Spray head device for gene synthesis and spray head mounting and adjusting structure thereof

Abstract

The utility model relates to a spray head device for gene synthesis and a spray head mounting and adjusting structure thereof, the spray head mounting and adjusting structure comprises a mounting base body, a movable cavity is arranged along the transverse direction, and a movable groove is arranged at the bottom of the movable cavity; the pressing piece is fixedly arranged on the outer port of the movable cavity; the first movable body is arranged in the movable cavity in a sliding mode and blocked by the pressing piece, and the first movable body is provided with a first mounting cavity communicating with the movable groove in the vertical direction; the first adjusting assembly penetrates through the pressing piece, is connected with the first movable body and can adjust the position of the first movable body in the transverse direction; the second movable body is movably inserted into the first movable body in the vertical direction, and a second mounting cavity communicating with the first mounting cavity is formed in the second movable body in the vertical direction; the second adjusting assembly is connected with the first movable body and the second movable body and can adjust the position of the second movable body in the vertical direction. The nozzle installation adjusting structure can adjust the position of the nozzle in the transverse direction and the vertical direction, and the requirement for nozzle installation precision can be conveniently met.

Description

Technical Field

[0001] The utility model relates to the technical field of gene synthesis, in particular to a nozzle device for gene synthesis and a nozzle installation and adjustment structure thereof. Background Art

[0002] Currently, gene synthesis operations utilize a technique similar to inkjet printing, where liquid is injected through a nozzle. Typically, probe sequences are set according to synthesis requirements, and the bioreaction fluids required for synthesis are sequentially printed through the nozzle to the designated locations.

[0003] The installation accuracy of the nozzle directly affects the quality of the synthesis. The most common method of fixing the nozzle is to tighten the nozzle with screws. The position of the nozzle cannot be adjusted after installation. The accuracy of the nozzle installation position depends entirely on the machining accuracy of the components. This requires high operation and has poor actual performance. Utility Model Content

[0004] Based on this, it is necessary to provide a nozzle device for gene synthesis and its nozzle installation adjustment structure that can adjust the nozzle position horizontally and vertically as needed to more conveniently meet the nozzle installation accuracy requirements in order to address the problem that the nozzle position cannot be adjusted and the installation accuracy requirements are high.

[0005] A nozzle installation and adjustment structure for gene synthesis, comprising:

[0006] A mounting base, wherein the height direction of the mounting base is vertical, the width direction is longitudinal, and the length direction is transverse, the mounting base is provided with a movable cavity along the transverse direction, and the bottom of the movable cavity is provided with a movable groove along the transverse direction;

[0007] A pressing member, fixedly arranged on the outer port of the movable cavity;

[0008] a first movable body, slidably disposed in the movable cavity and capable of being blocked by the pressing member, wherein the first movable body is vertically penetrated by a first mounting cavity communicating with the movable groove;

[0009] a first adjusting assembly passing through the pressing member and connected to the first movable body, wherein the first adjusting assembly is capable of adjusting the position of the first movable body in a lateral direction;

[0010] A second movable body is vertically movably inserted on the first movable body, and the second movable body is vertically penetrated by a second installation cavity communicating with the first installation cavity; and

[0011] The second adjusting component is connected to the first movable body and the second movable body respectively, and the second adjusting component can adjust the position of the second movable body in the vertical direction.

[0012] The above-mentioned nozzle installation and adjustment structure for gene synthesis has the nozzle inserted into the second installation cavity, the first installation cavity and the movable groove in sequence to form a pre-installation, and then the first movable body is driven by the first adjustment component to make the first movable body drive the nozzle to adjust the position horizontally, and the second movable body is driven by the second adjustment component to make the second movable body drive the nozzle to adjust the position vertically. This nozzle installation and adjustment structure can adjust the nozzle position horizontally and vertically as needed, and can more conveniently meet the nozzle installation accuracy requirements.

