Self-locking biological reaction bag

The sliding rod, movable plate, spring structure and spherical handle design of the self-locking bioreactor bag solve the problem of bacterial contamination caused by air entry, realize the self-locking and convenient maintenance of the reaction bag, and ensure the purity of the biological reaction.

CN223371658UActive Publication Date: 2025-09-23BIOTECH BIOTECHNOLOGY (CHENGDU) CO LTD
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Patent Information

Application Number
CN202422949199.4
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-12-02
Publication Date
2025-09-23
Estimated Expiration
2034-12-02

AI Technical Summary

Technical Problem

When the feed pipe of an existing bioreactor bag is closed, air easily enters, causing bacteria to contaminate the bioreactor in the reaction bag.

Method used

A self-locking bioreactor bag was designed, which includes a self-locking structure consisting of a sliding rod, a movable plate, a conical plug, and a spring. The opening and closing of the conical plug is controlled by the pressure of the biological liquid, which promptly blocks the feed tube to prevent air from entering. At the same time, the ball and handle structure facilitate the replacement of the filter tube.

Benefits of technology

It effectively prevents bacteria in the air from entering the reaction bag, ensures the purity of the biological reaction, and facilitates the maintenance and replacement of the self-locking structure.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model belongs to the technical field of biological reaction bags, and particularly relates to a self-locking type biological reaction bag which comprises a transparent reaction bag, two handles are fixedly connected to the upper surface of the transparent reaction bag, a feeding pipe is fixedly connected to the upper surface of the transparent reaction bag, a threaded hole is formed in the upper surface of the feeding pipe, and the transparent reaction bag is fixedly connected with the transparent reaction bag. A threaded hole is formed in the upper surface of the sliding rod, a fixed pipe is connected into the threaded hole in a threaded mode, a filter pipe is fixedly connected to the upper surface of the fixed pipe, and a self-locking structure is arranged in the filter pipe. The springs push the moving plates to move on the two sliding rods, the moving plates drive the conical plugs to be quickly plugged into the conical holes, the conical holes are blocked in time, and it is avoided that a large amount of air enters the transparent reaction bag, so that bacteria in the air affect biological reaction in the transparent reaction bag.
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Description

Technical Field

[0001] The utility model relates to the technical field of bioreactor bags, in particular to a self-locking bioreactor bag. Background Art

[0002] A bioreactor bag is a bag made of biodegradable polymer material and is mainly used in the production process of biological products. Bioreactor bags are widely used, especially in the production of biological products. They provide a convenient, efficient and environmentally friendly way to culture cells and conduct biological reactions. In addition, bioreactor bags also play an important role in scientific research and clinical trials.

[0003] However, in existing equipment, most bioreactor bags require staff to manually close the feed tube. Due to the staff's slow reaction speed, some air will enter the reaction bag when closing the feed tube. The air contains bacteria, which is not conducive to the biological reaction in the reaction bag. Therefore, a self-locking bioreactor bag is proposed. Utility Model Content

[0004] The purpose of the utility model is to solve the shortcomings of the prior art and to propose a self-locking bioreactor bag.

[0005] In order to achieve the above-mentioned purpose, the present invention adopts the following technical solutions: a self-locking biological reaction bag, comprising a transparent reaction bag, two handles fixedly connected to the upper surface of the transparent reaction bag, a feeding tube fixedly connected to the upper surface of the transparent reaction bag, a threaded hole provided on the upper surface of the feeding tube, a fixing tube threadedly connected in the threaded hole, a filter tube fixedly connected to the upper surface of the fixing tube, a self-locking structure provided in the filter tube, an anti-detachment connecting tube fixedly connected to the upper surface of the filter tube, a first sphere rotatably connected to the inside of the feeding tube, a first material delivery hole provided on one side of the first sphere, a rotating column fixedly connected to one side of the first sphere, one end of the rotating column passes through and is rotatably connected to one side of the feeding tube and is fixedly connected to the first handle.

[0006] As a further description of the above technical solution:

[0007] The interior of the filter tube is fixedly connected with a filter plate, the interior of the filter tube is fixedly connected with a fixed disk, and the bottom of the fixed disk is provided with a tapered groove.

[0008] As a further description of the above technical solution:

[0009] The self-locking structure comprises two sliding rods fixedly connected to the bottom of the filter tube, and the other ends of the two sliding rods are fixedly connected to the bottom of the fixed plate.

