Efficient mixing and stirring device for detecting vaccine adjuvant preparation

Abstract

The utility model discloses an efficient mixing and stirring device for detecting a vaccine adjuvant preparation, and belongs to the technical field of vaccine processing. The first stirring assembly, the second stirring assembly and the third stirring assembly are sequentially arranged on the stirring shaft, a vertical rod of the first stirring assembly is arranged on the side, close to the second stirring assembly, of the first stirring assembly, and the second stirring assembly and the stirring shaft form an inclined angle a in the rotating direction; the first transverse rods of the third stirring assemblies and the stirring shaft form inclination angles b, and the inclination angles b of the multiple third stirring assemblies are different. A plurality of groups of stirring assemblies are arranged on the stirring shaft of the stirring device, so that the mixed vaccine preparation adjuvant is fully stirred in a layered manner, and vertical rods are arranged on the stirring assemblies to form different angles, so that the mixed vaccine preparation adjuvant is circularly stirred from top to bottom; the situation that the uniformly stirred vaccine preparation adjuvant stands still in the mixing tank body and is separated, and then the stirring effect is influenced is avoided.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the vaccine processing technical field, and specifically relates to a high -efficient mixing stirring device for vaccine adjuvant preparation detection. BACKGROUND

[0002] In the process of vaccine adjuvant preparation research, different kinds of vaccine adjuvants need to be mixed together and experimental detection is carried out to observe the effect of mixing different kinds of vaccine adjuvants together. In the traditional vaccine adjuvant mixing process, the stirring mode is single, and the vaccine adjuvants cannot be well mixed together to react, which affects the detection of the effect of the vaccine adjuvant preparation by subsequent experimental personnel. SUMMARY

[0003] The utility model discloses a purpose at solving the process that the existing stirring device mixes vaccine adjuvant, and the stirring effect is not ideal, and the vaccine adjuvant cannot be mixed evenly into vaccine adjuvant preparation.

[0004] To achieve the above object, the utility model provides a technical scheme: a high -efficient mixing stirring device for vaccine adjuvant preparation detection of the utility model, containing the stirring shaft and the stirring assembly one, the stirring assembly two and the stirring assembly three that set gradually on the stirring shaft, multiple The stirring assembly one, the stirring assembly two and the stirring assembly three are arranged along the length direction interval of the stirring shaft;

[0005] The stirring assembly one contains the transverse rod that is fixedly connected on the stirring shaft and the vertical rod that is arranged at the top end of the transverse rod, the vertical rod is arranged at the side of the stirring assembly one close to the stirring assembly two, and the stirring assembly one drives the mixed vaccine adjuvant in the upper layer to flow to the middle layer by rotating;

[0006] The stirring assembly two contains the upper stirring blade and the lower stirring blade, the upper stirring blade and the lower stirring blade are mirror image symmetry arrangement, the upper stirring blade and the lower stirring blade form the included angle a, the range of the included angle a is 90 ° ~ 150 °, so that the mixed vaccine adjuvant in the middle layer moves away from the direction of the upper stirring blade and the lower stirring blade;

[0007] The stirring assembly two forms the inclination angle a along the rotation direction with the stirring shaft, and the inclination angle a of multiple stirring assembly twos is different, and the stirring assembly two drives the mixed vaccine adjuvant in the middle layer to flow to the upper layer and the lower layer by rotating;

[0008] The stirring assembly three comprises a transverse rod one fixedly connected to the stirring shaft and a plurality of stirring blocks arranged on the transverse rod one, and the transverse rod one forms an inclination angle b with the stirring shaft in the direction close to the stirring assembly two, the inclination angle b ranges from 30° to 60°, and the transverse rod one drives the flow of the lower layer mixed vaccine adjuvant to the middle layer in the rotating process.

[0009] Preferably, the stirring blocks are staggered along the upper side and the lower side of the transverse rod one.

[0010] Preferably, the length of the transverse rod one is L, the interval distance of the stirring blocks is d, and the interval distance d of the stirring blocks is 0.1 times the length L of the transverse rod one.

[0011] Preferably, the stirring system further comprises a stirring motor, and the stirring motor drives the stirring shaft to rotate.

[0012] Preferably, the stirring shaft is connected with a feeding metering pump, and the feeding metering pump is communicated with a feeding channel and the mixing tank body, so as to accurately control the feeding amount.

[0013] Preferably, the stirring system is connected with the discharging system, and the discharging system comprises a discharging motor and a discharging collection tank, and the discharging motor rotates to generate rotating pressure, so that the material in the mixing tank body is discharged into the discharging collection tank.

[0014] Preferably, the stirring system further comprises a control system.

