Blood vessel in-vitro simulation device and ECMO in-vitro simulation system

Abstract

The utility model relates to a blood vessel in-vitro simulation device and an ECMO in-vitro simulation system. The blood vessel in-vitro simulation device comprises a heart module used for simulating heart blood supply; the first resistance module is connected with the heart module, and the first resistance module is used for simulating the resistance and compliance of the aorta; the artery module is connected with the first resistance module, the artery module is used for simulating an artery blood vessel, and the artery module is made of a transparent material; the second resistance module is connected with the artery module, and the second resistance module is used for simulating resistance and compliance of peripheral blood vessels; a liquid storage tank and a puncture module; the detection module is used for detecting and adjusting the pressure and flow of the liquid entering and flowing out of the artery module; and the controller is respectively connected with the heart module and the detection module. The artery module of the blood vessel in-vitro simulation device is made of the transparent material, so that trainees can clearly know the blood vessel structure in the artery module, and the catheter indwelling difficulty during ECMO equipment training is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medical equipment, in particular to a blood vessel extracorporeal simulation device and an ECMO extracorporeal simulation system. BACKGROUND

[0002] When a patient is in acute shock, in order to maintain the stability of the patient's heartbeat function, the intervention of an ECMO (extracorporeal membrane oxygenation) device is needed. The use of the ECMO device is relatively complex, and special training is needed for clinical medical personnel. The existing training mostly uses animals or internal invisible simulation devices, so that there is great difficulty in the catheterization operation of the ECMO device. CONTENT OF THE UTILITY MODEL

[0003] Based on the above problems, the present application provides a blood vessel extracorporeal simulation device and an ECMO extracorporeal simulation system, which transparentizes the arterial module to facilitate catheterization training.

[0004] The present application provides a blood vessel extracorporeal simulation device, comprising:

[0005] a heart module for simulating blood supply of a heart;

[0006] a first resistance module connected to the heart module, the first resistance module being used for simulating resistance and compliance of a main artery;

[0007] an arterial module connected to the first resistance module, the arterial module being used for simulating an arterial blood vessel, and the arterial module being of a transparent material;

[0008] a second resistance module connected to the arterial module, the second resistance module being used for simulating resistance and compliance of a peripheral blood vessel;

[0009] a liquid storage tank connected to the second resistance module and the heart module respectively;

[0010] a puncture module connected to the arterial module, the puncture module being used for simulating tissue outside the arterial blood vessel;

[0011] a detection module for detecting and adjusting pressure and flow of liquid entering and flowing out of the arterial module;

[0012] a controller connected to the heart module and the detection module respectively.

[0013] According to some embodiments of the present application, the heart module comprises:

[0014] a pulsatile pump;

[0015] a first one-way valve connected to an output end of the pulsatile pump and the first resistance module respectively;

[0016] a second one-way valve connected to the input of the pulsatile pump and the reservoir, respectively.

[0017] According to some embodiments of the present application, the first resistance module comprises:

[0018] a first compliance chamber connected to the heart module, for simulating the compliance of the aorta;

[0019] a first proportional valve connected to the first compliance chamber and the arterial module, respectively, for simulating the resistance of the aortic sinus.

[0020] According to some embodiments of the present application, the arterial module comprises:

[0021] an aortic module connected to the first resistance module;

[0022] a first branch arterial module connected to the aortic module and the second resistance module, respectively, for simulating the head and upper limb arteries;

[0023] a second branch arterial module connected to the aortic module and the second resistance module, respectively, for simulating the thoracic arteries;

[0024] a third branch arterial module connected to the second branch arterial module and the second resistance module, respectively, for simulating the femoral arteries.

[0025] According to some embodiments of the present application, the detection module comprises:

[0026] an aortic detection module disposed between the first resistance module and the aortic module;

[0027] a first branch detection module disposed between the first branch arterial module and the second resistance module;

[0028] a second branch detection module disposed between the second branch arterial module and the second resistance module;

[0029] a third branch detection module disposed between the third branch arterial module and the second resistance module.

