Flow cell pressure relief device applied to liquid chromatograph

Abstract

The utility model provides a flow cell pressure relief device applied to a liquid chromatograph, and relates to the technical field of analytical instruments, the flow cell pressure relief device comprises a mobile phase, an infusion pump, a sample injector, a column oven, a detector and a work station, through a designed pressure relief protection assembly, the situation that a flow cell is broken due to overpressure caused by pipeline blockage or bending can be avoided, and the flow cell pressure relief device can be applied to a liquid chromatograph. And the working efficiency of the liquid chromatograph can be ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of analytical instruments, in particular to a flow cell pressure relief device applied to a liquid chromatograph. Background Art

[0002] The flow cell with pressure-resistant light detection can be used in analysis systems such as high performance liquid chromatography (HPLC), ultra-high performance liquid chromatography (UPLC) and flow injection analysis (FIA). As a key part of the flow analysis system, the flow cell is crucial to the performance of the entire analysis and monitoring system. The flow cells used by Shimadzu, Agilent, Thermo Fisher, and Wanyi have a pressure resistance of 2 MPa, while the flow cells used by Hitachi and Waters have a pressure resistance of 1 MPa. In order to avoid blockage in the flow cell, the diameter of the flow cell's rear pipe is usually designed to be larger than the inner wall pipe of the flow cell to avoid problems such as excessive pressure and blockage. The designed flow cell's rear pipe is often longer to ensure that the flow cell's rear pipe has a certain pressure maintenance, so that the flow rate of the test sample that has been layered after the chromatographic column flowing through the flow cell is in a stable state in the flow analysis system, so as to ensure normal peak broadening.

[0003] However, after long-term use of the existing circulation pool, there is still a problem of blockage in the pipeline behind the circulation pool, or the end of the circulation pool occasionally breaks during operation. The above situations will cause the pressure of the circulation pool to exceed its pressure resistance value, thereby causing the circulation pool to break due to overpressure. After the circulation pool breaks, the liquid chromatograph needs to be repaired and replaced before it can be used normally. Replacing the circulation pool is expensive and takes a certain amount of time, which affects the working efficiency of the liquid chromatograph. Utility Model Content

[0004] The purpose of the utility model is to provide a circulation cell pressure relief device for liquid chromatographs to alleviate the technical problem that when the pipeline behind the existing circulation cell is blocked or the end is broken, the pressure in the circulation cell exceeds its pressure resistance value, thereby causing the circulation cell to be over-pressured and broken, affecting the working efficiency of the liquid chromatograph.

[0005] The utility model provides a flow cell pressure relief device for a liquid chromatograph, comprising:

[0006] Infusion pumps, detectors, waste bottles, and pressure relief protection components;

[0007] The detector includes a circulation pool, and the waste liquid of the circulation pool is transported to the waste liquid bottle through a post-pool pipeline;

[0008] The pressure relief protection component can divert the liquid at the front end of the bent or blocked part and discharge it to the waste liquid bottle when the rear pipeline of the circulation pool is bent or blocked, causing the pressure of the circulation pool to exceed the pressure resistance value.

[0009] In an alternative embodiment,

[0010] The detector further comprises a light source and a photoelectric detection element respectively installed on both sides of the circulation cell. The light source provides light radiation to the circulation cell, and the photoelectric detection element absorbs the light radiation of the light source after passing through the circulation cell.

[0011] In an alternative embodiment,

[0012] The pressure relief protection assembly includes a three-way valve, one of the ports of the three-way valve is connected to a valve component, and a first connecting pipe is fixedly provided between the other end of the valve component and the waste liquid bottle, and a second connecting pipe and a third connecting pipe are also fixedly provided between the remaining two ports of the three-way valve and the post-pool pipeline of the circulation pool and the waste liquid bottle.

[0013] In an alternative embodiment,

[0014] The valve component is a pressure relief valve, which guides the waste liquid to be discharged.

[0015] In an alternative embodiment,

[0016] The valve component is a solenoid valve, and a pressure gauge is installed in the front pipeline of the circulation pool. The pressure gauge is used to detect the pressure of the circulation pool.

[0017] In an alternative embodiment,

[0018] The input end of the infusion pump is fixedly connected to a mobile phase, and the output end of the infusion pump is fixedly connected to an injector. The infusion pump is used to suck the sample to be detected in the mobile phase and transport it to the injector.

[0019] In an alternative embodiment,

[0020] A column temperature box is fixedly installed between the output end of the sample injector and the front pipeline of the circulation pool.

[0021] In an alternative embodiment,

[0022] The sample injector is a manual sample injector or an automatic sample injector.

