Multi-modal behavior analyzer
By designing a multimodal behavior analyzer, the problem of single functions of traditional instruments is solved, and the flexibility and efficiency and accuracy of multiple behavioral experiments are achieved, reducing the experimental cost.
Patent Information
- Application Number
- CN202422431138.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-09
- Publication Date
- 2025-08-22
- Estimated Expiration
- 2034-10-09
AI Technical Summary
Traditional experimental instruments have a single function and cannot perform behavioral analysis of multiple mice of different sizes at the same time. The experimental environment control is inaccurate, which affects the accuracy of experimental results and increases the cost and time of experiments.
A multimodal behavior analyzer is designed, including a box, metal grid frame, partition card slot, shaft handle, drawer and wide-angle camera, which can perform a variety of behavioral experiments, including continuous light, open field, metal grid, hot plate and light and dark box experiments, and realize a multifunctional experimental environment through the combination of magnet sheets and background plates.
It realizes diversified instrument functions, reduces the procurement cost of experimental equipment, improves the efficiency of use and experimental accuracy, and can flexibly adjust the angle of the metal grid and the light intensity in different experiments.
Smart Images
Figure CN223247296U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to a multimodal behavior analyzer, belonging to the technical field of medical experiments. Background Art
[0002] Many traditional experimental instruments can only perform a single type of behavioral test. For example, the open field test box is only used to evaluate the spontaneous activity and exploratory behavior of animals, but cannot perform other types of behavioral tests. The metal grid experimental instrument can only perform measurements at a single angle, and the detection is not comprehensive enough to perform other experiments. For example, when performing other large and small mouse behavioral analysis experiments, other corresponding experimental instruments are also needed. The functions of the experimental instruments are relatively single and cannot meet the requirements of other large and small mouse behavioral analysis experiments. Moreover, when conducting behavioral tests, the control of the experimental environment is not precise enough, which may affect the accuracy of the experimental results. Multiple devices and complex operating procedures increase experimental costs and time. Utility Model Content
[0003] In order to overcome the shortcomings of the existing technology, the utility model provides a multimodal behavior analyzer, which can effectively carry out a variety of analysis experiments on the behavior of mice and rats, diversify the functions of the experimental instrument, eliminate the need for other experimental instruments, and reduce the procurement cost of experimental equipment.
[0004] The technical solution adopted by the utility model to solve the technical problem is: a multimodal behavior analyzer, including a box, a metal grid frame, a partition card slot, a rotating shaft handle, a drawer and a wide-angle camera. The box is a 65×60×70cm hollow rectangular body, made of a transparent acrylic plate with a thickness of 5mm. The box has no top plate, and a drawer is slidably installed at the bottom of the box. The drawer door is located on one side of the 60×70 box; the middle of the upper end of the two panels of the 65×70 box is fixed with a A vertical partition slot, with the notches of the two partition slots facing each other; below the partition slot, a socket is provided at the upper center end of the two 65×70 panels of the box body, and the socket is connected to the hinge handle; except for the drawer side, a magnet piece A is embedded in the four corners of the other three sides of the box body. On the drawer side, a magnet piece A is embedded in the two corners above the box body and the two corners below the drawer door; a wide-angle camera with adjustable light intensity is installed at the two opposite corners of the upper end of the interior of the box body.
[0005] The rotating shaft handle includes a handle seat, a connecting seat and a square shaft. The handle seat and the connecting seat are both circular blocks, and the size of the connecting seat is smaller than that of the handle seat; the handle seat is fixed to one side of the connecting seat, and one end of the square shaft is fixedly connected to the other side of the connecting seat, and the centers of the handle seat, the connecting seat and the square shaft are all on the same axis; below the partition slot, a rectangular metal grid frame is provided in the box body, and a square hole is provided at the center position of both sides of the metal grid frame; the connecting seat of the rotating shaft handle is installed in the socket, and the square shaft is inserted into the square hole, and the rotating shaft handle can drive the metal grid frame to rotate.
[0006] Furthermore, the multimodal behavior analyzer also includes two background plates a, two background plates b and one background plate c. The size of background plate a is 65×70 cm, the size of background plate b is 60×70 cm, and the size of background plate c is 65×60 cm. Background plates a, background plates b and background plates c are all black or white acrylic plates. Magnet pieces B are embedded in the four corners of background plates a, background plates b and background plates c. After removing the rotating shaft handle and the partition slot, the two background plates a and the two background plates b are adsorbed on the four sides of the box by magnet pieces B and magnet pieces A, and background plate c is adsorbed on the top of the box. The thickness of background plates a, background plates b and background plates c are all 2 mm.