[0030] According to some embodiments of the present application, the aortic detection module comprises:

[0031] a first pressure sensor for detecting the pressure of the liquid entering the aortic module;

[0032] a first flow meter for detecting the flow of the liquid entering the aortic module.

[0033] According to some embodiments of the present application, the first branch detection module, the second branch detection module, and the third branch detection module each comprise:

[0034] a second pressure sensor for detecting the pressure of the liquid flowing out of the corresponding branch arterial module;

[0035] a second flow meter for detecting the flow of the liquid flowing out of the corresponding branch arterial module;

[0036] a Hoffman valve for adjusting the pressure and flow of the liquid flowing out of the corresponding branch arterial module.

[0037] According to some embodiments of the present application, the puncture module is connected to the third branch arterial module.

[0038] According to some embodiments of the present application, the second resistance module comprises:

[0039] a second proportional valve connected to the arterial module, the second proportional valve for simulating the resistance of the peripheral blood vessels;

[0040] a second compliance chamber connected to the second proportional valve and the liquid storage tank respectively, the second compliance chamber for simulating the compliance of the peripheral blood vessels.

[0041] The present application also provides an ECMO extracorporeal simulation system, comprising:

[0042] the vascular extracorporeal simulation device as described above;

[0043] an ECMO device connected to the puncture module.

[0044] The arterial module of the vascular extracorporeal simulation device of the present application is made of transparent material, so that the training personnel can clearly understand the vascular structure in the arterial module, thereby reducing the difficulty of catheterization during ECMO device training. BRIEF DESCRIPTION OF DRAWINGS

[0045] In order to more clearly illustrate the technical solutions of the present application, the following will briefly introduce the drawings needed to be used in the embodiments. Obviously, the drawings described below are only some embodiments of the present application, and other drawings can also be obtained by those skilled in the art based on these drawings without departing from the scope of the present application.

[0046] Figure 1 is a schematic diagram of the vascular extracorporeal simulation device of the embodiments of the present application. DETAILED DESCRIPTION

[0047] The technical solutions of the present application will be described clearly and completely in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, not all. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0048] As Figure 1 shown in the drawings, the embodiments of the present application provide a blood vessel simulation device 100, the blood vessel simulation device 100 comprising a heart module 1, a first resistance module 2, an artery module 3, a second resistance module 4, a liquid storage tank 5, a puncture module 6, a detection module 7 and a controller 8.

[0049] The heart module 1 is used to simulate the blood supply of the heart. For example, the heart module 1 comprises a pulsatile pump capable of delivering a liquid for simulating blood. The first resistance module 2 is connected to the heart module 1, and the first resistance module 2 is used to simulate the resistance and compliance of the aorta. The artery module 3 is connected to the first resistance module 2, and the artery module 3 is used to simulate the arterial blood vessels. Optionally, the artery module 3 is made in a 1:1 simulation of the human body's arteries. The artery module 3 is made of transparent material, for example, the material of the artery module 3 is high-transparency soft silicone. The training personnel can understand the structure of the arterial blood vessels by observing the artery module 3. The liquid delivered by the heart module 1 enters the artery module 3 through the first resistance module 2.

[0050] The second resistance module 4 is connected to the artery module 3, and the second resistance module 4 is used to simulate the resistance and compliance of the peripheral blood vessels of the human body. The liquid enters the second resistance module 4 after passing through the artery module 3.

[0051] The liquid storage tank 5 is connected to the second resistance module 4 and the heart module 1, respectively. For example, the inlet of the liquid storage tank 5 is connected to the second resistance module 4, and the outlet of the liquid storage tank 5 is connected to the heart module 1. The liquid storage tank 5 stores a liquid for simulating blood. Optionally, the liquid for simulating blood is a mixed solution of 40wt% glycerol and 60wt% water. The volume of the liquid stored in the liquid storage tank 5 is set according to the requirements.

[0052] The puncture module 6 is connected to the artery module 3, and the puncture module 4 is used to simulate the tissues outside the arterial blood vessels, for example, to simulate the human body's skin and muscles outside the arterial blood vessels. The puncture module 6 can be made of medical silicone, and the elasticity and hardness of the medical silicone are consistent with the basic tissues of the human body outside the arterial blood vessels. During ECMO device training, cannula puncture is performed on the puncture module 6 to enable the ECMO device to communicate with the artery module 3. Optionally, the puncture module 6 can be reused, reducing the training cost.

