when compressed.

[0019] Preferably, a plurality of gripper mixing devices are provided, and a synchronous belt is connected to the rotating synchronous wheels of the plurality of gripper mixing devices.

[0020] Several gripper mixing devices are set up to fill multiple reaction cups at the same time. The use of synchronous belts for transmission connection has various layout methods and can simultaneously drive multiple rotating synchronous wheels, thereby achieving simultaneous control of multiple gripper mixing components and making the structure more compact.

[0021] Preferably, the mixing power device further includes a tensioning wheel for tensioning the synchronous belt.

[0022] The tensioner is continuously pushed by the spring, which continuously provides tension to the synchronous belt, thus ensuring that the synchronous belt is not prone to slipping during transmission.

[0023] Compared with the existing technology, the beneficial effect of the present invention is: the present invention combines the gripper assembly and the mixing assembly, and provides power to the gripper mixing assembly through the mixing power device, so that the process of transportation during the injection and mixing process in the existing technology can be omitted, thereby improving the cleaning efficiency of the magnetic beads, and then improving the efficiency of the experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a three-dimensional structural diagram of the utility model.

[0025] Figure 2 It is a three-dimensional structural diagram of the utility model from another angle.

[0026] Figure 3 It is a schematic diagram of the layout of the mixing power device of the present utility model.

[0027] Figure 4 It is a front view of the gripper mixing assembly of the present utility model.

[0028] Figure 5 It is a cross-sectional view of the gripper mixing assembly of the present utility model.

[0029] In the figure: 1, liquid suction lifting plate, 11, liquid suction needle;

[0030] 2. Liquid injection lifting plate, 21. Rotating shaft fixing hole, 211. Flange bearing;

[0031] 3. Gripper mixing assembly, 31. Support frame, 311. Bracket perforation, 312. Injection spring, 313. Screw cap, 32. Injection needle, 33. Rotating shaft, 34. Flexible gripper, 35. Rotating synchronous wheel;

[0032] 4. Push assembly, 41. Push shaft, 42. Push block, 43. Push spring;

[0033] 5. Mixing power device, 51. Mixing drive device, 52. Mixing synchronous belt, 53. First tensioning pulley, 54. Second tensioning pulley, 55. Output synchronous pulley, 56. Output driven pulley;

[0034] 6. Liquid injection lifting device, 61. Screw motor, 62. Screw shaft;

[0035] 7. Liquid suction lifting device, 71. Vertical guide rail, 72. Liquid suction driving wheel, 73. Liquid suction driven wheel, 74. Vertical synchronous belt, 75. Slider. DETAILED DESCRIPTION

[0036] The technical solution of the present invention is further described in detail below through specific embodiments and in conjunction with the accompanying drawings:

[0037] Example 1: Reference Figures 1 to 5 As shown, a magnetic bead cleaning, liquid injection and mixing device includes a liquid suction lifting plate 1 and a liquid injection lifting plate 2. The liquid suction lifting plate 1 and the liquid injection lifting plate 2 can both move in the vertical direction, and the liquid suction lifting plate 1 is arranged above the liquid injection lifting plate 2. The liquid suction lifting plate 1 and the liquid injection lifting plate 2 are both lifted and lowered in the vertical direction by their respective lifting devices.

[0038] The liquid suction lifting plate 1 is provided with a liquid suction needle 11 which is lifted and lowered therewith, and the liquid injection lifting plate 2 is provided with a liquid suction needle guide seat corresponding to the liquid suction needle 11, and the liquid suction needle 11 slides in the liquid suction needle guide seat.

[0039] A gripper mixing assembly 3 is provided on the liquid injection lifting plate 2. The gripper mixing assembly 3 can grab the reaction cup for liquid injection and simultaneously mix the liquid in the reaction cup, thereby making the magnetic beads clean more thoroughly. In the prior art, the mixing assembly and the liquid injection assembly are separated from each other. In this embodiment, the gripper assembly and the mixing assembly are combined, so that the transportation process during the liquid injection and mixing process in the prior art can be omitted, thereby improving the cleaning efficiency of the magnetic beads and further improving the efficiency of the experiment.

