Freeze-dried collagen dressing

Abstract

The utility model discloses a freeze-dried collagen dressing, and relates to the field of medical cosmetology, the freeze-dried collagen dressing comprises a packaging box, freeze-dried collagen, a solvent, a sealed container, an injection container and a non-woven fabric, the freeze-dried collagen is filled in the sealed container, the solvent is filled in the injection container and is sealed, the non-woven fabric is placed in the packaging box in a sealed mode, a lining is arranged in the packaging box, and the lining is arranged in the packaging box. The lining is provided with grooves which can be used for placing a sealing container, an injection container and a packaging bag respectively. According to the utility model, the freeze-dried collagen, the solvent and the non-woven fabric can be separated, the stability is better, the validity period is longer, the transportation and the storage are convenient, and the use process is convenient, safe and sanitary.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the field of medical cosmetology, and particularly relates to a freeze-dried collagen dressing. BACKGROUND

[0002] Collagen is the main component of animal extracellular matrix protein, accounting for 25%-30% of total human body protein. Collagen is composed of three polypeptide chains, and each polypeptide chain is a left-handed helical structure. The three left-handed helical chains are intertwined into a right-handed helical structure, and the three-helix structure has high tensile strength. Collagen has biodegradability, low cytotoxicity and low antigen activity. As a dressing, it can promote cell growth and adhesion, and can be used for wound repair after laser surgery, reduce postoperative pain and shorten the duration of pain, reduce pigmentation, accelerate wound repair, and also achieve the effects of nourishing the skin and improving the skin.

[0003] At present, the collagen protein paste dressing on the market is mainly composed of collagen stock solution and non-woven fabric. Its functions include repairing damage, moisturizing, reducing scar formation, reducing pigmentation, pain relief and hemostasis. Its clinical applications mainly include treatment of acne vulgaris, facial allergic dermatosis, facial burn wound healing treatment and nursing, facial laser, postoperative repair treatment after photon therapy, etc.

[0004] However, the existing collagen paste dressing on the market has the following deficiencies: 1. The common composition form is to mix collagen solution and non-woven fabric together for packaging and storage. During long-term storage, the dissolution of non-woven fabric greatly reduces the stability of collagen. Once the structure of collagen changes, the performance of the product will be reduced, and further more, it may cause an increase in the allergic rate; 2. Such products are usually recommended to be stored in a cold place or a cool place, and the storage and transportation process may also cause collagen degradation; 3. Most products are outsourced for radiation sterilization. In order to reduce the proliferation of microorganisms in this process, some preservatives are usually added. These preservatives may enter the human body and cause irritation and other adverse reactions during contact with the wound.

[0005] Freeze-drying technology uses low temperature and vacuum conditions to remove most of the water, thus preserving the natural structure and biological activity of biological materials such as collagen. It has important roles in many aspects: 1. Improve biocompatibility: maintaining the natural structure of the material helps it better compatible with human tissues in medical applications, reducing immune rejection, increasing safety and effectiveness of use; 2. Enhance therapeutic effect: the preservation of biological activity makes collagen better in promoting cell growth, tissue repair and regeneration, such as in wound healing, tissue engineering and regenerative medicine; 3. Optimize functionality: collagen with biological activity can more effectively penetrate the skin, promote collagen synthesis, and achieve anti-wrinkle, moisturizing and skin tightening effects; 4. Prolong product stability: biological materials treated by freeze-drying technology have enhanced stability and can be stored at room temperature, making transportation and storage easier and prolonging the shelf life; 5. No need to add preservatives, etc., the product is more pure, reducing the risk of potential irritation, allergy, etc. Practical new type content

[0006] The utility model aims at the deficiency of prior art, provides a kind of freeze-dried collagen, solvent and non-woven fabric are separated, can guarantee the stability of collagen, maintain product use effect, longer effective period, and it is convenient to transport and store, easy to use freeze-dried collagen dressing.

[0007] To realize above technical purpose, the utility model uses following technical scheme:

[0008] A kind of freeze-dried collagen dressing, including packing box, freeze-dried collagen, solvent, sealed container, injection container and non-woven fabric, the freeze-dried collagen is filled in the sealed container, the solvent is filled in the injection container and is sealed, the non-woven fabric is sealed and placed in packing bag;

[0009] The packing box is equipped with inner liner, the inner liner is equipped with recess that can be placed the sealed container, the injection container and the packing bag respectively.

