Tear quantitative collection device

Abstract

The utility model discloses a tear quantitative collection device, and belongs to the technical field of medical instruments. The tear quantitative collection device comprises a sampling strip used for collecting tears; the sealing piece is connected with one end of the sampling strip; the handheld part is positioned at one end of the sealing piece away from the sampling strip. And one end of the sampling strip is packaged in the sealing element, and only a fixed area or a fixed length is reserved for sampling, so that the function of quantitatively collecting tears is realized. The width range of the sampling strip is set to be 0.5-10 mm, the exposed area range is set to be 1-25 mm < 2 >, and the edge of the sampling strip is used for being in contact with the ocular surface of a patient, so that irritant tears generated by the patient in the sampling process can be effectively avoided; meanwhile, edge type sampling is adopted, so that adhesion of the sampler to cells can be greatly reduced. For a xerophthalmia patient with a small amount of tears, the edge of the sampling strip can collect a small amount of tears of the fundus of the patient, multiple quantitative sampling can be carried out, and therefore the sufficient amount of tears can be collected.

Description

TECHNICAL FIELD

[0001] The utility model relates to a tear fluid quantitative collection device belongs to medical instrument technical field. BACKGROUND

[0002] Tears are secretions produced by the lacrimal glands, together with mucin and lipids, forming tear fluid. The proteins in tear fluid are crucial for the stability of the ocular surface environment and have anti-inflammatory, immunomodulatory, and ocular surface repair effects. Changes in tear fluid proteins can indicate the state of the ocular surface microenvironment and are associated with various pathologies, such as dry eye syndrome, diabetes, and multiple sclerosis. Therefore, the tear fluid collection method is a critical step in determining whether comprehensive and in-depth tear fluid analysis can be performed.

[0003] Currently, the main methods for collecting tear fluid are capillary tube method and Schirmer method. Dry eye syndrome patients have low tear fluid volume, and placing a capillary tube or Schirmer paper directly on the dry ocular surface can increase the discomfort of the patient, stimulate reflex tear secretion, and affect the accuracy of the test results. Some researchers in the prior art use a dilution Schirmer method, where physiological saline is used for pre-dilution before collecting tear fluid with Schirmer paper, but this method cannot achieve quantitative sampling. In addition, some in vitro diagnostic reagents have been marketed on the market, which use physiological saline to flush the ocular surface to collect tear fluid. Although this method can reduce ocular irritation, it cannot achieve quantitative sampling. SUMMARY

[0004] To solve the above problems, the utility model provides a tear fluid quantitative collection device, which can address the problem of low tear fluid volume in dry eye syndrome patients, uses a sampling strip edge for sampling, reduces irritation to the ocular surface, and prevents the patient from producing irritating tears. At the same time, by limiting the exposed area of the sampling strip, the function of quantitative tear fluid collection is achieved.

[0005] The utility model realizes the following technical solutions:

[0006] A tear fluid quantitative collection device, comprising:

[0007] A sampling strip for collecting tear fluid;

[0008] A sealing element connected to one end of the sampling strip;

[0009] A hand-held portion located at the end of the sealing element away from the sampling strip, the hand-held portion being connected to the sampling strip through the sealing element.

[0010] In one embodiment of the utility model, the hand-held portion is provided with a breaking point, the number of breaking points is two, and the breaking points are symmetrically distributed on both sides of the hand-held portion.

[0011] In an embodiment of the utility model, the handheld part is two, symmetrically distributed on both sides of the sealing element. The tear quantitative collection device is broken when diluting the sample, so that the sampling strip is separated from the handheld part.

[0012] In an embodiment of the utility model, the handheld part is two, symmetrically distributed on both sides of the sealing element. The tear quantitative collection device is broken when diluting the sample, so that the sampling strip is separated from the handheld part.

[0013] In an embodiment of the utility model, the sampling strip is a sheet structure.

[0014] In an embodiment of the utility model, the sampling strip is a linear structure.

[0015] In an embodiment of the utility model, the width of the sampling strip is 0.5mm-10mm. The sampling strip is narrow, and the stimulation to the subject is small during the collection process, so that irritating tears are not generated.

[0016] In an embodiment of the utility model, the exposed area of the sampling strip is 1mm 2 -25mm 2 The tear of the dry eye patient can be quantitatively collected.

[0017] In an embodiment of the utility model, the length of the sampling strip is 0.5mm-20mm.

