Cryopreservation tube picking assembly and biological sample cryopreservation device

Abstract

A cryopreservation tube picking assembly and a biological sample cryopreservation device.The cryopreservation tube picking assembly comprises a cryopreservation tube picking device, the cryopreservation tube picking device comprises a mounting part and a tray mounted on the mounting part, the tray is provided with a first placement position and a second placement position, a source cryopreservation box is placed in the first placement position, and a target cryopreservation box is placed in the second placement position; the mounting piece is further provided with a pipe taking piece, and the pipe taking piece is used for picking out the picked cryopreservation pipes in the source cryopreservation box and putting the picked cryopreservation pipes into the target cryopreservation box; the imaging assembly comprises an imaging device fixed below the tray and further comprises a main body, the main body is connected with a connecting piece, the connecting piece is connected to the mounting piece, the main body is located at the bottom of the mounting piece, and the first imaging device is fixed to the position, corresponding to the first placement position, of the main body and used for photographing the bottom of the source cryopreservation box; the second imaging device is fixed to the position, corresponding to the second placing position, of the body and used for photographing the bottom of the target cryopreservation box. And therefore, the unfrozen storage tubes can be conveniently picked.

Description

Technical Field

[0001] The present application relates to the technical field of biological sample freezing, and in particular to a freezing tube picking assembly and a biological sample freezing device. Background Art

[0002] With the rapid development of the biopharmaceutical industry, large-scale biobanks have emerged, and the storage capacity of biological samples is increasing. Generally, biological samples such as tissues and cells in clinical or laboratory settings are placed in cryotubes, which are then placed in cryoboxes for storage. However, in practice, cryotubes need to be removed from a cryobox and placed in another cryobox. However, this process makes it difficult to monitor the selection of cryotubes. Utility Model Content

[0003] In view of the above problems, the present application is proposed to provide a cryotube picking assembly and a biological sample freezing device that overcome the above problems or at least partially solve the above problems.

[0004] The present application provides a cryotube picking assembly, comprising: a cryotube picking device, comprising a mounting member and a tray mounted on the mounting member, the tray being provided with a first placement position and a second placement position, the first placement position being used to place a source cryobox, and the second placement position being used to place a target cryobox, the mounting member being further provided with a tube removal member, the tube removal member being used to remove a cryotube to be picked from the source cryobox and place it into the target cryobox; an imaging assembly, the imaging assembly comprising an imaging device, the imaging device being fixed below the tray and being used to photograph the bottoms of the source cryobox and the target cryobox, the imaging assembly further comprising a main body, the main body being connected to a connecting member, the connecting member being connected to the main body of the imaging assembly and positioning the main body at the bottom of the mounting member, the imaging device comprising a first imaging device and a second imaging device, the first imaging device being fixed at a position of the main body corresponding to the first placement position and being used to photograph the bottom of the source cryobox; the second imaging device being fixed at a position of the main body corresponding to the second placement position and being used to photograph the bottom of the target cryobox.

[0005] Optionally, the main body is provided with a first mounting hole, and the first imaging device is used to be installed at the first mounting hole; and / or the main body is provided with a second mounting hole, and the second imaging device is used to be installed at the second mounting hole.

[0006] Optionally, the first imaging device includes a first end having a lens and a second end opposite to the first end, and the second end of the first imaging device is at least partially located on a side of the first mounting hole away from the tray; and / or the second imaging device includes a first end having a lens and a second end opposite to the first end, and the second end of the second imaging device is at least partially located on a side of the second mounting hole away from the tray.

[0007] Optionally, the connecting member is also used to fix the second end of the first imaging device to the part located on the side of the first mounting hole away from the tray, and / or the second end of the second imaging device to the part located on the side of the second mounting hole away from the tray.

[0008] Optionally, the connecting member is further used to fixedly connect the first imaging device and / or the second imaging device.

[0009] Optionally, the freezing tube picking assembly further includes: at least one light emitting device, and the at least one light emitting device is arranged on a side of the main body facing the tray.

