Biological sample storage box

Abstract

The biological sample storage box comprises a box body, a refrigeration module and a test tube rack module, the box body is provided with a box cover and a box body, the box cover is pivotally connected to the box body, a temperature control opening is formed in the first side wall of the box body, and the temperature control opening penetrates through the first side wall; the refrigeration module comprises a semiconductor refrigeration sheet, a heat dissipation piece, a cold conduction block and a draught fan, the cold conduction block is located in the box body, the heat dissipation piece is embedded in the temperature control opening, and the cold conduction block, the semiconductor refrigeration sheet, the heat dissipation piece and the draught fan are sequentially and tightly arranged from the interior of the box body to the exterior; a partition plate is arranged in the box body, the partition plate extends in the length direction of the box body and abuts against the first side wall and the second side wall of the box body so that the inner space of the box body can be divided into a first cavity and a second cavity, and the test tube rack module is detachably connected into the first cavity and is perpendicular to the bottom face of the box body. According to the scheme, the temperature of the biological sample can be prevented from being out of control in the transportation process.

Description

Technical Field

[0001] The present application relates to the field of biological sample storage, and in particular to a biological sample storage box. Background Art

[0002] Medical environments need to meet specific hygiene standards to reduce the risk of infection for patients and medical workers. For example, in medical procedures such as blood drawing, medical staff need to monitor the types and numbers of bacteria in the operating environment so that they can take targeted disinfection and protective measures to prevent the spread of pathogens and bacterial infections. Therefore, biological sampling in medical environments is of great significance. When conducting biological sampling in medical environments, operators usually use sterile cotton swabs to collect biological samples from the environment, then place them in sterile test tubes for sealing. The operator will then transport the sealed biological samples to the laboratory for detailed analysis.

[0003] However, the current operating procedures for biological samples, from collection to transportation to the laboratory, lack effective cold chain management, which may lead to temperature loss during transportation, resulting in degradation of biological molecules in the samples, and ultimately affecting the laboratory's analysis results.

[0004] Therefore, in order to ensure that the conclusions obtained by the laboratory in biological sample analysis have higher accuracy, it is necessary to develop a biological sample storage box to solve these problems. Utility Model Content

[0005] The purpose of this application is to provide a biological sample storage box that can prevent the temperature of the sample from getting out of control during transportation.

[0006] To achieve the above-mentioned objectives, the present application provides, on the one hand, a biological sample storage box, comprising a box body, a refrigeration module and a test tube rack module, wherein the box body has a box cover and a box body, the box cover is pivotally connected to the box body, a temperature control port is provided on the first side wall of the box body, and the temperature control port passes through the first side wall; the refrigeration module comprises a semiconductor refrigeration plate, a heat sink, a cooling block and a fan, the cooling block is located inside the box body, the heat sink is embedded in the temperature control port and partially exposed to the first side wall, and the cooling block, the semiconductor refrigeration plate, the heat sink and the fan are arranged closely in sequence from the inside of the box body to the outside; a partition is provided inside the box body, the partition extends along the length direction of the box body and abuts against the first side wall and the second side wall of the box body to divide the internal space of the box body into a first chamber and a second chamber, the test tube rack module is detachably connected to the first chamber, and the test tube rack module is perpendicular to the bottom surface of the box body.

[0007] Furthermore, the test tube rack module includes a base, a bottle holding plate and a support frame, wherein one end of the support frame is connected to the base, and the other end of the support frame is connected to the bottle holding plate, the bottle holding plate is located above the base, and the bottle holding plate is parallel to the base; the base is a long strip plate structure, and the base is provided with a plurality of test tube holes, and the plurality of test tube holes are evenly distributed along the length direction of the base; the bottle holding plate has a plurality of clamping holes, the diameter of the clamping holes is the same as the diameter of the test tube holes, and the number of the clamping holes is the same as the number of the test tube holes, and a clamping hole is vertically arranged directly above each test tube hole.

[0008] Furthermore, the diameter of the clamping hole matches the diameter of the sampling test tube, and the clamping hole is provided with an auxiliary taking-and-placing notch, and the opening size of the auxiliary taking-and-placing notch is smaller than the diameter of the sampling test tube.

[0009] Furthermore, the support frame includes a plurality of support ribs, the length of the support ribs is smaller than the length of the sampling test tube, and there are four support ribs between each test tube hole and its corresponding clamping hole.

