Low-temperature preparation device for preparing refined cefditoren pivoxil

Abstract

The utility model discloses a low-temperature preparation device for preparing a cefditoren pivoxil refined product. The device comprises a mounting platform, wherein a first glass-lined reaction tank, a second glass-lined reaction tank, a high-level tank, an air compressor, a vacuum pump and a vacuum buffer tank are arranged at the top of the mounting platform; a centrifugal machine and a material filter are arranged below the mounting platform; the first glass-lined reaction tank is respectively communicated with the high-level tank and the second glass-lined reaction tank, and is communicated with the centrifugal machine through the material filter; the air compressor is respectively communicated with the second glass-lined reaction tank and the centrifugal machine through the air filter; the vacuum pump is communicated with the vacuum buffer tank; the vacuum buffer tank is also respectively communicated with the first glass-lined reaction tank and the high-level tank; the layout is compact; the production process is safe and reliable; the energy consumption is reduced; and the production efficiency of the refined cefditoren pivoxil is accelerated.

Description

Technical Field

[0001] The utility model relates to the technical field of production of refined cefditoren pivoxil, in particular to a low-temperature preparation device for preparing refined cefditoren pivoxil. Background Art

[0002] Cefditoren pivoxil refined product usually refers to the purified and processed cefditoren pivoxil raw material, which is an active ingredient used to produce cefditoren pivoxil pharmaceutical preparations (such as tablets, capsules, etc.).

[0003] The preparation of the refined cefditoren pivoxil mainly uses hydrochloric acid solution, hypromellose, cefditoren pivoxil and ammonia water as raw materials, and is obtained through multiple steps such as solution preparation, solution cooling, raw material dissolution, filtration, crystallization and washing. Utility Model Content

[0004] The technical problem to be solved by the utility model is to provide a low-temperature preparation device for preparing a refined product of cefditoren pivoxil, so as to accelerate the production efficiency of the refined product of cefditoren pivoxil.

[0005] The technical solutions adopted are:

[0006] A low-temperature preparation device for preparing a refined product of cefditoren pivoxil, the device comprising an installation platform, a first glass-lined reaction tank, a second glass-lined reaction tank, a high-position tank, an air compressor, a vacuum pump, and a vacuum buffer tank are arranged on the top of the installation platform; a centrifuge and a material filter are arranged below the installation platform;

[0007] The first glass-lined reaction tank is connected to the high-level tank and the second glass-lined reaction tank respectively, and is connected to the centrifuge through the material filter;

[0008] The air compressor is connected to the second glass-lined reaction tank and the centrifuge respectively through an air filter;

[0009] The vacuum pump is connected to the vacuum buffer tank, and the vacuum buffer tank is also connected to the first glass-lined reaction tank and the high-level tank respectively.

[0010] In a further preferred embodiment of the technical solution of the present invention, the first glass-lined reaction tank includes a first glass-lined reaction tank body and a first glass-lined reaction tank cover. The first glass-lined reaction tank cover is disposed on the top of the first glass-lined reaction tank body to form a first glass-lined reaction tank inner cavity with the first glass-lined reaction tank body. The first glass-lined reaction tank inner cavity is provided with a first stirring device. A first motor is provided on the top of the first glass-lined reaction tank cover. An output shaft of the first motor passes through the first glass-lined reaction tank cover and is connected to the first stirring device.

[0011] The top of the first glass-lined reaction tank lid is further provided with a first thermometer, a vacuum pipe connection port, a first titrator, and a second glass-lined reaction tank connection port, all of which are connected to the inner cavity of the first glass-lined reaction tank. The vacuum buffer tank is connected to the first glass-lined reaction tank via the vacuum pipe connection port, the overhead tank is connected to the first glass-lined reaction tank via the first titrator, and the second glass-lined reaction tank is connected to the first glass-lined reaction tank via the second glass-lined reaction tank connection port. A first glass-lined reaction tank discharge port is provided at the bottom of the first glass-lined reaction tank, and the first glass-lined reaction tank discharge port is connected to the overhead tank and the material filter via different pipes. The first glass-lined reaction tank is used to prepare an ammonia solution for producing a refined product of cefditoren pivoxil. After the ammonia solution is prepared, the ammonia solution is transferred to the overhead tank, and the liquid in the second glass-lined reaction tank is transferred to the first glass-lined reaction tank and combined with the ammonia solution in the overhead tank for titration and neutralization to precipitate crystals and form a suspension solution.

