Benol ester esterification synthesis tank

Abstract

The utility model provides a benorilate esterification synthesis tank, which belongs to the field of medicine synthesis equipment and aims to solve the problems that powder raw materials are blocked in a pipeline, the mixing degree of the raw materials is poorer, and the efficiency and the yield of esterification reaction are influenced. An esterification synthesis top tank is inserted into the top of the esterification synthesis bottom tank, a driving motor is fixedly mounted in the middle of the outer side of the top of the esterification synthesis top tank, a diffusion shaft column is rotationally connected into the esterification synthesis bottom tank, and the top end of the diffusion shaft column is connected with the bottom end of the driving motor; mixing blades are fixedly mounted at the bottom of the outer side wall of the diffusion shaft column in an annular array; according to the esterification synthesis tank for the benorilate, the raw material mixing pipe is connected to the inner side of the esterification synthesis top tank, and the raw material mixing pipe is arranged to be Y-shaped, so that the convenience of adding two raw materials of the benorilate is improved, and the two raw materials are mixed at the bottom of the raw material mixing pipe, so that the mixing uniformity of the raw materials is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of drug synthesis equipment, in particular to a benolate esterification synthesis tank. Background Art

[0002] Benoryl ester is an organic compound and a new type of anti-inflammatory, antipyretic, analgesic and rheumatic treatment drug. Benoryl ester is an esterification product of acetaminophen and acetylsalicyloyl chloride. The esterification reaction is one of the key steps in its synthesis process. When adding raw materials to the existing benoyl ester esterification synthesis tank, the raw materials are in powder form, and the circulation effect of the raw materials in the pipeline is poor. Therefore, blockage problems will occur in the pipeline, resulting in poor mixing of the raw materials, thereby affecting the efficiency and output of the esterification reaction. Utility Model Content

[0003] The purpose of the utility model is to provide a bernorate esterification synthesis tank to solve the problem of the existing bernorate esterification synthesis tank proposed in the above background art that the raw materials are in powder form, the circulation effect of the raw materials in the pipeline is poor, and thus blockage problems may occur in the pipeline, resulting in poor mixing of the raw materials, thereby affecting the efficiency and yield of the esterification reaction.

[0004] The purpose and effect of the Benoryl ester esterification synthesis tank of the utility model are achieved by the following specific technical means:

[0005] A bernorate esterification synthesis tank, wherein the bernorate esterification synthesis tank includes an esterification synthesis bottom tank; the top of the esterification synthesis bottom tank is plugged with an esterification synthesis top tank, a drive motor is fixedly installed at the middle of the top outer side of the esterification synthesis top tank, a diffusion shaft is rotatably connected in the esterification synthesis bottom tank, the top end of the diffusion shaft is connected to the bottom end of the drive motor, and mixing blades are fixedly installed in a ring array on the bottom of the outer side wall of the diffusion shaft.

[0006] Furthermore, an interlayer plate is fixedly connected to the upper side of the inner wall of the esterification synthesis bottom tank, an inverted conical circular hole is opened in the middle of the interlayer plate, and an injection tube is fixedly connected to the front side of the interlayer plate. The injection tube is "L"-shaped, and the top front end of the injection tube is fixedly connected to the top side wall of the front side of the esterification synthesis bottom tank.

[0007] Furthermore, a raw material mixing tube is fixedly connected to the inner wall of the esterification synthesis top tank, the raw material mixing tube is in a "Y" shape, and the tops of the front and rear ends of the raw material mixing tube are both contracted. A guide rod auxiliary tube is fixedly connected to the top of the inner wall of the esterification synthesis top tank, and the bottom of the guide rod auxiliary tube is fixedly connected to the middle of the top of the raw material mixing tube.

[0008] Furthermore, the end of the bottom driving shaft of the driving motor is provided with a matching connection groove in an annular shape and at equal distances. A guide block with a conical top is fixedly connected to the middle of the inner wall of the diffusion shaft column. The top of the guide block is fixedly connected to a connecting rod. The bottom of the connecting rod is fixedly connected to the dispersion blades. The top of the connecting rod is fixedly connected to a matching connection shaft. The matching connection shaft and the matching connection groove are clamped together. Diffusion holes are provided in an annular array in the outer wall of the diffusion shaft column at the guide block. The upper side of the diffusion hole and the top of the diffusion shaft column are connected.