[0010] Optionally, the at least one light-emitting device includes a first light-emitting device and a second light-emitting device, the first light-emitting device is located on one side of the first imaging device and the second imaging device, and the second light-emitting device is located on the other side of the first imaging device and the second imaging device.

[0011] Optionally, the main body includes a main body plate.

[0012] The present application also provides a biological sample freezing device, comprising: a cavity, which defines a storage area for storing a freezing box and a tube picking area for picking the selected freezing tubes from the freezing box; and a freezing tube picking assembly as described in any of the above items, wherein the tube picking assembly is arranged in the tube picking area.

[0013] The cryotube picking assembly and biological sample freezing device provided in the present application can take pictures of the bottom of the source cryotube box and the target cryotube box, thereby facilitating the understanding of the cryotube picking situation. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Other objects and advantages of the present application will become apparent from the following description of the present application with reference to the accompanying drawings, which will help to provide a comprehensive understanding of the present application.

[0015] Figure 1 is a front view of an imaging assembly according to some embodiments of the present application;

[0016] Figure 2 is a side view of an imaging assembly according to some embodiments of the present application;

[0017] Figure 3 is a perspective view of an imaging assembly according to some embodiments of the present application.

[0018] In the figure, 10 is an imaging assembly, 100 is a main body, 110 is a first mounting hole, 120 is a second mounting hole, 200 is a connecting piece, 300 is a first imaging device, 400 is a second imaging device, 500 is a first light-emitting device, and 600 is a second light-emitting device. DETAILED DESCRIPTION

[0019] To make the objectives, technical solutions, and advantages of this application more clear, the technical solutions of this application will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of this application. Obviously, the described embodiment is only one embodiment of this application, not all embodiments. Based on the described embodiment of this application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0020] Unless otherwise defined, technical or scientific terms used in this application should have the same meaning as commonly understood by persons having ordinary skills in the field to which this application belongs.

[0021] This embodiment provides an imaging assembly 10 for a cryopreservation tube picking device. Figure 1 1 is a front view of the imaging assembly 10 according to some embodiments of the present application: Figure 2 is a side view of the imaging assembly 10 according to some embodiments of the present application; Figure 3 is a perspective view of the imaging assembly 10 according to some embodiments of the present application.

[0022] The freezing tube picking device includes a mounting part and a tray mounted on the mounting part, the tray is provided with a first placement position and a second placement position, the first placement position is used to place the source freezing box, and the second placement position is used to place the target freezing box. The mounting part is also equipped with a tube picking part, and the tube picking part is used to pick out the frozen tube to be picked from the source freezing box and place it into the target freezing box.

[0023] The imaging assembly 10 includes: a main body 100, the main body 100 is connected to a connecting piece 200, the connecting piece 200 is used to connect to the mounting piece and position the main body 100 at the bottom of the mounting piece; a first imaging device 300, fixed to the position of the main body 100 corresponding to the first placement position, and used to take a picture of the bottom of the source cryopreservation box; a second imaging device 400, fixed to the position of the main body 100 corresponding to the second placement position, and used to take a picture of the bottom of the target cryopreservation box.

[0024] The present application also provides an imaging assembly for a cryotube picking device, the cryotube picking device comprising a mounting member and at least one tray mounted on the mounting member, the at least one tray being provided with a first placement position and a second placement position, the first placement position being used for placing a source cryobox, the second placement position being used for placing a target cryobox, the mounting member being further provided with a tube taking member, the tube taking member being used for picking out the picked cryotubes from the source cryobox and placing them into the target cryobox, the imaging assembly comprising: an imaging device fixed to the bottom of the tray, for taking pictures of the bottoms of the source cryobox and the target cryobox.

[0025] In some embodiments, the imaging assembly further includes: a main body, the main body being connected to a connecting piece, the connecting piece being used to connect to the mounting piece and position the main body at the bottom of the mounting piece; the imaging device including a first imaging device and a second imaging device, the first imaging device being fixed at a position of the main body corresponding to the first placement position, and being used to take a picture of the bottom of the source freezing box; the second imaging device being fixed at a position of the main body corresponding to the second placement position, and being used to take a picture of the bottom of the target freezing box.