[0018] In an embodiment of the utility model, the material of the sampling strip is ashless filter paper. The ashless filter paper has good absorption capacity, no stimulation to the eye surface, can avoid the generation of irritating tears, and has the advantages of easy processing, low cost and the like. The material of the sampling strip can also be one of sponge, fiber, PVA, paper, non-woven fabric, dust-free cloth, polyester fiber, glass fiber, nitrocellulose membrane and flocking. The sampling strip prepared by using the above materials has good absorption capacity for trace liquid and can quickly absorb tears.

[0019] Advantages

[0020] The tear quantitative collection device provided by the utility model comprises a sampling strip, a sealing element, a broken part and a handheld part. One end of the sampling strip is packaged in the sealing element, only a fixed area or a fixed length is left for sampling, and the function of quantitatively collecting tears is realized. The width range of the sampling strip is set to 0.5mm-10mm, and the exposed area range is set to 1mm 2 -25mm 2And use its edge contact patient eye surface, compared with the prior art, the sampling strip provided by the utility model is narrower, and the patient has no foreign body sensation, and irritation tear can be effectively avoided during sampling process; meanwhile, the edge type sampling can greatly reduce the cell adhesion of the sampler, and increase the accuracy of subsequent marker detection in tear.

[0021] The sealing member of the tear quantitative collection device not only fixes the sampling strip and the handheld part as a whole, but also can package one end of the sampling strip, wrap the excess sampling strip between the two sealing members, form a seal, so that even if the sampling strip absorbs too much tear, the excess tear will be packaged in the sealing member, and the tear amount that can be diluted by the diluent on the sampling strip is a fixed value. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1 A perspective view of an embodiment of the tear quantitative collection device provided by the utility model.

[0023] Figure 2 An exploded view of an embodiment of the tear quantitative collection device provided by the utility model.

[0024] Figure 3 A perspective view of another embodiment of the tear quantitative collection device provided by the utility model.

[0025] Figure 4 An exploded view of another embodiment of the tear quantitative collection device provided by the utility model.

[0026] In the figure: 1, sampling strip; 2, sealing member; 3, breaking point; 4, handheld part; 41, groove. DETAILED DESCRIPTION

[0027] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the utility model.

[0028] In the utility model, unless another definite provision and limitation, the term "connect", "connection", "fixed" should be broad sense understanding, for example, can be fixed connection, also can be detachable connection, or be integrated;Can be mechanical connection, also can be electrical connection;Can be directly connected, also can be indirectly connected through the intermediate medium, can be two elements inside the communication or two element's interaction relationship.For the ordinary skilled in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances.

[0029] In the utility model, unless another definite provision and limitation, the first feature is "on" or "under" the second feature can include the first and second features direct contact, also can include the first and second features are not direct contact but contact through the additional feature between them.Moreover, the first feature is "on", "above" and "on" the second feature includes the first feature is directly above and obliquely above the second feature, or just indicates that the first feature is higher than the second feature in horizontal height.The first feature is "under", "below" and "under" the second feature includes the first feature is directly below and obliquely below the second feature, or just indicates that the first feature is less than the second feature in horizontal height.

[0030] As Figure 1 And Figure 2 As shown in the application, a tear quantitative collection device is provided for collecting tears, especially suitable for dry eye patients or people with low tear volume.The tear quantitative collection device includes a sampling strip 1, which is a rectangular sheet structure or a linear structure, and can absorb the tears on the ocular surface to realize tear collection.The number of sealing members 2 is two, both of which are rectangular sheet structures, and are distributed on both sides of the sampling strip 1.The sealing members 2 have adhesion and can be pasted on both sides of the sampling strip 1, so that the sampling strip 1 is fixedly connected with the sealing members 2.The width of the sealing members 2 is greater than the width of the sampling strip 1, and one end of the sampling strip 1 can be packaged by the sealing members 2, so that the exposed part of the sampling strip 1 is a fixed area or a fixed length.When the sampling strip 1 is a sheet structure, the exposed part of the sampling strip 1 is a fixed area;When the sampling strip 1 is a linear structure, the exposed part of the sampling strip 1 is a fixed length;The fixed area or fixed length of the sampling strip 1 can be set according to actual sampling requirements, and the quantitative collection of tears is realized by wetting the sampling strip 1 with a fixed area or fixed length with tears.Meanwhile, the sealing members 2 package one end of the sampling strip 1 inside to form a seal, so that even if the sampling strip 1 absorbs too much tears, it will also be packaged inside the sealing members 2, and when the tears are dissolved with a diluent later, it can effectively prevent excess tears from being dissolved, thereby realizing the function of quantitative collection.