[0012] In a further preferred embodiment of the technical solution of the present invention, the second glass-lined reaction tank includes a second glass-lined reaction tank body and a second glass-lined reaction tank cover. The second glass-lined reaction tank cover is arranged on the top of the second glass-lined reaction tank body to form a second glass-lined reaction tank inner cavity with the second glass-lined reaction tank body. A second stirring device is provided in the second glass-lined reaction tank inner cavity. A second motor is provided on the top of the second glass-lined reaction tank cover. The second motor passes through the second glass-lined reaction tank cover and is connected to the second stirring device.

[0013] The top of the second glass-lined reaction tank cover is also provided with a second glass-lined reaction tank feed port, a second thermometer, a pressure gauge, a second glass-lined reaction tank air inlet, and a second titrator, all of which are connected to the inner cavity of the second glass-lined reaction tank. The air filter is connected to the second glass-lined reaction tank through the second glass-lined reaction tank air inlet. The bottom of the second glass-lined reaction tank is also provided with a second glass-lined reaction tank discharge port, which is connected to the first glass-lined reaction tank through a pipeline. The second glass-lined reaction tank is used to prepare hydrochloric acid solution, and simultaneously dissolves hypromellose and cefditoren pivoxil in the prepared hydrochloric acid solution.

[0014] In a further preferred embodiment of the technical solution of the present invention, a pipeline filter is provided in the pipeline connecting the second glass-lined reaction tank and the first glass-lined reaction tank, and is used to filter out impurities in the solution in the second glass-lined reaction tank.

[0015] In a further optimization of the technical solution of the present invention, the outer sides of the first glass-lined reaction tank and the second glass-lined reaction tank are respectively provided with interlayers, which are connected to an external water cooling device; they are used to control the temperature of the solution in the first glass-lined reaction tank and the second glass-lined reaction tank to ensure stability during the production process.

[0016] Further preferred embodiment of the technical solution of the present utility model, the centrifuge includes a body and a cover, the cover is hinged at the top of the body, and forms a centrifuge inner cavity with the body, and the top of the cover is provided with a centrifuge feed port, a centrifuge air inlet and a washing port, all of which are connected to the centrifuge inner cavity, the centrifuge feed port is connected to the material filter, the centrifuge air inlet is connected to the air filter, and the bottom of the centrifuge is provided with a drain port; it is used to separate the crystals and the solution of the suspension transferred from the first glass-lined reaction tank.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] 1. The utility model filters the liquid and air in the first glass-lined reaction tank, the second glass-lined reaction tank and the centrifuge through an air filter, a pipe filter and a material filter to ensure the purity of the refined cefditoren pivoxil produced.

[0019] 2. The present invention controls the temperature inside the first and second glass-lined reaction tanks by using an external water cooling device in conjunction with the interlayer on the outer sides of the first and second glass-lined reaction tanks in combination with the first and second thermometers, thereby ensuring the quality of the produced refined cefditoren pivoxil and the safety of the production process.

[0020] 3. The utility model utilizes the cooperation of a vacuum pump, a vacuum buffer tank and an air compressor to realize the transfer of solutions in different tanks. No additional pump is used to transfer the solutions, which reduces energy consumption, reduces the floor space occupied by the equipment, saves manpower and improves production efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is an axonometric view of the overall structure of this embodiment;

[0022] Figure 2 This is a rear view of the overall structure of this embodiment;