[0010] Furthermore, the heat sink includes heat fins and a substrate, wherein the substrate is recessed to one side to form a groove, the groove is embedded in the temperature control port, and the heat fins are fixed in the groove, and the fan is fitted with the heat fins; the semiconductor refrigeration sheet is arranged on a side away from the groove, and the semiconductor refrigeration sheet is fitted with the bottom of the groove.

[0011] Furthermore, a limiting plate is formed at the top of the groove, and the limiting plate is provided with screw holes so that the base plate can be fixed to the first side wall of the box body by bolt connection.

[0012] Furthermore, the refrigeration module also includes a thermal insulation plate, wherein the thermal insulation plate is provided with a accommodating hole, the shape of the accommodating hole is adapted to the shape of the semiconductor refrigeration plate, and the semiconductor refrigeration plate is clamped in the accommodating hole; one side of the thermal insulation plate is in contact with the bottom of the groove, and the other side of the thermal insulation plate is in contact with the cooling block, and the cooling block covers the accommodating hole.

[0013] Furthermore, the inner wall of the box cover and the inner wall of the box body are both covered with an insulation board, and the insulation board is provided with a metal coating, and the metal coating contains aluminum ions or silver ions.

[0014] Furthermore, a temperature sensor is provided inside the box body, and the temperature sensor is used to detect the temperature of the internal space of the box body.

[0015] Furthermore, a pull ring is respectively provided on the first side wall of the box body and the second side wall of the box body, and the pull ring is used to connect the shoulder strap.

[0016] It can be seen that the solution provided by the present application is that the biological sample storage box is composed of a box body, a refrigeration module and a test tube rack module. The refrigeration module contains a semiconductor refrigeration plate, which can absorb heat on one side (called the cooling surface) and release heat on the other side (called the heat dissipation surface) through the Peltier effect. In the present application, a temperature control port is provided on one side of the box body, and the heat sink in the refrigeration module is embedded in the temperature control port and exposed to the outside of the box body. At the same time, the heat sink is bonded to the heat dissipation surface of the semiconductor refrigeration plate, and the cooling block in the refrigeration module is provided inside the box body and is tightly bonded to the cooling surface of the semiconductor refrigeration plate. The cooling block can help the refrigeration plate absorb heat from the inside of the box body and transfer the heat to the heat sink through the refrigeration plate, thereby lowering the temperature inside the box body, and then maintaining the temperature inside the box body at a temperature suitable for sample storage. Furthermore, the interior of the box body is divided into a first chamber and a second chamber by a partition. The first chamber is provided with a test tube rack module, which can be used to place sterile test tubes and maintain their stability during transportation. The second chamber can be used to place items such as cotton swabs, swabs, and alcohol lamps to facilitate user sampling operations. The solution provided by this application can not only maintain the temperature inside the box at a specified temperature to prevent the temperature of biological samples from getting out of control during transportation, but also centrally place items required for sampling to improve the efficiency of sampling operations. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0018] Figure 1 is a three-dimensional diagram of a biological sample storage box in an open state according to an embodiment of the present application;

[0019] Figure 2 is a three-dimensional diagram of a biological sample storage box in a closed state according to an embodiment of the present application;

[0020] Figure 3 This is a three-dimensional diagram of a refrigeration module in one embodiment provided in this application;

[0021] Figure 4 This is an exploded view of the structure of a refrigeration module in one embodiment provided in this application;

[0022] Figure 5This is a three-dimensional diagram of a test tube rack module in an embodiment provided by the present application. DETAILED DESCRIPTION

[0023] To make the objects, technical solutions and advantages of the present application clearer, the embodiments of the present application will be described in further detail below with reference to the accompanying drawings. Terms such as "upper", "above", "lower", "below", "first end", "second end", "one end", "other end" and the like used in this application to indicate spatial relative positions are used for the purpose of convenience to describe the relationship of one unit or feature relative to another unit or feature as shown in the accompanying drawings. Terms of spatial relative position may be intended to include different orientations of the device during use or operation other than the orientation shown in the drawings. For example, if the device in the figure is turned over, the unit described as being "below" or "beneath" other units or features will be located "above" the other units or features. Therefore, the exemplary term "below" may encompass both the above and below orientations. The device may be oriented in other ways (rotated 90 degrees or in other orientations), and the spatially related descriptive terms used herein may be interpreted accordingly.