[0010] Preferably, the packing box includes a packing box upper shell and a packing box lower shell, the packing box upper shell is matched with the packing box lower shell, and the packing box lower shell is equipped with an inner liner.

[0011] Preferably, the sealed container includes a sealed bottle, a rubber plug and a sealed combination cover.

[0012] The sealed bottle includes a bottle mouth, a bottle neck and a bottle body, the bottle mouth, the bottle neck and the bottle body are integrally formed,

[0013] The rubber plug is inserted into the bottle mouth, and the outer diameter of the insertion part of the rubber plug is equal to the inner diameter of the bottle mouth.

[0014] The sealing combination cover comprises a sealing cover and an opening cover, the sealing cover is wrapped outside the rubber plug and the bottle mouth, the opening cover is covered above the sealing cover, and the middle part of the opening cover is connected with the middle part of the sealing cover.

[0015] When the opening cover is opened, the middle part of the opening cover drives the middle part of the sealing cover to move, and the rubber plug is exposed.

[0016] Preferably, the sealing cover is an aluminum cover, and the opening cover is a plastic cover.

[0017] Preferably, the injection container comprises a solvent cylinder, a push rod and a sealing device.

[0018] The solvent cylinder is a hollow cylinder and one end thereof is tapered to form an injection needle, and the injection needle is used for piercing the rubber plug.

[0019] The push rod is inserted into the inside of the solvent cylinder and moves along the axis of the solvent cylinder, and a solvent cavity is formed between the top end of the push rod and the solvent cylinder.

[0020] The sealing device is a cap, which is a hollow cylindrical structure and one end thereof is sleeved outside the injection needle, and the other end is sealingly arranged.

[0021] Preferably, the cap is made of rubber.

[0022] Preferably, the push rod comprises a push rod head, a push rod body and a push rod handle which are sequentially connected, and the outside of the push rod head is provided with a piston, and the maximum outer diameter of the piston is equal to the inner diameter of the solvent cylinder.

[0023] Preferably, one end of the piston is internally provided with a hollow thread, and the push rod head is connected with the piston through the hollow thread.

[0024] Preferably, the packaging bag is an aluminum foil vacuum packaging bag.

[0025] Preferably, a tearable sealing strip is arranged at the opening of the packaging bag.

[0026] Compared with the prior art, the present application has the following beneficial effects:

[0027] (1) The freeze-dried collagen dressing designed in the present application can realize independent packaging of freeze-dried collagen, solvent and non-woven fabric, and improve the stability of freeze-dried collagen, solvent and non-woven fabric, and will not fall off due to shaking, facilitating transportation and storage.

[0028] (2) The utility model discloses a rubber plug is inserted in the bottle mouth of the sealed bottle, and the insertion part of the rubber plug is equal to the outer diameter of the bottle mouth, so that the sealed bottle forms a sealed space, which can guarantee the stability and internal component activity of the freeze-dried collagen, prolong the effective period of the freeze-dried collagen, and the aluminum cover and the plastic cover are wrapped outside the rubber plug and the bottle mouth, which can further ensure good sealing performance while facilitating opening.

[0029] (3) The utility model discloses a injection container is set up, and the cap is set up on the injection container, so that the whole solvent cylinder is in sealed state, guarantees that solvent will not from solvent cylinder expose, facilitates and pulls and pushes, and push solvent movement, and the cap can also protect injection sharp head and will not break or knock.

[0030] (4) The utility model discloses an aluminum foil vacuum packaging bag, so that the packaging bag has good water -resisting, oxygen -resisting function, has good light -fastness, also has very strong isolation, and because there is the component of aluminum in it, therefore also has good oil resistance and softness, can guarantee the cleanliness of non -woven fabric, reduces the risk of non -woven fabric being contaminated, and the tearable seal strip is arranged at the opening of the packaging bag, so that when needing to use the dressing, the packaging bag can be torn along the tearable seal strip, and the hand is torn conveniently, and the practicality is stronger.