[0010] As a further description of the above technical solution:

[0011] The two sliding rods are slidably connected with a moving plate, the upper surface of the moving plate is fixedly connected to the conical plug, the conical plug is adapted to the conical groove, and a sealing gasket is fixedly connected to the side where the conical plug fits the conical groove.

[0012] As a further description of the above technical solution:

[0013] The bottom of the movable plate is fixedly connected with a spring, and the other end of the spring is fixedly connected with the inner bottom of the filter tube.

[0014] As a further description of the above technical solution:

[0015] The bottom of the transparent reaction bag is fixedly connected to a discharge pipe, one side of the discharge pipe is rotatably connected to a rotating handle, one end of the rotating handle is fixedly connected to a second sphere, one side of the second sphere is provided with a second feeding hole, and the second sphere is rotatably connected to the inside of the discharge pipe.

[0016] As a further description of the above technical solution:

[0017] The bottom of the transparent reaction bag is fixedly connected to a fixed plate, the upper surface of the fixed plate is rotatably connected to a rotating rod, a plurality of stirring fans are fixedly connected to the rotating rod, the bottom of the fixed plate is fixedly connected to a rotating motor, and the output shaft of the rotating motor is fixedly connected to the bottom of the rotating rod.

[0018] The utility model has the following beneficial effects:

[0019] 1. Compared with the prior art, the self-locking bioreactor bag is provided with a sliding rod, a movable plate, a conical plug, and a spring, and is connected to an external feed pipe through an anti-detachment connecting tube. Then, an external feed pump delivers the biological liquid through the feed pipe into the anti-detachment connecting tube, and then through the anti-detachment connecting tube into the filter tube. The biological liquid then squeezes the conical plug. The conical plug pushes the movable plate to slide on the two sliding rods and squeezes the spring, causing the conical plug to disengage from the conical hole. The liquid flows into the feed pipe through the gap between the conical plug and the conical hole, and then flows into the transparent reaction bag. When the external liquid delivery stops and the pressure of the biological liquid in the filter tube decreases, the elasticity of the spring causes the spring to push the movable plate on the two sliding rods. The movable plate drives the conical plug to quickly plug into the conical hole, blocking the conical hole in time, preventing a large amount of air from entering the transparent reaction bag, causing bacteria in the air to affect the biological reaction in the transparent reaction bag.

[0020] 2. Compared with the existing technology, the self-locking bioreactor bag is provided with a first sphere, a rotating column and a first handle. When the first handle is rotated, the first handle drives the rotating column to rotate, and the rotating column drives the first sphere to rotate, so that the first sphere blocks the feed tube, and then the filter tube is rotated and taken out through the fixed tube, thereby preventing air from entering the transparent reaction bag from the feed tube, making it convenient for staff to replace damaged self-locking structures. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a schematic diagram of the three-dimensional structure of a self-locking bioreactor bag proposed in the present invention;

[0022] Figure 2 This is a plan view of a self-locking bioreactor bag proposed in the present invention;

[0023] Figure 3 This is a schematic diagram of a filter tube of a self-locking bioreactor bag proposed in the present invention;

[0024] Figure 4 This is a cross-sectional view of a filter tube of a self-locking bioreactor bag proposed in the present invention;

[0025] Figure 5 This is an exploded view of the self-locking structure of a self-locking bioreactor bag proposed in the present invention;

[0026] Figure 6 This is a schematic diagram of a discharge pipe of a self-locking bioreactor bag proposed in the present invention;

[0027] Figure 7 This is an exploded view of the discharge pipe and the second sphere of a self-locking bioreactor bag proposed in the utility model;

[0028] Figure 8 This is a schematic diagram of a rotating rod and a stirring fan of a self-locking bioreactor bag proposed in the utility model.

[0029] Legend:

