Cell batch resuscitation device for biological medicine
By designing an automated cell batch recovery device and utilizing a brushless motor and a drying mechanism, efficient recovery and automatic drying of large batches of cells are achieved, solving the problems of cumbersome operation and water stain residue in existing technologies, and improving recovery efficiency and environmental cleanliness.
Patent Information
- Application Number
- CN202422400978.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-30
- Publication Date
- 2025-09-23
- Estimated Expiration
- 2034-09-30
AI Technical Summary
Existing cell recovery instruments are cumbersome to operate when recovering large quantities of cells, and water stains are easily left on the outer walls of the cryopreservation tubes, resulting in low recovery efficiency and inconvenience in cleaning.
A cell batch recovery device for biomedical use was designed. It uses a brushless motor, a connecting column, an electric push rod, and a drying mechanism to achieve automated thawing, recovery, and drying of batches of cryopreserved tubes, reducing manual operations.
It improves the efficiency of cell recovery, reduces manual operations, and ensures the cleanliness of the recovery environment.
Smart Images
Figure CN223373068U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of medical equipment, in particular to a cell batch recovery device for biomedicine. Background Art
[0002] Cells used in daily research need to be frozen for preservation. The freezing process is called cryopreservation. The corresponding process is called cell recovery. Cell recovery refers to the process of thawing cells frozen in liquid nitrogen or a -70°C refrigerator and then re-culturing them to resume cell growth. Cell subculture has the following problems:
[0003] Because the cell recovery process is often carried out using a cell recovery instrument, and the recovery method of the cell recovery instrument is to use a 37°C water bath to completely immerse the lower half of the cryopreservation tube containing the cells in thawed water for 3 minutes to thaw and recover, thereby completing the recovery of biomedical cells. However, when existing cell recovery instruments are used to recover cells, the number of cryopreservation tubes at a time is often small. When a large number of cells need to be recovered, the operator needs to repeatedly take out the cryopreservation tubes, resulting in low recovery efficiency of the cryopreservation tubes containing cells. At the same time, after the existing cell cryopreservation tubes are soaked in water, a large amount of water stains will remain on the outer wall when they are taken out, and they need to be manually cleaned and wiped dry, which is inconvenient to use. Utility Model Content
[0004] The utility model provides a biomedical cell batch recovery device to solve the problems raised in the above background technology.
[0005] In order to solve the above technical problems, the technical solution adopted by the present invention is:
[0006] A cell batch recovery device for biomedicine includes a recovery platform, a placement mechanism is provided on the top front side of the recovery platform, a thawing recovery box is provided at the top center of the recovery platform, a temperature sensor is fixedly installed on the right side of the thawing recovery box, a drying mechanism is provided on the top rear side of the recovery platform, the placement mechanism includes a driving column, the driving column is fixedly installed on the top front side of the recovery platform, a motor slot is provided on the top of the driving column, a brushless motor is fixedly installed in the inner cavity of the motor slot, four connecting columns are fixedly installed in a circular array on the side of the output shaft of the brushless motor, the bottom of the four connecting columns are provided with a card slot, and the other end of the four connecting columns is provided with a cell freezing tube placement mechanism.
[0007] A further improvement of the technical solution of the present invention is that the four cell freezing tube placement mechanisms all include fixed rings, and the four fixed rings are respectively fixedly mounted on one end of the four connecting columns away from the output shaft of the brushless motor, and one of the fixed rings is located above the thawing and recovery box.
[0008] A further improvement of the technical solution of the present utility model is that: a limiting ring is fixedly installed below the inner ring of the four fixing rings, and positioning holes that pass through the upper and lower parts are opened on the left and right sides of the top of the limiting ring. The inner rings of the two positioning holes opened by the limiting ring are clamped with plug rods, and the tops of the two plug rods are fixedly installed with limiting blocks, and a placement plate is fixedly installed between the opposite surfaces of the two limiting blocks. The placement plate has a number of freezing tube clamping holes that pass through the upper and lower parts, and a lifting U-shaped rod is fixedly installed on the top of the two limiting blocks.
[0009] A further improvement of the technical solution of the present utility model is that: a metal heat-conducting plate is fixedly installed on the upper inner side of the thawing and resuscitation box, a heating resistor rod is fixedly installed on the bottom of the metal heat-conducting plate, a heating power supply is fixedly installed on the right side of the bottom of the inner wall of the thawing and resuscitation box, and a plurality of heat dissipation holes are opened on the left side of the thawing and resuscitation box and penetrate into the inner cavity of the thawing and resuscitation box.
