Sample treatment device for protein chip detection

Abstract

The utility model relates to the technical field of medical drug detection equipment, and discloses a sample processing device for protein chip detection, which comprises two support frames and a plurality of uniformly distributed clamping plates, the upper ends of the adjacent sides of the two support frames are provided with first chutes, and the lower ends of the adjacent sides of the two support frames are provided with fixing components. According to the utility model, the two sides of the clamping plates are fixedly provided with the fixing plates, the two fixing plates are connected through the low-temperature-resistant tension spring, and the clamping plates are provided with the plurality of low-temperature-resistant silica gel convex blocks, so that the two clamping plates can be connected together through the low-temperature-resistant tension spring; according to the sampling tube fixing device, the low-temperature-resistant silica gel protruding blocks are arranged on the supporting plate, the placed sampling tube is clamped and fixed through the low-temperature-resistant silica gel protruding blocks, meanwhile, the cylindrical protruding blocks are fixed in the grooves formed in the supporting plate, the sampling tube can be supported, and therefore the number of freezable contact points between the sampling tube and the fixing device can be effectively reduced while the sampling tube is fixed.

Description

Technical Field

[0001] The utility model relates to the technical field of medical drug detection equipment, in particular to a sample processing device for protein chip detection. Background Art

[0002] Protein chip technology is a high-throughput protein detection method that enables rapid and efficient detection of specific proteins by immobilizing a large number of antibodies or antigens on the chip surface. This technology has the advantages of simple operation, fast detection speed, and high sensitivity, and has been widely used in proteomics research.

[0003] The basic principle of protein microarrays is to immobilize biomolecules such as peptides, proteins, enzymes, antigens, and antibodies onto a solid-phase medium (such as a glass slide, filter membrane, gel, microplate, nanobeads, etc.) using methods such as in situ synthesis, mechanical spotting, or covalent bonding to form a biomolecule array. The structure of a protein microarray typically includes a carrier and a biomolecule array immobilized on the carrier. The carrier can be any solid-phase medium, while the biomolecule array is composed of biomolecules such as peptides, proteins, enzymes, antigens, and antibodies arranged in a certain pattern.

[0004] Existing protein chip testing generally involves collecting serum or plasma, placing it in a sampling tube, and then refrigerating it at -80°C. However, after refrigerating the sampling tube, the existing sampling and processing device is easily frozen at the connection between the sampling tube and the sampling and processing device due to the influence of ultra-low temperature, making it difficult to remove the sampling tube, causing inconvenience in use. Utility Model Content

[0005] In order to make up for the above shortcomings, the utility model provides a sample processing device for protein chip detection, which aims to improve the problem in the existing technology that after the sampling tube is refrigerated, the sampling tube will freeze due to the influence of ultra-low temperature, making it difficult to take out later, causing inconvenience in use.

[0006] In order to achieve the above-mentioned object, the present invention adopts the following technical solution: a sample processing device for protein chip detection, comprising two support frames and a plurality of evenly distributed clamping plates, wherein the upper ends of adjacent sides of the two support frames are each provided with a first slide groove, and the lower ends of adjacent sides of the two support frames are provided with a fixing assembly;

[0007] The fixing assembly includes two second slide grooves, and the left and right ends of the multiple splints are fixedly connected with a fixing plate, the adjacent side of the fixing plate is fixedly connected with a low-temperature resistant tension spring, the adjacent side of the multiple splints are fixedly connected with a plurality of evenly distributed low-temperature resistant silicone protrusions, the adjacent sides of the two support frames are provided with a plurality of evenly distributed supporting plates, the tops of the multiple supporting plates are provided with a plurality of evenly distributed grooves, the inner bottom walls of the multiple grooves are fixedly connected with a plurality of evenly distributed cylindrical protrusions, the left and right sides of the multiple supporting plates are fixedly connected with sliders, and the bottom ends of the two support frames are provided with a heating assembly.

