Quality control calibration device

Abstract

The utility model discloses a quality control calibration device, which can conveniently and quickly enable a liquid dripping pen tube to dip hydrophobic liquid from a liquid box, and can not only enable the hydrophobic liquid dipped on the liquid dripping pen tube not to be too much before a hydrophobic liquid ring is prepared to be dripped on a glass slide, but also enable the movement path of the liquid dripping pen tube to be reasonable, thereby improving the quality of the glass slide. Therefore, the quality of the hydrophobic liquid ring on the glass slide can be guaranteed to be qualified, and the hydrophobic liquid is not easy to throw around when the liquid dripping pen tube moves. The main structure of the device comprises a base, an upper shell, a stand column arranged on the base and a frame plate arranged on the stand column, a liquid box is arranged on the base, liquid absorption sponge is arranged in the liquid box, a liquid dispensing pen tube is arranged on the upper shell, a vertical rack is arranged on the liquid dispensing pen tube, a gear shaft and a pressing gear are arranged in the upper shell, and a control mechanism comprises an outer drive transverse shaft and a control pressing rod. The gear shaft is sleeved with a reset coil spring, a through hole located above the liquid box is formed in the frame plate, the lower end of the liquid dispensing pen tube, the through hole and the liquid box are sequentially arranged from top to bottom, and a shell bottom opening is formed in the bottom of the upper shell.

Description

Technical Field

[0001] The utility model belongs to the technical field of immunohistochemistry, and in particular relates to a quality control calibration device. Background Art

[0002] Immunohistochemistry is the application of the basic principle of immunology - antigen-antibody reaction, that is, the principle of specific binding between antigen and antibody. Through chemical reaction, the color developer (fluorescein, enzyme, metal ion, isotope) labeled with antibody is used to color the antigen (peptide and protein) in tissue cells, and the location, qualitative and relative quantitative research is carried out on it. This is called immunohistochemistry or immunocytochemistry.

[0003] The immunohistochemistry testing process involves quality control steps, which are preferably performed at designated locations on the slide to facilitate subsequent sample loading and observation. A common calibration method is to use a spotting ring. Specifically, the operator dips a hydrophobic liquid into a dotted tube (a hollow tube) and then applies it to the slide, creating a ring of hydrophobic liquid. Once the ring dries (or solidifies), a calibration ring forms. This allows for better positioning of sample loading and observation locations (for example, reagents added to the dried hydrophobic ring area will not flow turbulently and their positions are clearly defined), facilitating subsequent testing and experimental procedures. It's best to use a hydrophobic liquid that dries (or solidifies) easily, such as liquid paraffin.

[0004] The current spot calibration ring method relies on the operator holding a liquid dot tube, using the lower end of the liquid dot tube to dip some hydrophobic liquid, and then pressing the lower end of the liquid dot tube on the surface of the slide. Some of the hydrophobic liquid at the lower end of the liquid dot tube can be stained on the slide and form a hydrophobic liquid ring on the slide, and then the hydrophobic liquid ring will dry (or solidify).

[0005] However, the current point calibration ring method has two obvious defects: first, the amount of hydrophobic liquid required on the slide is actually very small, but when the lower end of the liquid dot tube is used to pick up the hydrophobic liquid, the amount of hydrophobic liquid picked up is almost certainly too much, which can easily lead to the hydrophobic liquid ring formed on the slide being unqualified (for example, the amount of hydrophobic liquid is too much, resulting in a very small center hole in the hydrophobic liquid ring); second, when the operator moves the liquid dot tube with his hand, the hydrophobic liquid can be accidentally thrown around (this is related to both the excessive amount of hydrophobic liquid picked up and the moving path of the liquid dot tube). Utility Model Content

[0006] The utility model provides a quality control calibration device, which can conveniently and quickly allow a liquid-dispensing pen tube to pick up a hydrophobic liquid from a liquid box. Before preparing to dispense a hydrophobic liquid ring on a glass slide, the liquid-dispensing pen tube can prevent excessive amount of hydrophobic liquid from being taken up, and the moving path of the liquid-dispensing pen tube can be reasonable, thereby ensuring that the quality of the hydrophobic liquid ring on the glass slide is qualified, and the hydrophobic liquid is not easily thrown around when the liquid-dispensing pen tube moves.