[0015] Compared with the prior art, the technical scheme has the following beneficial effects:

[0016] The high-efficiency mixing and stirring device for vaccine adjuvant preparation detection comprises a stirring shaft and stirring assemblies one, two and three arranged on the stirring shaft in sequence, the stirring assemblies one, two and three are arranged at intervals along the length direction of the stirring shaft, the vertical rod of the stirring assembly one is arranged on the side of the stirring assembly one close to the stirring assembly two, the stirring assembly two forms an inclination angle a with the stirring shaft along the rotating direction, the inclination angles a of the plurality of stirring assemblies two are different, the transverse rod one of the stirring assembly three forms an inclination angle b with the stirring shaft along the direction close to the stirring assembly two, and the inclination angles b of the plurality of stirring assemblies three are different. BRIEF DESCRIPTION OF DRAWINGS

[0017] Fig. 1 It is a whole structure schematic view of a high-efficiency mixing and stirring device for vaccine adjuvant preparation detection of the utility model.

[0018] Fig. 2 It is a stirring assembly structure schematic view of a high-efficiency mixing and stirring device for vaccine adjuvant preparation detection of the utility model.

[0019] The label explanation in the schematic view is as follows:

[0020] Stirring system; 110, stirring motor; 120, feed metering pump; 130, feed channel; 140, mixing tank body, 150, stirring shaft; 160, stirring assembly one; 161, horizontal rod; 162, vertical rod; 170, stirring assembly two; 180, stirring assembly three; 181, horizontal rod one; 182, stirring block;

[0021] 200, discharge system; 210, discharge motor; 220, discharge collection tank;

[0022] 300, control system. DETAILED DESCRIPTION

[0023] In order to make the person skilled in the art better understand the present application, the technical solutions in the embodiments of the present application will be described clearly and completely below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by the person skilled in the art without creative labor should belong to the scope of protection of the present application.

[0024] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and do not necessarily describe a specific order or sequence. It should be understood that the data thus used can be interchanged under appropriate circumstances, so that the embodiments of the present application described herein can be implemented. In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusion, for example, a process, method, system, product or device including a series of steps or units does not necessarily limit to those steps or units clearly listed, but can include other steps or units not clearly listed or inherent to these processes, methods, products or devices.

[0025] In the present application, the terms "upper", "lower", "left", "right", "front", "back", "top", "bottom", "inner", "outer", "middle", "vertical", "horizontal", "transverse", "longitudinal", and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. These terms are mainly used to better describe the present application and its embodiments, and are not intended to limit the indicated devices, elements or components to have a specific orientation, or to be constructed and operated in a specific orientation.

[0026] In addition, in addition to indicating the orientation or positional relationship, the above-mentioned partial terms can also be used to indicate other meanings, for example, the term "upper" can also be used to indicate a certain dependent relationship or connection relationship in some cases. For those skilled in the art, the specific meaning of these terms in the present application can be understood according to the specific situation.

[0027] In addition, the terms "mount", "set", "provided with", "connected", "connected", "sleeved" should be broadly understood. For example, it can be fixedly connected, detachably connected, or integrally constructed; it can be mechanically connected or electrically connected; it can be directly connected, or indirectly connected through an intermediate medium, or internal communication between two devices, elements or components. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific situation.

[0028] It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict. The present application will be described in detail below with reference to the drawings and in conjunction with the embodiments.

[0029] Referring to the drawings Figs. 1-2 The high-efficiency mixing and stirring device for detecting the vaccine adjuvant preparation of the embodiment comprises a stirring system 100, a discharging system 200 and a control system 300. The stirring system 100 fully stirs the mixed vaccine adjuvant, and the mixed vaccine adjuvant is uniformly mixed. The discharging system 200 is used to discharge the uniformly stirred vaccine adjuvant preparation for subsequent use. The stirring system 100 is connected to the discharging system 200, and the uniformly stirred vaccine adjuvant preparation is discharged from the stirring system 100 to the discharging system 200 for subsequent detection by the experimental personnel. The control system 300 is connected to the stirring system 100 and the discharging system 200, respectively. The control system 300 realizes accurate control of the stirring speed, stirring time and other parameters, and is provided with safety protection devices such as overload protection and overheating protection, to ensure the safety and reliability of the equipment during operation.

[0030] The high-efficiency mixing and stirring device for detecting a vaccine adjuvant preparation of the embodiment comprises a stirring shaft 150 and stirring assemblies one 160, stirring assemblies two 170 and stirring assemblies three 180 arranged on the stirring shaft 150 in sequence, the stirring shaft 150 is arranged to rotate in the clockwise direction, the stirring assemblies one 160, the stirring assemblies two 170 and the stirring assemblies three 180 are arranged in sequence from top to bottom along the length direction of the stirring shaft 150;

[0031] The stirring assemblies one 160 comprises a transverse rod 161 fixedly connected to the stirring shaft 150 and a vertical rod 162 arranged at the top end of the transverse rod 161, the vertical rod 162 is arranged on the side of the stirring assemblies one 160 close to the stirring assemblies two 170, the stirring assemblies one 160 drives the upper layer of mixed vaccine adjuvant to flow to the middle layer by rotating;