[0023] In an alternative embodiment,

[0024] A chromatographic column is fixedly installed inside the column oven, and the chromatographic column is used to separate and purify the sample to be detected.

[0025] In an alternative embodiment,

[0026] The diameter of the first communicating tube is greater than the diameter of the second communicating tube.

[0027] Compared with the prior art, the beneficial effects of the present invention are:

[0028] The utility model provides a circulation pool pressure relief device applied to a liquid chromatograph. Through the designed pressure relief protection component, the circulation pool can be prevented from being broken by overpressure due to pipe blockage or bending, thereby ensuring the working efficiency of the liquid chromatograph. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the specific implementation methods of the utility model or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0030] Figure 1 This is a schematic diagram of the structure of the passive pressure relief solution of the circulation pool of the utility model;

[0031] Figure 2 This is a schematic diagram of the structure of the active pressure relief solution of the circulation pool of the utility model.

[0032] Icons: 1-mobile phase; 2-infusion pump; 3-injector; 4-column oven; 401-chromatographic column; 5-detector; 501-light source; 502-circulation cell; 503-photoelectric detection element; 6-three-way valve; 7-workstation; 8-waste bottle; 9-pressure relief valve; 10-solenoid valve; 11-pressure gauge. DETAILED DESCRIPTION

[0033] The following is a clear and complete description of the technical solution of the present invention in conjunction with the accompanying drawings. Obviously, the embodiments described are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0034] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating positions or relationships, are based on the positions or relationships shown in the accompanying drawings and are intended solely to facilitate the description of this utility model and simplify the description. They do not indicate or imply that the devices or components referred to must have a specific orientation, be constructed, or operate in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0035] In the description of this utility model, it should be noted that, unless otherwise expressly specified or limited, the terms "installed," "connected," and "connected" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integral connections; mechanical connections, electrical connections; direct connections, indirect connections through an intermediate medium, and internal communication between two components. Those skilled in the art will understand the specific meanings of the above terms in this utility model based on specific circumstances.

[0036] The following is a detailed description of the specific embodiments of the present invention in conjunction with the accompanying drawings. It should be understood that the specific embodiments described herein are only used to illustrate and explain the present invention and are not intended to limit the present invention.

[0037] Example 1

[0038] See also Figure 1 — Figure 2 , this embodiment provides a flow cell pressure relief device for a liquid chromatograph, comprising:

[0039] Infusion pump 2, detector 5, waste liquid bottle 8, and pressure relief protection component;

[0040] The detector 5 includes a circulation pool 502, and the waste liquid of the circulation pool 502 is transported to the waste liquid bottle 8 through the pipeline after the pool;

[0041] The pressure relief protection component can divert the liquid at the front end of the bent or blocked part to the waste liquid bottle 8 when the pipeline behind the circulation pool 502 is bent or blocked, causing the pressure of the circulation pool 502 to exceed the pressure resistance value.

[0042] The utility model provides a circulation pool pressure relief device for liquid chromatographs. Through the designed pressure relief protection component, the circulation pool 502 can be prevented from being broken by overpressure due to pipe blockage or bending, thereby ensuring the working efficiency of the liquid chromatograph.

[0043] Based on the above embodiment, the detector 5 in the flow cell pressure relief device for liquid chromatograph provided in this embodiment further includes a light source 501 and a photoelectric detection element 503 respectively installed on both sides of the flow cell 502. The light source 501 provides light radiation to the flow cell 502, and the photoelectric detection element 503 absorbs the light radiation of the light source 501 after it passes through the flow cell 502.

[0044] The light source 501 emits light of a specific wavelength. The compounds in the sample absorb the light radiation to different degrees, causing the light intensity to change. The photoelectric detection element 503 receives the changed light radiation and converts it into an electrical signal and transmits it to the workstation 7.

[0045] The pressure relief protection assembly includes a three-way valve 6, one of the ports of the three-way valve 6 is connected to a valve component, and a first connecting pipe is fixedly provided between the other end of the valve component and the waste liquid bottle 8, and a second connecting pipe and a third connecting pipe are fixedly provided between the remaining two ports of the three-way valve 6 and the post-pool pipeline of the circulation pool 502 and the waste liquid bottle 8;

[0046] The three-way valve 6 can provide a pipeline for the valve component to facilitate the discharge of waste liquid after the circulation pool 502 is blocked. At the same time, when it is not blocked, the circulation pool 502 can also directly discharge waste liquid through one end of the three-way valve 6.