[0024] Furthermore, the terms "installed," "disposed," "provided with," "connected," "slidingly connected," "fixed," and "socketed" should be interpreted broadly. For example, "connected" can mean a fixed connection, a removable connection, or an integral structure; it can be a mechanical connection or an electrical connection; it can be a direct connection, an indirect connection through an intermediary, or internal communication between two devices, elements, or components. Those skilled in the art will understand the specific meanings of these terms in this application based on the specific circumstances.

[0025] Healthcare environments must meet specific hygiene standards to reduce infection risks for patients and healthcare workers. For example, during invasive medical procedures like blood drawing, healthcare workers need to monitor the types and abundance of bacteria in the operating environment so they can implement targeted disinfection and protective measures to prevent the spread of pathogens and bacterial infections. Another example is hospital infection control personnel who need to understand the bacterial presence in wards to assess infection risks and develop and implement infection control plans. Therefore, biological sampling in healthcare environments is crucial.

[0026] When operators conduct biological sampling in medical environments, they usually use sterile cotton swabs to collect biological samples in the environment, and then place them in sterile test tubes for sealing. The operators will then transport the sealed biological samples to the laboratory for detailed analysis.

[0027] However, due to cost and equipment size considerations, operators cannot carry refrigeration equipment such as refrigerators when collecting samples. As a result, the current operation process lacks effective cold chain management from the collection of biological samples to the transportation to the laboratory. This can lead to temperature loss during sample transportation. For example, certain proteins or nucleic acids quickly lose their activity at room temperature, which can affect subsequent laboratory analysis results.

[0028] Therefore, how to optimize the storage method of biological samples to maintain a low-temperature storage environment for the samples has become an urgent issue to be solved in this field.

[0029] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the embodiments described in this application are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without making any creative work are within the scope of protection of this application.

[0030] Please refer to Figures 1 to 5 The present application provides a biological sample storage box equipped with a refrigeration system that can adjust the temperature inside the box to a low temperature level suitable for storing biological samples. At the same time, the biological sample storage box is compact and can be carried by operators, making it particularly suitable for on-site collection and large-scale mobile collection scenarios.

[0031] In one practicable embodiment, a biological sample storage box includes a box body 1, a refrigeration module 2, and a test tube rack module 3. The box body 1 has a lid 11 and a main body 12. The lid 11 is pivotally connected to the main body 12 via at least one hinge, allowing the lid 11 to be opened and closed by rotating about the hinge's axis. A temperature control port (not shown) is defined in a first sidewall 121 of the main body 12 and extends through the first sidewall 121.

[0032] The refrigeration module 2 includes a semiconductor refrigeration sheet 21, a heat sink 22, a cooling block 23 and a fan 24, wherein the cooling block 23 is located inside the box body 12. The shape of the heat sink 22 matches the opening shape of the above-mentioned temperature control port, so that the heat sink 22 can be embedded in the above-mentioned temperature control port. When the heat sink 22 is embedded in the above-mentioned temperature control port, a part of the structure of the heat sink 22 needs to be exposed to the first side wall 121 of the box body 12, that is, the heat sink 22 is at least partially exposed from the above-mentioned temperature control port. At the same time, the cooling block 23, the semiconductor refrigeration sheet 21, the heat sink 22 and the fan 24 are arranged closely in sequence from the inside of the box body 12 to the outside. That is to say, from the inside to the outside of the box body 12, the cooling block 23, the semiconductor refrigeration sheet 21, the heat sink 22 and the fan 24 are installed in sequence and fit closely to each other, thereby forming a heat transfer structure from the inside of the box body 12 to the outside of the box body 12.

[0033] In this embodiment, when the semiconductor refrigeration plate 21 is powered, it can absorb heat on one side (for ease of understanding, this application refers to this side as the cooling surface) and release heat on the other side (for ease of understanding, this application refers to this side as the heat dissipation surface) through the Peltier effect. The cooling block 23 can be made of a material with high thermal conductivity, for example, the cooling block 23 can be made of metal aluminum or an aluminum alloy. The cooling block 23 is located inside the box body 12 and is in close contact with the cooling surface of the semiconductor refrigeration plate 21.

[0034] When the semiconductor refrigeration plate 21 is working, a temperature difference will occur between the cooling surface of the semiconductor refrigeration plate 21 and the cooling block 23. Specifically, the temperature of the cooling surface of the semiconductor refrigeration plate 21 will be lower than the temperature of the cooling block 23. In this way, the cooling block 23 can transfer the heat inside the box body 12 to the semiconductor refrigeration plate 21, and the semiconductor refrigeration plate 21 transfers the heat to the heat sink 22. The fan 24 then dissipates the heat accumulated in the heat sink 22 into the air, thereby reducing the temperature inside the box body 12. Furthermore, an MCU (Microcontroller Unit) is provided inside the box body 12. Through a preset MCU control program, the working state of the semiconductor refrigeration plate 21 can be adjusted, thereby controlling the temperature inside the box body 12 to approximately 4°C.