[0013] In one embodiment, the wall of the movable cavity extends toward the middle to form a slide rail, and a slider protrudes from the outer side of the first movable body, and the slider slides in cooperation with the slide rail. The sliding cooperation between the slider and the slide rail enables the first movable body to slide more smoothly and stably in the horizontal direction of the movable cavity.

[0014] In one embodiment, the first adjustment assembly includes a first elastic member and a micrometer assembly, the first elastic member respectively abuts against the inner end of the movable cavity and the side of the first movable body away from the clamping member; the micrometer assembly passes through the clamping member and abuts against the first movable body, and the micrometer assembly can extend and retract into the movable cavity.

[0015] In one embodiment, the micrometer assembly includes a micrometer knob and a micrometer top screw. The micrometer knob passes through the clamping member and abuts against the first movable body. The clamping member is provided with a top screw threaded hole in the vertical direction. The micrometer top screw is threadedly connected to the top screw threaded hole and tightens the micrometer knob. The position of the micrometer knob is first fixed by the micrometer top screw, and then the micrometer knob is rotated so that the telescopic end of the micrometer knob pushes the first movable body, and the nozzle is driven by the first movable body to achieve lateral adjustment. The micrometer knob can adjust the lateral displacement of the nozzle with an accuracy of up to micrometer level (0.001mm accuracy), and is easy to operate and can be completed by directly rotating.

[0016] In one embodiment, the first movable body includes a first main body and a first base, the first base being disposed on top of the first main body and having a larger cross-sectional area than the first main body. One first fixing screw passes through the first base and is threadedly connected to the mounting base, while the other first fixing screw passes through the first base and is threadedly connected to the pressing member. This can further enhance the locking and positioning of the nozzle in the lateral direction.

[0017] In one embodiment, the first base includes a first side edge and a second side edge opposite to each other in the transverse direction, the first side edge is provided with a first slot extending inward in the transverse direction, the second side edge is provided with a second slot extending inward in the transverse direction, one of the first fixing screws passes through the first slot, and another of the first fixing screws passes through the second slot.

[0018] In one embodiment, the second adjustment assembly includes a second fixing screw and a second elastic member. The second movable body is vertically provided with a second adjustment threaded hole, and the first movable body is provided with a first adjustment threaded hole corresponding to the second adjustment threaded hole. The second fixing screw is threadedly connected to the second adjustment threaded hole and the first adjustment threaded hole, respectively. The ends of the second elastic member abut the second movable body and the first movable body, respectively. By tightening and loosening the second fixing screw, combined with the elastic force of the second elastic member, the vertical position of the nozzle can be simply and effectively adjusted, with a vertical movement adjustment accuracy of up to 0.005mm.

[0019] In one embodiment, two second fixing screws and two second elastic members are provided and spaced apart in the transverse or longitudinal direction, so as to make the vertical adjustment of the nozzle more stable.

[0020] In one embodiment, the movable chambers are provided in a plurality and spaced longitudinally apart; the pressing member is elongated and longitudinally fixed to the outer port of each movable chamber; a first movable body, a first adjustment assembly, a second movable body, and a second adjustment assembly form a set of adjustment units, and multiple sets of adjustment units are provided, with each set of adjustment units correspondingly located within one movable chamber. This enables a multi-channel nozzle structure, with adjustable nozzle positions, and batch injection, resulting in higher efficiency.