[0023] Explanation of the accompanying symbols: 1-installation platform, 2-first glass-lined reaction tank, 3-second glass-lined reaction tank, 4-high-level tank, 5-centrifuge, 6-air compressor, 7-air filter, 8-material filter, 9-vacuum pump, 10-vacuum buffer tank, 21-first thermometer, 22-first titrator, 31-second thermometer, 32-pressure gauge, 33-second titrator. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical solutions and advantages of this utility model more clear, the following Figure 1-2 And embodiments, the utility model is further described in detail. Example

[0025] like Figure 1-2As shown, a low-temperature preparation device for preparing a refined product of cefditoren pivoxil in this embodiment includes an installation platform 1, on the top of which are respectively provided a first glass-lined reaction tank 2, a second glass-lined reaction tank 3, a high-level tank 4, an air compressor 6, an air filter 7, a vacuum pump 9 and a vacuum buffer tank 10; a centrifuge 5 and a material filter 8 are provided below the installation platform 1.

[0026] The first glass-lined reaction tank 2 is communicated with the high-level tank 4 and the second glass-lined reaction tank 3 respectively, and is communicated with the centrifuge 5 through the material filter 8 .

[0027] The air compressor 6 is connected to the second glass-lined reaction tank 3 and the centrifuge 5 through the air filter 7 respectively.

[0028] The vacuum pump 9 is connected to the vacuum buffer tank 10, and the vacuum buffer tank 10 is also connected to the first glass-lined reaction tank 2 and the high-level tank 4 respectively.

[0029] The mounting platform 1 is provided with mounting openings for the first glass-lined reaction tank 2 and the second glass-lined reaction tank 3 , respectively. The first glass-lined reaction tank 2 and the second glass-lined reaction tank 3 are respectively mounted at the mounting openings through mounting seats.

[0030] Half of the first glass-lined reaction tank 2 and the second glass-lined reaction tank 3 are above the installation platform 1 , and half are below the installation platform 1 .

[0031] The first glass-lined reaction tank 2 includes a first glass-lined reaction tank body and a first glass-lined reaction tank cover. The first glass-lined reaction tank cover is arranged on the top of the first glass-lined reaction tank body, and together with the first glass-lined reaction tank body, forms an inner cavity of the first glass-lined reaction tank 2. The inner cavity of the first glass-lined reaction tank 2 is provided with a first stirring device, and the top of the first glass-lined reaction tank cover is provided with a first motor. The output shaft of the motor passes through the first glass-lined reaction tank cover and is connected to the first stirring device.

[0032] like Figure 2 As shown, the cover of the first glass-lined reactor is respectively provided with a vacuum pipe connection port, a second glass-lined reactor 3 connection port, a sight light port for the first glass-lined reactor 2, a sight glass port for the first glass-lined reactor 2, a first titration port, and a first thermometer 21. The vacuum pipe connection port is connected to the vacuum buffer tank 10 via a vacuum pipe. An external sight light can be connected to the first glass-lined reactor 2 via the sight light port for the first glass-lined reactor 2 for illumination, facilitating observation of the liquid in the first glass-lined reactor 2 through the sight glass port for the first glass-lined reactor 2. A first titrator 22 is provided at the first titration port. The first titrator 22 is connected to the header tank 4 for controlling the flow rate of the liquid from the header tank 4 to the first glass-lined reactor 2. The first thermometer 21 is used to monitor the temperature of the liquid in the first glass-lined reactor 2.

[0033] In this embodiment, the staff can also measure the pH value of the liquid in the first glass-lined reaction tank 2 through the sight light port.

[0034] A discharge port is provided at the bottom of the first glass-lined reaction tank 2, which is connected to the high-level tank 4 and the material filter 8 through different pipes. A control valve is provided at the discharge port to control whether to discharge the material.

[0035] In this embodiment, the volume of the first glass-lined reaction tank 2 is 500L.

[0036] The second glass-lined reaction tank 3 includes a second glass-lined reaction tank body and a second glass-lined reaction tank cover. The second glass-lined reaction tank cover is arranged on the top of the second glass-lined reaction tank body, and forms an inner cavity of the second glass-lined reaction tank 3 with the second glass-lined reaction tank body. A second stirring device is provided in the inner cavity of the second glass-lined reaction tank 3, and a second motor is provided on the top of the second glass-lined reaction tank cover. The second motor passes through the second glass-lined reaction tank cover and is connected to the second stirring device.