[0010] A further improvement of the technical solution of the present utility model is that four supporting legs are fixedly installed in a rectangular array at the bottom of the resuscitation platform, an electric push rod is fixedly installed at the bottom center of the resuscitation platform, and the output end of the electric push rod passes through the top of the resuscitation platform and is fixedly connected to the bottom center of the thawing and resuscitation box.
[0011] A further improvement of the technical solution of the present utility model is that: the wiping mechanism includes a support column, which is fixedly installed on the top rear side of the recovery platform, and a driving long plate is fixedly installed on the top of the support column, and a slide groove is provided on the top of the driving long plate, and a motor is fixedly installed on the rear side of the driving long plate, and the output shaft of the motor passes through the inner cavity of the slide groove and is fixedly installed with a reciprocating screw, and the front end of the reciprocating screw is movably connected to the front side of the inner wall of the slide groove, and the outer wall of the reciprocating screw is threadedly installed with a moving block, and the top of the moving block is fixedly installed with an L-shaped plate, and the front end of the horizontal part of the L-shaped plate is fixedly installed with a cleaning cross plate, and a number of sponge vertical blocks overlapping each other are evenly fixed on the top of the cleaning cross plate, and the top of the sponge vertical block and the bottom of the fixed ring are on the same horizontal line.
[0012] Due to the adoption of the above technical solution, the present invention has achieved the following technical advancements compared to the prior art:
[0013] 1. The utility model provides a batch cell recovery device for biomedicine. Through the mutual cooperation among a brushless motor, a connecting column, a cell cryopreservation tube placement mechanism, an electric push rod, and a thawing and recovery box, a large number of cell cryopreservation tubes can be quickly thawed and recovered, reducing the staff's repeated removal and placement of cryopreservation tubes, thereby improving the recovery efficiency of biomedical cells.
[0014] 2. The utility model provides a biomedical cell batch recovery device. Through the mutual cooperation among the motor, reciprocating screw, moving block, L-shaped plate, cleaning horizontal plate, and sponge vertical block, the outer wall of the cell cryopreservation tube that has been thawed and recovered by hot water can be automatically and quickly absorbed water each time, without the need for manual wiping, preventing water stains from dripping into the recovery environment, reducing manual labor while ensuring the cleanliness of the recovery environment. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] Figure 1 It is an overall schematic diagram of the structure of the utility model;
[0016] Figure 2 This is a schematic diagram of the placement mechanism of the utility model structure;
[0017] Figure 3 This is a schematic diagram of the cell cryopreservation tube placement mechanism of the utility model;
[0018] Figure 4 This is a cross-sectional diagram of a thawing and recovery box of the utility model structure;
[0019] Figure 5 This is a schematic diagram of the drying mechanism of the utility model structure.
[0020] In the figure: 1. Recovery platform; 11. Support leg; 12. Electric push rod; 2. Placement mechanism; 21. Drive column; 22. Motor slot; 23. Brushless motor; 24. Connecting column; 25. Card slot; 26. Cell cryopreservation tube placement mechanism; 261. Fixed ring; 262. Limiting ring; 263. Positioning hole; 264. Insert rod; 265. Limiting block; 266. Placement plate; 267. Cryopreservation tube card hole; 268. Lifting U-shaped rod; 3. Thawing and recovery box; 31. Metal heat conduction plate; 32. Heating resistor rod; 33. Heating power supply; 34. Heat dissipation hole; 4. Temperature sensor; 5. Drying mechanism; 51. Support column; 52. Drive long plate; 53. Slide; 54. Motor; 55. Reciprocating screw; 56. Moving block; 57. L-shaped plate; 58. Cleaning horizontal plate; 59. Sponge vertical block. DETAILED DESCRIPTION
[0021] In order to make the technical means, creative features, objectives and effects achieved by the present invention easier to understand, the present invention is further described below in conjunction with specific implementation methods.