[0026] Cryotubes are special containers used in laboratories to preserve biological samples at low temperatures. These biological samples may include cell tissues, DNA, RNA, etc. A cryobox is a storage device specifically used to store biological samples in a low-temperature environment. There are several small slots inside the box for storing cryotubes. A cryobox can hold multiple cryotubes. When a user uses a cryotube, the user needs to pick out the cryotube. The cryotube that needs to be picked is called a picked cryotube (for the convenience of description only, it does not mean that the shape, structure, etc. of the picked cryotube are necessarily different from other cryotubes). A cryotube picking device can be used to pick the picked cryotube.

[0027] The mounting components of the cryotube picking device can be various structures such as discs, blocks, or plates. The bottoms of the boat, source cryobox, and target cryobox can be hollow, transparent, or translucent. The tube removal device can be a clamp, suction device, or clamping device for clamping, sucking, or holding the cryotube to be picked.

[0028] The first imaging device 300 and the second imaging device 400 may be a camera, a video camera, etc.

[0029] The imaging assembly 10, cryotube picker assembly, and biological sample cryopreservation device provided in this embodiment can photograph the bottoms of source and target cryoboxes, thereby facilitating the understanding of cryotube removal. Furthermore, the main body 100 is located at the bottom of the mounting assembly, thereby preventing interference with mechanisms such as the tube removal assembly.

[0030] Specifically, the picking status of the cryotube can be determined by an artificial intelligence algorithm or a set algorithm, for example, whether the cryotube is successfully picked and placed in the correct position. In other embodiments, the photographic results can be output for manual judgment.

[0031] In some embodiments, the main body 100 defines a first mounting hole 110, and the first imaging device 300 is mounted in the first mounting hole 110; and / or the main body 100 defines a second mounting hole 120, and the second imaging device 400 is mounted in the second mounting hole 120. The mounting hole method is easy to implement and has low processing difficulty.

[0032] In some embodiments, the first imaging device 300 includes a first end having a lens and a second end opposite to the first end, and the second end of the first imaging device 300 is at least partially located on a side of the first mounting hole 110 away from the tray; and / or the second imaging device 400 includes a first end having a lens and a second end opposite to the first end, and the second end of the second imaging device 400 is at least partially located on a side of the second mounting hole 120 away from the tray.

[0033] The side of each mounting hole close to the tray can have cooling capacity to ensure the safety of the sample. The second ends of the first imaging device 300 and the second imaging device 400 are arranged on the side of the mounting hole away from the tray to avoid damage by the cooling capacity.

[0034] In some embodiments, the connector 200 is further configured to securely connect the portion of the second end of the first imaging device 300 located on the side of the first mounting hole 110 away from the tray, and / or the portion of the second end of the second imaging device 400 located on the side of the second mounting hole 120 away from the tray. This ensures that the first imaging device 300 and the second imaging device 400 are more securely positioned and facilitate installation.

[0035] In some embodiments, the connector 200 is further used to securely connect the first imaging device 300 and / or the second imaging device 400. This ensures that the first imaging device 300 and the second imaging device 400 are more securely positioned and are easier to install.

[0036] The imaging assembly 10 may further include at least one light emitting device, which is disposed on the side of the main body 100 facing the tray. Thus, the photographic effect of the first imaging device 300 and the second imaging device 400 is ensured.

[0037] In some embodiments, the at least one light-emitting device includes a first light-emitting device 500 and a second light-emitting device 600. The first light-emitting device 500 is located on one side of the first imaging device 300 and the second imaging device 400, and the second light-emitting device 600 is located on the other side of the first imaging device 300 and the second imaging device 400. This makes the light more uniform.

[0038] The main body may include a main body plate. The main body plate can receive a dropped cryotube.

[0039] This embodiment also provides a cryotube picking assembly, comprising: a cryotube picking device, comprising a mounting member and a tray mounted on the mounting member, the tray being provided with a first placement position and a second placement position, the first placement position being used to place a source cryobox, the second placement position being used to place a target cryobox, the mounting member being further provided with a tube taking member, the tube taking member being used to take out the picked cryotube from the source cryobox and place it into the target cryobox; an imaging assembly 10 as described above, wherein the connecting member 200 connected to the main body 100 of the imaging assembly 10 is connected to the mounting member, and the main body 100 is located at the bottom of the mounting member.