[0030] 1. Transparent reaction bag; 2. Handle; 3. Feed tube; 4. Filter tube; 5. Anti-detachment connecting tube; 6. Self-locking structure; 601. Sliding rod; 602. Moving plate; 603. Conical plug; 604. Spring; 7. First sphere; 8. Rotating column; 9. First handle; 10. Filter plate; 11. Fixed plate; 12. Discharge tube; 13. Second sphere; 14. Rotating handle; 15. Fixed plate; 16. Rotating rod; 17. Stirring fan; 18. Rotating motor. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0032] Reference Figures 1 to 8 The bottle cap 12 is fixedly connected to the bottom of the bottle cap 12, and a rotating handle 14 is rotatably connected to one side of the bottle cap 12. One end of the rotating handle 14 is fixedly connected to the second sphere 13, and a second feeding hole is provided on one side of the second sphere 13. The second sphere 13 is rotatably connected to the inside of the bottle cap 12. The upper surface of the transparent reaction bag 1 is fixedly connected to the two handles 2. The upper surface of the transparent reaction bag 1 is fixedly connected to the feeding pipe 3. The upper surface of the feeding pipe 3 is provided with a threaded hole, and the threaded hole is threadedly connected to the fixing pipe. The upper surface of the fixing pipe is fixedly connected to the filter tube 4. The filter plate 10 is fixedly connected to the inside of the filter tube 4 to filter the liquid medicine to prevent liquid medicine residue from entering the transparent reaction bag 1 and affecting the liquid medicine reaction. The filter tube 4 is fixedly connected to a fixing disk 11, and the bottom of the fixing disk 11 is provided with a conical groove. The filter tube 4 is provided with a self-locking structure 6. The upper surface of the filter tube 4 is fixedly connected to an anti-detachment connecting tube 5.

[0033] In order to achieve the purpose of replacing the self-locking structure 6, the inside of the feeding tube 3 is rotatably connected to the first sphere 7, and a first feeding hole is opened on one side of the first sphere 7. A rotating column 8 is fixedly connected to one side of the first sphere 7. One end of the rotating column 8 passes through and is rotatably connected to one side of the feeding tube 3 and is fixedly connected to a first handle 9. When the first handle 9 is rotated, the first handle 9 drives the rotating column 8 to rotate, and the rotating column 8 drives the first sphere 7 to rotate, so that the first sphere 7 blocks the feeding tube 3, and then the filter tube 4 is rotated and the filter tube 4 is taken out through the fixed tube to prevent air from entering the transparent reaction bag 1 from the feeding tube 3, making it convenient for the staff to replace the damaged self-locking structure 6;

[0034] In order to prevent a large amount of air from entering the transparent reaction bag 1, the self-locking structure 6 includes two sliding rods 601 fixedly connected to the bottom of the filter tube 4, the other ends of the two sliding rods 601 are fixedly connected to the bottom of the fixed disk 11, and a movable plate 602 is slidably connected to the two sliding rods 601. The bottom of the movable plate 602 is fixedly connected with a spring 604, and the other end of the spring 604 is fixedly connected to the inner bottom of the filter tube 4. The upper surface of the movable plate 602 is fixedly connected to the conical plug 603, and the conical plug 603 is adapted to the conical groove. A sealing gasket is fixedly connected to one side of the conical plug 603 that fits the conical groove. It is connected to the external feed pipe through the anti-detachment connecting pipe 5, and then the external feed pump transports the biological liquid into the anti-detachment connecting pipe 5 through the feed pipe. Then, the liquid is transported into the filter tube 4 through the anti-detachment connecting tube 5, and then the conical plug 603 is squeezed by the biological liquid. The conical plug 603 pushes the movable plate 602 to slide on the two sliding rods 601 and squeezes the spring 604, so that the conical plug 603 is separated from the conical hole, and the liquid flows into the feeding tube 3 from the gap between the conical plug 603 and the conical hole, and then flows into the transparent reaction bag 1. When the external liquid delivery stops and the pressure of the biological liquid in the filter tube 4 decreases, the elasticity of the spring 604 causes the spring 604 to push the movable plate 602 to move on the two sliding rods 601, and the movable plate 602 drives the conical plug 603 to quickly plug into the conical hole, blocking the conical hole in time, and preventing a large amount of air from entering the transparent reaction bag 1, causing bacteria in the air to affect the biological reaction in the transparent reaction bag 1;

[0035] In order to achieve the purpose of stirring, the bottom of the transparent reaction bag 1 is fixedly connected to a fixed plate 15, the upper surface of the fixed plate 15 is rotatably connected to a rotating rod 16, and a plurality of stirring fans 17 are fixedly connected to the rotating rod 16. The bottom of the fixed plate 15 is fixedly connected to a rotating motor 18, and the output shaft of the rotating motor 18 is fixedly connected to the bottom of the rotating rod 16. The rotating motor 18 drives the rotating rod 16 to rotate, and the rotating rod 16 drives the plurality of stirring fans 17 to rotate. The plurality of stirring fans 17 stir the biological liquid, which is conducive to uniform mixing reaction of the liquid.