[0009] Furthermore, a temperature control rod is fixedly connected to the bottom of the inner wall of the esterification synthesis bottom tank, and external pipes are fixedly connected to the front and rear sides of the temperature control rod at the bottom of the esterification synthesis bottom tank. A connecting nested ring is fixedly connected to the top of the outer wall of the diffusion shaft column, and the bottom of the connecting nested ring is slidably connected to a circular hole opened in the middle of the internal partition plate of the esterification synthesis bottom tank, and the bottom of the diffusion shaft column is rotatably connected to the top of the temperature control rod.

[0010] Furthermore, the mixing blades are provided in an annular array with eight of them, the top of the inner wall of the mixing blade is fixedly connected to the bottom of the outer wall of the diffusion shaft column, the bottom of the inner wall of the mixing blade is slidably connected to the outer wall of the temperature control rod of the esterification synthesis bottom tank, and four inclined guide wings are installed at equal distances on the outer wall of the mixing blade.

[0011] The utility model provides a benrolate esterification synthesis tank, which has the following beneficial effects:

[0012] 1. By connecting a raw material mixing pipe on the inner side of the esterification synthesis top tank and setting the raw material mixing pipe into a "Y" shape, the convenience of adding the two raw materials of benoyl ester is improved, and the two raw materials are intersected at the bottom of the raw material mixing pipe, thereby improving the uniformity of the raw material mixing. In addition, by setting a guide rod auxiliary pipe in the esterification synthesis top tank, the guide rod auxiliary pipe provides a restriction for the top connection of the connecting rod of the drive shaft of the drive motor and the diffusion shaft column, thereby improving the connection reliability.

[0013] 2. By opening a fitting connection groove at the bottom end of the driving shaft of the driving motor and arranging a fitting connection shaft at the top of the connecting rod of the diffusion shaft column, power is transmitted by engaging the fitting connection shaft and the fitting connection groove, and the driving shaft and the connecting rod of the driving motor can be easily separated. The bottom of the connecting rod is connected with a dispersion fan blade, and a guide block with a conical top is fixedly connected to the middle of the interior of the diffusion shaft column, and a diffusion hole is opened in the side wall of the diffusion shaft column outside the guide block. When the diffusion shaft column rotates, the two mixed raw materials can be evenly dispersed into the esterification synthesis bottom tank through the dispersion fan blades and the guide block.

[0014] 3. By connecting the mixing blades at the bottom of the outer wall of the diffusion shaft, and the mixing blades are connected to the outer wall of the temperature control rod, when the diffusion shaft drives the mixing blades to rotate, the raw materials in the esterification synthesis bottom tank are stirred by specially arranged guide wings to increase the turbulence of the materials and improve the mixing effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a schematic diagram of the axial structure of the utility model;

[0016] Figure 2 This is a schematic diagram of the cross-sectional structure of the esterification synthesis bottom tank and the esterification synthesis top tank of the utility model;

[0017] Figure 3 This is a schematic diagram of the split and cutaway structure of the utility model;

[0018] Figure 4 This is a schematic diagram of the cross-section structure of the esterification synthesis bottom tank and the diffusion shaft column of the utility model;

[0019] Figure 5 This is a schematic diagram of the split structure of the drive motor and the diffusion shaft column of the utility model;

[0020] Figure 6 For this utility model Figure 5 A is an enlarged structural diagram of FIG.

[0021] In the figure, the corresponding relationship between component names and drawing numbers is as follows:

[0022] 1. Esterification synthesis bottom tank; 101. Interlayer plate; 102. Liquid injection pipe; 103. Temperature control rod; 104. External discharge pipe; 2. Esterification synthesis top tank; 201. Raw material mixing pipe; 202. Guide rod auxiliary pipe; 3. Drive motor; 301. Fitting connection groove; 4. Diffusion shaft column; 401. Connecting nested ring; 402. Connecting rod; 403. Fitting connection shaft; 404. Diffusion hole; 405. Guide block; 5. Mixing blade; 501. Guide wing. DETAILED DESCRIPTION

[0023] The embodiments of the present invention are described in further detail below with reference to the accompanying drawings and examples.