[0037] like Figure 2 As shown, the top of the second glass-lined reaction tank 3 is respectively provided with a second glass-lined reaction tank 3 feed port, a second titration port, a second glass-lined reaction tank 3 air inlet, a second glass-lined reaction tank 3 sight light port, a second glass-lined reaction tank 3 sight glass port, a pressure gauge 32 and a second thermometer 31. The second glass-lined reaction tank 3 feed port, the second titration port, the second glass-lined reaction tank 3 air inlet, the second glass-lined reaction tank 3 sight light port, the second glass-lined reaction tank 3 sight glass port, the pressure gauge 32 and the second thermometer 31 are respectively connected to the inner cavity of the second glass-lined reaction tank 3. An external sight light can be connected to the second glass-lined reaction tank 3 through the sight glass port of the second glass-lined reaction tank 3 for lighting, so that the staff can observe the situation of the liquid in the second glass-lined reaction tank 3 through the sight glass port of the second glass-lined reaction tank 3; the air inlet of the second glass-lined reaction tank 3 is connected to the air filter 7 through a pipe, so that the air compressor 6 is connected to the second glass-lined reaction tank 3; a second titrator 33 is provided at the second titration port, and the second titrator 33 is connected to an external pipe for controlling the flow rate of adding liquid to the second glass-lined reaction tank 3.

[0038] The second thermometer 31 is used to monitor the temperature of the liquid in the second glass-lined reaction tank 3 , and the pressure gauge 32 is used to monitor the internal pressure in the second glass-lined reaction tank 3 .

[0039] In this embodiment, the staff can also measure the pH value of the liquid in the second glass-lined reaction tank 3 through the sight glass port of the second glass-lined reaction tank 3 .

[0040] A second glass-lined reactor 3 discharge port is provided at the bottom of the second glass-lined reactor 3 . A control valve is provided at the discharge port. The discharge port is connected to the second glass-lined reactor 3 connection port on the cover of the first glass-lined reactor 3 via a liquid infusion tube. A pipeline filter is provided at one end of the liquid infusion tube to filter out impurities in the solution discharged from the first glass-lined reactor 2 .

[0041] In this embodiment, the volume of the second glass-lined reaction tank 3 is 300L.

[0042] In this embodiment, the outer sides of the first glass-lined reaction tank 2 and the second glass-lined reaction tank 3 are respectively provided with interlayers, and the interlayers are respectively provided with a water outlet and a water inlet. The water outlet and the water inlet are respectively connected to an external water cooling device through pipes, so as to reduce the temperature in the first glass-lined reaction tank 2 and the second glass-lined reaction tank 3 through water circulation.

[0043] In this embodiment, the high-position tank 4 is arranged on the left side of the first glass-lined reaction tank 2 and is fixed to the top of the installation platform 1 by a high-position tank 4 fixing frame, with a certain height difference from the first glass-lined reaction tank 2.

[0044] In this embodiment, the centrifuge 5 includes a body and a cover. The cover is hinged at the top of the body to form an inner cavity of the centrifuge 5 with the body. The top of the cover is provided with a centrifuge 5 feed port, a centrifuge 5 air inlet and a washing port, all of which are connected to the inner cavity of the centrifuge 5. The centrifuge 5 feed port is connected to the material filter 8, and the liquid discharged from the first glass-lined reaction tank 2 is filtered by the material filter 8 to remove impurities and then flows into the centrifuge 5. The centrifuge 5 air inlet is connected to the air filter 7, and a drain port is provided at the bottom of the centrifuge 5.