[0035] It should be noted that a lithium battery is installed at the bottom of the box body 12 and is electrically connected to the semiconductor cooling chip 21. The lithium battery can provide energy for the semiconductor cooling chip 21 to maintain its normal operation. Thermally conductive silicone can be applied between the cooling block 23 and the cooling surface of the semiconductor cooling chip 21 to further improve the efficiency of the cooling block 23 in transferring heat from the inside of the box body 12 to the semiconductor cooling chip 21.

[0036] Optionally, the refrigeration module 2 further includes a mesh cover 25, which is connected to one side of the air outlet of the fan 24 to prevent the operator from accidentally touching the rotating blades of the fan 24 to avoid injury to the operator.

[0037] It should be noted that, in this application, a semiconductor cooling plate 21, a cooling block 23, a fan 24, and a mesh cover 25 together constitute a cooling structure. To improve the cooling efficiency of the cooling module 2, in other embodiments, the cooling module 2 may include multiple cooling structures as described above. When multiple cooling structures are present, the multiple cooling structures may share a heat sink 22 or each cooling structure may be provided with a corresponding heat sink 22.

[0038] In this embodiment, a partition 122 is provided within the box body 12. The partition 122 extends along the length of the box body 12, and the ends of the partition 122 abut against the first side wall 121 and the second side wall 123 of the box body 12, respectively, thereby dividing the interior space of the box body 12 into a first chamber a and a second chamber b. A test tube rack module 3 is removably connected to the first chamber a via bolts. The test tube rack module 3 is used to place sterile test tubes, test tubes with lids, and other sampling tubes. When the test tube rack module 3 is installed in the first chamber a, the test tube rack module 3 is perpendicular to the bottom surface of the box body 12 to prevent the sampling tubes from falling or rolling. Furthermore, the second chamber b can be used to place medical items such as sterile sampling sticks, sterile swabs, alcohol lamps, and sterile culture dishes to facilitate sampling operations by medical staff.

[0039] In one feasible embodiment, the test tube rack module 3 includes a base 31, a bottle holding plate 32, and a support frame 33, wherein one end of the support frame 33 is connected to the base 31, and the other end of the support frame 33 is connected to the bottle holding plate 32. The bottle holding plate 32 is located above the base 31 and is substantially parallel to the base 31. The base 31 is an elongated plate-like structure, and is provided with a plurality of test tube holes 311. The plurality of test tube holes 311 are evenly distributed along the length of the base 31. The bottle holding plate 32 is also an elongated plate-like structure, and is provided with a plurality of clamping holes 321. The diameter of the clamping holes 321 is the same as the diameter of the test tube holes 311, and the number of the clamping holes 321 is the same as the number of the test tube holes 311. In addition, a clamping hole 321 is provided vertically directly above each test tube hole 311. The test tube hole 311 and its corresponding clamping hole 321 together form a test tube holder, which can be used to place a sampling test tube and fix and support the sampling test tube, thereby preventing liquid or solid samples in the sampling test tube from spilling.

[0040] In one feasible embodiment, the diameter of the clamping holes 321 must match the diameter of the sample tube, and each clamping hole 321 is provided with an auxiliary access notch 3211. The auxiliary access notch 3211 can serve as a foothold for the operator's fingers, making it more convenient for the operator to remove and place the sample tube. Furthermore, the opening size of the auxiliary access notch 3211 should be smaller than the diameter of the sample tube to prevent the sample tube from slipping out of the auxiliary access notch 3211.

[0041] Optionally, the support frame 33 includes a plurality of support ribs 331 , the length of the support ribs 331 is smaller than the length of the sampling test tube, and there are four support ribs 331 between each test tube hole 311 and its corresponding clamping hole 321 .

