Nucleic acid extractor

Abstract

The utility model discloses a nucleic acid extraction instrument, which comprises a shell, a magnetic bar module, a magnetic bar sleeve module and a base, and is characterized by further comprising a power module connected with the magnetic bar module and the magnetic bar sleeve module and used for controlling the magnetic bar module and the magnetic bar sleeve module to move up and down and transversely; a kit to be detected is placed on the working platform, and the working platform is provided with a heating assembly for providing heat energy for the kit and a limiting assembly for limiting the movement of the kit; wherein the working platform is connected with the base through a supporting part, a sliding groove is transversely formed in the bottom face of the working platform, a roller matched with the sliding groove is arranged on the upper surface of the supporting part, and the working platform is in sliding connection with the roller. When the magnetic bar sleeve module interferes with the opening of the kit due to the fact that the displacement precision of the magnetic bar sleeve module has an error, the magnetic bar sleeve module can enable the working platform to deviate by a certain distance, so that the magnetic bar sleeve module smoothly enters the kit, and damage caused by collision between the magnetic bar sleeve and the kit is avoided.

Description

Technical Field

[0001] The utility model belongs to the technical field of nucleic acid extraction, and in particular relates to a nucleic acid extraction instrument. Background Art

[0002] The magnetic rod nucleic acid extractor is mainly based on the magnetic bead nucleic acid extraction technology. This technology uses magnetic beads as carriers to achieve the extraction and purification of nucleic acids through the characteristics of magnetic beads adsorbing nucleic acids under high salt and low pH values, and separating from nucleic acids under low salt and high pH values.

[0003] Existing nucleic acid extraction instruments typically place the reagent kit on the instrument's work platform. A motor then controls the lateral or longitudinal movement of a magnetic rod and magnetic rod sleeve, allowing them to enter the kit and remove the magnetic beads. The magnetic rod sleeve must be slightly smaller than the opening above the kit to facilitate entry. However, the motor's precision can sometimes cause errors, resulting in the actual displacement of the magnetic rod and magnetic rod sleeve failing to reach or exceeding the set displacement. In these cases, the magnetic rod sleeve risks interfering with the kit during descent, potentially damaging the magnetic rod sleeve or the kit. Therefore, a nucleic acid extraction instrument with improved docking tolerance is needed. Utility Model Content

[0004] In order to solve the above technical problems, the utility model provides a nucleic acid extraction instrument. When the magnetic rod sleeve and the reagent box are not properly docked and interference occurs, the reagent box will be offset by a certain distance, avoiding damage caused by collision between the magnetic rod sleeve and the reagent box.

[0005] Specifically, the utility model discloses a nucleic acid extraction instrument, comprising a housing, a magnetic rod module, a magnetic rod cover module and a base, characterized in that it also includes:

[0006] A power module, which is connected to the magnetic rod module and the magnetic rod sleeve module and controls their up and down movement and lateral movement;

[0007] A working platform, on which a test kit to be tested is placed, and the working platform has a heating component for providing heat energy to the test kit and a limiting component for limiting the movement of the test kit; wherein,

[0008] The working platform is connected to the base through a supporting portion. The bottom surface of the working platform is provided with a transversely arranged sliding groove. The upper surface of the supporting portion is provided with a roller matching the sliding groove. The working platform is slidably connected to the roller.

[0009] Furthermore, several reset components are provided between the working platform and the shell. The reset components are reset springs. The reset springs are provided on both sides of the working platform, and the axial direction of the reset spring is consistent with the movement direction of the working platform. One end of the reset spring is connected to the first clamping part of the working platform, and the other end is connected to the second clamping part of the shell.

[0010] Furthermore, the heating assembly is provided with two groups, including a heat insulation plate and a plurality of heating plates, the plurality of heating plates are installed in the placement grooves of the working platform, the heat insulation plate is arranged above the heating plate and has a through hole allowing the heating plate to pass through.

[0011] Furthermore, the limit assembly includes a limit block, a plunger ball and a compression spring. The limit block is arranged on both sides of the test kit, the plunger ball is arranged in the mounting hole of the limit block, one end of the compression spring is connected to the mounting hole, and the other end is connected to the plunger ball.