[0007] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0008] A quality control calibration device comprises a base, an upper shell, a column arranged on the base, and a frame plate arranged on the column;

[0009] The base is provided with a liquid box with an upper end opening, a liquid absorbing sponge is provided in the liquid box, the upper shell is provided with a liquid dispensing pen tube that can move up and down along the upper shell, the liquid dispensing pen tube is provided with a vertical rack, the upper shell is provided with a gear shaft rotatably connected to the upper shell and a downward pressure gear coaxially fixed with the gear shaft, and the downward pressure gear is meshed with the vertical rack;

[0010] It also includes an operating mechanism for driving the downward pressure gear to rotate, the operating mechanism includes an external drive horizontal shaft for driving the gear shaft and an operating pressure rod fixed to the external drive horizontal shaft, a reset coil spring is sleeved on the gear shaft, one end of the reset coil spring is connected to the gear shaft, and the other end of the reset coil spring is connected to the upper shell;

[0011] The frame plate is provided with a through hole located above the liquid box. The lower end of the liquid dispensing pen tube, the through hole and the liquid box are arranged in sequence from top to bottom. The bottom of the upper shell is provided with a shell bottom opening for the vertical rack to pass through, and the liquid dispensing pen tube passes through the shell bottom opening.

[0012] Preferably, the base is provided with an electric heater that contacts the liquid box and is used to heat the liquid box, and the dispensing pen tube is provided with an electric heater that contacts the dispensing pen tube and is used to heat the dispensing pen tube.

[0013] Preferably, the liquid box is provided with a box cover for covering the upper opening of the liquid box.

[0014] Preferably, an outer scraping elastic ring for contacting the outer side wall of the liquid dispensing pen tube is fixed in the through hole, and the outer scraping elastic ring is coaxially arranged with the liquid dispensing pen tube.

[0015] Preferably, the upper shell is provided with a hanger fixed to the upper shell, and also includes an inner scraper rod, the upper end of the inner scraper rod is fixed to the hanger, the upper end of the liquid-dispensing pen tube is located in the upper shell, and the lower end of the liquid-dispensing pen tube is located below the upper shell. The inner scraper rod passes through the tube hole of the liquid-dispensing pen tube, and the inner scraper rod is in sliding contact with the tube hole of the liquid-dispensing pen tube, and the lower end of the inner scraper rod is located above the frame plate.

[0016] Preferably, a lower guide hemisphere is provided at the lower end of the inner scraper rod, and the lower guide hemisphere is located above the frame plate.

[0017] Preferably, a protective coil spring is provided on the gear shaft, and a cylindrical groove opening at one end of the external drive horizontal shaft is provided on the external drive horizontal shaft. The gear shaft is rotatably connected to the external drive horizontal shaft through a bearing, the gear shaft is fixed to the inner ring of the bearing, the bearing is located in the cylindrical groove, the outer ring of the bearing is fixed to the cylindrical groove, one end of the protective coil spring is connected to the external drive horizontal shaft, and the other end of the protective coil spring is connected to the gear shaft.

[0018] Preferably, a fixed friction block is provided on the upper shell, and a dynamic friction block that can make frictional contact with the fixed friction block is provided on the external drive horizontal axis. The fixed friction block is located outside the upper shell, and the dynamic friction block is located outside the upper shell. When the lower end of the liquid dispensing pen tube is above the liquid box and the distance between the lower end of the liquid dispensing pen tube and the opening of the upper end of the liquid box is less than 2 mm, the dynamic friction block contacts the fixed friction block.

[0019] Preferably, the top of the liquid box is provided with an outer flange, the outer flange is supported on the top surface of the base, and the liquid box is slidably matched with the limiting groove.