[0024] Example 1:

[0025] As attached Figure 1 To the attached Figure 6 As shown:

[0026] The utility model provides a Benoryl ester esterification synthesis tank, comprising: an esterification synthesis bottom tank 1; an esterification synthesis top tank 2 is plugged into the top of the esterification synthesis bottom tank 1; a driving motor 3 is fixedly installed at the middle of the top outer side of the esterification synthesis top tank 2; a diffusion shaft column 4 is rotatably connected in the esterification synthesis bottom tank 1; the top end of the diffusion shaft column 4 is connected to the bottom end of the driving motor 3; a mixing blade 5 is fixedly installed in a ring array at the bottom of the outer wall of the diffusion shaft column 4; an interlayer plate 101 is fixedly connected to the upper side of the inner side wall of the esterification synthesis bottom tank 1; an inverted cone-shaped circular hole is opened in the middle of the interlayer plate 101; and a front side of the interlayer plate 101 is fixedly connected to the inner side wall of the esterification synthesis bottom tank 1. The liquid injection tube 102 is in an "L" shape, and the top front end of the liquid injection tube 102 is fixedly connected to the top side wall of the front side of the esterification synthesis bottom tank 1. Its specific function is to set an interlayer plate 101 in the esterification synthesis bottom tank 1, and an inverted cone-shaped circular hole is opened in the middle of the interlayer plate 101, which is connected to the bottom of the nested ring 401 connected to the top of the outer wall of the diffusion shaft column 4, thereby limiting the position of the diffusion shaft column 4, and the liquid injection tube 102 connected to the front side of the interlayer plate 101 is used to add auxiliary liquid to the bottom space of the esterification synthesis bottom tank 1, so as to improve the esterification reaction effect of the benoyl ester by adding the auxiliary liquid.

[0027] Among them, a raw material mixing tube 201 is fixedly connected to the inner wall of the esterification synthesis top tank 2, and the raw material mixing tube 201 is in a "Y" shape. The tops of the front and rear ends of the raw material mixing tube 201 are both contracted. A guide rod auxiliary tube 202 is fixedly connected to the top of the inner wall of the esterification synthesis top tank 2, and the driving shaft of the driving motor 3 is rotatably connected in the guide rod auxiliary tube 202. The bottom of the guide rod auxiliary tube 202 is fixedly connected to the middle of the top of the raw material mixing tube 201. The specific function is to connect the raw material mixing tube 201 on the inner side of the esterification synthesis top tank 2 and set the raw material mixing tube 201 in a "Y" shape to improve the convenience of adding the two raw materials of benoyl ester, and make the two raw materials intersect at the bottom of the raw material mixing tube 201, thereby improving the uniformity of the mixing of the raw materials, and to set the guide rod auxiliary tube 202 in the esterification synthesis top tank 2 so that the guide rod auxiliary tube 202 can provide a restriction for the connection between the driving shaft of the driving motor 3 and the top of the connecting rod 402 of the diffusion shaft column 4, thereby improving the connection reliability.

[0028] Among them, the end of the bottom driving shaft of the driving motor 3 is provided with a matching connection groove 301 in an annular shape and equal distances, and a guide block 405 with a conical top is fixedly connected to the middle of the inner wall of the diffusion shaft column 4, and the top of the guide block 405 is fixedly connected to a connecting rod 402, and the bottom of the connecting rod 402 is fixedly connected to the dispersion fan blades, and the top of the connecting rod 402 is fixedly connected to a matching connection shaft 403, and the matching connection shaft 403 is snapped into the matching connection groove 301, and a diffusion hole 404 is provided in an annular array in the outer wall of the diffusion shaft column 4 at the guide block 405, and the upper side of the diffusion hole 404 is connected to the top of the diffusion shaft column 4. The specific function is to open the diffusion hole 404 at the bottom end of the driving shaft of the driving motor 3. A fitting connection groove 301 is provided, and a fitting connection shaft 403 is provided on the top of the connecting rod 402 of the diffusion shaft column 4, so that power is transmitted by engaging the fitting connection shaft 403 and the fitting connection groove 301, and the driving shaft of the driving motor 3 and the connecting rod 402 are conveniently separated, and a dispersion fan blade is connected to the bottom of the connecting rod 402, and a guide block 405 with a conical top is fixedly connected to the middle of the interior of the diffusion shaft column 4, and a diffusion hole 404 is opened in the side wall of the diffusion shaft column 4 outside the guide block 405. When the diffusion shaft column 4 rotates, the two mixed raw materials can be evenly dispersed into the esterification synthesis bottom tank 1 through the dispersion fan blades and the guide block 405.