[0021] The present invention also proposes a nozzle device for gene synthesis, comprising: the nozzle installation and adjustment structure for gene synthesis as described above, a nozzle, a nozzle top screw, a first visual camera, and a second visual camera, wherein the nozzle vertically passes through the second installation cavity, the first installation cavity, and the movable groove in sequence, and the nozzle top screw is screwed into the second movable body in the horizontal or vertical direction and presses the nozzle tightly; the first visual camera is located on one side of the nozzle along the horizontal interval; the nozzle sprays the reagent on the printing plane, and the second visual camera is located vertically directly above the printing plane. In the nozzle device for gene synthesis, the vertical position of the nozzle can be detected by the first visual camera, and the horizontal position of the nozzle can be detected by the second visual camera. The nozzle position is then adjusted by the nozzle installation and adjustment structure, and the nozzle top screw presses the nozzle tightly, thereby forming a set of nozzle position detection and position adjustment operating structures with high precision. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a structural diagram of the first embodiment of the nozzle installation and adjustment structure of the utility model;

[0023] Figure 2 This is a structural diagram of the second embodiment of the nozzle installation and adjustment structure of the utility model;

[0024] Figure 3 This is a schematic diagram of the exploded structure of the nozzle installation adjustment structure of the utility model;

[0025] Figure 4 This is a structural diagram of the third embodiment of the nozzle installation adjustment structure of the present utility model.

[0026] In the accompanying drawings, the components represented by the reference numerals are as follows:

[0027] 100. Nozzle installation and adjustment structure; 1. Installation base; 11. Movable cavity; 111. Slide rail; 12. Movable groove; 2. Pressing member; 21. Top screw threaded hole; 3. First movable body; 31. First installation cavity; 32. Slider; 33. First body; 34. First base top; 341. First slot; 342. Second slot; 35. First adjustment threaded hole; 4. First adjustment assembly; 41. First elastic member; 42. Micrometer assembly; 421. Micrometer knob; 422. Micrometer top screw; 5. Second movable body; 51. Second installation cavity; 52. Second adjustment threaded hole; 53. Flange; 6. Second adjustment assembly; 61. Second fixing screw; 62. Second elastic member; 7. First fixing screw; 81. Nozzle; 82. Nozzle top screw; 91. First visual camera. DETAILED DESCRIPTION

[0028] To make the above-mentioned purposes, features, and advantages of the present invention more clearly understood, the following provides a clear and complete description of the specific embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the specific details described below are only a portion of the embodiments of the present invention, and the present invention can also be implemented in many other embodiments different from those described herein. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without inventive effort are also within the scope of protection of the present invention.

[0029] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly attached to the other element or there may be an intermediate element. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only implementation methods.

[0030] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0031] See also Figures 1 to 3 In one embodiment, a nozzle installation and adjustment structure 100 for gene synthesis includes: a mounting base 1, a pressing member 2, a first movable body 3, a first adjustment component 4, a second movable body 5 and a second adjustment component 6. The height direction of the mounting base 1 is vertical, the width direction is longitudinal, and the length direction is transverse. The mounting base 1 is provided with a movable cavity 11 along the transverse direction, and a movable groove 12 is provided at the bottom of the movable cavity 11 along the transverse direction. The pressing member 2 is fixedly arranged on the outer end of the movable cavity 11. The first movable body 3 is slidably arranged in the movable cavity 11, and the first movable body 3 can be blocked and limited by the pressing member 2. The first movable body 3 is provided with a first mounting cavity 31 connected to the movable groove 12 along the vertical direction. The first adjustment component 4 passes through the pressing member 2 and is connected to the first movable body 3. The first adjustment component 4 can adjust the position of the first movable body 3 along the transverse direction. The second movable body 5 is movably inserted on the first movable body 3 along the vertical direction. The second movable body 5 is provided with a second mounting cavity 51 connected to the first mounting cavity 31 along the vertical direction. The second adjusting assembly 6 is connected to the first movable body 3 and the second movable body 5 respectively. The second adjusting assembly 6 can adjust the position of the second movable body 5 in the vertical direction.

[0032] The above-mentioned nozzle installation and adjustment structure 100 for gene synthesis, the nozzle is inserted into the second installation cavity 51, the first installation cavity 31 and the movable groove 12 in sequence to form a pre-installation, and then the first adjustment component 4 drives the first movable body 3, so that the first movable body 3 drives the nozzle to adjust the position horizontally, and the second adjustment component 6 drives the second movable body 5, so that the second movable body 5 drives the nozzle to adjust the position vertically. The nozzle installation and adjustment structure 100 can adjust the nozzle position horizontally and vertically as needed, and more conveniently meet the nozzle installation accuracy requirements.