[0020] The beneficial effects of the present invention are as follows: the dispensing pen tube can be conveniently and quickly dipped into the hydrophobic liquid from the liquid box; before preparing to dispense the hydrophobic liquid ring on the glass slide, the amount of hydrophobic liquid on the dispensing pen tube is not too much; the moving path of the dispensing pen tube is reasonable, thereby ensuring that the hydrophobic liquid ring on the glass slide is of qualified quality, and the hydrophobic liquid is not easily thrown around when the dispensing pen tube moves; the liquid scraping operation can be performed on both the outside and the inside of the dispensing pen tube, which can further ensure that the hydrophobic liquid near the lower end of the dispensing pen tube is not too much; and the protective structure prevents damage to the glass slide and the dispensing pen tube even if the operator accidentally applies excessive force. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a structural diagram of the utility model;

[0022] Figure 2 yes Figure 1 Enlarged view of point A in the middle;

[0023] Figure 3 It is a side view of the utility model;

[0024] Figure 4 It is a schematic diagram of the internal structure of the utility model;

[0025] Figure 5 yes Figure 4 Enlarged view of point B in the middle;

[0026] Figure 6 yes Figure 4 Enlarged view of point C in the middle;

[0027] Figure 7 This is a schematic diagram of the structure of the pressure gear of the utility model;

[0028] Figure 8This is a schematic diagram of the structure of the protective coil spring of the utility model;

[0029] Figure 9 It is a structural diagram of embodiment 2 of the present utility model.

[0030] Figure numerals: base 1, liquid box 101, liquid-absorbing sponge 102, outer flange 103, box cover 104, upper shell 2, shell bottom 2a, hanger 201, column 3, frame plate 4, through hole 4a, outer scraper elastic ring 401, liquid-dispensing pen tube 5, vertical rack 501, gear shaft 502, downward pressure gear 503, reset coil spring 504, protection coil spring 505, bearing 506, external drive horizontal shaft 601, cylindrical groove 601a, operating pressure rod 602, grip ball 603, inner scraper core rod 7, lower guide hemisphere 701, fixed friction block 801, dynamic friction block 802. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making creative efforts shall fall within the scope of protection of the present invention.

[0032] Example 1

[0033] like Figure 1 、 Figure 2 、 Figure 3 、 Figure 4 、 Figure 5 、 Figure 6 、 Figure 7 As shown, a quality control calibration device includes a base 1, an upper shell 2, a column 3 provided on the base 1, and a frame plate 4 provided on the column 3;

[0034] The base 1 is provided with a liquid box 101 with an upper end opening and a heating plate for heating the liquid box, a liquid absorbing sponge 102 is provided in the liquid box, the upper shell 2 is provided with a liquid dispensing pen tube 5 that can move up and down along the upper shell 2, the liquid dispensing pen tube 5 is provided with a vertical rack 501, the upper shell 2 is provided with a gear shaft 502 rotatably connected to the upper shell 2 and a downward pressure gear 503 coaxially fixed with the gear shaft 502, and the downward pressure gear 503 is meshed with the vertical rack 501;

[0035] The device further includes an operating mechanism for driving the downward pressure gear 503 to rotate. The operating mechanism includes an external drive horizontal shaft 601 for driving the gear shaft 502 and an operating pressure rod 602 fixed to the external drive horizontal shaft 601. A return coil spring 504 is sleeved on the gear shaft 502. One end of the return coil spring 504 is connected to the gear shaft 502, and the other end of the return coil spring 504 is connected to the upper shell 2.

[0036] The frame 4 is provided with a through hole 4a located above the liquid box 101. The lower end of the dot pen tube 5, the through hole 4a and the liquid box 101 are arranged in sequence from top to bottom. The bottom of the upper shell 2 is provided with a shell bottom opening 2a for the vertical rack 501 to pass through, and the dot pen tube 5 passes through the shell bottom opening 2a.

[0037] The upper shell 2 is fixed to the column 3, and the external drive horizontal shaft 601 is rotatably connected to the upper shell 2. The external drive horizontal shaft 601 is coaxially arranged with the gear shaft 502. When the lower end of the liquid-dispensing pen tube 5 is dipped in the liquid box 101 to pick up the hydrophobic liquid, the lower end of the vertical rack 501 is above the frame plate 4.

[0038] Normally, under the maintenance of the return coil spring 504, the gear shaft 502 and the associated structures (including the downward pressure gear 503, the vertical rack 501, the liquid dispensing pen tube 5, etc.) remain stationary, the lower end of the liquid dispensing pen tube 5 is above the frame 4, and there is a gap between the lower end of the liquid dispensing pen tube 5 and the frame 4.