[0008] As a further description of the above technical solution:

[0009] The heating assembly includes a support base, which is arranged at the bottom end of the support frame, a stepper motor is fixedly connected to the right end of the support base, a heating box is provided in the middle of the support base, movable blocks are fixedly connected to the front and rear ends of the middle of the heating box, a reciprocating screw rod is threadedly connected to the middle of the movable block on the front side, and a guide rod is provided in the middle of the movable block on the rear side, two ceramic pads are fixedly connected to the inner bottom wall of the heating box, an intelligent temperature control panel is fixedly connected to the right end of the heating box, and a heating tube is fixedly connected to the left end of the intelligent temperature control panel.

[0010] As a further description of the above technical solution:

[0011] The plurality of clamps are all slidably connected to the inner side wall of the first sliding groove, and the plurality of sliders are all slidably connected to the inner side wall of the second sliding groove.

[0012] As a further description of the above technical solution:

[0013] The right end of the reciprocating screw rod is fixedly connected to the output end of the stepping motor, and the left and right ends of the guide rod are both fixedly connected to the inner side wall of the support base.

[0014] As a further description of the above technical solution:

[0015] Slots are provided at both left and right ends of the support base, and the bottom ends of the two support frames are clamped on the inner side walls of the slots.

[0016] As a further description of the above technical solution:

[0017] The top ends of the two support frames are fixedly connected with handles, and the outer side walls of the two handles are provided with protective covers.

[0018] As a further description of the above technical solution:

[0019] The bottom end of the support base is fixedly connected to a plurality of evenly distributed supporting legs, and the bottom ends of the plurality of supporting legs are all fixedly connected to anti-slip pads.

[0020] The utility model has the following beneficial effects:

[0021] 1. In the utility model, fixing plates are fixed on both sides of the splint, and the two fixing plates are connected by low-temperature resistant tension springs, and multiple low-temperature resistant silicone protrusions are installed on the splints, so that the two splints can be connected together by the low-temperature resistant tension springs, and the low-temperature resistant silicone protrusions can be used to clamp and fix the placed sampling tubes. At the same time, cylindrical protrusions are fixed in the grooves opened on the support plate, which can support the sampling tubes. Therefore, while completing the fixation of the sampling tubes, the contact points between the sampling tubes and the fixing device that can be frozen can be effectively reduced.

[0022] 2. In the utility model, a heating box is arranged inside the support base, and movable blocks are fixed at the front and rear ends of the heating box, and a reciprocating screw is arranged in the middle of the front movable block, and the right end of the reciprocating screw is connected to the output end of the stepper motor installed on the right side of the support base. At the same time, a heating tube is installed inside the heating box, so that the reciprocating screw can be driven to rotate by the stepper motor, so that the heating box can perform reciprocating motion, and the heat generated by the heating tube can melt the ice frozen between the sampling tube and the fixing device, so that the sampling tube is easy to take out and the rate of subsequent detection is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a three-dimensional diagram of a sample processing device for protein chip detection proposed by the present invention;

[0024] Figure 2 This is a schematic diagram of a low-temperature resistant silicone bump of a sample processing device for protein chip detection proposed by the present invention;

[0025] Figure 3 This is a schematic diagram of a support base of a sample processing device for protein chip detection proposed in the present invention;

[0026] Figure 4 This is a schematic diagram of a heating box of a sample processing device for protein chip detection proposed by the present invention.

[0027] Legend:

[0028] 1. Support frame; 2. First slide; 3. Second slide; 4. Clamp; 5. Fixed plate; 6. Low-temperature resistant tension spring; 7. Low-temperature resistant silicone bump; 8. Support plate; 9. Groove; 10. Cylindrical bump; 11. Slider; 12. Support base; 13. Stepper motor; 14. Heating box; 15. Movable block; 16. Reciprocating screw; 17. Guide rod; 18. Ceramic pad; 19. Intelligent temperature control panel; 20. Heating tube; 21. Slot; 22. Handle; 23. Protective cover; 24. Leg; 25. Anti-slip pad. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0030] Reference Figure 1 and Figure 2 The present invention provides an embodiment of a sample processing device for protein chip detection, comprising two support frames 1 and a plurality of evenly distributed clamping plates 4, wherein the upper ends of adjacent sides of the two support frames 1 are each provided with a first slide groove 2, and the lower ends of adjacent sides of the two support frames 1 are provided with a fixing assembly;