[0033] In one embodiment, the wall of the movable cavity 11 extends toward the middle to form a slide rail 111. A slider 32 is protruding from the outside of the first movable body 3, and the slider 32 slidably engages with the slide rail 111. The slidable engagement between the slider 32 and the slide rail 111 enables the first movable body 3 to slide smoothly and stably in the lateral direction of the movable cavity 11.

[0034] The first adjustment component 4 and the second adjustment component 6 can adopt a motor-coupled screw drive structure or a cylinder drive structure. Of course, other structures can also be adopted to meet higher adjustment accuracy.

[0035] In one embodiment of the first adjustment assembly 4, the first adjustment assembly 4 includes a first elastic member 41 and a micrometer assembly 42. The first elastic member 41 abuts against the inner end of the movable cavity 11 and the side of the first movable body 3 away from the pressing member 2, respectively. The micrometer assembly 42 passes through the pressing member 2 and abuts against the first movable body 3. The micrometer assembly 42 can extend and retract into the movable cavity 11. When the micrometer assembly 42 extends into the movable cavity 11, the first elastic member 41 is compressed, and the first movable body 3 drives the nozzle to move laterally into the movable cavity 11. When the micrometer assembly 42 contracts out of the movable cavity 11, under the elastic restoring force of the first elastic member 41, the first movable body 3 drives the nozzle to move laterally out of the movable cavity 11.

[0036] In one embodiment, the micrometer assembly 42 includes a micrometer knob 421 and a micrometer top screw 422. The micrometer knob 421 passes through the clamping member 2 in the horizontal direction and abuts against the first movable body 3. The clamping member 2 is provided with a top screw threaded hole 21 in the vertical direction. The micrometer top screw 422 is threadedly connected to the top screw threaded hole 21 and tightens the micrometer knob 421. In actual operation, the main body position of the micrometer knob 421 is first fixed by the micrometer top screw 422, and then the micrometer knob 421 is rotated so that the telescopic end of the micrometer knob 421 pushes the first movable body 3, and the nozzle is driven by the first movable body 3 to achieve lateral adjustment. The micrometer knob 421 can adjust the lateral displacement of the nozzle with an accuracy of up to micrometer level (0.001mm accuracy) and is easy to operate. The operation can be completed by simply rotating it.

[0037] To further enhance the locking and positioning of the nozzle's lateral position after adjusting the position of the first movable body 3, the nozzle installation and adjustment structure 100 for gene synthesis further includes at least two first fixing screws 7. The first movable body 3 includes a first body 33 and a first base 34. The first base 34 is located at the top of the first body 33 and has a larger cross-sectional area than the first body 33. One first fixing screw 7 passes through the first base 34 and is threadedly connected to the mounting base 1. The other first fixing screw 7 passes through the first base 34 and is threadedly connected to the pressing member 2. The first body 33 is slidably engaged with the movable cavity 11.

[0038] Furthermore, the first base 34 includes a first side and a second side facing each other in the transverse direction. The first side has a first slot 341 extending inward in the transverse direction, and the second side has a second slot 342 extending inward in the transverse direction. One first fixing screw 7 passes through the first slot 341, and another first fixing screw 7 passes through the second slot 342. The first base 34 can be rectangular in shape, with the first slot 341 and the second slot 342 located at two opposite corners of the first base 34 in the transverse direction, thereby stably locking the first movable body 3.