[0039] When a hydrophobic liquid ring needs to be applied to a slide, the operator depresses the operating lever 602, which, via the external drive horizontal shaft 601, drives the gear shaft 502 to rotate. The gear shaft 502, through the downward pressure gear 503 and the vertical rack 501, drives the dispensing pen tube 5 downward. The lower end of the dispensing pen tube 5 first passes through the through hole 4a and finally enters the liquid box 101, where it contacts the absorbent sponge 102, thereby picking up the hydrophobic liquid. Compared to the situation where the hydrophobic liquid is directly in the liquid box, applying the dispensing pen tube with the absorbent sponge can effectively limit the amount of hydrophobic liquid picked up by the dispensing pen tube. When the gear shaft 502 rotates, the reset coil spring 504 deforms and stores energy.

[0040] After the lower end of the dispensing pen tube 5 is dipped into the hydrophobic liquid in the liquid box 101, the operator lifts the operating pressure rod 602 with his hand, and rotates the operating pressure rod 602 along the axis of the external drive horizontal axis 601 to reset, thereby resetting the gear shaft 502, the downward pressure gear 503, the vertical rack 501, the dispensing pen tube 5, etc.

[0041] Afterwards, the slide is placed on the shelf 4. The operator again depresses the operating lever 602, driving the dispensing pen tube 5 downward. When the lower end of the dispensing pen tube 5 contacts the slide, some of the hydrophobic liquid at the lower end of the dispensing pen tube 5 is transferred to the slide, forming a hydrophobic liquid ring on the slide. The operator then lifts the operating lever 602, rotating it along the axis of the external drive horizontal axis 601 to reset the slide. This resets the gear shaft 502, the downward pressure gear 503, the vertical rack 501, the dispensing pen tube 5, and so on. The hydrophobic liquid ring on the slide dries (or solidifies), forming a calibration ring. Furthermore, the dispensing pen tube 5 moves straight up and down, providing a simple and clear path. Generally speaking, the hydrophobic liquid is less likely to be thrown laterally.

[0042] The base 1 is provided with an electric heater that contacts the liquid box 101 and is used to heat the liquid box 101 , and the dispensing pen tube 5 is provided with an electric heater that contacts the dispensing pen tube 5 and is used to heat the dispensing pen tube 5 .

[0043] When the hydrophobic liquid used is solid at room temperature, an electric heater can be used. For example, paraffin wax, when operating the present invention, is heated to above 60°C using an electric heater to produce liquid paraffin. Simultaneously, the dispensing pen tube should also be heated to prevent premature solidification of the paraffin wax on the dispensing pen tube. The electric heater can be a conventional heating device such as a hot plate or heating wire. The heater used to heat the dispensing pen tube should be connected to an external power source via a flexible electrical wire (such as conventional plastic-coated copper wire) to accommodate the vertical movement of the dispensing pen tube.

[0044] like Figure 1 、 Figure 2 As shown, an outer scraping elastic ring 401 for contacting the outer side wall of the dispensing pen tube 5 is fixed in the through hole 4 a , and the outer scraping elastic ring 401 is coaxially arranged with the dispensing pen tube 5 .

[0045] In this embodiment, when the dispensing pen tube 5 is moved downward to pick up the hydrophobic liquid, the lower end of the dispensing pen tube 5 first passes through the outer scraping elastic ring 401. After the lower end of the dispensing pen tube 5 picks up the hydrophobic liquid, the outer scraping elastic ring scrapes off the hydrophobic liquid on the outer wall of the dispensing pen tube 5 when the dispensing pen tube 5 is moved upward to return to its original position. This prevents excessive hydrophobic liquid from remaining near the lower end of the dispensing pen tube 5. The small amount of hydrophobic liquid remaining at the lower end of the dispensing pen tube 5 also creates a clearer hydrophobic liquid ring on the slide, preventing problems such as a small central hole in the hydrophobic liquid ring caused by excessive amounts of hydrophobic liquid.

[0046] It should be noted that the hydrophobic liquid scraped off by the outer scraping elastic ring 401 can fall back into the liquid box 101. When the operating lever 602 needs to be reset, the hand can be changed from "pressing down the operating lever 602" to "resting on the operating lever 602". Then, under the action of the reset coil spring 504, the operating lever 602 can also be rotated along the axis of the outer drive horizontal shaft 601 to reset.