[0032] The stirring assemblies two 170 comprises upper stirring blades 171 and lower stirring blades 172, the upper stirring blades 171 and the lower stirring blades 172 are arranged in mirror symmetry, the upper stirring blades 171 and the lower stirring blades 172 form an included angle a, the range of the included angle a is 90°~150°, so that the middle layer of mixed vaccine adjuvant moves away from the upper stirring blades 171 and the lower stirring blades 172;

[0033] The stirring assemblies three 180 comprises a transverse rod one 181 fixedly connected to the stirring shaft 150 and a plurality of stirring blocks 182 arranged on the transverse rod one 181, along the direction close to the stirring assemblies two 170, the transverse rod one 181 forms an inclined angle b with the stirring shaft 150, the range of the inclined angle b is 30°~60°, the transverse rod one 181 drives the lower layer of mixed vaccine adjuvant to flow to the middle layer in the process of rotating.

[0034] The stirring system 100 comprises a stirring motor 110 and a stirring shaft 150, the stirring motor 110 drives the stirring shaft 150 to rotate through a speed reducer, a stirring assembly one 160, a stirring assembly two 170 and a stirring assembly three 180 are sequentially connected along the length direction of the stirring shaft 150 from top to bottom, the stirring assembly one 160 comprises a transverse rod 161 fixedly connected on the stirring shaft 150 and a vertical rod 162 arranged at the top end of the transverse rod 161, the vertical rod 162 is arranged at the side of the stirring assembly one 160 close to the stirring assembly two 170, when the stirring shaft 150 drives the stirring assembly one 160 to rotate, the transverse rod 161 and the vertical rod 162 drive the mixed vaccine adjuvant in the upper layer to mix and flow to the middle layer, the stirring assembly two 170 forms an inclination angle a with the stirring shaft 150 along the rotation direction, the inclination angles a of the plurality of stirring assembly two 170 are different, the range of the inclination angle a is 15°~30°, when the inclination angle a is less than 15°, the stirring assembly two 170 is close to parallel with the rotation direction, in the rotating process, the stirring assembly two 170 can only drive the mixed vaccine adjuvant to rotate, and cannot move to the upper layer and the lower layer space, when the inclination angle a is greater than 30°, the stirring assembly two 170 is close to vertical with the rotation direction, in the rotating process of the stirring assembly two 170, the resistance is large, and the rotation is not good, which has an influence on the stirring effect, and the inclination arrangement of the plurality of stirring assembly two 170 fully stirs the mixed vaccine adjuvant and drives the mixed vaccine adjuvant to flow to the upper layer and the lower layer, the stirring assembly three 180 comprises a transverse rod one 181 fixedly connected on the stirring shaft 150 and a plurality of stirring blocks 182 arranged on the transverse rod one 181, along the direction close to the stirring assembly two 170, the transverse rod one 181 forms an inclination angle b with the stirring shaft 150, the inclination angles b of the plurality of stirring assembly three 180 are different, the range of the inclination angle b is 30°~60°, when the inclination angle b of the stirring assembly three 180 is less than 30°, the stirring space formed between the stirring assembly three 180 and the stirring shaft 150 is small, and the lower mixed vaccine adjuvant cannot be effectively stirred, when the inclination angle b of the stirring assembly three 180 is greater than 60°, the stirring space formed between the stirring assembly three 180 and the stirring shaft 150 is large, in the stirring process, the stirring assembly three 180 can only drive the mixed vaccine adjuvant close to the stirring assembly three 180 to stir, and the mixed vaccine adjuvant close to the stirring shaft 150 lacks driving force, thereby reducing the stirring effect, the stirring blocks 182 are arranged in a staggered manner along the upper side and the lower side of the transverse rod one 181, the length of the transverse rod one 181 is L, the interval distance of the stirring blocks 182 is d, the interval distance d of the stirring blocks 182 is 0.1 times, the mixing block 182 is arranged on the upper side and the lower side of the transverse rod one 181, and is arranged at intervals along the length direction of the transverse rod one 181, so that the lower layer mixed vaccine adjuvant is fully stirred, and the mixed vaccine adjuvant in the lower layer is driven to the middle layer in the stirring process through the transverse rod one 181 and the stirring shaft 150 forming a suitable inclination angle b, so that the mixed vaccine preparation which is uniformly stirred is prevented from being separated due to standing in the bottom space.