[0029] Among them, a temperature control rod 103 is fixedly connected to the bottom of the inner wall of the esterification synthesis bottom tank 1, and an external pipe 104 is fixedly connected to the front and rear sides of the temperature control rod 103 at the bottom of the esterification synthesis bottom tank 1. A connecting nested ring 401 is fixedly connected to the top of the outer wall of the diffusion shaft column 4. The bottom of the connecting nested ring 401 is slidably connected to the circular hole opened in the middle of the internal partition plate 101 of the esterification synthesis bottom tank 1, and the bottom of the diffusion shaft column 4 is rotatably connected to the top of the temperature control rod 103. The specific function is to fix the temperature control rod 103 at the bottom of the inner wall of the esterification synthesis bottom tank 1 so that the temperature of the chemical reaction in the esterification synthesis bottom tank 1 can be controlled by the temperature control rod 103, so as to improve the efficiency of the esterification reaction and reduce the occurrence of side reactions, thereby improving the quality and yield of benoyl ester.

[0030] Among them, eight mixing blades 5 are arranged in a circular array, the top of the inner wall of the mixing blade 5 is fixedly connected to the bottom of the outer wall of the diffusion shaft column 4, and the bottom of the inner wall of the mixing blade 5 is slidingly connected to the outer wall of the temperature control adjustment rod 103 of the esterification synthesis bottom tank 1. Four inclined guide wings 501 are installed at equal distances on the outer wall of the mixing blade 5. The specific function is that the mixing blade 5 is connected to the bottom of the outer wall of the diffusion shaft column 4, and the mixing blade 5 is rotatably connected to the outer wall of the temperature control adjustment rod 103, so that when the mixing blade 5 is driven to rotate by the diffusion shaft column 4, the raw materials in the esterification synthesis bottom tank 1 are stirred by the specially arranged guide wings 501 to increase the turbulence of the material and improve the mixing effect.

[0031] The specific usage and function of this embodiment are as follows:

[0032] When using the Benoryl ester esterification synthesis tank, an interlayer plate 101 is set in the esterification synthesis bottom tank 1, and an inverted tapered circular hole is opened in the middle of the interlayer plate 101 and connected to the bottom of the nested ring 401 at the top of the outer wall of the diffusion shaft column 4, thereby limiting the position of the diffusion shaft column 4, and the injection pipe 102 connected to the front side of the interlayer plate 101 is used to add auxiliary liquid to the bottom space of the esterification synthesis bottom tank 1, and the raw material mixing pipe 201 is connected to the inner side of the esterification synthesis top tank 2, and the raw material mixing pipe 201 is set into a "Y" shape to improve the convenience of adding the two raw materials of Benoryl ester, and the two raw materials are intersected at the bottom of the raw material mixing pipe 201, thereby improving the uniformity of the raw material mixing, and a guide rod auxiliary pipe 202 is set in the esterification synthesis top tank 2, so that the guide rod auxiliary pipe 202 provides a restriction for the connection between the driving shaft of the driving motor 3 and the top of the connecting rod 402 of the diffusion shaft column 4, thereby improving the connection reliability, and the raw material mixing pipe 201 is connected to the inner side of the esterification synthesis top tank 2. A mating connection groove 301 is provided at the bottom end of the driving shaft, and a mating connection shaft 403 is provided at the top of the connecting rod 402 of the diffusion shaft column 4, so that power is transmitted by engaging the mating connection shaft 403 and the mating connection groove 301, and the driving shaft of the driving motor 3 and the connecting rod 402 are conveniently separated, and a dispersion fan blade is connected to the bottom of the connecting rod 402, and a guide block 405 with a conical top is fixedly connected to the middle of the interior of the diffusion shaft column 4, and a diffusion hole 404 is provided in the side wall of the diffusion shaft column 4 outside the guide block 405. When the diffusion shaft column 4 rotates, the two mixed raw materials can be evenly dispersed into the esterification synthesis bottom tank 1 through the dispersion fan blades and the guide block 405, and the mixing blades 5 are connected to the bottom of the outer wall of the diffusion shaft column 4, and the mixing blades 5 are rotatably connected to the outer wall of the temperature control adjustment rod 103, so that when the mixing blades 5 are driven to rotate by the diffusion shaft column 4, the raw materials in the esterification synthesis bottom tank 1 are stirred by the specially arranged guide wings 501.