[0031] (5) The whole use process safety of the utility model discloses, can keep the biological activity of collagen protein to the maximum extent, improves the uniformity and the active lasting time of collagen protein stock solution. BRIEF DESCRIPTION OF DRAWINGS

[0032] Figure 1 It is the whole structure schematic diagram of the freeze-dried collagen dressing of the utility model,

[0033] Figure 2 It is the sealed container structure schematic diagram of the utility model,

[0034] Figure 3 It is the rubber plug structure schematic diagram of the utility model,

[0035] Figure 4 It is the structure schematic diagram of the sealing cover and opening cover of the utility model,

[0036] Figure 5 It is the injection container structure schematic diagram of the utility model,

[0037] Figure 6 It is the solvent cylinder structure schematic diagram of the utility model,

[0038] Figure 7 It is the piston structure schematic diagram of the utility model,

[0039] Figure 8 It is the push rod structure schematic diagram of the utility model,

[0040] Figure 9 It is the cap structure schematic view of the utility model;

[0041] Figure 10 It is the packaging bag structure schematic view of the utility model.

[0042] Mark explanation:

[0043] 1, packaging box; 11, packaging box upper shell; 12, packaging box lower shell; 2, sealed container; 21, sealed bottle; 22, rubber plug; 23, sealing combination cover; 231, sealing cover; 232, opening cover; 3, injection container; 31, solvent cylinder; 311, injection sharp head; 32, push rod; 321, push rod head; 322, push rod body; 323, push rod handle; 324, piston; 33, cap; 4, packaging bag; 41, tearable seal. Specific implementation

[0044] The technical scheme in the embodiments of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor belong to the scope of protection of the utility model.

[0045] In the description of the utility model, it is understood that the orientation or positional relationship indicated by the terms "coaxial", "bottom", "one end", "top", "middle", "the other end", "upper", "one side", "top", "inner", "front", "central", "both ends" is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, so it cannot be understood as a limitation on the utility model.

[0046] In the utility model, unless otherwise explicitly specified and limited, the terms "mounting", "setting", "connection", "fixing", "screw connection" and the like should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or it can be integrated;It can be mechanically connected, or it can be electrically connected;It can be directly connected, or it can be indirectly connected through an intermediate medium;It can be the communication or interaction relationship between two elements, unless otherwise explicitly limited, those skilled in the art can understand the specific meaning of the above terms in the utility model according to the specific situation.

[0047] Example 1

[0048] CombineFigures 1-10 The utility model discloses a freeze-dried collagen dressing, including packing box 1, freeze-dried collagen, solvent, sealed container 2, injection container 3 and non -woven fabric, the freeze-dried collagen is filled in the sealed container 2, the solvent is filled in the injection container 3 and is sealed, the non -woven fabric sealed placement is in packing bag 4, the packing box 1 is equipped with inner liner (not shown in drawing), the recess of being able to place the sealed container 2, the injection container 3 and the packing bag 4 respectively is equipped on the inner liner, can realize freeze-dried collagen, solvent and non -woven fabric independent packing, and improve the stability of freeze-dried collagen, solvent and non -woven fabric, and will not fall off because of shaking, convenient transportation and storage.

[0049] Example 2

[0050] Combination Figures 1-10 As shown in the figure, in the embodiment, the packing box 1 includes packing box upper shell 11 and packing box lower shell 12, the packing box upper shell 11 is matched with the packing box lower shell 12, the packing box lower shell 12 is equipped with an inner liner, the sealed container 2 includes a sealed bottle 21, a rubber plug 22 and a sealing combination cover 23, specifically, the sealed bottle 21 can be selected from a vial, the sealed bottle 21 includes a bottle mouth, a bottle neck and a bottle body, the bottle mouth, the bottle neck and the bottle body are integrally formed, the rubber plug 22 is inserted into the bottle mouth, the outer diameter of the insertion part of the rubber plug 22 is equal to the inner diameter of the bottle mouth, the sealing combination cover 23 includes a sealing cap 231 and an opening cap 232, specifically, the sealing cap 231 is an aluminum cap, the opening cap 232 is a plastic cap, the aluminum cap is wrapped outside the rubber plug 22 and the bottle mouth, the plastic cap is covered above the aluminum cap, the middle part of the plastic cap is connected with the middle part of the aluminum cap, when the plastic cap is opened, the middle part of the plastic cap drives the middle part of the aluminum cap to move, exposing the rubber plug 22, by inserting the rubber plug 22 into the bottle mouth of the sealed bottle 21, the outer diameter of the insertion part of the rubber plug 22 is equal to the outer diameter of the bottle mouth, so that the sealed bottle 21 forms a sealed space, which can ensure the stability of the freeze-dried collagen and the activity of the internal components, and prolong the effective period of the freeze-dried collagen, and by wrapping the aluminum cap and the plastic cap outside the rubber plug 22 and the bottle mouth, the aluminum cap and the plastic cap can be easily opened, and the sealing performance can be further ensured;