[0012] Furthermore, the magnetic bar module includes a magnetic bar mounting frame and a magnetic bar connected to the magnetic bar mounting frame.

[0013] Furthermore, the magnetic rod sleeve module includes a magnetic rod sleeve mounting frame, a magnetic rod sleeve connected to the magnetic rod sleeve mounting frame, and a vibrator. The magnetic rod sleeve is plugged into the magnetic rod sleeve mounting frame through a plug-in plate, and the vibrator is connected to the magnetic rod sleeve mounting frame.

[0014] Furthermore, the power module includes a first motor, a second motor, a third motor and a driving support frame. The first motor is arranged on one side of the driving support frame and is connected to the driving support frame through a first transmission assembly. The second motor is arranged on the driving support frame and is connected to the magnetic rod module through a second transmission assembly. The third motor is arranged on the driving support frame and is connected to the magnetic rod sleeve module through a third transmission assembly.

[0015] The beneficial effects of the present invention are:

[0016] When the displacement accuracy of the magnetic rod sleeve module is incorrect, causing the magnetic rod sleeve module to interfere with the opening of the reagent reagent box, the magnetic rod sleeve module will offset the working platform by a certain distance, allowing the magnetic rod sleeve module to smoothly enter the reagent reagent box, thereby avoiding damage caused by collision between the magnetic rod sleeve and the reagent reagent. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art.

[0018] Figure 1 This is a schematic diagram of a nucleic acid extraction instrument;

[0019] Figure 2 This is a top view of the nucleic acid extraction instrument;

[0020] Figure 3 This is a cross-sectional view of the nucleic acid extraction instrument in the direction of A;

[0021] Figure 4 This is a schematic diagram of the internal structure of the nucleic acid extraction instrument;

[0022] Figure 5 This is a schematic diagram of the interior of the nucleic acid extraction instrument from another perspective;

[0023] Figure 6 This is a bottom view of the internal perspective of the nucleic acid extraction instrument;

[0024] Figure 7 This is a partial enlarged view of the reset component of the nucleic acid extraction instrument;

[0025] Figure 8 This is a partial enlarged view of the heating component of the nucleic acid extraction instrument;

[0026] Figure 9 This is a partial enlarged view of the assembly of the nucleic acid extraction instrument working platform;

[0027] Figure 10 This is a schematic diagram of the limiting component of the nucleic acid extraction instrument;

[0028] Figure 11 This is a cross-sectional view of the limiting component of the nucleic acid extractor.

[0029] The numbers involved in the accompanying drawings are as follows: shell 1, support part 101, roller 102, second clamping part 103, magnetic rod module 2, magnetic rod mounting frame 21, magnetic rod 22, magnetic rod sleeve module 3, magnetic rod sleeve mounting frame 31, magnetic rod sleeve 32, vibrator 33, plug plate 34, base 4, power module 5, first motor 51, first transmission assembly 52, second motor 53, second transmission assembly 54, third motor 55, third transmission assembly 56, drive support frame 57, limit plate 58, limit hole 581, working platform 6, slide 61, first clamping part 62, placement slot 63, reagent box 7, heating assembly 8, heat insulation board 81, through hole 811, heating plate 82, limit assembly 9, limit block 91, mounting hole 911, plunger bumper 92, compression spring 93, limit baffle 94, return spring 10. DETAILED DESCRIPTION

[0030] The present invention will be further described in detail below with reference to the accompanying drawings.

[0031] like Figure 1-11 As shown, the utility model discloses a nucleic acid extraction instrument, comprising a housing 1, a magnetic rod module 2, a magnetic rod cover module 3 and a base 4, characterized in that it also includes:

[0032] Power module 5, which is connected to magnetic rod module 2 and magnetic rod sleeve module 3, and controls their up and down movement and lateral movement;

[0033] A working platform 6 is provided on which a test kit 7 to be tested is placed. The working platform 6 has a heating component 8 for providing heat energy to the test kit 7 and a limiting component 9 for limiting the movement of the test kit 7; wherein,

[0034] The working platform 6 is connected to the base 4 through the support part 101. The bottom surface of the working platform 6 is provided with a transversely arranged slide groove 61. The upper surface of the support part 101 has a roller 102 matching the slide groove 61. The working platform 6 is slidably connected to the roller 102.