[0022] like Figure 1 、 Figure 2 、 Figure 3As shown, the utility model provides a cell batch recovery device for biomedicine, including a recovery platform 1, a placement mechanism 2 is provided on the top front side of the recovery platform 1, a thawing recovery box 3 is provided at the top center of the recovery platform 1, a temperature sensor 4 is fixedly installed on the right side of the thawing recovery box 3, a drying mechanism 5 is provided on the top rear side of the recovery platform 1, the placement mechanism 2 includes a driving column 21, the driving column 21 is fixedly installed on the top front side of the recovery platform 1, a motor slot 22 is provided on the top of the driving column 21, a brushless motor 23 is fixedly installed in the inner cavity of the motor slot 22, four connecting columns 24 are fixedly installed in a circular array on the side of the output shaft of the brushless motor 23, the bottom of the four connecting columns 24 are provided with a card slot 25, and the other end of the four connecting columns 24 are provided with a cell freezing tube placement mechanism 26. Each cell cryopreservation tube placement mechanism 26 includes a fixing ring 261, and the four fixing rings 261 are respectively fixedly mounted on one end of the four connecting columns 24 away from the output shaft of the brushless motor 23, one of the fixing rings 261 is located above the thawing and recovery box 3, and a limiting ring 262 is fixedly mounted below the inner ring of the four fixing rings 261. Positioning holes 263 that pass through the upper and lower parts are opened on the left and right sides of the top of the limiting ring 262. The inner rings of the two positioning holes 263 opened by the limiting ring 262 are clamped with an insertion rod 264, and the tops of the two insertion rods 264 are fixedly mounted with a limiting block 265. A placing plate 266 is fixedly mounted between the opposite surfaces of the two limiting blocks 265. The placing plate 266 is opened with a plurality of cryopreservation tube clamping holes 267 that pass through the upper and lower parts, and a lifting U-shaped rod 268 is fixedly mounted on the top of the two limiting blocks 265;
[0023] During use, the operator can be located at the front side of the recovery platform 1, and use the lifting U-shaped rod 268 to pull out the placement plate 266 of the inner ring of the four fixed rings 261, and pass the cryopreservation tubes used to store cells through the cryopreservation tube clamping holes 267 one by one until they are against the outlet end of the top of the cryopreservation tube. Then, the four placement plates 266 are aligned one by one with the two positioning holes 263 opened in the inner ring limiting ring 262 of the four fixed rings 261, and the insertion rod 264 at the bottom of the limiting block 265 is passed through the positioning hole 263 to complete the placement. By pre-adjusting the brushless motor 23 in the motor slot 22, each rotation is only ninety degrees, so that the four fixed rings 261 are located above the thawing and recovery box 3 one by one, which is convenient for batch thawing and recovery.
[0024] like Figure 4As shown, a metal heat conducting plate 31 is fixedly installed on the upper inner side of the thawing and resuscitation box 3, a heating resistor rod 32 is fixedly installed on the bottom of the metal heat conducting plate 31, a heating power supply 33 is fixedly installed on the right side of the bottom inner wall of the thawing and resuscitation box 3, and a plurality of heat dissipation holes 34 are opened on the left side of the thawing and resuscitation box 3, which penetrate into the inner cavity of the thawing and resuscitation box 3. Four supporting legs 11 are fixedly installed in a rectangular array at the bottom of the resuscitation platform 1, and an electric push rod 12 is fixedly installed at the bottom center of the resuscitation platform 1. The output end of the electric push rod 12 penetrates the top of the resuscitation platform 1 and is fixedly connected to the bottom center of the thawing and resuscitation box 3;
[0025] During thawing, the electric push rod 12 at the bottom of the recovery platform 1 is started to raise the thawing and recovery box 3 as a whole. When it rises to the point where the front end of the top of the thawing and recovery box 3 is stuck in the card slot 25, the bottoms of several fixed cryovials will be located in the water on the top of the metal heat conducting plate 31. By starting the heating power supply 33 in advance, the heating resistor rod 32 can heat the metal heat conducting plate 31 until the temperature sensor 4 makes the water source on the top of the metal heat conducting plate 31 maintain a suitable temperature for recovery. The heating power supply 33 is then stopped. At the same time, the excess heat or gas generated by the heating resistor rod 32 during heating will be dissipated from the heat dissipation hole 34, and finally the hot water on the top of the metal heat conducting plate 31 will heat the cryovials for thawing and recovery. After each thawing is completed, the electric push rod 12 can be started again to drive the thawing and recovery box 3 to descend, and the brushless motor 23 can be driven to rotate ninety degrees, thereby switching to the next batch of cryovials for repeated heating and recovery operations. The heated cryovials can be removed and replaced with new cryovials. This process can be repeated to perform large-scale cell thawing and recovery work.