[0035] The stirring shaft 150 is connected with a feeding metering pump 120, the feeding metering pump 120 is driven by the stirring shaft 150 to move, in this process, the volume of the pump cavity is periodically changed to accurately control the feeding amount, the feeding metering pump 120 is communicated with a feeding channel 130, which is used for feeding the mixed vaccine adjuvant into the feeding metering pump 120, so as to facilitate further processing and production, the feeding metering pump 120 is communicated with a mixing tank 140, the mixing tank 140 is made of high-strength high-silicon glass material, which is smooth inside and has no dead angle, so as to facilitate cleaning and disinfection after processing, the mixing tank 140 is provided with a stirring cavity, the stirring assembly one 160, the stirring assembly two 170 and the stirring assembly three 180 are arranged in the stirring cavity of the mixing tank 140, so as to fully stir the mixed vaccine adjuvant in the mixing tank 140.

[0036] The discharging system 200 comprises a discharging motor 210 and a discharging collection tank 220, the discharging collection tank 220 is communicated with the mixing tank 140, which is used for receiving the mixed vaccine adjuvant preparation which is uniformly stirred from the mixing tank 140 and storing, so as to be used by researchers for subsequent detection or analysis, the discharging motor 210 is connected with the discharging collection tank 220, and pressure is generated by rotation, on the one hand, the mixed vaccine adjuvant preparation which is uniformly stirred in the mixing tank 140 is discharged, and on the other hand, the mixed vaccine adjuvant which is uniformly stirred in the mixing tank 140 is stirred to maintain uniformity.

[0037] The above embodiment only expresses certain implementation manners of the present application, which is described in detail, but cannot be understood as a limitation on the patent scope of the present application; it should be pointed out that, for ordinary skilled persons in the art, without departing from the concept of the present application, a number of modifications and improvements can be made, which all belong to the protection scope of the present application; therefore, the protection scope of the present application patent should be subject to the appended claims.

Claims

1. A high efficiency mixing and stirring device for vaccine adjuvant formulation testing, characterized by: The stirring shaft (150) is arranged to rotate in a clockwise direction, and the stirring assembly one (160), the stirring assembly two (170) and the stirring assembly three (180) are arranged in a spaced manner from top to bottom along the length direction of the stirring shaft (150). The stirring assembly one (160) comprises a transverse rod (161) fixedly connected to the stirring shaft (150) and a vertical rod (162) arranged at the top end of the transverse rod (161), and the vertical rod (162) is arranged at the side of the stirring assembly one (160) close to the stirring assembly two (170), and the stirring assembly one (160) drives the upper layer of mixed vaccine adjuvant to flow to the middle layer by rotating. The stirring assembly two (170) comprises an upper stirring blade (171) and a lower stirring blade (172), and the upper stirring blade (171) and the lower stirring blade (172) are arranged in a mirror image symmetry, and the upper stirring blade (171) and the lower stirring blade (172) form an included angle a, and the range of the included angle a is 90°-150°, so that the middle layer of mixed vaccine adjuvant moves away from the upper stirring blade (171) and the lower stirring blade (172). The stirring assembly three (180) comprises a transverse rod one (181) fixedly connected to the stirring shaft (150) and a plurality of stirring blocks (182) arranged on the transverse rod one (181), and the transverse rod one (181) forms an inclined angle b with the stirring shaft (150) in the direction close to the stirring assembly two (170), and the range of the inclined angle b is 30°-60°, and the transverse rod one (181) drives the lower layer of mixed vaccine adjuvant to flow to the middle layer in the rotating process.

2. The high efficiency mixing and stirring device for detecting a vaccine adjuvant preparation according to claim 1, characterized in that: The stirring blocks (182) are arranged in a staggered manner along the upper side and the lower side of the transverse rod one (181).

3. The high efficiency mixing and stirring device for detecting a vaccine adjuvant preparation according to claim 2, characterized in that: The length of the transverse rod one (181) is L, the interval distance of the stirring blocks (182) is d, and the interval distance d of the stirring blocks (182) is 0.1 times the length L of the transverse rod one (181).

4. The high efficiency mixing and stirring device for detecting a vaccine adjuvant preparation according to claim 3, characterized in that: The stirring system (100) further comprises a stirring motor (110) for rotating the stirring shaft (150).

5. The high efficiency mixing and stirring device for detecting a vaccine adjuvant preparation according to claim 4, characterized in that: The stirring shaft (150) is connected with a feed metering pump (120), and the feed metering pump (120) is communicated with a feed channel (130) and a mixing tank (140) to accurately control the amount of feed.

6. The high efficiency mixing and stirring device for detecting a vaccine adjuvant preparation according to claim 5, characterized in that: The stirring system (100) is connected with a discharge system (200), and the discharge system (200) comprises a discharge motor (210) and a discharge collection tank (220), and the discharge motor (210) rotates to generate rotating pressure, so that the material in the mixing tank (140) is discharged into the discharge collection tank (220).

7. The high efficiency mixing and stirring device for detecting a vaccine adjuvant preparation according to claim 6, characterized in that: Further comprising a control system (300).

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