[0035] The power module 5 is connected to the magnetic rod module 2 and the magnetic rod sleeve module 3 and controls their movement, so that they enter the reagent box 7. When an error occurs in the displacement accuracy of the magnetic rod sleeve module 3, causing the magnetic rod sleeve module 3 to interfere with the opening of the reagent box 7, the magnetic rod sleeve module 3 will cause the working platform 6 to offset a certain distance, so that the magnetic rod sleeve module 3 can smoothly enter the reagent box 7, avoiding damage caused by collision between the magnetic rod sleeve 32 and the reagent box 7.

[0036] In some embodiments of the present invention, an alarm detection device can also be set on one side of the working platform 6. When the working platform 6 moves, the alarm detection device is triggered to remind the staff to adjust the equipment accuracy, thereby improving the stability and service life of the equipment.

[0037] In some embodiments of the present invention, a plurality of reset components are further provided between the work platform 6 and the housing 1. The reset components are reset springs 10. The reset springs 10 are provided on both sides of the work platform 6, and the axial direction of the reset springs 10 is consistent with the movement direction of the work platform 6. One end of the reset spring 10 is connected to the first clamping portion 62 of the work platform 6, and the other end is connected to the second clamping portion 103 of the housing 1. When the magnetic rod sleeve module 3 moves downward and interferes with the opening of the reagent box 7, the magnetic rod sleeve module 3 continues to move downward, applying a pushing force to the reagent box 7. The pushing force causes the work platform 6 to deflect, allowing the magnetic rod sleeve 32 to enter the reagent box 7. When the magnetic rod sleeve 32 moves upward and leaves the reagent box 7, the pushing force disappears, and the work platform 6 is reset.

[0038] In some embodiments of the present invention, the heating assembly 8 comprises two groups, including a heat shield 81 and a plurality of heating plates 82. The plurality of heating plates 82 are mounted in the placement slot 63 of the work platform 6. The heat shield 81 is positioned above the heating plates 82 and has through-holes 811 through which the heating plates 82 pass. The heating plates 82 heat the reagents in the reagent box 7, thereby increasing the speed at which the reagents release nucleic acids.

[0039] In some embodiments of the present invention, the limiting assembly 9 includes a limiting block 91, a plunger ball 92 and a compression spring 93. The limiting block 91 is provided on both sides of the reagent box 7. The plunger ball 92 is provided in the mounting hole 911 of the limiting block 91. One end of the compression spring 93 is connected to the mounting hole 911, and the other end is connected to the plunger ball 92. When the reagent box 7 is placed, the force of the compression spring 93 is overcome to provide downward pressure to the reagent box 7, so that the plunger ball 92 abuts against the reagent box 7, limiting the left and right movement of the reagent box 7. In addition, the limiting assembly 9 also includes a limiting baffle 94. The limiting baffle 94 is provided at both ends of the reagent box 7 and is connected to the upper surface of the working platform 6, which limits the forward and backward movement of the reagent box 7 and improves the positioning accuracy of the reagent box 7.

[0040] In some embodiments of the present invention, the magnetic bar module 2 includes a magnetic bar mounting frame 21 and a magnetic bar 22 connected to the magnetic bar mounting frame 21 .

[0041] In some embodiments of the present invention, the magnetic rod sleeve module 3 includes a magnetic rod sleeve mounting frame 31, a magnetic rod sleeve 32 connected to the magnetic rod sleeve mounting frame 31, and a vibrator 33. The magnetic rod sleeve 32 is plugged into the magnetic rod sleeve mounting frame 31 via an insert plate 34, and the vibrator 33 is connected to the magnetic rod sleeve mounting frame 31. When the vibrator 33 is activated, the magnetic rod sleeve 32 vibrates, which, when in contact with the reagent, can accelerate the efficiency of nucleic acid extraction.