[0040] The gripper mixing assembly 3 in this embodiment includes a support frame 31, an injection needle 32 disposed at the top of the support frame 31, and a rotating shaft 33 rotatably disposed on the injection lifting disk 2; the injection lifting disk 2 is provided with a rotating shaft fixing hole 21, and flange bearings 211 are symmetrically disposed at both ends of the rotating shaft fixing hole 21; the rotating shaft 33 is rotatably disposed within the flange bearings 211. The bottom of the support frame 31 is fixedly connected to the injection lifting disk 2, and the top of the support frame 31 passes over the upper liquid suction lifting disk 1, so that the top of the support is higher than the height of the liquid suction lifting disk 1. Therefore, the top of the injection needle 32 is also higher than the liquid suction lifting disk 1.

[0041] A support hole 311 is provided at the top of the support frame 31. A nut column 313 is disposed within the support hole 311. The injection needle 32 is inserted through a nut and disposed within the nut column 313. An injection spring 312 is disposed within the nut column 313 and abuts between the nut and the injection needle 32. The injection spring 312 acts as a buffer for the injection needle 32, thereby preventing damage to the injection needle 32 or the cuvette when the injection needle 32 contacts the cuvette.

[0042] The lower end of the rotating shaft 33 is connected to a flexible gripper 34 , which can grab the reaction cup from the outside of the cup body.

[0043] A push assembly 4 extends through the center of the rotating shaft 33. Once the flexible gripper grasps the cuvette, the cuvette can be ejected from the gripper by controlling the push assembly 4. An injection needle 32 extends through the push assembly 4, with its base positioned at the center of the flexible gripper 34.

[0044] The mixing power device can drive the rotating shaft 33 to rotate. When the reaction cup is grasped by the flexible clamp, the mixing power device can drive the rotating shaft 33 to rotate. The rotation of the rotating shaft 33 drives the flexible clamp to rotate, thereby causing the reaction cup to rotate, so that the liquid in the reaction cup is mixed, thereby improving the cleaning function of the magnetic beads.

[0045] The pushing assembly 4 in this embodiment realizes the pushing function by cooperating with the liquid suction lifting plate 1. Of course, the pushing assembly 4 can also be controlled by a separate cylinder.

[0046] In one embodiment, the pushing assembly 4 includes a pushing shaft 41, a pushing block 42 provided on the top of the pushing shaft 41, and a pushing spring 43 for pushing the pushing block 42 to return to its original position. The pushing spring 43 is sleeved on the outer periphery of the pushing shaft 41. A center hole is provided through the center of the rotating shaft 33, and the pushing shaft 41 is slidably provided in the center hole. When the rotating shaft 33 rotates, it does not affect the pushing shaft 41. A pushing shaft 41 hole is provided in the center of the pushing shaft 41, and the injection needle 32 is passed through the pushing shaft 41 hole. When the pushing shaft 41 moves up and down, it does not affect the injection needle 32. The pushing block 42 is located at the bottom of the liquid suction lifting plate 1. When the liquid suction lifting plate 1 descends, the liquid suction lifting plate 1 can act on the pushing block 42, causing the pushing block to move downward, thereby driving the pushing shaft 41 to move downward, thereby ejecting the reaction cup from the flexible clamp. The push assembly 4 in this embodiment cooperates with the liquid suction lift plate 1 to achieve the push function. Of course, the push shaft 41 can be controlled by a separate cylinder. Therefore, in this application, the liquid suction lift plate 1 is used to realize the function of ejecting the reaction cup from the flexible clamping claw, eliminating the installation of other push force devices, making the overall structure more compact.

[0047] In one embodiment, the mixing power device 5 includes a rotating synchronous wheel 35 coaxially connected to the rotating shaft 33 and a mixing drive device 51. The mixing drive device 51 provides power. In this embodiment, the mixing drive device 51 utilizes a DC motor, which includes but is not limited to a DC motor. An output synchronous wheel 55 is provided on the output shaft of the mixing drive device 51. The output synchronous wheel 55 is connected to the mixing synchronous wheel via a mixing synchronous belt 522. Using a synchronous belt for transmission connection allows for diverse layouts and can simultaneously drive multiple rotating synchronous wheels 35, thereby enabling simultaneous control of multiple gripper mixing assemblies 3, while also making the structure more compact.