[0042] In a feasible embodiment, the heat sink 22 includes a heat sink fin 221 and a substrate 222, and the heat sink fin 221 and the substrate 222 can be made of aluminum alloy. The substrate 222 is recessed to one side to form a groove structure, which can be embedded in the above-mentioned temperature control port, and the heat sink fin 221 can be fixed in the above-mentioned groove structure by a welding process. The fan 24 is fitted with the heat sink fin 221, and when the fan 24 is working, it can take away the heat accumulated on the heat sink fin 221. In this embodiment, the semiconductor refrigeration plate 21 is arranged on the side away from the above-mentioned groove structure, and the heat dissipation surface of the semiconductor refrigeration plate 21 is tightly fitted with the bottom of the above-mentioned groove structure. Furthermore, thermal conductive silicone can be applied between the heat dissipation surface of the semiconductor refrigeration plate 21 and the bottom of the above-mentioned groove structure to improve the efficiency of the semiconductor refrigeration plate 21 in transferring heat to the heat sink 22.

[0043] Optionally, a limiting plate 2221 is formed on the top of the groove structure, and screw holes are provided on the limiting plate 2221, so that the base plate 222 can be fixed to the first side wall 121 of the box body 12 by bolt connection.

[0044] In a feasible embodiment, the refrigeration module 2 also includes a thermal insulation sheet 26. A receiving hole 261 is provided on the thermal insulation sheet 26, and the shape of the receiving hole 261 is adapted to the shape of the semiconductor refrigeration sheet 21, and the semiconductor refrigeration sheet 21 can be snapped into the above-mentioned receiving hole 261. One side of the thermal insulation sheet 26 is in contact with the bottom of the above-mentioned groove structure, and the other side of the thermal insulation sheet 26 is in contact with the cooling block 23, and the cooling block 23 completely covers the above-mentioned receiving hole 261, that is, the thermal insulation sheet 26 is arranged between the heat sink 22 and the cooling block 23. The thermal insulation sheet 26 can be made of ceramic material, which has good performance in blocking heat transfer. The thermal insulation sheet 26 can prevent the heat on the heat sink 22 from being transferred to the cooling block 23, thereby avoiding the temperature increase of the cooling block 23.

[0045] Optionally, the inner wall of the box cover 11 and the inner wall of the box body 12 are both covered with an insulation board 13, and the insulation board 13 can be made of materials such as polystyrene. The insulation board 13 can reduce the heat exchange between the interior of the box body 1 and the external environment, thereby maintaining the stability of the internal temperature of the box body 1. At the same time, the insulation board 13 can also reduce the energy consumption required to maintain the internal temperature of the box body 1, and ultimately extend the continuous working time of the refrigeration module 2. Furthermore, the surface of the insulation board 13 is provided with a metal coating, which contains aluminum ions or silver ions. Specifically, a metal coating can be formed on the surface of the insulation board 13 by vacuum aluminum coating or silver coating. The above-mentioned metal coating can not only reduce heat radiation and prevent water vapor penetration, keep the interior of the box body 1 dry, but also inhibit the growth and reproduction of bacteria.

[0046] Optionally, a temperature sensor 14 is provided inside the box body 12. The temperature sensor 14 is used to detect the temperature of the internal space of the box body 12. The temperature sensor 14 can feed back the temperature value of the internal space of the box body 12 to the MCU, so that the MCU can adjust the working state of the semiconductor refrigeration plate 21 according to the real-time temperature inside the box body 12.

[0047] Optionally, a pull ring 15 is provided on the first side wall 121 of the box body 12 and the second side wall 123 of the box body 12 , respectively. The pull ring 15 is used to connect a shoulder strap to facilitate the operator to carry the biological sample storage box.

[0048] Optionally, a lock 16 is further provided on the box body 1, which can ensure that the box body remains sealed after closing and prevent the box body 1 from being accidentally opened.

[0049] It can be seen that the solution provided by the present application is that the biological sample storage box is composed of a box body, a refrigeration module and a test tube rack module. The refrigeration module contains a semiconductor refrigeration plate, which can absorb heat on one side (called the cooling surface) and release heat on the other side (called the heat dissipation surface) through the Peltier effect. In the present application, a temperature control port is provided on one side of the box body, and the heat sink in the refrigeration module is embedded in the temperature control port and exposed to the outside of the box body. At the same time, the heat sink is bonded to the heat dissipation surface of the semiconductor refrigeration plate, and the cooling block in the refrigeration module is provided inside the box body and is tightly bonded to the cooling surface of the semiconductor refrigeration plate. The cooling block can help the refrigeration plate absorb heat from the inside of the box body and transfer the heat to the heat sink through the refrigeration plate, thereby lowering the temperature inside the box body, and then maintaining the temperature inside the box body at a temperature suitable for sample storage. Furthermore, the interior of the box body is divided into a first chamber and a second chamber by a partition. The first chamber is provided with a test tube rack module, which can be used to place sterile test tubes and maintain their stability during transportation. The second chamber can be used to place items such as cotton swabs, swabs, and alcohol lamps to facilitate user sampling operations. The solution provided by this application can not only maintain the temperature inside the box at a specified temperature to prevent the temperature of biological samples from getting out of control during transportation, but also centrally place items required for sampling to improve the efficiency of sampling operations.