[0031] The fixing assembly includes two second slide grooves 3, the left and right ends of the multiple splints 4 are fixedly connected with a fixing plate 5, the adjacent side of the fixing plate 5 is fixedly connected with a low-temperature resistant tension spring 6, the adjacent side of the multiple splints 4 is fixedly connected with a plurality of evenly distributed low-temperature resistant silicone protrusions 7, the adjacent side of the two support frames 1 is provided with a plurality of evenly distributed supporting plates 8, the tops of the multiple supporting plates 8 are provided with a plurality of evenly distributed grooves 9, the inner bottom walls of the multiple grooves 9 are fixedly connected with a plurality of evenly distributed cylindrical protrusions 10, the left and right sides of the multiple supporting plates 8 are fixedly connected with sliders 11, and the bottom ends of the two support frames 1 are provided with a heating assembly; the multiple splints 4 are slidably connected to the inner side wall of the first slide groove 2, and the multiple sliders 11 are slidably connected to the inner side wall of the second slide groove 3;

[0032] Specifically, by providing the low-temperature resistant silicone protrusions 7 and the cylindrical protrusions 10 , the sampling tube can be fixed while reducing the contact area with the sampling tube.

[0033] Reference Figure 1 、 Figure 3 and Figure 4The heating assembly includes a support base 12, which is arranged at the bottom end of the support frame 1, and the right end of the support base 12 is fixedly connected to the stepping motor 13. A heating box 14 is provided in the middle of the support base 12, and movable blocks 15 are fixedly connected to the front and rear ends of the middle of the heating box 14. A reciprocating screw rod 16 is threadedly connected to the middle of the front movable block 15, and a guide rod 17 is provided in the middle of the rear movable block 15. Two ceramic pads 18 are fixedly connected to the inner bottom wall of the heating box 14, and the right end of the heating box 14 is fixedly connected to the intelligent temperature control panel 19, and the left end of the intelligent temperature control panel 19 is fixedly connected to the heating tube 20; the right end of the reciprocating screw rod 16 is fixedly connected to the output end of the stepping motor 13, and the left and right ends of the guide rod 17 are fixedly connected to the inner side wall of the support base 12; slots 21 are provided at the left and right ends of the support base 12, and the bottom ends of the two support frames 1 are clamped in the inner side walls of the slots 21;

[0034] Specifically, by fixing two ceramic pads 18 on the inner bottom wall of the heating box 14 , the heating tube 20 can be supported.

[0035] Reference Figure 1 and Figure 2 The top ends of the two support frames 1 are fixedly connected with handles 22, and the outer walls of the two handles 22 are provided with protective covers 23; the bottom end of the support base 12 is fixedly connected with multiple evenly distributed support legs 24, and the bottom ends of the multiple support legs 24 are fixedly connected with anti-slip pads 25.

[0036] Specifically, by providing a protective cover 23 on the outer side wall of the handle 22 , the operator can be prevented from being frostbitten by low temperatures when holding the handle 22 .

[0037] It should be noted that: (low-temperature resistant silicone bumps 7, stepper motor 13, intelligent temperature control panel 19) are all well known or can be checked by professionals in the relevant technical fields of this utility, so they are not described here.

[0038] Working principle: When the user needs to use the device, first place the sampling tube in the groove 9 opened on the supporting plate 8, and then fix the fixing plates 5 on both sides of the splint 4. At the same time, the two fixing plates 5 are connected by a low-temperature resistant tension spring 6, and a plurality of low-temperature resistant silicone protrusions 7 are installed on the splint 4, so that the two splints 4 can be connected together by the low-temperature resistant tension spring 6, and the low-temperature resistant silicone protrusions 7 can be used to clamp and fix the placed sampling tube. At the same time, a cylindrical protrusion 10 is fixed in the groove 9 opened on the supporting plate 8. The low-temperature resistant silicone protrusions 7 and the cylindrical protrusions 10 can be used to fix the sampling tube while reducing the contact area between the sampling tube and the supporting plate 8;