[0007] Furthermore, magnets c that attract each other are embedded and installed at the midline positions of the two background plates a and the background plate c, and the two background plates a and the background plate c can be divided into two.
[0008] Furthermore, the multimodal behavior analyzer also includes a partition plate, which has a semi-elliptical hole at the lower middle position, 8 cm wide and 5 cm high. The partition plate is a black acrylic plate; after removing the rotating shaft handle and the metal grid frame, the two ends of the partition plate can be inserted into the two partition plate slots.
[0009] Furthermore, the multimodal behavior analyzer also includes an intelligent hot plate instrument and a magnetic charging device. The bottom plate of the drawer slot is the intelligent hot plate instrument. There is a gap between the bottom plate of the box and the bottom of the drawer, and the bottom plate of the box is made of stainless steel; on the side corresponding to the drawer, the inside of the box is equipped with a magnetic charging device electrically connected to the intelligent hot plate instrument; the front side panel of the drawer slot is provided with a metal sheet that can contact the magnetic charging device.
[0010] Furthermore, the metal grid frame is surrounded by iron sheets and has a wire mesh inside.
[0011] Furthermore, a 360° scale is provided on the box body around the handle base, and a pointer is provided on the handle base.
[0012] Furthermore, a magnetic patch is provided on the inner side of the drawer door, and a magnetic handle is provided on the outer side of the drawer door.
[0013] The beneficial effects of the present invention are as follows: the present invention can be used for five behavioral experiments, namely, a continuous illumination experiment, an open field experiment, a multi-angle metal grid experiment, a hot plate experiment, and a light-dark box experiment, thereby diversifying the functions of the experimental instrument, greatly reducing the purchase cost of the instrument, and improving the efficiency of the instrument. When conducting a metal grid experiment, the multimodal behavior analyzer can also tilt the metal grid at different angles according to experimental needs; the utility model has the characteristics and advantages of being economical and practical, having multiple functions, high accuracy, and a wide range of applications. BRIEF DESCRIPTION OF THE DRAWINGS
[0014] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.
[0015] Figure 1 It is the main view of the present utility model.
[0016] Figure 2 yes Figure 1 Top view of .
[0017] Figure 3 yes Figure 1 side view.
[0018] Figure 4 It is a schematic diagram of the installation of the rotating shaft handle of the utility model.
[0019] Figure 5 It is a side view of the rotating shaft handle of the present utility model.
[0020] Figure 6 It is a schematic diagram of the utility model when adsorbing background plate a, background plate b and background plate c.
[0021] Figure 7 yes Figure 5 Top view of .
[0022] Figure 8 It is a schematic diagram of the partition plate of the present invention.
[0023] Figure 9 This is a schematic diagram of the utility model when the background plate a and the background plate c are divided into two.
[0024] Figure 10 It is a cross-sectional schematic diagram of the utility model when the partition plate is installed.
[0025] Figure 11 It is a schematic diagram of the positions of the square holes on the metal grid frame of the present invention.
[0026] Figure 12 It is a schematic diagram of the position of the jacks on the box body of the utility model.
[0027] Numbers in the figure:
[0028] 1. Box body, 101. Jack, 2. Metal grid frame, 201. Square hole, 3. Partition slot, 4. Rotating shaft handle, 401. Handle base, 402. Connecting base, 403. Square shaft, 5. Drawer, 6. Magnetic patch, 7. Magnetic handle, 8. Smart hot plate instrument, 9. Wide-angle camera, 10. Background plate a, 11. Background plate b, 12. Background plate c, 13. Magnet c, 14. Divider, 1401. Semi-elliptical hole, 15. Magnetic charging device, 16. Magnet sheet A, 17. Magnet sheet B. DETAILED DESCRIPTION
[0029] like Figure 1 As shown in FIG12 , a multimodal behavior analyzer includes a box 1, a metal grid frame 2, a partition card slot 3, a rotating shaft handle 4, a drawer 5 and a wide-angle camera 9. The box 1 is a 65×60×70 cm hollow rectangular body, made of a transparent acrylic plate with a thickness of 5 mm. The box 1 has no top plate, and a drawer 5 is slidably installed at the bottom of the box 1. The drawer door of the drawer 5 is located on one side of the 60×70 side of the box 1; a vertical partition card slot 3 is fixed at the middle position of the upper end of the two 65×70 panels of the box 1. The notches of the board slot 3 are opposite to each other; at the lower position of the partition slot 3, a socket 101 is provided at the upper center of the two 65×70 panels of the box body 1, and the socket 101 is connected to the shaft handle 4; except for the drawer 5 side, the four corners of the other three sides of the box body 1 are inlaid with a magnet piece A16, and on the drawer 5 side, the two upper corners of the box body 1 and the two lower corners of the drawer door are inlaid with a magnet piece A16; a wide-angle camera 9 with adjustable light intensity is installed at the two opposite corners of the upper end of the interior of the box body 1.