[0048] Several gripper mixing devices are provided, and a mixing timing belt 52 is connected to the rotating synchronous pulleys 35 of the gripper mixing devices. A single mixing timing belt 52 can drive multiple rotating synchronous pulleys 35. A tensioning pulley is also provided to tension the mixing timing belt 52.

[0049] Taking the present application as an example, two gripper mixing devices are provided in the present application. Both gripper mixing devices are provided with a rotating synchronous wheel 35. For ease of distinction, the rotating shafts 33 on the two gripper mixing devices are named the first rotating synchronous wheel 35 and the second rotating synchronous wheel 35. As shown in the figure, an output driven wheel 56 is provided on the upper end surface of the liquid injection lifting plate 2, a first tensioning wheel 53 is provided between the first rotating synchronous wheel 35 and the driven wheel, and a second tensioning wheel 54 is provided between the first rotating synchronous wheel 35 and the second rotating synchronous wheel 35. The synchronous belt is wound around the output synchronous wheel 55, the output driven wheel 56, the first tensioning wheel 53, the first rotating synchronous wheel 35, the second tensioning wheel 54, and the second rotating synchronous wheel 35 in sequence. In addition, the first tensioning wheel 53 is slidably provided on the liquid injection lifting plate 2. The first tensioning wheel 53 is continuously pushed by the spring, thereby continuously providing tension to the synchronous belt, thereby ensuring that the synchronous belt is not prone to slipping during transmission.

[0050] The working principle of the present application is as follows: when the reaction cup runs to the bottom of the injection needle 32, the injection lifting plate 2 descends until the flexible gripper 34 completely wraps the upper edge of the reaction cup, then the reaction cup is lifted to a certain height, and then the liquid is injected into the reaction cup through the injection needle 32. After that, the mixing drive device 51 runs, so that the mixing synchronous belt 52 moves, thereby driving the rotating synchronous wheel 35 to rotate, so that the flexible gripper 34 rotates, thereby mixing the liquid in the reaction cup and making the magnetic beads clean more clean. After the mixing is completed, the injection lifting plate 2 descends to a certain height, and then the liquid suction lifting plate 1 descends. The liquid suction lifting plate 1 presses the push block 42 to descend together, so that the push shaft 41 overcomes the force of the push spring 43 and moves downward until the lower end of the push shaft 41 pushes the reaction cup out of the rotating gripper. After that, the liquid suction lifting plate 1 and the injection lifting plate 2 reset and wait for the next work.

[0051] Therefore, through the above structure and steps, it can be seen that the present invention combines the gripper component and the mixing component, so that the transportation process during the injection and mixing process in the prior art can be omitted, thereby improving the cleaning efficiency of the magnetic beads and further improving the efficiency of the experiment.

[0052] Example 2: Reference Figures 1 to 5 As shown, a magnetic bead cleaning, liquid injection and mixing device includes a liquid suction lifting plate 1 and a liquid injection lifting plate 2. The liquid suction lifting plate 1 and the liquid injection lifting plate 2 can both move in the vertical direction, and the liquid suction lifting plate 1 is arranged above the liquid injection lifting plate 2. The liquid suction lifting plate 1 and the liquid injection lifting plate 2 are both lifted and lowered in the vertical direction by their respective lifting devices.

[0053] The liquid suction lifting plate 1 is provided with a liquid suction needle 11 which is lifted and lowered therewith, and the liquid injection lifting plate 2 is provided with a liquid suction needle guide seat corresponding to the liquid suction needle 11, and the liquid suction needle 11 slides in the liquid suction needle guide seat.