[0039] After the refrigeration treatment is completed, the operator holds the protective cover 23 provided on the outer wall of the handle 22, takes out the support frame 1 and the sampling tube together, and then inserts the bottom end of the support frame 1 into the slots 21 opened at the left and right ends of the support base 12, and sets a heating box 14 inside the support base 12. At the same time, movable blocks 15 are fixed at the front and rear ends of the heating box 14, and a reciprocating screw 16 is set in the middle of the front movable block 15, and the right end of the reciprocating screw 16 is connected to the output end of the stepping motor 13 installed on the right side of the support base 12. At the same time, a heating tube 20 is installed inside the heating box 14, so that the reciprocating screw 16 can be driven to rotate by the stepping motor 13, so that the heating box 14 can reciprocate, so that the heat generated by the heating tube 20 can melt the ice frozen between the sampling tube and the fixing device, so that the sampling tube is easy to take out and the speed of subsequent detection is improved.

[0040] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent replacements for some of the technical features therein. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A sample processing device for protein chip detection, comprising two support frames (1) and a plurality of evenly distributed clamping plates (4), characterized in that: A first sliding groove (2) is provided at the upper ends of adjacent sides of the two support frames (1), and a fixing assembly is provided at the lower ends of adjacent sides of the two support frames (1); The fixing assembly includes two second slide grooves (3), the left and right ends of the plurality of splints (4) are fixedly connected with a fixing plate (5), the adjacent side of the fixing plate (5) is fixedly connected with a low-temperature resistant tension spring (6), the adjacent side of the plurality of splints (4) are fixedly connected with a plurality of evenly distributed low-temperature resistant silicone protrusions (7), the adjacent side of the two support frames (1) is provided with a plurality of evenly distributed supporting plates (8), the tops of the plurality of supporting plates (8) are provided with a plurality of evenly distributed grooves (9), the inner bottom walls of the plurality of grooves (9) are fixedly connected with a plurality of evenly distributed columnar protrusions (10), the left and right sides of the plurality of supporting plates (8) are fixedly connected with a slider (11), and the bottom ends of the two support frames (1) are provided with a heating assembly.

2. A sample processing device for protein chip detection according to claim 1, characterized in that: The heating assembly comprises a support base (12), the support base (12) being arranged at the bottom end of the support frame (1), the right end of the support base (12) being fixedly connected to a stepping motor (13), a heating box (14) being arranged in the middle of the support base (12), movable blocks (15) being fixedly connected at both the front and rear ends of the middle of the heating box (14), a reciprocating screw rod (16) being threadedly connected in the middle of the movable block (15) on the front side, and a guide rod (17) being arranged in the middle of the movable block (15) on the rear side, an inner bottom wall of the heating box (14) being fixedly connected to two ceramic pads (18), the right end of the heating box (14) being fixedly connected to an intelligent temperature control panel (19), and the left end of the intelligent temperature control panel (19) being fixedly connected to a heating tube (20).

3. A sample processing device for protein chip detection according to claim 1, characterized in that: The plurality of clamping plates (4) are all slidably connected to the inner side wall of the first sliding groove (2), and the plurality of sliding blocks (11) are all slidably connected to the inner side wall of the second sliding groove (3).

4. A sample processing device for protein chip detection according to claim 2, characterized in that: The right end of the reciprocating screw rod (16) is fixedly connected to the output end of the stepping motor (13), and the left and right ends of the guide rod (17) are fixedly connected to the inner side wall of the support base (12).

5. The sample processing device for protein chip detection according to claim 2, characterized in that: Slots (21) are provided at both left and right ends of the support base (12), and the bottom ends of the two support frames (1) are clamped on the inner side walls of the slots (21).

6. The sample processing device for protein chip detection according to claim 1, characterized in that: The top ends of the two support frames (1) are fixedly connected with handles (22), and the outer side walls of the two handles (22) are provided with protective sleeves (23).

7. A sample processing device for protein chip detection according to claim 2, characterized in that: The bottom end of the support base (12) is fixedly connected to a plurality of evenly distributed supporting legs (24), and the bottom ends of the plurality of supporting legs (24) are all fixedly connected to anti-slip pads (25).

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