Testing device for manufacturing Raman hot spots

Abstract

The utility model discloses a test device for manufacturing Raman hot spots, which comprises a working table, a heating device, a heating device, a heating device and a control device, wherein the working table is provided with a liquid pool and a hot spot pool; the liquid pool is communicated with the hot spot pool through a liquid channel, the liquid channel is provided with a filter assembly, and the filter assembly comprises a nano filter membrane; the hot spot pool is provided with a heat supply assembly, and the heat supply assembly comprises a reinforced particle layer and a heating chip. According to the utility model, the liquid pool is communicated with the hot spot pool through the liquid channel, and the liquid channel is provided with the nano filter membrane for filtering the flowing liquid; the hot spot pool is provided with a heat supply assembly, the heat supply assembly comprises a reinforced particle layer and a heating chip, the randomness of hot spot generation is effectively reduced, and the efficiency of hot spot generation is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of surface enhanced Raman spectroscopy, in particular to a test device for producing Raman hotspots. Background Art

[0002] Raman spectroscopy, like infrared spectroscopy, is a molecular vibration spectrum that can reflect the characteristic structure of molecules. However, the Raman scattering effect is a very weak process, and its light intensity is generally only about 10 times that of the incident light intensity. -10 Therefore, Raman signals are very weak, and any Raman spectroscopy study of surface adsorbed species almost always requires the use of some kind of enhancement effect. Raman spectroscopy analysis includes qualitative and quantitative analysis, while SERS spectral processing and identification includes spectral preprocessing, feature extraction, feature classification (qualitative analysis), and mathematical modeling (quantitative analysis). Due to factors such as the low signal-to-noise ratio of Raman spectroscopy in trace detection, weak signals being overwhelmed by the fluorescence background, and interference from other unknown components in complex systems, automatic SERS signal identification presents great challenges.

[0003] Currently, when creating Raman hotspots for surface enhanced Raman scattering (SERS), the hotspots are randomly generated in the liquid due to the uneven distribution of materials (such as metal nanoparticles) used in the manufacturing process, which leads to aggregation or precipitation. This is uncertain and reduces the efficiency of hotspot generation. Utility Model Content

[0004] The purpose of the present invention is to solve the above problems and provide a test device for producing Raman hotspots.

[0005] In order to achieve the above-mentioned purpose, the present invention specifically adopts the following technical solutions, including:

[0006] A workbench, wherein a liquid pool and a hot spot pool are provided on the workbench;

[0007] The liquid pool and the hot spot pool are connected via a liquid channel, and the liquid channel is provided with a filter component, and the filter component includes a nanofiltration membrane;

[0008] The hot spot pool is provided with a heating component, and the heating component includes a reinforcing particle layer and a heating chip.

[0009] As a further description of the above technical solution, a liquid outlet is provided at one end of the liquid pool.

[0010] As a further description of the above technical solution, a liquid inlet is provided at one end of the hot spot pool.

[0011] As a further description of the above technical solution, the hot spot pool is concave to form a receiving cavity.

[0012] As a further description of the above technical solution, one end of the liquid channel is connected to the liquid outlet of the liquid pool.

[0013] As a further description of the above technical solution, the other end of the liquid channel is connected to the liquid inlet of the hot spot pool.

[0014] As a further description of the above technical solution, the nanofiltration membrane is arranged in the middle of the liquid channel.

[0015] As a further description of the above technical solution, the pore size of the nanofiltration membrane is 1-50 nm.

[0016] As a further description of the above technical solution, the enhanced particle layer covers the surface of the hot spot pool.

[0017] As a further description of the above technical solution, the heating chip is arranged at the bottom of the hot spot pool.

[0018] The beneficial effects of the utility model are as follows:

[0019] In the utility model, the liquid pool and the hot spot pool are connected by a liquid channel, and the liquid channel is provided with a nanofiltration membrane to filter the liquid flowing through; the hot spot pool is provided with a heating component, and the heating component includes an enhanced particle layer and a heating chip, which effectively reduces the randomness of the hot spot generation and improves the efficiency of the hot spot generation.

[0020] In order to more clearly illustrate the structural features and functions of the present invention, the present invention will be described in detail below with reference to the accompanying drawings and specific embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a structural schematic diagram of the test device proposed by the utility model;

[0022] Figure 2 yes Figure 1 Schematic diagram of the structure of the hot spot pool.

[0023] Reference numerals:

[0024] 1. Workbench; 2. Liquid pool; 21. Liquid outlet; 3. Hot spot pool; 31. Liquid inlet; 32. Receiving chamber; 4. Liquid channel; 5. Filter component; 51. Nanofiltration membrane; 6. Heating component; 61. Enhanced particle layer; 62. Heating chip. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention.