[0031] In some embodiments, the tear quantitative collection device further comprises a hand-held portion 4, which is convenient for the collector to hold when sampling. The hand-held portion 4 is a rectangular plate structure, and there are two of them, which are fixedly connected to the two sides of the sealing member 2 away from the sampling strip 1. Since the sealing member 2 has a certain viscosity, the sampling strip 1 and the hand-held portion 4 are bonded into a whole through the sealing member 2. The end of the hand-held portion 4 close to the sealing member 2 is provided with a breaking point 3, which is located between the sealing member 2 and the hand-held portion 4. The breaking point 3 is a groove structure, and there are two of them, which are symmetrically distributed on the two sides of the hand-held portion 4. It can also be a cut ring groove, which is convenient for breaking the tear quantitative collection device when diluting the sample, so that the sampling strip 1 and the hand-held portion 4 are separated.

[0032] As shown in Figure 3 and Figure 4 In another embodiment, the present application provides a tear quantitative collection device, which comprises a sampling strip 1. The sampling strip 1 is a rectangular sheet structure or a linear structure, and its edge can absorb the tear fluid on the ocular surface to realize the function of tear collection. There are two sealing members 2, which are both rectangular sheet structures and are distributed on the two sides of the sampling strip 1. The sealing member 2 has viscosity and can be pasted on the two sides of the sampling strip 1, so that the sampling strip 1 and the sealing member 2 are fixedly connected. The width of the sealing member 2 is greater than the width of the sampling strip 1, and one end of the sampling strip 1 can be packaged by the sealing member 2, so that the exposed part of the sampling strip 1 is a fixed area or a fixed length. When the sampling strip 1 is a sheet structure, the exposed part of the sampling strip 1 is a fixed area; when the sampling strip 1 is a linear structure, the exposed part of the sampling strip 1 is a fixed length. The fixed area or fixed length of the sampling strip 1 can be set according to the actual sampling requirement, and the quantitative collection of tear fluid is realized by the sampling strip 1 with a fixed area or fixed length wetted by tear fluid. At the same time, the sealing member 2 packages one end of the sampling strip 1 inside to form a seal, so that even if the sampling strip 1 absorbs too much tear fluid, it will also be packaged inside the sealing member 2. When the tear fluid is dissolved out by the dilution liquid later, it can effectively prevent the excess tear fluid from being dissolved out, thereby realizing the function of quantitative collection.

[0033] In some embodiments, the tear quantitative collection device further comprises a hand-held portion 4, which is convenient for the collector to hold when sampling. The hand-held portion 4 is a rectangular plate structure, and there are two of them, which are fixedly connected to the two sides of the sealing member 2 away from the sampling strip 1. Since the sealing member 2 has a certain viscosity, the sampling strip 1 and the hand-held portion 4 are bonded into a whole through the sealing member 2. The end of the hand-held portion 4 close to the sealing member 2 is provided with a breaking point 3, which is located between the sealing member 2 and the hand-held portion 4. The breaking point 3 is a groove structure, and there are two of them, which are symmetrically distributed on the two sides of the hand-held portion 4. It can also be a cut ring groove, which is convenient for breaking the tear quantitative collection device when diluting the sample, so that the sampling strip 1 and the hand-held portion 4 are separated.

[0034] Optionally, the material of the sampling strip 1 is one of sponge, fiber, PVA, paper, non-woven fabric, dust-free cloth, polyester fiber, glass fiber, nitrocellulose membrane, and flocked fabric. The sampling strip 1 made of the above materials has good absorption capacity for trace liquid and can quickly absorb the tear liquid. Preferably, the material of the sampling strip 1 is ashless filter paper. The ashless filter paper has good absorption capacity, no irritation to the ocular surface, can avoid the generation of irritating tear liquid, and has the advantages of easy processing and low cost.

[0035] In the present application, 10 subjects are selected, and sampling strips 1 with different widths are used for tear liquid collection. The experimental results are shown in Table 1.

[0036] Table 1: Tear liquid collection data of sampling strips with different widths

[0037]

[0038]

[0039] From the data in Table 1, when the width of the sampling strip 1 is 0.5mm-10mm, the stimulation to the subjects during the collection process is small, and no irritating tear liquid is generated. Therefore, optionally, the width of the sampling strip 1 is 0.5mm-10mm.

[0040] In the present application, 20 dry eye patients are selected for basic tear liquid collection to estimate the amount of basic tear liquid that can be easily collected from dry eye patients. A sampling strip 1 with a width of 2mm is used for sampling. The edge of the sampling strip 1 is placed in the lower fornix of the dry eye patient for 5 seconds and then taken out. By calculating the weight change before and after sampling, the amount of basic tear liquid that can be easily collected from dry eye patients is obtained. During the period, the generation of irritating tear liquid should be avoided. The experimental results are shown in Table 2.