[0026] like Figure 5 As shown, the drying mechanism 5 includes a support column 51, which is fixedly mounted on the top rear side of the recovery platform 1, and a driving long plate 52 is fixedly mounted on the top of the support column 51. A slide groove 53 is provided on the top of the driving long plate 52, and a motor 54 is fixedly mounted on the rear side of the driving long plate 52. The output shaft of the motor 54 passes through the inner cavity of the slide groove 53 and is fixedly mounted with a reciprocating screw 55. The front end of the reciprocating screw 55 is movably connected to the front side of the inner wall of the slide groove 53, and a moving block 56 is threadedly mounted on the outer wall of the reciprocating screw 55. An L-shaped plate 57 is fixedly mounted on the top of the moving block 56, and a cleaning cross plate 58 is fixedly mounted on the horizontal front end of the L-shaped plate 57. A number of sponge vertical blocks 59 overlapping each other are evenly fixed on the top of the cleaning cross plate 58, and the top of the sponge vertical block 59 is on the same horizontal line as the bottom of the fixing ring 261.
[0027] Each time the thawing and recovery box 3 is lowered, the motor 54 on the rear side of the long plate 52 can be directly started to drive the reciprocating screw 55 to rotate in the slide groove 53. The threaded connection between the moving block 56 and the reciprocating screw 55 can be used to make the L-shaped plate 57 drive the cleaning horizontal plate 58 to move forward. The sponge vertical block 59 on the top of the cleaning horizontal plate 58 can be used to wipe and absorb water from the bottom of several frozen tubes. Because the frozen tubes are small and have fewer water stains, it is only necessary to squeeze the sponge vertical block 59 regularly to drain the water.
[0028] The following is a detailed description of the working principle of the biomedical cell batch recovery device.
[0029] like Figure 1-5 As shown, when in use, the operator can be located at the front side of the recovery platform 1, and use the lifting U-shaped rod 268 to pull out the placement plate 266 of the inner ring of the four fixing rings 261, and pass the cryopreservation tubes for storing cells through the cryopreservation tube clamping holes 267 one by one until they are against the outlet end of the top of the cryopreservation tube. Then, the four placement plates 266 are aligned with the two positioning holes 263 opened in the inner ring limit ring 262 of the four fixing rings 261 one by one, and the insertion rod 264 at the bottom of the limit block 265 is passed through the positioning hole 263 to complete the placement, and by adjusting the motor slot 22 in advance, the operator can remove the placement plate 266 from the inner ring of the four fixing rings 261. The brushless motor 23 inside the thaw box 3 rotates only ninety degrees each time, so that the four fixing rings 261 are located above the thawing and recovery box 3 one by one, which is convenient for batch thawing and recovery. When thawing, the electric push rod 12 at the bottom of the recovery platform 1 is started to make the thawing and recovery box 3 rise as a whole. When it rises to the top, the bottoms of several cryopreservation tubes will be located in the water on the top of the metal heat conducting plate 31. By starting the heating power supply 33 in advance, the heating resistor rod 32 can heat the metal heat conducting plate 31 until the temperature sensor 4 makes the top of the metal heat conducting plate 31 When the water source maintains a suitable temperature for revival, the heating power supply 33 is stopped, and the excess heat or gas generated by the heating resistor rod 32 during heating will be dissipated from the heat dissipation hole 34, and finally the hot water on the top of the metal heat conducting plate 31 will heat the frozen tubes for thawing and reviving. After each thawing is completed, the electric push rod 12 can be started again to drive the thawing and reviving box 3 to descend, and drive the brushless motor 23 to rotate ninety degrees, so as to switch to the next batch of frozen tubes for repeated heating and revival operations. The heated frozen tubes can be removed and replaced with new ones, and so on. For batch cell thawing and recovery work, each time the thawing and recovery box 3 is lowered, the motor 54 on the rear side of the long plate 52 can be directly started to drive the reciprocating screw 55 to rotate in the slide 53. The moving block 56 is connected to the reciprocating screw 55 through a thread, so that the L-shaped plate 57 can drive the cleaning horizontal plate 58 to move forward. The sponge vertical block 59 on the top of the cleaning horizontal plate 58 can be used to wipe and absorb water from the bottom of several cryopreservation tubes. Because the cryopreservation tubes are small and have less water stains, it is only necessary to squeeze the sponge vertical block 59 regularly to drain the water.