[0051] The injection container 3 includes a solvent cylinder 31, a push rod 32 and a sealing device;

[0052] The solvent cylinder 31 is a hollow cylinder, the solvent cylinder 31 is made of glass, one end of which is gradually reduced in diameter and then fixed to a certain diameter and extended to form a injection needle 311, the top end of the injection needle 311 has a hole, the injection needle 311 is used to pierce the rubber plug 22, the push rod 32 is inserted into the inside of the solvent cylinder 31 and moves along the axis of the solvent cylinder 31, similar to the principle of a syringe, when the push rod 32 is pulled, the solvent can be absorbed through the injection needle 311 and stored in the solvent cylinder 31, when the push rod 32 is pushed, the solvent in the inside of the solvent cylinder 31 overflows from the injection needle 311;

[0053] The push rod 32 comprises a push rod head 321, a push rod body 322 and a push rod handle 323 connected in turn, the cross section of the push rod body 322 is cross-shaped, the outside of the push rod head 321 is provided with a piston 324, specifically, one end of the piston 324 is internally provided with a hollow thread, the push rod head 321 is connected with the piston 324 through the hollow thread, the maximum outer diameter of the piston 324 is equal to the inner diameter of the solvent cylinder 31, and the piston 324 at the push rod head 321 forms a sealed solvent cavity with the solvent cylinder 31;

[0054] The sealing device is a cap 33, specifically, the cap 33 is made of rubber, the cap 33 is a hollow cylindrical structure and is sleeved on the outside of the injection needle 311 at one end, and is sealingly arranged at the other end, by arranging the piston 324 on the push rod head 321 and sleeving the cap 33 on the outside of the injection needle 311, the entire solvent cylinder 31 is in a sealed state, so that the solvent cannot be exposed from the solvent cylinder 31, and it is convenient to pull and push, the solvent is moved, and the cap 33 can also protect the injection needle 311 from breaking or bumping.

[0055] Embodiment 3

[0056] Combined Figures 1-10 As shown, in this embodiment, the packaging bag 4 is an aluminum foil vacuum packaging bag, and a tearable sealing strip 41 is arranged at the opening of the packaging bag 4, the aluminum foil vacuum packaging bag is selected so that the packaging bag 4 has good water and oxygen barrier functions, has good light shielding property and strong insulation, and has good oil resistance and softness due to the aluminum component inside, so as to ensure the cleanliness of the non-woven fabric and reduce the risk of pollution of the non-woven fabric; by arranging the tearable sealing strip 41 at the opening of the packaging bag 4, when the dressing needs to be used, the packaging bag 4 can be torn along the tearable sealing strip 41, which is convenient to tear by hand and has stronger practicality.

[0057] In the process of making the freeze-dried collagen dressing, the freeze-dried collagen dressing is divided into three parts, i.e. freeze-dried collagen (which can be freeze-dried fibers, freeze-dried powder, freeze-dried flocculation and freeze-dried velvet, etc.), solvent and non-woven fabric, wherein the freeze-dried collagen is filled in a sealed container 2, a rubber plug 22 is half-filled, placed in a vacuum freeze-drying box for freeze-drying, sealed and stored by using a sealing bottle 21, a rubber plug 22 and a sealing combination cover 23, the push rod 32 is pulled, the solvent is sucked into the inside of the solvent cylinder 31 by the injection sharp head 311, preferably, a scale can be arranged on the solvent cylinder 31 to facilitate reading the suction amount of the solvent; after the suction is completed, the cap 33 is buckled with the injection sharp head 311 to be sealed and then stored; at the same time, the non-woven fabric is packaged by using a packaging bag 4 to ensure that the freeze-dried collagen, the solvent and the non-woven fabric are separated. The sealed container 2, the injection container 3 and the packaging bag 4 are placed in the groove of the inner liner and can be fixed in the packaging box 1 and will not fall off due to shaking, the sealing container 3 and the packaging bag 4 have good sealing performance and can block air and various microorganisms to improve the stability and safety of the freeze-dried collagen, the solvent and the non-woven fabric.