[0036] Working principle: The anti-detachment connecting tube 5 is connected to the external feeding tube, and then the external feeding pump transports the biological liquid through the feeding tube into the anti-detachment connecting tube 5, and then transports it into the filter tube 4 through the anti-detachment connecting tube 5, and then squeezes the conical plug 603 through the biological liquid. The conical plug 603 pushes the movable plate 602 to slide on the two sliding rods 601 and squeezes the spring 604, and the conical plug 603 is separated from the conical hole. The liquid flows into the feeding tube 3 from the gap between the conical plug 603 and the conical hole, and then flows into the transparent reaction bag 1. When the external liquid delivery stops and the pressure of the biological liquid in the filter tube 4 decreases, the spring 604 is pressed. The elasticity causes the spring 604 to push the movable plate 602 to move on the two sliding rods 601. The movable plate 602 drives the conical plug 603 to quickly plug into the conical hole, blocking the conical hole in time to prevent a large amount of air from entering the transparent reaction bag 1, causing bacteria in the air to affect the biological reaction in the transparent reaction bag 1. The first handle 9 is rotated, and the first handle 9 drives the rotating column 8 to rotate. The rotating column 8 drives the first sphere 7 to rotate, so that the first sphere 7 blocks the feeding tube 3, and then the filter tube 4 is rotated and the filter tube 4 is taken out through the fixed tube to prevent air from entering the transparent reaction bag 1 from the feeding tube 3, making it convenient for the staff to replace the damaged self-locking structure 6.

[0037] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent replacements for some of the technical features therein. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A self-locking bioreactor bag, comprising a transparent reaction bag (1), characterized in that: The upper surface of the transparent reaction bag (1) is fixedly connected to two handles (2), the upper surface of the transparent reaction bag (1) is fixedly connected to a feeding tube (3), the upper surface of the feeding tube (3) is provided with a threaded hole, a fixing tube is threadedly connected in the threaded hole, the upper surface of the fixing tube is fixedly connected to a filter tube (4), a self-locking structure (6) is provided in the filter tube (4), the upper surface of the filter tube (4) is fixedly connected to an anti-detachment connecting tube (5), the inside of the feeding tube (3) is rotatably connected to a first sphere (7), a first feeding hole is provided on one side of the first sphere (7), a rotating column (8) is fixedly connected to one side of the first sphere (7), one end of the rotating column (8) passes through and is rotatably connected to one side of the feeding tube (3) and is fixedly connected to a first handle (9).

2. A self-locking bioreactor bag according to claim 1, characterized in that: A filter plate (10) is fixedly connected to the interior of the filter tube (4), and a fixed disk (11) is fixedly connected to the interior of the filter tube (4), wherein a conical groove is provided at the bottom of the fixed disk (11).

3. The self-locking bioreactor bag according to claim 2, characterized in that: The self-locking structure (6) comprises two sliding rods (601) fixedly connected to the bottom of the filter tube (4), and the other ends of the two sliding rods (601) are fixedly connected to the bottom of the fixed plate (11).

4. The self-locking bioreactor bag according to claim 3, characterized in that: A movable plate (602) is slidably connected to the two sliding rods (601), and the upper surface of the movable plate (602) is fixedly connected to a conical plug (603). The conical plug (603) is adapted to the conical groove, and a sealing gasket is fixedly connected to the side of the conical plug (603) that is in contact with the conical groove.

5. The self-locking bioreactor bag according to claim 4, characterized in that: A spring (604) is fixedly connected to the bottom of the movable plate (602), and the other end of the spring (604) is fixedly connected to the inner bottom of the filter tube (4).

6. The self-locking bioreactor bag according to claim 1, characterized in that: The bottom of the transparent reaction bag (1) is fixedly connected to a discharge pipe (12), one side of the discharge pipe (12) is rotatably connected to a rotating handle (14), one end of the rotating handle (14) is fixedly connected to a second sphere (13), one side of the second sphere (13) is provided with a second feeding hole, and the second sphere (13) is rotatably connected to the inside of the discharge pipe (12).

7. The self-locking bioreactor bag according to claim 1, characterized in that: The bottom of the transparent reaction bag (1) is fixedly connected to a fixed plate (15), the upper surface of the fixed plate (15) is rotatably connected to a rotating rod (16), a plurality of stirring fans (17) are fixedly connected to the rotating rod (16), the bottom of the fixed plate (15) is fixedly connected to a rotating motor (18), and the output shaft of the rotating motor (18) is fixedly connected to the bottom of the rotating rod (16).