[0047] like Figure 4 、 Figure 5 As shown, the upper shell 2 is provided with a hanger 201 fixed to the upper shell 2, and also includes an inner scraper rod 7, the upper end of the inner scraper rod 7 is fixed to the hanger 201, the upper end of the liquid-dispensing pen tube 5 is located in the upper shell 2, and the lower end of the liquid-dispensing pen tube 5 is located below the upper shell 2, the inner scraper rod 7 passes through the tube hole of the liquid-dispensing pen tube 5, and the inner scraper rod 7 is in sliding contact with the tube hole of the liquid-dispensing pen tube 5, and the lower end of the inner scraper rod 7 is located above the frame plate 4.

[0048] After the lower end of the dispensing pen tube 5 is dipped in the hydrophobic liquid, a small amount of hydrophobic liquid will also be deposited within the tube hole of the dispensing pen tube 5. During the upward repositioning process of the dispensing pen tube 5, the internal scraper rod 7 scrapes the hydrophobic liquid from the tube hole of the dispensing pen tube 5, further ensuring that the hydrophobic liquid at the lower end of the dispensing pen tube 5 is not excessive. When the lower end of the dispensing pen tube 5 contacts the glass slide, this prevents the hydrophobic liquid in the tube hole of the dispensing pen tube 5 from flowing into the hydrophobic liquid ring, causing the hydrophobic liquid ring to fail. The hydrophobic liquid scraped off by the internal scraper rod 7 can fall back into the liquid box 101. The internal scraper rod 7 also serves as a sliding guide for the dispensing pen tube 5.

[0049] like Figure 8 As shown, a protective coil spring 505 is sleeved on the gear shaft 502, and a cylindrical groove 601a opening at one end of the external drive horizontal shaft 601 is provided on the external drive horizontal shaft 601. The gear shaft 502 is rotatably connected to the external drive horizontal shaft 601 through a bearing 506. The gear shaft 502 is fixed to the inner ring of the bearing 506. The bearing 506 is located in the cylindrical groove 601a. The outer ring of the bearing 506 is fixed to the cylindrical groove 601a. One end of the protective coil spring 505 is connected to the external drive horizontal shaft 601, and the other end of the protective coil spring 505 is connected to the gear shaft 502.

[0050] The stiffness coefficient of the protection coil spring 505 is greater than the stiffness coefficient of the return coil spring 504 .

[0051] As mentioned above, after placing the slide on the shelf 4, the operator presses down the control lever 602 again, driving the liquid-dispensing pen tube 5 to move downward. After the lower end of the liquid-dispensing pen tube 5 contacts the slide, part of the hydrophobic liquid at the lower end of the liquid-dispensing pen tube 5 can be stained with the slide and form a liquid hydrophobic liquid ring on the slide. When the operator presses down the control lever 602 to drive the liquid-dispensing pen tube 5 to contact the slide, if the operator uses too much force, it is easy to cause the liquid-dispensing pen tube 5 to have an excessive impact on the slide. In this solution, when the operator presses down the control lever 602, the external drive horizontal shaft 601 rotates, and the external drive horizontal shaft 601 drives the gear shaft 502 to rotate via the protective coil spring 505, thereby ultimately driving the liquid-dispensing pen tube 5 to move downward. In this way, after the lower end of the liquid-dispensing pen tube 5 contacts the slide, if the control lever 602 continues to be pressed down, the liquid-dispensing pen tube 5 will not continue to move downward, and the protective coil spring 505 will continue to store energy. In this way, even if the operator accidentally applies excessive force, it is unlikely to cause damage to the slide glass or the dot pen tube 5.

[0052] like Figure 1 、 Figure 3 、 Figure 4 As shown, the top of the liquid box 101 is provided with an outer flange 103, the outer flange 103 is supported on the top surface of the base 1, and the liquid box 101 is slidably matched with the limiting groove.

[0053] The liquid box slides in the up and down direction.

[0054] The liquid box 101 can be placed on the top surface of the base 1 by relying on the outer flange 103, so that the liquid box 101 can be easily replaced.

[0055] One end of the operating rod 602 is connected to the external drive horizontal shaft 601, and the other end of the operating rod 602 is provided with a grip ball 603. The grip ball 603 can operate the operating rod 602 more conveniently.