[0053] The detection module 7 is used to detect and adjust the pressure and flow rate of the liquid flowing through the artery module 3, for example, the detection module 7 can detect and adjust the pressure and flow rate of the liquid entering and flowing out of the artery module 3. Adjusting the pressure and flow rate of the liquid entering and flowing out of the artery module 3 can simulate the blood flow state of the artery under different conditions of the patient.

[0054] The controller 8 is connected to the heart module 1 and the detection module 7 respectively. The controller 8 can control the heart module 1 to work, and can also control the detection module 7 to adjust the pressure and flow of the liquid entering and flowing out of the arterial module 3. Optionally, the controller 8 is a computer, and the controller 8 is connected to the heart module 1 and the detection module 7 in communication.

[0055] The arterial module 3 of the embodiment is of a transparent material, so that the training personnel can clearly understand the vascular structure in the arterial module, and the difficulty of catheterization during ECMO equipment training is reduced. By adjusting the pressure and flow of the liquid entering and flowing out of the arterial module 3 through the detection module 7, the blood flow state of the artery under different conditions of the patient can be simulated, and the authenticity of the simulation is improved.

[0056] In some embodiments, the heart module 1 comprises a pulsatile pump 11, a first one-way valve 12, and a second one-way valve 13. The pulsatile pump 11 is used to simulate the beating of the heart. The inlet of the first one-way valve 12 is connected to the pulsatile pump 11, and the outlet of the first one-way valve 12 is connected to the first resistance module 2 to prevent the liquid in the first resistance module 2 from flowing back. The inlet of the second one-way valve 13 is connected to the outlet of the liquid storage tank 5, and the outlet of the second one-way valve 13 is connected to the pulsatile pump 11 to prevent the liquid in the pulsatile pump 11 from flowing back to the liquid storage tank 5.

[0057] In some embodiments, the first resistance module 2 comprises a first compliance chamber 21 and a first proportional valve 22. The first compliance chamber 21 can be an existing compliance chamber, and the inlet of the first compliance chamber 21 is connected to the first one-way valve 12 of the heart module 1. The first compliance chamber 21 is used to simulate the compliance of the human aorta. The first proportional valve 22 is connected to the first compliance chamber 21 and the arterial module 3 respectively, and the first proportional valve 22 is used to simulate the resistance of the aortic sinus. Optionally, the first proportional valve 22 is manually adjusted according to the needs to simulate the resistance of the real aortic sinus.

[0058] In some embodiments, the arterial module 3 comprises an aortic module 31, a first branch arterial module 32, a second branch arterial module 33, and a third branch arterial module 34. The aortic module 31 is connected to the first proportional valve 22 of the first resistance module 2, and the aortic module 31 is used to simulate the aorta. The liquid delivered by the heart module 1 all enters the aortic module 31.

[0059] The first branch arterial module 32 is connected to the aortic module 31 and the second resistance module 4 respectively, and the first branch arterial module 32 is used to simulate the head and upper limb arteries. Part of the liquid in the aortic module 31 enters the first branch arterial module 32, and the liquid enters the second resistance module 4 after passing through the first branch arterial module 32.

[0060] The second branch artery module 33 is connected to the aorta module 31 and the second resistance module 4, respectively, and is used to simulate thoracic arteries. Another part of the liquid in the aorta module 31 enters the second branch artery module 33.

[0061] The third branch artery module 34 is connected to the second branch artery module 33 and the second resistance module 4, respectively, and is used to simulate femoral arteries. Part of the liquid in the second branch artery module 33 enters the second resistance module 4, and another part of the liquid in the second branch artery module 33 enters the third branch artery module 34. The liquid passes through the third branch artery module 34 and then enters the second resistance module 4.