[0047] The valve component is a pressure relief valve 9, which guides the waste liquid to be discharged;

[0048] The pressure relief valve 9 is a passive pressure relief protection. The opening pressure of the pressure relief valve 9 is 1.9Mpa±0.1Mpa. Since the pressure resistance of the circulation pool 502 is 2Mpa, the pressure relief valve 9 sets 1.9Mpa±0.1Mpa as its own opening pressure, thereby avoiding the overpressure and fragmentation of the circulation pool 502 due to pipeline blockage. At the same time, the pressure relief valve 9 has an opening detection device, which can prompt the user to check for faults after opening.

[0049] The input end of the infusion pump 2 is fixedly connected to the mobile phase 1, and the output end of the infusion pump 2 is fixedly connected to the injector 3. The infusion pump 2 is used to suck the sample to be tested in the mobile phase 1 and transport it to the injector 3;

[0050] The infusion pump 2 meets the delivery requirements of the samples to be tested, and the sample injector 3 enables the samples to be delivered to the circulation pool 502 in batches for testing. By testing the samples in batches multiple times, the randomness of the test data is avoided and the test data is more convincing.

[0051] In addition, optionally, the infusion pump 2 can be equipped with an overpressure protection pump stop function. When the pressure sensor detects that the pressure is too high, the overpressure protection pump stop operation can be performed, which can avoid overpressure fracture caused by blockage inside the circulation pool to a certain extent.

[0052] A column oven 4 is fixedly installed between the output end of the sample injector 3 and the front pipeline of the circulation pool 502;

[0053] The placement of the column oven 4 provides a suitable temperature for the separation and purification of the sample to be detected, thereby improving the accuracy and repeatability of the analysis sample and ensuring the reliability of the analysis result.

[0054] The sample injector 3 is a manual sample injector or an automatic sample injector;

[0055] If the sample injector 3 is a manual sample injector, the manual sample injector is smaller in size and has less impact on the entire flow analysis system;

[0056] If the sample injector 3 is an automatic sample injector, the automatic sample injector can automatically complete the injection of the sample to be tested according to a pre-set program without manual intervention. The automatic sample injector has higher accuracy and repeatability.

[0057] The column oven 4 is fixedly equipped with a chromatographic column 401, which is used to separate and purify the sample to be tested;

[0058] The column oven 4 extends the service life of the chromatographic column 401 by stably controlling the operating temperature of the chromatographic column 401. The coordinated use of the column oven 4 and the chromatographic column 401 ensures the accuracy and repeatability of samples during liquid chromatography analysis.

[0059] The diameter of the first connecting pipe is greater than the diameter of the second connecting pipe;

[0060] The difference in diameter between the first connecting pipe and the second connecting pipe makes it easier for the waste liquid to flow through the first connecting pipe, the pressure relief valve 9 and finally be discharged into the waste liquid bottle 8 after the circulation pool 502 is blocked.

[0061] Working principle:

[0062] The staff first turns on the injector 3 and the detector 5, so that the light source 501 and the photoelectric detection element 503 are in working state, and finally turns on the infusion pump 2 to make it operate normally. Under the action of the infusion pump 2, the sample to be detected in the mobile phase 1 is transported to the inside of the injector 3 in batches, thereby realizing the injection of the sample to be detected. After the injection is completed, the sample to be detected flows along the pipeline to the chromatographic column 401 in the column oven 4. After the sample to be detected is separated and purified by the chromatographic column 401, it flows to the detector 5 for detection. The sample to be detected is injected into the interior of the circulation pool 502 from the front pipeline of the detector 5, and the light source 501 irradiates the sample inside the circulation pool 502. The photoelectric detection element 503 collects the light from the light source 501 through the sample inside the circulation pool 502 and processes it into an electrical signal. The photoelectric detection element 503 finally transmits the electrical signal to the workstation 7. After the sample detection is completed, the waste liquid generated flows out from the back pipeline of the circulation pool 502 and flows into the three-way valve 6 through the second connecting pipe.

[0063] If the pipeline after the circulation pool 502 is not blocked, the pipeline where the pressure relief valve 9 is located is reversely locked, and the waste liquid cannot be discharged from the first connecting pipe to the waste liquid bottle 8. At this time, the waste liquid is directly discharged into the waste liquid bottle 8 through the third connecting pipe;

[0064] If the pipeline behind the circulation pool 502 is blocked, after the pressure at the front end of the pressure relief valve 9 reaches 1.9Mpa±0.1Mpa, the pressure relief valve 9 will work and the waste liquid inside the circulation pool 502 will be discharged into the waste liquid bottle 8 through the second connecting pipe, the three-way valve 6, the pressure relief valve 9 and the first connecting pipe in sequence. At the same time, the opening detection device in the pressure relief valve 9 will operate to prompt the user to check the fault. After the current sample test is completed, the infusion pump 2 will stop working.