[0039] In one embodiment of the second adjustment assembly 6, the second adjustment assembly 6 includes a second fixing screw 61 and a second elastic member 62. A second adjustment threaded hole 52 is vertically defined through the second movable body 5, and a first adjustment threaded hole 35 is defined in the first movable body 3, corresponding to the second adjustment threaded hole 52. The second fixing screw 61 is vertically threadedly connected to the second adjustment threaded hole 52 and the first adjustment threaded hole 35, respectively. The ends of the second elastic member 62 abut against the second movable body 5 and the first movable body 3, respectively. By tightening and loosening the second fixing screw 61, combined with the elastic force of the second elastic member 62, the vertical position of the nozzle can be easily and effectively adjusted, with a maximum vertical adjustment accuracy of 0.005 mm.

[0040] Furthermore, two second fixing screws 61 and two second elastic members 62 are provided and spaced apart in the transverse direction or the longitudinal direction, so as to achieve a more stable adjustment of the second movable body 5 in the vertical direction.

[0041] The first elastic member 41 and the second elastic member 62 may both be springs.

[0042] In order to make the second movable body 5 and the first movable body 3 cooperate more smoothly, the bottom of the second movable body 5 can be protruded with a cylindrical flange 53. The first movable body 3 is vertically provided with a cylindrical matching hole, and the flange 53 is movably inserted into the matching hole. In addition, the first installation cavity 31 can be directly used as the matching hole.

[0043] See also Figure 3 In another embodiment, multiple movable cavities 11 are provided, spaced longitudinally. The pressing member 2 is elongated and fixed longitudinally to the outer port of each movable cavity 11. A first movable body 3, a first adjustment assembly 4, a second movable body 5, and a second adjustment assembly 6 form a set of adjustment units. Multiple sets of adjustment units are provided, with each set corresponding to a movable cavity 11. This enables a multi-channel nozzle structure with adjustable nozzle positions and batch injection, resulting in higher efficiency.

[0044] See also Figure 1 and Figure 4The present invention also proposes a nozzle device for gene synthesis, comprising: the nozzle mounting and adjustment structure 100 for gene synthesis described above, a nozzle 81, a nozzle top screw 82, a first visual camera 91, and a second visual camera. The nozzle 81 vertically passes through the second mounting cavity 51, the first mounting cavity 31, and the movable groove 12 in sequence. The nozzle top screw 82 is screwed into the second movable body 5 laterally or longitudinally to hold the nozzle 81 in place. The first visual camera 91 is laterally spaced to one side of the nozzle 81. The nozzle 81 sprays reagent on the printing surface, and the second visual camera is vertically positioned directly above the printing surface. In this nozzle device for gene synthesis, the vertical position of the nozzle 81 can be detected by the first visual camera 91, and the horizontal position of the nozzle 81 can be detected by the second visual camera. The position of the nozzle 81 is then adjusted by the nozzle mounting and adjustment structure 100, and the nozzle top screw 82 holds the nozzle 81 in place, thereby forming a highly accurate operating structure for detecting and adjusting the position of the nozzle 81.

[0045] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0046] The above-described embodiments merely represent several implementation methods of the present invention. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the utility model patent. It should be noted that a person skilled in the art would be able to make various modifications, substitutions, and improvements without departing from the concept of the present invention, all of which are intended to fall within the scope of protection of the present invention. Therefore, the scope of protection of the present utility model patent should be determined by the claims.

Claims

1. A nozzle installation and adjustment structure for gene synthesis, characterized in that: include: A mounting base, wherein the height direction of the mounting base is vertical, the width direction is longitudinal, and the length direction is transverse, the mounting base is provided with a movable cavity along the transverse direction, and the bottom of the movable cavity is provided with a movable groove along the transverse direction; A pressing member, fixedly arranged on the outer port of the movable cavity; a first movable body, slidably disposed in the movable cavity and capable of being blocked by the pressing member, wherein the first movable body is vertically penetrated by a first mounting cavity communicating with the movable groove; a first adjusting assembly passing through the pressing member and connected to the first movable body, wherein the first adjusting assembly is capable of adjusting the position of the first movable body in a lateral direction; a second movable body, movably inserted on the first movable body in a vertical direction, wherein the second movable body is vertically penetrated by a second installation cavity communicating with the first installation cavity; and The second adjusting component is connected to the first movable body and the second movable body respectively, and the second adjusting component can adjust the position of the second movable body in the vertical direction.