[0042] In some embodiments of the present invention, the power module 5 includes a first motor 51, a second motor 53, a third motor 55, and a drive support frame 57. The first motor 51 is located on one side of the drive support frame 57 and is connected to the drive support frame 57 via a first transmission assembly 52. ​​The second motor 53 is located on the drive support frame 57 and is connected to the magnetic rod module 2 via a second transmission assembly 54. The third motor 55 is located on the drive support frame 57 and is connected to the magnetic rod sleeve module 3 via a third transmission assembly 56. The first motor 51 controls the drive support frame 57 to perform lateral reciprocating motion, the second motor 53 controls the magnetic rod module 2 to perform vertical reciprocating motion, and the third motor 55 controls the magnetic rod sleeve module 3 to perform vertical reciprocating motion. In addition, the drive support frame 57 is also connected to a limit plate 58. The limit plate 58 has a limit hole 581 that limits the vertical movement of the magnetic rod module 2 and the magnetic rod sleeve module 3, thereby improving the stability of the device operation.

[0043] For those skilled in the art, several modifications and improvements can be made without departing from the inventive concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention.

Claims

1. A nucleic acid extraction instrument, comprising a housing (1), a magnetic rod module (2), a magnetic rod cover module (3) and a base (4), characterized in that: Also includes: A power module (5), the power module (5) is connected to the magnetic rod module (2) and the magnetic rod sleeve module (3), and controls the vertical movement and lateral movement thereof; A working platform (6) is provided on which a reagent kit (7) to be tested is placed, and the working platform (6) has a heating component (8) for providing heat energy to the reagent kit (7) and a limiting component (9) for limiting the movement of the reagent kit (7); wherein, The working platform (6) is connected to the base (4) via a supporting portion (101); a transversely arranged sliding groove (61) is provided on the bottom surface of the working platform (6); a roller (102) matching the sliding groove (61) is provided on the upper surface of the supporting portion (101); and the working platform (6) is slidably connected to the roller (102).

2. The nucleic acid extraction instrument according to claim 1, characterized in that A plurality of reset components are further provided between the working platform (6) and the housing (1). The reset components are reset springs (10). The reset springs (10) are provided on both sides of the working platform (6), and the axial direction of the reset springs (10) is consistent with the movement direction of the working platform (6). One end of the reset spring (10) is connected to the first clamping portion (62) of the working platform (6), and the other end is connected to the second clamping portion (103) of the housing (1).

3. The nucleic acid extraction instrument according to claim 1, characterized in that The heating assembly (8) is provided with two groups, including a heat insulation plate (81) and a plurality of heating plates (82), wherein the plurality of heating plates (82) are installed in the placement groove (63) of the working platform (6), and the heat insulation plate (81) is arranged above the heating plate (82) and has a through hole (811) allowing the heating plate (82) to pass through.

4. The nucleic acid extraction instrument according to claim 1, characterized in that The limiting assembly (9) comprises a limiting block (91), a plunger ball (92) and a compression spring (93); the limiting block (91) is arranged on both sides of the reagent box (7); the plunger ball (92) is arranged in a mounting hole (911) of the limiting block (91); one end of the compression spring (93) is connected to the mounting hole (911), and the other end is connected to the plunger ball (92).

5. The nucleic acid extraction instrument according to claim 1, characterized in that The magnetic bar module (2) comprises a magnetic bar mounting frame (21) and a magnetic bar (22) connected to the magnetic bar mounting frame (21).

6. The nucleic acid extraction instrument according to claim 1, characterized in that The magnetic rod sleeve module (3) comprises a magnetic rod sleeve mounting frame (31), a magnetic rod sleeve (32) connected to the magnetic rod sleeve mounting frame (31), and a vibrator (33); the magnetic rod sleeve (32) is plugged into the magnetic rod sleeve mounting frame (31) via a plug-in plate (34); and the vibrator (33) is connected to the magnetic rod sleeve mounting frame (31).

7. The nucleic acid extraction instrument according to claim 1, characterized in that The power module (5) comprises a first motor (51), a second motor (53), a third motor (55) and a driving support frame (57); the first motor (51) is arranged on one side of the driving support frame (57) and is connected to the driving support frame (57) via a first transmission assembly (52); the second motor (53) is arranged on the driving support frame (57) and is connected to the magnetic rod module (2) via a second transmission assembly (54); the third motor (55) is arranged on the driving support frame (57) and is connected to the magnetic rod sleeve module (3) via a third transmission assembly (56).

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