[0058] In use, the following steps can be performed:

[0059] S1: the plastic cover of the sealing combination cover and the cap on the injection container are removed, the injection sharp head can pierce the rubber plug, the push rod is pushed towards the injection sharp head, the solvent in the inside of the injection container is injected into the sealing bottle, the injection sharp head is pulled out when the piston can not move any more, and the solvent is almost completely transferred into the sealing bottle;

[0060] S2: the rubber plug is buckled and the sealing bottle is upside down for about 5 minutes, and the freeze-dried collagen is dissolved to form a collagen solution.

[0061] S3: the injection sharp head pierces the rubber plug again, the sealing bottle is inverted, and the push rod is slowly pulled in the opposite direction, so that the collagen solution is almost completely sucked into the injection container.

[0062] S4: the tearable seal of the aluminum foil vacuum packaging bag is torn, the push rod is pushed towards the injection sharp head, the collagen solution in the injection container is injected onto the non-woven fabric in the aluminum foil vacuum packaging bag, and the collagen solution is almost completely transferred onto the non-woven fabric when the piston can not move any more.

[0063] S5: the non-woven fabric with the collagen solution is taken out for application.

[0064] The whole process is safe and hygienic, the biological activity of the collagen protein is maintained to the greatest extent, and the uniformity and the long-lasting time of the activity of the collagen protein stock solution are improved.

[0065] The above only describes the embodiments of the present application and does not limit the present application. Any modification, equivalent replacement and improvement made within the scope of the present application should be included in the protection scope of the present application.

Claims

1. A lyophilized collagen dressing, characterized in that, The package includes a package box, a lyophilized collagen, a solvent, a sealed container, an injection container and a non-woven fabric, the lyophilized collagen is filled in the sealed container, the solvent is filled in the injection container and sealed, and the non-woven fabric is sealed and placed in the package bag. The package box is provided with an inner liner, and the inner liner is provided with grooves for respectively placing the sealed container, the injection container and the package bag.

2. The lyophilized collagen dressing of claim 1, wherein, The package box includes a package box upper shell and a package box lower shell, the package box upper shell is matched with the package box lower shell, and the package box lower shell is provided with an inner liner.

3. The lyophilized collagen dressing of claim 2, wherein, The sealed container includes a sealed bottle, a rubber plug and a sealing combination cover. The sealed bottle includes a bottle mouth, a bottle neck and a bottle body, the bottle mouth, the bottle neck and the bottle body are integrally formed, The rubber plug is inserted into the bottle mouth, and the outer diameter of the insertion part of the rubber plug is equal to the inner diameter of the bottle mouth. The sealing combination cover includes a sealing cover and an opening cover, the sealing cover is wrapped outside the rubber plug and the bottle mouth, the opening cover is covered above the sealing cover, and the middle part of the opening cover is connected with the middle part of the sealing cover. When the opening cover is opened, the middle part of the opening cover drives the middle part of the sealing cover to move, and the rubber plug is exposed.

4. The lyophilized collagen dressing of claim 3, wherein, The sealing cover is an aluminum cover, and the opening cover is a plastic cover.

5. The lyophilized collagen dressing of claim 4, wherein, The injection container includes a solvent cylinder, a push rod and a sealing device. The solvent cylinder is a hollow cylindrical structure, and one end of the solvent cylinder is tapered to form an injection tip, the injection tip is used to pierce the rubber plug, The push rod is inserted into the inside of the solvent cylinder and moves along the axis of the solvent cylinder, and a solvent cavity is formed between the top end of the push rod and the solvent cylinder. The sealing device is a protective cap, the protective cap is a hollow cylindrical structure, one end of the protective cap is sleeved outside the injection tip, and the other end of the protective cap is sealed.

6. The lyophilized collagen dressing of claim 5, wherein, The protective cap is made of rubber.

7. The lyophilized collagen dressing of claim 5, wherein, The push rod includes a push rod head, a push rod body and a push rod handle connected in sequence, the outside of the push rod head is provided with a piston, and the maximum outer diameter of the piston is equal to the inner diameter of the solvent cylinder.

8. The lyophilized collagen dressing of claim 7, wherein, One end of the piston is provided with a hollow thread, and the push rod head and the piston are connected through the hollow thread.

9. The lyophilized collagen dressing according to any one of claims 1 to 8, characterized in that, The package bag is an aluminum foil vacuum packaging bag.

10. The lyophilized collagen dressing of claim 9, wherein, The opening of the package bag is provided with a tearable sealing strip.

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