[0054] A gripper mixing assembly 3 is provided on the liquid injection lifting plate 2. The gripper mixing assembly 3 can grab the reaction cup for liquid injection and simultaneously mix the liquid in the reaction cup, thereby making the magnetic beads clean more thoroughly. In the prior art, the mixing assembly and the liquid injection assembly are separated from each other. In this embodiment, the gripper assembly and the mixing assembly are combined, so that the transportation process during the liquid injection and mixing process in the prior art can be omitted, thereby improving the cleaning efficiency of the magnetic beads and further improving the efficiency of the experiment.

[0055] The gripper mixing assembly 3 in this embodiment includes a support frame 31, an injection needle 32 disposed at the top of the support frame 31, and a rotating shaft 33 rotatably disposed on the injection lifting disk 2; the injection lifting disk 2 is provided with a rotating shaft fixing hole 21, and flange bearings 211 are symmetrically disposed at both ends of the rotating shaft fixing hole 21; the rotating shaft 33 is rotatably disposed within the flange bearings 211. The bottom of the support frame 31 is fixedly connected to the injection lifting disk 2, and the top of the support frame 31 passes over the upper liquid suction lifting disk 1, so that the top of the support is higher than the height of the liquid suction lifting disk 1. Therefore, the top of the injection needle 32 is also higher than the liquid suction lifting disk 1.

[0056] A support hole 311 is provided at the top of the support frame 31. A nut column 313 is disposed within the support hole 311. The injection needle 32 is inserted through a nut and disposed within the nut column 313. An injection spring 312 is disposed within the nut column 313 and abuts between the nut and the injection needle 32. The injection spring 312 acts as a buffer for the injection needle 32, thereby preventing damage to the injection needle 32 or the cuvette when the injection needle 32 contacts the cuvette.

[0057] The lower end of the rotating shaft 33 is connected to a flexible gripper 34 , which can grab the reaction cup from the outside of the cup body.

[0058] A push assembly 4 extends through the center of the rotating shaft 33. Once the flexible gripper grasps the cuvette, the cuvette can be ejected from the gripper by controlling the push assembly 4. An injection needle 32 extends through the push assembly 4, with its base positioned at the center of the flexible gripper 34.

[0059] The mixing power device can drive the rotating shaft 33 to rotate. When the reaction cup is grasped by the flexible clamp, the mixing power device can drive the rotating shaft 33 to rotate. The rotation of the rotating shaft 33 drives the flexible clamp to rotate, thereby causing the reaction cup to rotate, so that the liquid in the reaction cup is mixed, thereby improving the cleaning function of the magnetic beads.

[0060] The pushing assembly 4 in this embodiment realizes the pushing function by cooperating with the liquid suction lifting plate 1. Of course, the pushing assembly 4 can also be controlled by a separate cylinder.

[0061] In one embodiment, the pushing assembly 4 includes a pushing shaft 41, a pushing block 42 provided on the top of the pushing shaft 41, and a pushing spring 43 for pushing the pushing block 42 to return to its original position. The pushing spring 43 is sleeved on the outer periphery of the pushing shaft 41. A center hole is provided through the center of the rotating shaft 33, and the pushing shaft 41 is slidably provided in the center hole. When the rotating shaft 33 rotates, it does not affect the pushing shaft 41. A pushing shaft 41 hole is provided in the center of the pushing shaft 41, and the injection needle 32 is passed through the pushing shaft 41 hole. When the pushing shaft 41 moves up and down, it does not affect the injection needle 32. The pushing block 42 is located at the bottom of the liquid suction lifting plate 1. When the liquid suction lifting plate 1 descends, the liquid suction lifting plate 1 can act on the pushing block 42, causing the pushing block to move downward, thereby driving the pushing shaft 41 to move downward, thereby ejecting the reaction cup from the flexible clamp. The push assembly 4 in this embodiment cooperates with the liquid suction lift plate 1 to achieve the push function. Of course, the push shaft 41 can be controlled by a separate cylinder. Therefore, in this application, the liquid suction lift plate 1 is used to realize the function of ejecting the reaction cup from the flexible clamping claw, eliminating the installation of other push force devices, making the overall structure more compact.