2. The nozzle installation and adjustment structure for gene synthesis according to claim 1, characterized in that: The cavity wall of the movable cavity extends toward the middle to form a slide rail. A slider is protruded from the outer side of the first movable body. The slider is slidably matched with the slide rail.

3. The nozzle installation and adjustment structure for gene synthesis according to claim 1, characterized in that: The first adjustment assembly includes a first elastic member and a micrometer assembly, the first elastic member respectively abuts against the inner end of the movable cavity and the side of the first movable body away from the clamping member; the micrometer assembly passes through the clamping member and abuts against the first movable body, and the micrometer assembly can extend and retract into the movable cavity.

4. The nozzle installation and adjustment structure for gene synthesis according to claim 3, characterized in that: The micrometer assembly includes a micrometer knob and a micrometer top screw. The micrometer knob passes through the clamping piece and abuts against the first movable body. The clamping piece is vertically provided with a top screw threaded hole. The micrometer top screw is threadedly connected to the top screw threaded hole and tightens the micrometer knob.

5. The nozzle installation and adjustment structure for gene synthesis according to claim 1, characterized in that: It also includes at least two first fixing screws. The first movable body includes a first body and a first base top. The first base top is arranged on the top of the first body, and the cross-sectional area of ​​the first base top is larger than the cross-sectional area of ​​the first body. One first fixing screw passes through the first base top and is threadedly connected to the mounting base, and the other first fixing screw passes through the first base top and is threadedly connected to the clamping piece.

6. The nozzle installation and adjustment structure for gene synthesis according to claim 5, characterized in that: The first base includes a first side edge and a second side edge opposite to each other in the transverse direction. The first side edge is provided with a first slot extending inward in the transverse direction, and the second side edge is provided with a second slot extending inward in the transverse direction. One of the first fixing screws passes through the first slot, and another of the first fixing screws passes through the second slot.

7. The nozzle installation and adjustment structure for gene synthesis according to claim 1, characterized in that: The second adjustment assembly includes a second fixing screw and a second elastic member. The second movable body is vertically penetrated by a second adjustment threaded hole. The first movable body is provided with a first adjustment threaded hole corresponding to the second adjustment threaded hole. The second fixing screw is threadedly connected to the second adjustment threaded hole and the first adjustment threaded hole in sequence. The two ends of the second elastic member are respectively in contact with the second movable body and the first movable body.

8. The nozzle installation and adjustment structure for gene synthesis according to claim 7, characterized in that: There are two second fixing screws and two second elastic members, and they are spaced apart in the transverse direction or the longitudinal direction.

9. The nozzle installation and adjustment structure for gene synthesis according to claim 1, characterized in that: There are multiple movable cavities, and they are spaced apart in the longitudinal direction; the pressing piece is long and strip-shaped, and is fixedly arranged on the outer port of each movable cavity in the longitudinal direction; one first movable body, one first adjustment component, one second movable body and one second adjustment component constitute a group of adjustment units, and there are multiple groups of adjustment units, and one group of adjustment units is correspondingly arranged in one movable cavity.

10. A nozzle device for gene synthesis, characterized in that: include: The nozzle installation and adjustment structure for gene synthesis, the nozzle, the nozzle top screw, the first visual camera and the second visual camera as described in any one of claims 1 to 9, wherein the nozzle passes through the second installation cavity, the first installation cavity and the movable groove in sequence along the vertical direction, the nozzle top screw is screwed into the second movable body along the horizontal or vertical direction, and the nozzle is pressed tightly; the first visual camera is located on one side of the nozzle along the horizontal interval; the nozzle sprays the reagent on the printing plane, and the second visual camera is located vertically directly above the printing plane.

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