[0065] Example 2

[0066] See also Figure 2 , recorded in this embodiment are optional implementations of the pressure gauge 11 and the solenoid valve 10:

[0067] The valve component is a solenoid valve 10. A pressure gauge 11 is installed in the pipeline before the circulation pool 502. The pressure gauge 11 is used to detect the pressure of the circulation pool 502. The pressure in the circulation pool 502 is P.

[0068] When P≤2Mpa, the solenoid valve 10 is in a closed state;

[0069] When P>2Mpa, the solenoid valve 10 is in the open state;

[0070] The pressure gauge 11 is a micro pressure sensor with the characteristics of small size and pressure detection range of 0-5Mpa. The pressure gauge 11 monitors and senses the pressure in the circulation pool 502, thereby controlling the opening and closing of the normally closed solenoid valve 10.

[0071] In this embodiment:

[0072] The installed pressure gauge 11 continuously detects the pressure of the pipeline in front of the circulation pool 502. When the pressure gauge 11 detects that the pressure of the pipeline in front of the circulation pool 502 is greater than 2Mpa, the liquid chromatography analysis system will first open the normally closed solenoid valve 10, so that the waste liquid flows out from the pipeline where the normally closed solenoid valve 10 is located to the waste liquid bottle 8, and then control the infusion pump 2 to stop running.

[0073] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the above embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A flow cell pressure relief device for a liquid chromatograph, characterized in that: include: An infusion pump (2), a detector (5), a waste liquid bottle (8), and a pressure relief protection component; The detector (5) includes a circulation pool (502), and the waste liquid of the circulation pool (502) is transported to the waste liquid bottle (8) through a post-pool pipeline; The pressure relief protection component can divert and discharge the liquid at the front end of the bent or blocked part to the waste liquid bottle (8) when the pipeline behind the circulation pool (502) is bent or blocked, causing the pressure of the circulation pool (502) to exceed the pressure resistance value.

2. The pressure relief device for a flow cell used in a liquid chromatograph according to claim 1, characterized in that: The detector (5) further comprises a light source (501) and a photoelectric detection element (503) respectively mounted on both sides of the circulation pool (502), wherein the light source (501) provides light radiation to the circulation pool (502), and the photoelectric detection element (503) absorbs the light radiation of the light source (501) after passing through the circulation pool (502).

3. The flow cell pressure relief device for liquid chromatograph according to claim 2, characterized in that: The pressure relief protection assembly comprises a three-way valve (6), one of the ports of the three-way valve (6) is connected to a valve component, and a first connecting pipe is fixedly provided between the other end of the valve component and the waste liquid bottle (8), and a second connecting pipe and a third connecting pipe are fixedly provided between the remaining two ports of the three-way valve (6) and the post-pool pipeline of the circulation pool (502) and the waste liquid bottle (8).

4. The pressure relief device for a flow cell used in a liquid chromatograph according to claim 3, characterized in that: The valve component is a pressure relief valve (9), and the pressure relief valve (9) guides the waste liquid to be discharged.

5. The pressure relief device for a flow cell used in a liquid chromatograph according to claim 3, characterized in that: The valve component is a solenoid valve (10), and a pressure gauge (11) is installed in the pipeline in front of the circulation pool (502). The pressure gauge (11) is used to detect the pressure of the circulation pool (502).

6. The pressure relief device for a flow cell used in a liquid chromatograph according to claim 1, characterized in that: The input end of the infusion pump (2) is fixedly connected to a mobile phase (1), and the output end of the infusion pump (2) is fixedly connected to an injector (3). The infusion pump (2) is used to suck the sample to be detected in the mobile phase (1) and transport it to the injector (3).

7. The pressure relief device for a flow cell used in a liquid chromatograph according to claim 6, characterized in that: A column temperature box (4) is fixedly installed between the output end of the sample injector (3) and the front pipeline of the circulation pool (502).

8. The pressure relief device for a flow cell used in a liquid chromatograph according to claim 6, characterized in that: The sample injector (3) is a manual sample injector or an automatic sample injector.

9. The pressure relief device for a flow cell used in a liquid chromatograph according to claim 7, characterized in that: A chromatographic column (401) is fixedly mounted inside the column oven (4), and the chromatographic column (401) is used to separate and purify samples to be detected.

10. The pressure relief device for a flow cell used in a liquid chromatograph according to claim 3, characterized in that: The diameter of the first communicating tube is greater than the diameter of the second communicating tube.

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