[0062] In one embodiment, the mixing power device 5 includes a rotating synchronous wheel 35 coaxially connected to the rotating shaft 33 and a mixing drive device 51. The mixing drive device 51 provides power. In this embodiment, the mixing drive device 51 utilizes a servo motor, which includes but is not limited to a servo motor. An output synchronous wheel 55 is provided on the output shaft of the mixing drive device 51. The output synchronous wheel 55 is connected to the mixing synchronous wheel via a mixing synchronous belt 522. The use of a synchronous belt for transmission connection allows for a variety of arrangements and can simultaneously drive multiple rotating synchronous wheels 35, thereby achieving simultaneous control of multiple gripper mixing assemblies 3, while also making the structure more compact.

[0063] Several gripper mixing devices are provided, and a mixing timing belt 52 is connected to the rotating synchronous pulleys 35 of the gripper mixing devices. A single mixing timing belt 52 can drive multiple rotating synchronous pulleys 35. A tensioning pulley is also provided to tension the mixing timing belt 52.

[0064] Taking the present application as an example, two gripper mixing devices are provided in the present application. Both gripper mixing devices are provided with a rotating synchronous wheel 35. For ease of distinction, the rotating shafts 33 on the two gripper mixing devices are named the first rotating synchronous wheel 35 and the second rotating synchronous wheel 35. As shown in the figure, an output driven wheel 56 is provided on the upper end surface of the liquid injection lifting plate 2, a first tensioning wheel 53 is provided between the first rotating synchronous wheel 35 and the driven wheel, and a second tensioning wheel 54 is provided between the first rotating synchronous wheel 35 and the second rotating synchronous wheel 35. The synchronous belt is wound around the output synchronous wheel 55, the output driven wheel 56, the first tensioning wheel 53, the first rotating synchronous wheel 35, the second tensioning wheel 54, and the second rotating synchronous wheel 35 in sequence. In addition, the first tensioning wheel 53 is slidably provided on the liquid injection lifting plate 2. The first tensioning wheel 53 is continuously pushed by the spring, thereby continuously providing tension to the synchronous belt, thereby ensuring that the synchronous belt is not prone to slipping during transmission.

[0065] Reference Figures 1 to 5 As shown, the structure of this embodiment is similar to that of embodiment 1, except that the liquid suction lift plate 1 and the liquid injection lift plate 2 are both lifted vertically by their own lifting devices. The liquid suction lift plate 1 is lifted by the liquid suction lift device 7, while the liquid injection lift plate 2 is lifted by the liquid injection lift device 6.

[0066] The liquid injection lifting device 6 includes a screw motor 61 fixedly mounted on the liquid injection lifting plate 2, and a screw shaft 62 is inserted into the screw motor 61. The bottom of the screw shaft 62 is fixed to the machine through a screw seat, so that the screw motor 61 can move along the screw shaft 62, thereby driving the liquid injection lifting plate 2 to move in the vertical direction.

[0067] The liquid suction lifting device 7 includes a vertical guide rail 71 arranged in the vertical direction, and two wheels arranged along the vertical guide rail 71 are arranged on the side of the vertical guide rail 71. The two wheels are respectively a liquid suction driving wheel 72 and a liquid suction driven wheel 73. The liquid suction driving wheel 72 is fixedly connected to the output shaft of the stepper motor. A vertical synchronous belt 74 is wound around the liquid suction driving wheel 72 and the liquid suction driven wheel 73. A slider 75 is fixedly connected to the liquid suction lifting plate 1. The slider 75 slides with the vertical guide rail 71, and the slider 75 is fixedly connected to the synchronous belt. Therefore, when the stepper motor moves, the vertical synchronous belt 74 moves, thereby driving the liquid suction lifting plate 1 to slide along the vertical direction. Therefore, by controlling the speed and rotation direction of the stepper motor, the displacement of the liquid suction lifting plate 1 moving up and down can be controlled.