[0045] This embodiment provides a low-temperature preparation device for preparing a refined product of cefditoren pivoxil, and the specific method of use is as follows:

[0046] First, prepare a hydrochloric acid solution in the second glass-lined reaction tank 3: connect one end of a pipe to the feed port of the second glass-lined reaction tank 3, and connect the other end of the pipe to a pure water pipe. Then, inject pure water into the second glass-lined reaction tank 3. Then, connect the second titrator 33 to the external hydrochloric acid pipe, and inject hydrochloric acid into the second glass-lined reaction tank 3. During this process, the pH value of the hydrochloric acid solution can be measured by a pH measuring instrument through the sight glass port of the second glass-lined reaction tank 3 until the appropriate concentration of the hydrochloric acid solution is prepared.

[0047] Turn on the second motor to drive the second stirring device to rotate, add hypromellose and cefditoren pivoxil from the feed port of the second glass-lined reaction tank 3, the second stirring device accelerates the dissolution of hypromellose and cefditoren pivoxil, turn on the external water cooling device, use the water cooling device to inject chilled water into the interlayer, and use water circulation to reduce the temperature of the solution in the second glass-lined reaction tank 3 until it drops below 5°C.

[0048] Prepare an ammonia solution in the first glass-lined reaction tank 2 in the same manner as the hydrochloric acid solution. Connect the discharge port of the first glass-lined reaction tank 2 and the overhead tank 4 via a pipeline. After the temperature drops below 5°C, start the vacuum pump 9. After the vacuum gauge of the vacuum buffer tank 10 reaches above 0.09 MPa, open the control valve at the discharge port of the first glass-lined reaction tank 2 and use the vacuum to move the ammonia solution to the overhead tank 4.

[0049] Open the air compressor 6 and the control valve at the discharge port of the second glass-lined reaction tank 3 to filter the prepared solution in the second glass-lined reaction tank 3 and transfer it to the first glass-lined reaction tank 2 through the infusion tube. Use the pressure gauge 32 to monitor the pressure changes inside the second glass-lined reaction tank 3 during the whole process.

[0050] The ammonia solution in the high-level tank 4 is adjusted in flow rate by the first titrator 22 and flows into the first glass-lined reaction tank 2. During the entire process, the temperature in the first glass-lined reaction tank 2 is controlled at 0-5°C. The first stirring device, driven by the first motor, mixes the ammonia solution and the solution in the first glass-lined reaction tank 2, causing the refined cefditoren pivoxil to slowly crystallize and precipitate. At this time, the first glass-lined reaction tank 2 is a suspension containing crystals.

[0051] At this time, the discharge port of the first glass-lined reaction tank 2 and the material filter 8 are connected by a pipeline. The control valve at the discharge port of the first glass-lined reaction tank 2 is opened. Under the action of gravity, the suspension in the first glass-lined reaction tank 2 is filtered through the material filter 8 to remove impurities and then transferred to the centrifuge 5. Centrifugation is performed to separate the solution and crystals. The solution is discharged through the liquid outlet of the centrifuge 5, leaving the crystals inside the centrifuge 5.

[0052] The washing port of the centrifuge 5 is connected to an external pure water pipeline to wash the crystals.

[0053] The above embodiments are only for illustrating the technical idea of ​​the present invention and cannot be used to limit the protection scope of the present invention. Any changes made on the basis of the technical solution in accordance with the technical idea proposed by the present invention shall fall within the protection scope of the present invention.

Claims

1. A low-temperature preparation device for preparing a refined product of cefditoren pivoxil, characterized in that: The device comprises an installation platform (1), wherein a first glass-lined reaction tank (2), a second glass-lined reaction tank (3), a high-level tank (4), an air compressor (6), a vacuum pump (9) and a vacuum buffer tank (10) are provided on the top of the installation platform (1); a centrifuge (5) and a material filter (8) are provided below the installation platform (1); The first glass-lined reaction tank (2) is connected to the high-level tank (4) and the second glass-lined reaction tank (3), and is connected to the centrifuge (5) through the material filter (8); The air compressor (6) is connected to the second glass-lined reaction tank (3) and the centrifuge (5) respectively through the air filter (7); The vacuum pump (9) is connected to the vacuum buffer tank (10), and the vacuum buffer tank (10) is also connected to the first glass-lined reaction tank (2) and the high-level tank (4).