[0062] In some embodiments, the detection module 7 includes an aorta detection module 71, a first branch detection module 72, a second branch detection module 73, and a third branch detection module 74. The aorta detection module 71 is arranged between the first resistance module 2 and the aorta module 31, and is used to detect the pressure and flow rate of the liquid entering the aorta module 31.

[0063] The first branch detection module 72, the second branch detection module 73, and the third branch detection module 74 are all arranged between the artery module 3 and the second resistance module 4. Among them, the first branch detection module 72 is arranged between the first branch artery module 32 and the second resistance module 4, and is used to detect and adjust the pressure and flow rate of the liquid flowing out of the first branch artery module 32. The second branch detection module 73 is arranged between the second branch artery module 33 and the second resistance module 4, and is used to detect and adjust the pressure and flow rate of the liquid flowing out of the second branch artery module 33. The third branch detection module 74 is arranged between the third branch artery module 34 and the second resistance module 4, and is used to detect and adjust the pressure and flow rate of the liquid flowing out of the third branch artery module 34.

[0064] In some embodiments, the aorta detection module 71 includes a first pressure sensor 711 and a first flow meter 712. The first pressure sensor 711 is connected to the first proportional valve 22, and the first flow meter 712 is connected to the first pressure sensor 711 and the aorta module 31, respectively. The first pressure sensor 711 is used to detect the pressure of the liquid entering the aorta module 31, and the first flow meter 712 is used to detect the flow rate of the liquid entering the aorta module 31.

[0065] The first pressure sensor 711 and the first flow meter 712 are respectively in communication connection with the controller 8, and the controller 8 can display the real-time detection results of the first pressure sensor 711 and the first flow meter 712, so that the training personnel can know the pressure and flow rate of the liquid entering the aorta module 31 in real time.

[0066] In some embodiments, the first branch detection module 72, the second branch detection module 73 and the third branch detection module 74 each include a second pressure sensor 75, a second flow meter 76 and a Hoffman valve 77 arranged in sequence. The second pressure sensor 75 is connected to the corresponding branch arterial module, the second flow meter 76 is connected to the second pressure sensor 75 and the Hoffman valve 77 respectively, and the Hoffman valve 77 is connected to the second resistance module 4.

[0067] The second pressure sensor 75 is used to detect the pressure of the liquid flowing out of the corresponding branch arterial module. The second flow meter 76 is used to detect the flow of the liquid flowing out of the corresponding branch arterial module. The Hoffman valve 77 is used to adjust the pressure and flow of the liquid flowing out of the corresponding branch arterial module. The second pressure sensor 75, the second flow meter 76 and the Hoffman valve 77 are respectively connected in communication with the controller 8, and the controller 8 can display the real-time detection results of the second pressure sensor 75 and the second flow meter 76. The controller 8 can control the Hoffman valve 77 to adjust the pressure and flow of the liquid flowing out of the corresponding branch arterial module to simulate the blood flow state of each branch artery in different pathologies.

[0068] In some embodiments, the puncture module 6 is connected to the third branch arterial module 34. The cannula of the ECMO device is usually located at the femoral artery of the human body, and the puncture module 6 is located outside the third branch arterial module 34 to facilitate the puncture training of the ECMO device.

[0069] In some embodiments, the second resistance module 4 includes a second proportional valve 41 and a second compliance chamber 42. The second proportional valve 41 is connected to the arterial module 3, and the liquid flowing out of the arterial module 3 enters the second resistance module 4. The second proportional valve 41 is used to simulate the resistance of the peripheral blood vessels. The second compliance chamber 42 is connected to the second proportional valve 41 and the liquid storage tank 5 respectively, and the second compliance chamber 42 is used to simulate the compliance of the peripheral blood vessels. The second compliance chamber 42 is selected from existing compliance chambers. Alternatively, the second proportional valve 41 is manually adjusted according to the needs to simulate the resistance of the real peripheral blood vessels.

[0070] One embodiment of the present application provides an ECMO in-vitro simulation system, which includes the blood vessel in-vitro simulation device 100 and the ECMO device 200 as described above. The connecting pipe of the ECMO device 200 can pass through the puncture module 6 to communicate with the arterial module 3 to perform the puncture training of the ECMO device for the trainee.