[0040] This embodiment further provides a biological sample freezing device, comprising: a cavity defining a storage area for storing a cryopreservation box and a tube picking area for picking a cryopreservation tube from the cryopreservation box; and the aforementioned cryopreservation tube picking assembly, the tube picking assembly being disposed in the tube picking area. The biological sample freezing device may be a refrigerator, a cold storage, a storage device including a liquid nitrogen tank, or the like.

[0041] The imaging assembly 10, cryotube picking assembly, and biological sample freezing device provided in this embodiment can take pictures of the bottoms of the source cryotube box and the target cryotube box, thereby facilitating understanding of the cryotube picking situation.

[0042] Regarding the embodiments of the present application, it should also be noted that, in the absence of conflict, the embodiments of the present application and the features therein can be combined with each other to obtain new embodiments.

[0043] The above are only specific implementation methods of the present application, but the protection scope of the present application is not limited thereto. The protection scope of the present application shall be based on the protection scope of the claims.

Claims

1. A cryotube pick assembly, characterized in that: include: A cryotube picking device includes a mounting member and a tray mounted on the mounting member, wherein the tray is provided with a first placement position and a second placement position, wherein the first placement position is used to place a source cryobox, and the second placement position is used to place a target cryobox, and the mounting member is further provided with a tube removal member, wherein the tube removal member is used to remove a cryotube to be picked from the source cryobox and place it into the target cryobox; an imaging assembly, the imaging assembly including an imaging device, the imaging device being fixed below the tray and being used to photograph the bottoms of the source and target cryopreservation boxes, the imaging assembly also including a main body connected to a connector, the connector connected to the main body of the imaging assembly being connected to the mounting member and positioning the main body at the bottom of the mounting member, the imaging device including a first imaging device and a second imaging device, the first imaging device being fixed to a position of the main body corresponding to the first placement position and being used to photograph the bottom of the source cryopreservation box; The second imaging device is fixed at a position of the main body corresponding to the second placement position, and is used to take pictures of the bottom of the target freezing box.

2. The cryotube pick assembly according to claim 1, characterized in that: The main body is provided with a first mounting hole, and the first imaging device is used to be mounted at the first mounting hole; and / or the main body is provided with a second mounting hole, and the second imaging device is used to be mounted at the second mounting hole.

3. The cryotube pick assembly according to claim 2, characterized in that: The first imaging device includes a first end having a lens and a second end opposite to the first end, and the second end of the first imaging device is at least partially located on a side of the first mounting hole away from the tray; and / or the second imaging device includes a first end having a lens and a second end opposite to the first end, and the second end of the second imaging device is at least partially located on a side of the second mounting hole away from the tray.

4. The cryotube pick assembly according to claim 3, characterized in that: The connecting member is further used to fix the second end of the first imaging device to a portion located on the side of the first mounting hole away from the tray, and / or the second end of the second imaging device to a portion located on the side of the second mounting hole away from the tray.

5. The cryotube pick assembly according to claim 1, characterized in that: The connecting member is also used to fixedly connect the first imaging device and / or the second imaging device.

6. The cryotube pick assembly according to claim 1, characterized in that: Also includes: At least one light emitting device is disposed on a side of the main body facing the tray.

7. The cryotube pick assembly according to claim 6, characterized in that: The at least one light emitting device includes a first light emitting device and a second light emitting device. The first light emitting device is located on one side of the first imaging device and the second imaging device, and the second light emitting device is located on the other side of the first imaging device and the second imaging device.

8. The cryotube pick assembly according to claim 1, characterized in that: The main body includes a main body plate.

9. A biological sample freezing device, characterized in that: include: a cavity defining a storage area for storing the cryopreservation box and a tube picking area for picking the cryopreserved tubes from the cryopreservation box; The cryotube picking assembly according to any one of claims 1 to 8, wherein the picking assembly is arranged in the picking area.

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