[0026] like Figure 1-Figure 2 As shown, in one embodiment, a test device for producing a Raman hotspot includes: a workbench 1, on which a liquid pool 2 and a hotspot pool 3 are provided;

[0027] Furthermore, a liquid outlet 21 is provided at one end of the liquid pool 2 , and a liquid inlet 31 is provided at one end of the hot spot pool 3 . The liquid pool 2 and the hot spot pool 3 are connected via a liquid channel 4 .

[0028] Specifically, one end of the liquid channel 4 is connected to the liquid outlet 21 of the liquid pool 2, and the other end of the liquid channel 4 is connected to the liquid inlet 31 of the hot spot pool 3, so that the liquid flows from the liquid outlet 21 of the liquid pool 2 through the liquid channel 4 and then enters from the liquid inlet 31 of the hot spot pool 3.

[0029] Please continue reading Figure 1 In the present application, the liquid channel 4 is further provided with a filter assembly 5, which includes a nanofiltration membrane 51. The nanofiltration membrane 51 can remove large particles or impurities in the liquid, ensuring that only tiny nanoparticles or solutes pass through. By controlling the speed at which the liquid flows through the nanofiltration membrane 51, the distribution of nanoparticles in the liquid channel 4 can be adjusted to maintain the performance and stability of the substrate.

[0030] Specifically, the nanofiltration membrane 51 is disposed in the middle of the liquid channel 4 , and the pore size of the nanofiltration membrane 51 is 1-50 nm.

[0031] It's important to explain that when molecules in a liquid adsorb on the surface of precious metal particles, they become polarized by the photoelectric field under laser irradiation, generating a localized electric field. Typically, the localized electric field in the gaps between the particles is greater than the external electric field, creating what are known as "hot spots." Molecules in these hot spots generate strong Raman scattering.

[0032] Please continue reading Figure 2 In the present application, the hotspot pool 3 is concave to form a receiving cavity 32. The hotspot pool 3 is also provided with a heating component 6. The heating component 6 includes an enhanced particle layer 61 and a heating chip 62, which can effectively reduce the randomness of hotspot generation and improve the efficiency of hotspot generation.

[0033] Furthermore, the enhanced particle layer 61 covers the surface of the hot spot pool 3 , and the heating chip 62 is disposed at the bottom of the hot spot pool 3 .

[0034] Specifically, the enhanced particle layer 61 uses AgNPs@SiO2 nano-enhanced particles. Silver nanoparticles have a strong local electric field enhancement effect and can significantly enhance the Raman scattering signal. When the silver nanoparticles come into contact with the molecules to be measured, the enhancement of the local electric field will lead to a significant improvement in the Raman signal, increasing the detection capability of low-concentration analytes; the silica coating can protect the silver nanoparticles, prevent their oxidation and degradation, ensure the uniformity of the nanoparticles in the hot spot area, and thus stabilize the SERS hotspot, improving the uniformity and repeatability of the overall signal.

[0035] The heating chip 62 can precisely control the temperature of the hot spot area. The temperature change can affect the local electric field and surface enhancement effect of the nanoparticles, helping to reduce signal fluctuations caused by temperature gradients and further improve the repeatability and reliability of the overall signal.

[0036] The above description of the disclosed embodiments will enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A test device for producing Raman hotspots, characterized in that: include: A workbench (1), wherein a liquid pool (2) and a hot spot pool (3) are provided on the workbench (1); The liquid pool (2) and the hot spot pool (3) are connected via a liquid channel (4), and the liquid channel (4) is provided with a filter component (5), and the filter component (5) includes a nanofiltration membrane (51); The hot spot pool (3) is provided with a heating component (6), and the heating component (6) comprises a reinforced particle layer (61) and a heating chip (62).

2. The experimental device for producing Raman hotspots according to claim 1, characterized in that: A liquid outlet (21) is provided at one end of the liquid pool (2).

3. The experimental device for producing Raman hotspots according to claim 1, characterized in that: A liquid inlet (31) is provided at one end of the hot spot pool (3).

4. The experimental device for producing Raman hotspots according to claim 1, characterized in that: The hot spot pool (3) is concave to form a receiving cavity (32).

5. The experimental device for producing Raman hotspots according to claim 1, characterized in that: One end of the liquid channel (4) is connected to the liquid outlet (21) of the liquid pool (2).

6. The experimental device for producing Raman hotspots according to claim 1, characterized in that: The other end of the liquid channel (4) is connected to the liquid inlet (31) of the hot spot pool (3).

7. The experimental device for producing Raman hotspots according to claim 1, characterized in that: The nanofiltration membrane (51) is arranged in the middle of the liquid channel (4).

8. The experimental device for producing Raman hotspots according to claim 1, characterized in that: The pore size of the nanofiltration membrane (51) is 1-50 nm.

9. The experimental device for producing Raman hotspots according to claim 1, characterized in that: The enhanced particle layer (61) covers the surface of the hot spot pool (3).

10. The experimental device for producing Raman hotspots according to claim 1, characterized in that: The heating chip (62) is arranged at the bottom of the hot spot pool (3).

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