[0071] Alternatively, the first proportional valve 22, the three Hoffman valves 77 and the second proportional valve 41 are adjusted according to the human blood vessel parameters in different pathologies, and then the intervention effect of the ECMO device 200 is simulated by collecting the parameters of each pressure sensor and flow meter after the intervention of the ECMO device 200, so as to analyze the data for the experimenters.

[0072] The above has introduced the embodiments of the present application in detail. The principles and implementation manners of the present application are described by applying specific examples in this paper, and the above embodiment descriptions are only used to help understand the technical solutions of the present application and the core ideas thereof. Therefore, the changes or deformations made by the person skilled in the art according to the ideas of the present application, based on the specific implementation manners and application ranges of the present application, all belong to the protection scope of the present application. In summary, the content of the present specification should not be understood as the limitation of the present application.

Claims

1. A vascular in-vitro simulation device, characterized in that, Comprising: a heart module for simulating blood supply of heart; a first resistance module connected to the heart module, the first resistance module for simulating resistance of aorta and compliance of aorta; an artery module connected to the first resistance module, the artery module for simulating artery blood vessels, the artery module being transparent material; a second resistance module connected to the artery module, the second resistance module for simulating resistance of peripheral blood vessels and compliance of peripheral blood vessels; a liquid storage tank connected to the second resistance module and the heart module respectively; a puncture module connected to the artery module, the puncture module for simulating tissue outside the artery blood vessels; a detection module for detecting and adjusting pressure and flow of liquid into and out of the artery module; a controller connected to the heart module and the detection module respectively.

2. The vascular in-vitro simulation device of claim 1, wherein, The heart module comprises: a pulsatile pump; a first one-way valve connected to an output of the pulsatile pump and the first resistance module respectively; a second one-way valve connected to an input of the pulsatile pump and the liquid storage tank respectively.

3. The vascular in-vitro simulation device of claim 1, wherein, The first resistance module comprises: a first compliance cavity connected to the heart module for simulating compliance of the aorta; a first proportional valve connected to the first compliance cavity and the artery module respectively, the first proportional valve for simulating resistance of aortic sinus.

4. The vascular in-vitro simulation device of claim 1, wherein, The artery module comprises: an aorta module connected to the first resistance module; a first branch artery module connected to the aorta module and the second resistance module respectively, and for simulating head and upper limb arteries; a second branch artery module connected to the aorta module and the second resistance module respectively, and for simulating thoracic arteries; a third branch artery module connected to the second branch artery module and the second resistance module respectively, and for simulating femoral arteries.

5. The vascular in-vitro simulation device of claim 4, wherein, The detection module comprises: an aorta detection module arranged between the first resistance module and the aorta module; a first branch detection module arranged between the first branch artery module and the second resistance module; a second branch detection module arranged between the second branch artery module and the second resistance module; a third branch detection module arranged between the third branch artery module and the second resistance module.

6. The vascular in-vitro simulation device of claim 5, wherein, The aorta detection module comprises: a first pressure sensor for detecting pressure of liquid into the aorta module; a first flow meter for detecting flow of liquid into the aorta module.

7. The vascular in-vitro simulation device of claim 5, wherein, The first branch detection module, the second branch detection module and the third branch detection module each comprise: a second pressure sensor for detecting pressure of liquid out of the corresponding branch artery module; a second flow meter for detecting flow of liquid out of the corresponding branch artery module; a Hoffman valve for adjusting pressure and flow of liquid out of the corresponding branch artery module.

8. The vascular in-vitro simulation device of claim 4, wherein, The puncture module is connected to the third branch artery module.

9. The vascular in-vitro simulation device of claim 1, wherein, The second resistance module comprises: a second proportional valve connected to the artery module, the second proportional valve for simulating resistance of peripheral blood vessels; a second compliance cavity connected to the second proportional valve and the liquid storage tank respectively, the second compliance cavity for simulating compliance of peripheral blood vessels.

10. An ECMO extracorporeal simulation system, characterized in that, Comprising: The vascular phantom device according to any one of claims 1 to 9; The ECMO device is connected to the puncture module.

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