[0030] While the present invention has been generally described above, it is readily apparent to those skilled in the art that modifications or improvements may be made to the present invention. Therefore, modifications or improvements that do not depart from the spirit of the present invention are intended to be within the scope of protection of the present invention.
Claims
1. A biomedical cell batch recovery device, comprising a recovery platform (1), characterized in that: The top front side of the recovery platform (1) is provided with a placement mechanism (2), the top center of the recovery platform (1) is provided with a thawing recovery box (3), the right side of the thawing recovery box (3) is fixedly installed with a temperature sensor (4), the top rear side of the recovery platform (1) is provided with a drying mechanism (5), the placement mechanism (2) includes a driving column (21), the driving column (21) is fixedly installed on the top front side of the recovery platform (1), the top of the driving column (21) is provided with a motor slot (22), the inner cavity of the motor slot (22) is fixedly installed with a brushless motor (23), the output shaft side of the brushless motor (23) is fixedly provided with four connecting columns (24) in a circular array, the bottom of the four connecting columns (24) are provided with a card slot (25), and the other end of the four connecting columns (24) are provided with a cell cryopreservation tube placement mechanism (26).
2. The biomedical cell batch recovery device according to claim 1, characterized in that: The four cell cryopreservation tube placement mechanisms (26) each include a fixing ring (261), and the four fixing rings (261) are respectively fixedly mounted on one end of four connecting columns (24) away from the output shaft of the brushless motor (23), and one of the fixing rings (261) is located above the thawing and recovery box (3).
3. The biomedical cell batch recovery device according to claim 2, characterized in that: A limiting ring (262) is fixedly installed below the inner ring of the four fixing rings (261), and positioning holes (263) that pass through from top to bottom are opened on the left and right sides of the top of the limiting ring (262). The inner rings of the two positioning holes (263) opened by the limiting ring (262) are clamped with plug rods (264), and the tops of the two plug rods (264) are fixedly installed with limiting blocks (265). A placement plate (266) is fixedly installed between the opposite surfaces of the two limiting blocks (265), and the placement plate (266) is provided with a plurality of freezing tube clamping holes (267) that pass through from top to bottom. A lifting U-shaped rod (268) is fixedly installed on the top of the two limiting blocks (265).
4. The biomedical cell batch recovery device according to claim 1, characterized in that: A metal heat conducting plate (31) is fixedly mounted on the upper inner side of the thawing and recovery box (3), a heating resistor rod (32) is fixedly mounted on the bottom of the metal heat conducting plate (31), a heating power supply (33) is fixedly mounted on the right side of the bottom inner wall of the thawing and recovery box (3), and a plurality of heat dissipation holes (34) penetrating into the inner cavity of the thawing and recovery box (3) are opened on the left side of the thawing and recovery box (3).
5. The biomedical cell batch recovery device according to claim 4, characterized in that: Four supporting legs (11) are fixedly installed in a rectangular array at the bottom of the resuscitation platform (1), and an electric push rod (12) is fixedly installed at the bottom center of the resuscitation platform (1). The output end of the electric push rod (12) passes through the top of the resuscitation platform (1) and is fixedly connected to the bottom center of the thawing resuscitation box (3).
6. The biomedical cell batch recovery device according to claim 2, characterized in that: The drying mechanism (5) includes a support column (51), the support column (51) is fixedly mounted on the top rear side of the recovery platform (1), a driving long plate (52) is fixedly mounted on the top of the support column (51), a sliding groove (53) is provided on the top of the driving long plate (52), a motor (54) is fixedly mounted on the rear side of the driving long plate (52), the output shaft of the motor (54) passes through the inner cavity of the sliding groove (53) and is fixedly mounted with a reciprocating screw (55), and the reciprocating screw (55) The front end is movably connected to the front side of the inner wall of the slide groove (53), the outer wall of the reciprocating screw (55) is threadedly installed with a moving block (56), the top of the moving block (56) is fixedly installed with an L-shaped plate (57), the horizontal front end of the L-shaped plate (57) is fixedly installed with a cleaning horizontal plate (58), and the top of the cleaning horizontal plate (58) is evenly fixed with a number of sponge vertical blocks (59) that overlap each other, and the top of the sponge vertical block (59) is on the same horizontal line as the bottom of the fixed ring (261).