[0033] Example 2:

[0034] By increasing the number of branches of the raw material mixing tube 201, multiple raw materials can be added simultaneously, thereby improving the convenience of raw material addition and increasing the yield of the benrolate esterification reaction.

Claims

1. A Benoryl ester esterification synthesis tank, characterized in that: It includes an esterification synthesis bottom tank; the top of the esterification synthesis bottom tank is plugged with an esterification synthesis top tank, a driving motor is fixedly installed at the middle of the top outer side of the esterification synthesis top tank, a diffusion shaft column is rotatably connected in the esterification synthesis bottom tank, the top end of the diffusion shaft column is connected to the bottom end of the driving motor, and mixing blades are fixedly installed in a ring array on the bottom of the outer side wall of the diffusion shaft column.

2. The benoyl ester esterification synthesis tank according to claim 1, characterized in that: An interlayer plate is fixedly connected to the upper side of the inner wall of the esterification synthesis bottom tank, and an inverted cone-shaped circular hole is opened in the middle of the interlayer plate. An injection tube is fixedly connected to the front side of the interlayer plate. The injection tube is "L"-shaped, and the top front end of the injection tube is fixedly connected to the top side wall of the front side of the esterification synthesis bottom tank.

3. The benoyl ester esterification synthesis tank according to claim 1, characterized in that: A raw material mixing tube is fixedly connected to the inner wall of the esterification synthesis top tank. The raw material mixing tube is in a "Y" shape, and the tops of the front and rear ends of the raw material mixing tube are both contracted. A guide rod auxiliary tube is fixedly connected to the top of the inner wall of the esterification synthesis top tank, and the bottom of the guide rod auxiliary tube is fixedly connected to the middle of the top of the raw material mixing tube.

4. The benoyl ester esterification synthesis tank according to claim 1, characterized in that: The end of the bottom driving shaft of the driving motor is provided with a ring-shaped matching connection groove at equal intervals. A guide block with a conical top is fixedly connected to the middle of the inner wall of the diffusion shaft column. The top of the guide block is fixedly connected to a connecting rod. The bottom of the connecting rod is fixedly connected to the dispersion blades. The top of the connecting rod is fixedly connected to a matching connection shaft. The matching connection shaft and the matching connection groove are snap-fitted together. Diffusion holes are provided in a ring-shaped array in the outer wall of the diffusion shaft column at the guide block. The upper side of the diffusion hole and the top of the diffusion shaft column are connected.

5. The benoyl ester esterification synthesis tank according to claim 1, characterized in that: A temperature control rod is fixedly connected to the bottom of the inner wall of the esterification synthesis bottom tank, and external pipes are fixedly connected to the front and rear sides of the temperature control rod at the bottom of the esterification synthesis bottom tank. A connecting nested ring is fixedly connected to the top of the outer wall of the diffusion shaft column, and the bottom of the connecting nested ring is slidably connected to a circular hole opened in the middle of the internal partition plate of the esterification synthesis bottom tank, and the bottom of the diffusion shaft column is rotatably connected to the top of the temperature control rod.

6. The benoyl ester esterification synthesis tank according to claim 1, characterized in that: The mixing blades are arranged in an annular array with eight of them. The top of the inner wall of the mixing blade is fixedly connected to the bottom of the outer wall of the diffusion shaft column. The bottom of the inner wall of the mixing blade is slidably connected to the outer wall of the temperature control rod of the esterification synthesis bottom tank. Four inclined guide wings are installed at equal distances on the outer wall of the mixing blade.

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