[0030] The rotating shaft handle 4 includes a handle seat 401, a connecting seat 402 and a square shaft 403. The handle seat 401 and the connecting seat 402 are both circular blocks, and the diameter of the connecting seat 402 is smaller than the diameter of the handle seat 401; the handle seat 401 is fixed to one side of the connecting seat 402, and one end of the square shaft 403 is fixedly connected to the other side of the connecting seat 402. The centers of the handle seat 401, the connecting seat 402 and the square shaft 403 are all on the same axis; below the partition slot 3, a rectangular metal grid frame 2 is provided in the box body 1, and a square hole 201 is provided at the center position of both sides of the metal grid frame 2; the connecting seat 402 of the rotating shaft handle 4 is installed in the socket 101, and the square shaft 403 is inserted into the square hole 201, and the rotating shaft handle 4 can drive the metal grid frame 2 to rotate.
[0031] The multimodal behavior analyzer also includes two background plates a10, two background plates b11, and one background plate c12. The size of background plate a10 is 65×70 cm, the size of background plate b11 is 60×70 cm, and the size of background plate c12 is 65×60 cm. Background plates a10, b11, and c12 are all black or white acrylic plates. The four corners of background plates a10, b11, and c12 are all inlaid with magnet pieces B1. 7; After removing the shaft handle 4 and the partition slot 3, the two background plates a10 and the two background plates b11 are adsorbed on the four sides of the box body 1 through the magnet pieces B17 and the magnet pieces A16, and the background plate c12 is adsorbed on the top of the box body 1; the two background plates a10 and the background plates c12 are embedded with mutually adsorbed magnets c13 at the midline positions, and the two background plates a10 and the background plates c12 can be split into two; the thickness of the background plates a10, background plates b11 and background plates c12 are all 2 mm.
[0032] The multimodal behavior analyzer also includes a partition plate 14, which has a semi-elliptical hole 1401 at the lower middle position, 8 cm wide and 5 cm high. The partition plate 14 is a black acrylic plate; after removing the rotating shaft handle 4 and the metal grid frame 2, the two ends of the partition plate 14 can be inserted into the two partition card slots 3.
[0033] The multimodal behavior analyzer also includes an intelligent hot plate instrument 8 and a magnetic charging device 15. The bottom plate of the drawer 5 is the intelligent hot plate instrument 8. There is a gap between the bottom plate of the box 1 and the bottom of the drawer 5. The bottom plate of the box 1 is made of stainless steel. On the side corresponding to the drawer 5, the inside of the box 1 is equipped with a magnetic charging device 15, which is electrically connected to the intelligent hot plate instrument 8. A metal sheet that can contact the magnetic charging device 15 is provided on the front side panel of the drawer 5 slot.
[0034] The metal grid frame 2 is surrounded by iron sheets and has a wire mesh inside. The wire mesh has a size of 49 cm×44 cm, and the metal grid frame 2 has a size of 59×54 cm.
[0035] A 360° scale is provided on the box body 1 around the handle base 401 , and a pointer is provided on the handle base 401 ; a magnetic patch 6 is provided on the inner side of the drawer door of the drawer 5 , and a magnetic handle 7 is provided on the outer side of the drawer door.
[0036] During use, the instrument can be used for five behavioral experiments, namely, continuous light experiment, open field test, metal grid experiment, hot plate experiment and light-dark box experiment. The metal grid frame 2, hinge handle 4, background plate a10, background plate b11, background plate c12 and partition plate 14 are all used separately for different experiments; when the drawer 5 needs to be opened, the magnetic patch 6 and the magnetic handle 7 can be adsorbed on the drawer door.