[0050] The above description is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application should be included in the scope of protection of the present application.

Claims

1. A biological sample storage box, characterized in that: It includes a box body, a refrigeration module and a test tube rack module, among which, The box body comprises a box cover and a box body, wherein the box cover is pivotally connected to the box body, and a temperature control port is provided on a first side wall of the box body, and the temperature control port passes through the first side wall; The refrigeration module includes a semiconductor refrigeration sheet, a heat sink, a cooling block, and a fan. The cooling block is located inside the box body. The heat sink is embedded in the temperature control port and partially exposed on the first side wall. The cooling block, the semiconductor refrigeration sheet, the heat sink, and the fan are arranged closely together from the inside of the box body to the outside. A partition is provided inside the box body, extending along the length direction of the box body and abutting against the first side wall and the second side wall of the box body to divide the internal space of the box body into a first chamber and a second chamber. The test tube rack module is detachably connected to the first chamber, and the test tube rack module is perpendicular to the bottom surface of the box body.

2. The biological sample storage box according to claim 1, characterized in that: The test tube rack module includes a base, a bottle holder plate and a support frame, wherein: One end of the support frame is connected to the base, and the other end of the support frame is connected to the bottle holding plate. The bottle holding plate is located above the base, and the bottle holding plate is parallel to the base. The base is a long strip-shaped plate structure, and is provided with a plurality of test tube holes, which are evenly distributed along the length direction of the base; The bottle holding plate has a plurality of clamping holes, the diameter of the clamping holes is the same as the diameter of the test tube holes, and the number of the clamping holes is the same as the number of the test tube holes, and a clamping hole is vertically arranged directly above each test tube hole.

3. The biological sample storage box according to claim 2, characterized in that: The diameter of the clamping hole matches the diameter of the sampling test tube, and the clamping hole is provided with an auxiliary taking-and-placing notch, the opening size of the auxiliary taking-and-placing notch is smaller than the diameter of the sampling test tube.

4. The biological sample storage box according to claim 3, characterized in that: The support frame includes a plurality of support ribs, the length of the support ribs is smaller than the length of the sampling test tube, and there are four support ribs between each test tube hole and its corresponding clamping hole.

5. The biological sample storage box according to claim 4, characterized in that: The heat sink includes heat dissipation fins and a base plate, wherein: The base plate is recessed to one side to form a groove, the groove is embedded in the temperature control port, and the heat dissipation fin is fixed in the groove, and the fan is in contact with the heat dissipation fin; The semiconductor refrigeration plate is arranged on a side away from the groove, and the semiconductor refrigeration plate is in contact with the bottom of the groove.

6. The biological sample storage box according to claim 5, characterized in that: A limiting plate is formed on the top of the groove, and the limiting plate is provided with screw holes so that the base plate is fixed to the first side wall of the box body by bolt connection.

7. The biological sample storage box according to claim 6, characterized in that: The refrigeration module also includes a heat insulation sheet, wherein: The heat insulation sheet is provided with a receiving hole, the shape of the receiving hole is adapted to the shape of the semiconductor refrigeration sheet, and the semiconductor refrigeration sheet is clamped in the receiving hole; One side of the heat insulation sheet is in contact with the bottom of the groove, and the other side of the heat insulation sheet is in contact with the cooling block, and the cooling block covers the accommodating hole.

8. The biological sample storage box according to claim 1, characterized in that: The inner wall of the box cover and the inner wall of the box body are both covered with a heat-insulating plate, and the heat-insulating plate is provided with a metal coating containing aluminum ions or silver ions.

9. The biological sample storage box according to claim 1, characterized in that: A temperature sensor is provided inside the box body, and the temperature sensor is used to detect the temperature of the internal space of the box body.

10. The biological sample storage box according to claim 1, characterized in that: A pull ring is respectively provided on the first side wall of the box body and the second side wall of the box body, and the pull ring is used to connect the shoulder strap.

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