[0056] Example 2

[0057] Based on Example 1, Figure 9 As shown, the liquid box 101 is provided with a box cover 104 for covering the upper opening of the liquid box 101 .

[0058] When the hydrophobic liquid used is highly volatile, a box cover 104 can be used. Before the dispensing pen tube 5 is dipped in the hydrophobic liquid, the box cover 104 is removed. After the dispensing pen tube 5 is dipped in the hydrophobic liquid, the box cover 104 is put back on. The specific form is not limited, as long as it can be opened and closed.

[0059] A lower guide hemisphere 701 is provided at the lower end of the inner scraper rod 7 , and the lower guide hemisphere 701 is located above the frame plate 4 .

[0060] The “hydrophobic liquid in the tube hole of the dispensing pen tube 5 ” scraped by the inner scraping core rod 7 can be gathered downwards through the lower guide hemisphere 701 and fall back into the liquid box 101 through the central hole of the outer scraping elastic ring 401 .

[0061] The diameter of the central hole of the outer scraping elastic ring 401 is M, D>M>d, Md=N, and N is greater than 1 mm.

[0062] The center hole of the outer scraping elastic ring 401 is slightly smaller than the outer diameter of the dispensing pen tube 5. This allows the outer scraping elastic ring 401 to more closely adhere to the outer wall of the dispensing pen tube 5 as the dispensing pen tube 5 passes through it, effectively scraping off the hydrophobic liquid from the outer wall of the dispensing pen tube 5. Furthermore, the outer scraping elastic ring 401 also scrapes the hydrophobic liquid from the lower end of the dispensing pen tube 5 near the outer wall of the dispensing pen tube 5, further preventing excessive amounts of hydrophobic liquid from forming on and near the outer wall of the dispensing pen tube 5.

[0063] like Figure 9 As shown, a fixed friction block 801 is provided on the upper shell 2, and a dynamic friction block 802 that can make friction contact with the fixed friction block 801 is provided on the external drive horizontal shaft 601. The fixed friction block 801 is located outside the upper shell 2, and the dynamic friction block 802 is located outside the upper shell 2. When the lower end of the dot pen tube 5 is above the liquid box 101 and the distance between the lower end of the dot pen tube 5 and the upper end opening of the liquid box 101 is less than 2 mm, the dynamic friction block 802 contacts the fixed friction block 801.

[0064] When the dispensing pen tube 5 is lowered to pick up the hydrophobic liquid, if the operator applies excessive force, the lower end of the dispensing pen tube 5 may rapidly impact the surface of the hydrophobic liquid in the liquid box 101 and the bottom of the liquid box 101. This could cause the hydrophobic liquid to splash out and damage the liquid box 101 or the dispensing pen tube 5. In this embodiment, as the operating lever 602 is pressed downward and the external drive shaft 601 rotates, when the lower end of the dispensing pen tube 5 is about to enter the hydrophobic liquid, the dynamic friction block 802 on the external drive shaft 601 begins to contact the fixed friction block 801 on the upper shell 2. This friction limits the speed and allows the operator to sense the situation and reduce force. This prevents the lower end of the dispensing pen tube 5 from rapidly impacting the surface of the hydrophobic liquid in the liquid box 101, causing the hydrophobic liquid to splash out, and also prevents the lower end of the dispensing pen tube 5 from rapidly impacting the bottom of the liquid box 101.

[0065] The above is a detailed introduction to the embodiments of the present invention. Specific examples are used in this article to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method and core idea of the present invention. At the same time, for those skilled in the art, based on the idea of the present invention, there will be changes in the specific implementation methods and application scope. In summary, the contents of this specification should not be understood as limiting the present invention.