[0037] 1) Continuous illumination experiment:
[0038] After removing the rotating handle 4 and the metal grid frame 2, the two wide-angle cameras 9 at opposite corners of the instrument can fully record the experimental process and conditions of large and small mice. The light source provided by the wide-angle cameras 9 is used for continuous illumination experiments, and the light intensity can be adjusted. Five black background plates with magnets are used. Two background plates a10 and two background plates b11 are attached to the four sides of the box 1, and background plate c12 covers the top suspended part to simulate a dark environment and reduce interference from the surrounding environment. After the experiment is completed, the covering black background plates are removed and the drawer 5 is pulled out to remove the experimental mice. Continuous illumination experiments can be used to study the effects of continuous illumination on skeletal muscle mass and exercise endurance in rats after aerobic exercise, or to study the effects of circadian rhythm disorders on hormones in rats. The white background plates a10, b11, and c12 are used in the same way as the black background plates, making it easier to photograph black and white mice while they are inside.
[0039] 2) Open field test
[0040] Similar to the continuous light experiment, four black background boards, two background boards a10 and two background boards b11, are used to completely cover the four sides of the box 1, but the top of the box 1 is not covered. The experimental mice are placed in the box 1, and the wide-angle camera 9 can be used to record the behavioral responses of the rats in the box, such as gait, facial expressions, movements, etc.; the number of grids crossed, central area movement time, grooming number, standing number and other indicators of the mice and rats can be recorded through computer software. After the experiment is completed, the background board b11 on the side of drawer 5 is removed, and the drawer 5 is pulled to take out the mice and rats.
[0041] 3) Multi-angle metal grid experiment
[0042] Install the metal mesh frame 2 in the box 1, connect the connecting seat 402 of the rotating shaft handle 4 to the socket 101, and insert the square shaft 403 into the square hole 201. Place the rat on the metal mesh frame 2. After the rat grasps the wire mesh firmly, manually rotate the handle seats 401 on both sides to flip the metal mesh frame 2 over according to the angle required for the experiment. This can measure the falling time and hanging time of the rat at different angles. The matching measurement system can directly display the data to be measured, which can be used to evaluate the muscle function or nerve regeneration / damage of the rat. After the experiment is completed, pull the drawer 5 below to take it out and clean it.
[0043] 4) Hot plate test
[0044] The bottom plate of the drawer 5 is an intelligent hot plate instrument 8, which is a constant temperature heating device with a temperature adjustment range of 18 to 60°C. When the external power supply is turned on and the bottom of the drawer 5 is heated to a certain temperature, mice and rats will lick their paws, jump, and other behaviors due to pain. The wide-angle camera 9 records the time when the animal shows pain reaction when it is placed on the hot plate, which is the pain domain, an important indicator for evaluating the response to pain; a magnetic charging device 15 is installed between the front side panel of the drawer 5 and the inside of the box 1. If the drawer 5 is pulled out and the interface is separated, the power connection is cut off. If the drawer is completely pushed into the box 1, the intelligent hot plate instrument 8 can be connected to the power supply for the experiment.
[0045] 5) Light and dark box experiment
[0046] After removing the metal grid frame 2 and the rotating shaft handle 4, the partition slot 3 inside the box 1 is placed into the partition board 14 with a semi-elliptical hole 1401, and half of the background board c12 is used as the upper cover to block the light from above. The background board a10 split in half is placed on both sides of the box 1 to block the light on both sides, and a background board b11 blocks the light from the back, which is the dark side; the other side is turned on with additional light, which is the bright side. Use a wide-angle camera 9 to illuminate and record indicators such as the time that mice and rats stay in the light and dark areas, the number of times they cross the semi-elliptical hole 1401, etc., to assess the anxiety level of mice and rats.