[0041] Table 2: Amount of basic tear liquid

[0042]

[0043] From the data in Table 2, the basic tear liquid of dry eye patients is less, and the amount of tear liquid that can be easily collected from dry eye patients is between 1mg-5.9mg, which can wet a sampling strip 1 of 2.5mm 2 in length. Therefore, when the sampling strip 1 is in a sheet structure, the exposed area range is 1mm 2 -25mm 2 .

[0044] Optionally, the length of the sampling strip 1 is 0.5mm-20mm. The length of the sampling strip 1 should not be too long. The amount of tear liquid of dry eye patients is less, and the rear end of the sampling strip 1 cannot be wetted when it is too long, causing waste.

[0045] Optionally, the handheld part 4 is made of hard material, which can provide support for the sampling strip 1; preferably, the handheld part 4 is made of PVD material.

[0046] The utility model works: one end of sampling strip 1 is encapsulated in sealing element 2, only fixed area or fixed length is left for sampling, sealing element 2 is fixedly connected with handheld part 4, and the side of handheld part 4 close to sealing element 2 is provided with breaking point 3. Put the tear liquid quantitative collection device into the sterilization bag, and after the ethylene oxide sterilization, it is ready for use. When sampling using the device, the edge of the exposed part of sampling strip 1 is contacted with the ocular surface of the patient to collect tear liquid, and within 10 seconds, 2 to 3 times of collection can obtain the quantitative tear liquid of dry eye patient, and no irritating tear liquid is generated. After tear liquid collection is completed, sampling strip 1 is placed in diluent and is broken through breaking point 3, which not only can make sampling strip 1 and diluent fully fuse, but also can prevent handheld part 4 from causing pollution to the sample. The device can also be directly assembled to chromatography test paper strip and used. The device encapsulates one end of sampling strip 1 in sealing element 2, only fixed area or fixed length is left for sampling, and quantitative sampling is realized. Sampling strip 1 selects ashless filter paper with small width, and edge type sampling is adopted, which can effectively avoid the stimulation to the eye of the patient and prevent the generation of irritating tear liquid.

[0047] The technical features of the above embodiments can be combined arbitrarily, and to make the description concise, all possible combinations of the technical features in the above embodiments are not described, however, as long as the combinations of the technical features do not exist contradictory, they should be considered as the scope of the description.

[0048] The above embodiments only express several implementation manners of the utility model, and the description is more specific and detailed, but it should not be understood as the limitation of the scope of the invention patent. It should be pointed out that for ordinary skilled persons in the art, on the premise of not departing from the concept of the utility model, a number of modifications and improvements can be made, which all belong to the protection scope of the utility model.

[0049] The principle and implementation manner of the utility model are described by applying specific embodiments in the present article, and the above embodiment description is only used to help understand the method and core idea of the utility model. It should be pointed out that for ordinary skilled persons in the technical field, on the premise of not departing from the principle of the utility model, a number of improvements and modifications can be made to the utility model, and these improvements and modifications also fall within the protection scope of the utility model claims. Therefore, the protection scope of the utility model patent should be subject to the appended claims.

Claims

1. A tear fluid quantitative collection device, characterized by, The utility model relates to a sampling device for collecting tear liquid, comprising: a sampling strip (1) for collecting tear liquid; a seal (2) connected to one end of the sampling strip (1); a hand-held part (4) located at the end of the seal (2) away from the sampling strip (1), the hand-held part (4) being connected to the sampling strip (1) through the seal (2).

2. A device for quantitative collection of tears according to claim 1, characterized in that The hand-held part (4) is provided with two breaking points (3) symmetrically distributed on both sides of the hand-held part (4).

3. A device for quantitative collection of tears according to claim 2, characterized in that The number of hand-held parts (4) is two, symmetrically distributed on both sides of the seal (2).

4. The device of claim 2, wherein the device is a tear collection device. One end of the hand-held part (4) is provided with a groove (41) abutting against both sides of the seal (2) away from the sampling strip (1).

5. The device of claim 1, wherein the device is a tear fluid collection device. The sampling strip (1) has a sheet structure.

6. The device of claim 1, wherein the device is a tear fluid collection device. The sampling strip (1) has a linear structure.

7. A device for quantitative collection of tears according to claim 5, characterized in that The width of the sampling strip (1) is 0.5mm-10mm.

8. A device for quantitative collection of tears according to claim 7, characterized in that The sampling strip (1) has an exposed area of 1 mm 2 ~ 25 mm 2 .

9. A device for quantitative collection of tears according to claim 5 or 6, characterized in that The length of the sampling strip (1) is 0.5mm-20mm.

10. A device for quantitative collection of tears according to claim 9, characterized in that The material of the sampling strip (1) is ashless filter paper.

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