Claims

1. A quality control calibration device, characterized in that: It comprises a base (1), an upper shell (2), a column (3) provided on the base (1), and a frame plate (4) provided on the column (3); The base (1) is provided with a liquid box (101) with an upper end opening, a liquid absorbing sponge (102) is provided in the liquid box (101), the upper shell (2) is provided with a liquid dispensing pen tube (5) that can move up and down along the upper shell (2), the liquid dispensing pen tube (5) is provided with a vertical rack (501), the upper shell (2) is provided with a gear shaft (502) rotatably connected to the upper shell (2) and a downward pressure gear (503) coaxially fixed with the gear shaft (502), and the downward pressure gear (503) is meshed with the vertical rack (501); The device further comprises an operating mechanism for driving the downward pressure gear (503) to rotate, the operating mechanism comprising an external drive transverse shaft (601) for driving the gear shaft (502) and an operating pressure rod (602) fixed to the external drive transverse shaft (601), a return coil spring (504) being sleeved on the gear shaft (502), one end of the return coil spring (504) being connected to the gear shaft (502), and the other end of the return coil spring (504) being connected to the upper shell (2); The frame plate (4) is provided with a through hole (4a) located above the liquid box (101); the lower end of the liquid-dispensing pen tube (5), the through hole (4a) and the liquid box (101) are arranged in sequence from top to bottom; the bottom of the upper shell (2) is provided with a shell bottom opening (2a) for the vertical rack (501) to pass through; and the liquid-dispensing pen tube (5) passes through the shell bottom opening (2a).

2. A quality control calibration device according to claim 1, characterized in that: The base (1) is provided with an electric heater that contacts the liquid box (101) and is used to heat the liquid box (101), and the liquid-dispensing pen tube (5) is provided with an electric heater that contacts the liquid-dispensing pen tube (5) and is used to heat the liquid-dispensing pen tube (5).

3. A quality control calibration device according to claim 1, characterized in that: The liquid box (101) is provided with a box cover (104) for covering the upper opening of the liquid box (101).

4. A quality control calibration device according to claim 1, 2 or 3, characterized in that: An outer scraping elastic ring (401) for contacting the outer side wall of the liquid dispensing pen tube (5) is fixed in the through hole (4a), and the outer scraping elastic ring (401) is coaxially arranged with the liquid dispensing pen tube (5).

5. A quality control calibration device according to claim 1, 2 or 3, characterized in that: The upper shell (2) is provided with a hanging seat (201) fixed to the upper shell (2), and also includes an inner scraper rod (7), the upper end of the inner scraper rod (7) is fixed to the hanging seat (201), the upper end of the liquid-pointing pen tube (5) is located in the upper shell (2), the lower end of the liquid-pointing pen tube (5) is located below the upper shell (2), the inner scraper rod (7) passes through the tube hole of the liquid-pointing pen tube (5), and the inner scraper rod (7) is in sliding contact with the tube hole of the liquid-pointing pen tube (5), and the lower end of the inner scraper rod (7) is located above the frame plate (4).

6. A quality control calibration device according to claim 5, characterized in that: A lower guide hemisphere (701) is provided at the lower end of the inner scraper rod (7), and the lower guide hemisphere (701) is located above the frame plate (4).

7. A quality control calibration device according to claim 1, 2 or 3, characterized in that: The gear shaft (502) is provided with a protective coil spring (505), the external drive transverse shaft (601) is provided with a cylindrical groove (601a) opening at one end of the external drive transverse shaft (601), the gear shaft (502) is rotatably connected to the external drive transverse shaft (601) via a bearing (506), the gear shaft (502) is fixed to the inner ring of the bearing (506), the bearing (506) is located in the cylindrical groove (601a), the outer ring of the bearing (506) is fixed to the cylindrical groove (601a), one end of the protective coil spring (505) is connected to the external drive transverse shaft (601), and the other end of the protective coil spring (505) is connected to the gear shaft (502).

8. A quality control calibration device according to claim 1, characterized in that: The upper shell (2) is provided with a fixed friction block (801), and the external drive transverse shaft (601) is provided with a dynamic friction block (802) capable of frictionally contacting the fixed friction block (801). The fixed friction block (801) is located outside the upper shell (2), and the dynamic friction block (802) is located outside the upper shell (2). When the lower end of the liquid-point pen tube (5) is above the liquid box (101) and the distance between the lower end of the liquid-point pen tube (5) and the upper end opening of the liquid box (101) is less than 2 mm, the dynamic friction block (802) contacts the fixed friction block (801).

9. A quality control calibration device according to claim 1, 2 or 3, characterized in that: The top of the liquid box (101) is provided with an outer flange (103), the outer flange (103) is supported on the top surface of the base (1), and the liquid box (101) is slidably engaged with the limiting groove.

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