Claims
1. A multimodal behavior analyzer, characterized in that: The invention comprises a box body (1), a metal grid frame (2), a partition card slot (3), a rotating shaft handle (4), a drawer (5) and a wide-angle camera (9), wherein the box body (1) is a 65×60×70cm hollow rectangular body, and the material is a transparent acrylic plate, and the thickness of the acrylic plate is 5mm. The box body (1) has no top plate, and a drawer (5) is slidably installed at the bottom of the box body (1), and the drawer door of the drawer (5) is located on one side of the 60×70 of the box body (1); a vertical partition card slot (3) is fixed at the middle position of the upper end of the two panels of the 65×70 of the box body (1), and the grooves of the two partition card slots (3) are fixed. The openings are opposite to each other; at the lower position of the partition slot (3), a socket (101) is provided at the upper center of the two 65×70 panels of the box body (1), and the socket (101) is connected to the rotating shaft handle (4); except for the drawer (5) side, the box body (1) is inlaid with a magnet piece A (16) at the four corners of the other three sides. On the drawer (5) side, a magnet piece A (16) is inlaid at the two upper corners of the box body (1) and the two lower corners of the drawer door; a wide-angle camera (9) with adjustable light intensity is installed at the two opposite corners of the upper end of the box body (1); The rotating shaft handle (4) includes a handle seat (401), a connecting seat (402) and a square shaft (403). The handle seat (401) and the connecting seat (402) are both circular blocks. The diameter of the connecting seat (402) is smaller than the diameter of the handle seat (401). The handle seat (401) is fixed to one side of the connecting seat (402). One end of the square shaft (403) is fixedly connected to the other side of the connecting seat (402). The handle seat (401), the connecting seat (402) and The centers of the square shafts (403) are all on the same axis; a rectangular metal mesh frame (2) is provided in the box body (1) below the partition slot (3), and a square hole (201) is provided at the center position of both sides of the metal mesh frame (2); the connecting seat (402) of the rotating shaft handle (4) is installed in the socket (101), and the square shaft (403) is inserted into the square hole (201), and the rotating shaft handle (4) can drive the metal mesh frame (2) to rotate.
2. A multimodal behavior analyzer according to claim 1, characterized in that: The invention also includes two background plates a (10), two background plates b (11) and one background plate c (12), wherein the size of the background plate a (10) is 65×70, the size of the background plate b (11) is 60×70, and the size of the background plate c (12) is 65×60. The background plates a (10), the background plates b (11) and the background plates c (12) are all black or white acrylic plates. The four corners of the background plates a (10), the background plates b (11) and the background plates c (12) are all inlaid with magnet pieces B (17). After removing the rotating shaft handle (4) and the partition card slot (3), the two background plates a (10) and the two background plates b (11) are adsorbed on the four sides of the box body (1) by the magnet pieces B (17) and the magnet piece A (16), and the background plate c (12) is adsorbed on the top of the box body (1). The thickness of the background plates a (10), the background plates b (11) and the background plates c (12) are all 2 mm.
3. A multimodal behavior analyzer according to claim 2, characterized in that: The midline positions of the two background plates a (10) and the background plate c (12) are both inlaid with mutually attracted magnets c (13), and the two background plates a (10) and the background plate c (12) can be divided into two.
4. The multimodal behavior analyzer according to claim 1, wherein: The utility model further comprises a partition plate (14), wherein a half-elliptical hole (1401) is provided at the lower middle position of the partition plate (14), which is 8 cm wide and 5 cm high. The partition plate (14) is a black acrylic plate. After removing the rotating shaft handle (4) and the metal grid frame (2), the two ends of the partition plate (14) can be inserted into the two partition plate slots (3).
5. The multimodal behavior analyzer according to claim 1, characterized in that: The invention also includes an intelligent hot plate instrument (8) and a magnetic charging device (15), the bottom plate of the drawer (5) is the intelligent hot plate instrument (8), the bottom plate of the box body (1) and the bottom of the drawer (5) are spaced apart, and the bottom plate of the box body (1) is made of stainless steel; a magnetic charging device (15) is installed on the side corresponding to the drawer (5), the side inside the box body (1), and the magnetic charging device (15) is electrically connected to the intelligent hot plate instrument (8); and a metal sheet capable of contacting the magnetic charging device (15) is provided on the front side plate of the drawer (5) slot.
6. The multimodal behavior analyzer according to claim 1, characterized in that: The metal grid frame (2) is surrounded by iron sheets and has a wire mesh inside. The wire mesh has a size of 49 cm × 44 cm, and the size of the metal grid frame (2) is 59 × 54 cm.
7. The multimodal behavior analyzer according to claim 1, characterized in that: A 360° scale is provided on the box body (1) around the handle base (401), and a pointer is provided on the handle base (401).
8. The multimodal behavior analyzer according to claim 1, characterized in that: A magnetic patch (6) is provided on the inner side of the drawer door of the drawer (5), and a magnetic handle (7) is provided on the outer side of the drawer door.