2. The low-temperature preparation device for preparing a refined product of cefditoren pivoxil according to claim 1, characterized in that: The first glass-lined reaction tank (2) comprises a first glass-lined reaction tank body and a first glass-lined reaction tank cover, the first glass-lined reaction tank cover is arranged on the top of the first glass-lined reaction tank body, and forms an inner cavity of the first glass-lined reaction tank (2) with the first glass-lined reaction tank body, the inner cavity of the first glass-lined reaction tank (2) is provided with a first stirring device, the top of the first glass-lined reaction tank cover is provided with a first motor, and the output shaft of the first motor passes through the first glass-lined reaction tank cover and is connected to the first stirring device; The top of the first glass-lined reaction tank cover is also provided with a first thermometer (21), a vacuum pipe connection port, a first titrator (22) and a second glass-lined reaction tank (3) connection port, all of which are connected to the inner cavity of the first glass-lined reaction tank (2). The vacuum buffer tank (10) is connected to the first glass-lined reaction tank (2) through the vacuum pipe connection port, the high-level tank (4) is connected to the first glass-lined reaction tank (2) through the first titrator (22), and the second glass-lined reaction tank (3) is connected to the first glass-lined reaction tank (2) through the second glass-lined reaction tank (3) connection port. The bottom of the first glass-lined reaction tank (2) is provided with a first glass-lined reaction tank (2) discharge port, and the first glass-lined reaction tank (2) discharge port is connected to the high-level tank (4) and the material filter (8) through different pipes.

3. A low-temperature preparation device for preparing a refined product of cefditoren pivoxil according to claim 2, characterized in that: The second glass-lined reaction tank (3) comprises a second glass-lined reaction tank body and a second glass-lined reaction tank cover, the second glass-lined reaction tank cover is arranged on the top of the second glass-lined reaction tank body, and forms an inner cavity of the second glass-lined reaction tank (3) with the second glass-lined reaction tank body, a second stirring device is provided in the inner cavity of the second glass-lined reaction tank (3), a second motor is provided on the top of the second glass-lined reaction tank cover, and the second motor passes through the second glass-lined reaction tank cover and is connected to the second stirring device; The top of the second glass-lined reaction tank cover is also provided with a second glass-lined reaction tank (3) feed port, a second thermometer (31), a pressure gauge (32), a second glass-lined reaction tank (3) air inlet, and a second titrator (33), all of which are connected to the inner cavity of the second glass-lined reaction tank (3). The air filter (7) is connected to the second glass-lined reaction tank (3) through the second glass-lined reaction tank (3) air inlet. The bottom of the second glass-lined reaction tank (3) is also provided with a second glass-lined reaction tank (3) discharge port, and the second glass-lined reaction tank (3) discharge port is connected to the first glass-lined reaction tank (2) through a pipeline.

4. A low-temperature preparation device for preparing a refined product of cefditoren pivoxil according to claim 3, characterized in that: A pipeline filter is provided in the pipeline connecting the second glass-lined reaction tank (3) and the first glass-lined reaction tank (2).

5. The low-temperature preparation device for preparing a refined product of cefditoren pivoxil according to claim 1, characterized in that: The outer sides of the first glass-lined reaction tank (2) and the second glass-lined reaction tank (3) are respectively provided with interlayers, and the interlayers are connected to an external water cooling device.

6. The low-temperature preparation device for preparing a refined product of cefditoren pivoxil according to claim 1, characterized in that: The centrifuge (5) includes a body and a cover. The cover is hinged to the top of the body and forms an inner cavity of the centrifuge (5) with the body. The top of the cover is provided with a centrifuge (5) feed port, a centrifuge (5) air inlet and a washing port, all of which are connected to the inner cavity of the centrifuge (5). The centrifuge (5) feed port is connected to the material filter (8), the centrifuge (5) air inlet is connected to the air filter (7), and a drain port is provided at the bottom of the centrifuge (5).

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