[0068] The working principle of the present application is as follows: when the reaction cup runs to the bottom of the injection needle 32, the injection lifting plate 2 descends until the flexible gripper 34 completely wraps the upper edge of the reaction cup, then the reaction cup is lifted to a certain height, and then the liquid is injected into the reaction cup through the injection needle 32. After that, the mixing drive device 51 runs, so that the mixing synchronous belt 52 moves, thereby driving the rotating synchronous wheel 35 to rotate, so that the flexible gripper 34 rotates, thereby mixing the liquid in the reaction cup and making the magnetic beads clean more clean. After the mixing is completed, the injection lifting plate 2 descends to a certain height, and then the liquid suction lifting plate 1 descends. The liquid suction lifting plate 1 presses the push block 42 to descend together, so that the push shaft 41 overcomes the force of the push spring 43 and moves downward until the lower end of the push shaft 41 pushes the reaction cup out of the rotating gripper. After that, the liquid suction lifting plate 1 and the injection lifting plate 2 reset and wait for the next work.

[0069] Therefore, through the above structure and steps, it can be seen that the present invention combines the gripper component and the mixing component, so that the transportation process during the injection and mixing process in the prior art can be omitted, thereby improving the cleaning efficiency of the magnetic beads and further improving the efficiency of the experiment.

[0070] The above-described embodiments are only preferred solutions of the present invention and do not limit the present invention in any form. Other variations and modifications are possible without exceeding the technical solutions described in the claims.

Claims

1. A magnetic bead cleaning, injection and mixing device, characterized in that: It includes a liquid suction lifting plate and a liquid injection lifting plate, both of which can move in the vertical direction and are arranged on the upper and lower sides; A gripper and mixing assembly is provided on the injection lift plate; the gripper and mixing assembly comprises a support frame, an injection needle disposed at the top of the support frame, and a rotating shaft rotatably disposed on the injection lift plate; a flexible gripper is connected to the lower end of the rotating shaft; a pusher assembly is provided through the center of the rotating shaft; the injection needle is provided through the pusher assembly, and the bottom of the injection needle is located at the center of the flexible gripper; The mixing power device drives the rotating shaft to rotate.

2. The magnetic bead cleaning, injection and mixing device according to claim 1, wherein: The pushing assembly includes a pushing shaft, a pushing block arranged on the top of the pushing shaft and a pushing spring for pushing the pushing block to reset; a center hole is provided through the center of the rotating shaft, and the pushing shaft is slidably provided in the center hole; a pushing shaft hole is provided in the center of the pushing shaft, and the injection needle is provided in the pushing shaft hole; the pushing block is located at the bottom of the liquid suction lifting plate.

3. The magnetic bead cleaning, liquid injection and mixing device according to claim 1 or 2, characterized in that: The mixing power device includes a rotating synchronous wheel coaxially connected to the rotating shaft and a mixing drive device; an output synchronous wheel is provided on the output shaft of the mixing drive device, and the output synchronous wheel and the rotating synchronous wheel are connected through a synchronous belt transmission.

4. The magnetic bead cleaning, liquid injection and mixing device according to claim 1 or 2, characterized in that: A bracket through-hole is provided on the top of the support frame, a nut column is provided in the bracket through-hole, and the injection needle is provided in the nut column through the nut; an injection spring is provided in the nut column, and the injection spring abuts between the nut and the injection needle.

5. The magnetic bead cleaning, liquid injection and mixing device according to claim 1 or 2, characterized in that: A rotating shaft fixing hole is provided on the liquid injection lifting plate, and flange bearings are provided at both ends of the rotating shaft fixing hole; the rotating shaft is provided in the flange bearings.

6. The magnetic bead cleaning, injection and mixing device according to claim 2, wherein: The push spring is sleeved on the periphery of the push shaft.

7. The magnetic bead cleaning, liquid injection and mixing device according to claim 3, characterized in that: A plurality of gripper mixing devices are provided, and a synchronous belt is connected with the rotating synchronous wheels of the plurality of gripper mixing devices.

8. The magnetic bead cleaning, liquid injection and mixing device according to claim 3, characterized in that: The mixing power device also includes a tensioning wheel that tensions the synchronous belt.

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