Ultrasonic cleaning device and sample analyzer

Abstract

The utility model provides an ultrasonic cleaning device, a sample analyzer and a cleaning method. The sample analyzer comprises a pipetting needle, an ultrasonic cleaning device, a needle moving component and a cleaning liquid supply device, the ultrasonic cleaning device comprises a cleaning part, a transduction assembly, a medium circulation assembly and a bearing assembly, the cleaning part is provided with a cleaning pool, a first step capable of abutting against the cleaning part is arranged in an assembling cavity of the medium circulation assembly, and the bearing assembly enables the cleaning part to be kept in the assembling cavity; a first sealing ring and a second sealing ring are arranged between the front end face of the cleaning part and the first step and between the bottom end face of the cleaning part and the bearing assembly correspondingly, and the two sealing rings are located at the positions where the local amplitude is smaller than or equal to the preset amplitude during vibration. Based on the technical scheme of the utility model, the positions of the first sealing ring and the second sealing ring are smaller than the preset amplitude and are actually equivalent to the pitch plane positions, and the sealing assembly is carried out at the positions, so that the sealing reliability of the transduction assembly is ensured, and the waterproof property of the transduction assembly is ensured.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical instrument cleaning technical field, in particular to an ultrasonic cleaning device and sample analyzer. BACKGROUND

[0002] In the field of in-vitro diagnosis, pipetting needle for pipetting sample or reagent is a commonly used part, in order to prevent the problem of carrying pollution, the corresponding pipetting needle needs to be cleaned after each pipetting is completed, but the pipetting needle of the prior art is often not cleaned thoroughly, which affects the detection result due to cross contamination. At present, ultrasonic cleaning means is used to solve this problem. Ultrasonic cleaning is to use the cavitation effect of ultrasonic wave propagation in cleaning liquid to form high temperature and high pressure and high speed jet flow, which acts on the pollutants on the surface of the sample needle, so that the pollutants are stripped and dispersed, thereby achieving the purpose of cleaning.

[0003] The utility model solves the assembly problem between ultrasonic transducing assembly and cleaning device complete machine, to carry out high -efficient reliable ultrasonic cleaning. UTILITY MODEL CONTENTS

[0004] In order to solve the technical problems existing in the prior art, the utility model provides an ultrasonic cleaning device, a sample analyzer and a cleaning method.

[0005] Firstly, the utility model provides a sample analyzer, which comprises:

[0006] Pipetting needle, which is used for sucking sample or reagent and injecting into reaction container;

[0007] Ultrasonic cleaning device, which is used for ultrasonic cleaning of the pipetting needle;

[0008] Needle moving assembly, which is used for driving the pipetting needle to move into the ultrasonic cleaning device for ultrasonic cleaning; And

[0009] Cleaning liquid supply device, which is used for providing cleaning liquid to the ultrasonic cleaning device;

[0010] The ultrasonic cleaning device comprises a cleaning part, a transducing assembly, a medium circulating assembly and a supporting assembly, the cleaning part is configured with a cleaning pool for containing the cleaning liquid, the transducing assembly is used for emitting ultrasonic wave to the cleaning liquid in the cleaning pool, the medium circulating assembly is configured with an assembly cavity for containing the cleaning part, the assembly cavity is configured with a first step capable of abutting against the front end of the cleaning part, the supporting assembly is used for supporting the cleaning part, and the supporting assembly is configured to be fixed to the bottom surface of the medium circulating assembly, so that the cleaning part is kept in the assembly cavity;

[0011] The first sealing ring and the second sealing ring are respectively arranged between the front end surface of the cleaning part and the first step and between the bottom end surface of the cleaning part and the supporting assembly, and the first sealing ring and the second sealing ring are located at positions where the local amplitude of the cleaning part is less than or equal to a preset amplitude when the transducing assembly generates vibration.

[0012] In one embodiment, the preset amplitude is close to 0 in value.

[0013] In one embodiment, 3-5 liquid inlet holes are arranged on the pool wall of the cleaning pool near the pool bottom.

[0014] In one embodiment, the internal space of the cleaning pool is configured as a first cavity, a second cavity and a third cavity sequentially communicated in the direction from the pool opening to the pool bottom of the cleaning pool.

[0015] The diameter of the second cavity gradually increases in the direction from the pool opening to the pool bottom of the cleaning pool, so that the cavity wall of the second cavity is formed as an inclined surface towards the third cavity.

[0016] In one embodiment, the first cavity and the third cavity are both configured as a cylindrical structure with a constant diameter at any axial position, and the diameter of the first cavity is smaller than that of the third cavity.

[0017] The diameter of the second cavity near the first cavity is equal to the diameter of the first cavity, and the diameter of the second cavity near the third cavity is smaller than or equal to the diameter of the third cavity.

[0018] In one embodiment, the transducing assembly comprises a front cover plate, an ultrasonic transducing unit and a rear cover plate arranged sequentially, and the front cover plate, the ultrasonic transducing unit and the rear cover plate are connected as a whole by a fastener penetrating from the rear cover plate to the front cover plate.

[0019] The cleaning part is integrally formed with the front cover plate, and the cleaning part is located at the end of the front cover plate away from the ultrasonic transducing unit, and the pool bottom of the cleaning pool corresponds to the ultrasonic transducing unit.

[0020] In one embodiment, the ultrasonic transducing unit is configured to emit ultrasonic waves towards the center of the pool bottom of the cleaning pool, and the sound field energy of the ultrasonic waves is concentrated in the area where the axis of the third cavity is located.

[0021] In one embodiment, the ultrasonic transducing unit comprises a plurality of electrode sheets and a plurality of piezoelectric ceramics arranged in overlap, and the electrode sheets and the piezoelectric ceramics are arranged alternately in the overlap direction.

[0022] In one embodiment, the medium circulating assembly is configured with an overflow tank, the overflow tank is configured with an overflow platform which is higher than the bottom surface of the overflow tank, the assembly cavity is configured on the overflow platform, and two ends of the assembly cavity respectively penetrate the surface of the overflow platform and the bottom surface of the medium circulating assembly, and the bottom surface of the overflow tank is provided with a liquid outlet;

[0023] The cleaning part is accommodated in the assembly cavity, and the cleaning tank is configured such that the cleaning medium can overflow to the surface of the overflow platform, so that the cleaning medium flows into the bottom of the overflow tank through the surface of the overflow platform and is discharged through the liquid outlet.

[0024] In one embodiment, the assembly cavity is configured with a liquid inlet on the cavity wall which communicates with the assembly cavity, and the liquid inlet is communicated with a liquid inlet hole configured on the tank wall of the cleaning tank when the cleaning tank is fitted in the assembly cavity.

[0025] In one embodiment, the liquid inlet and the liquid outlet are respectively fitted with a liquid inlet connector and a liquid outlet connector.

[0026] In one embodiment, the first sealing ring and the second sealing ring are both configured as a corner structure;

[0027] The first part of the first sealing ring is located between the first step and the front end surface of the cleaning part, and the second part is located between the cavity wall of the assembly cavity and the front end side surface of the cleaning part;

[0028] The first part of the second sealing ring is located between the surface of the supporting assembly and the bottom surface of the cleaning part, and the second part is located between the cavity wall of the assembly cavity and the bottom end side surface of the cleaning part.

[0029] In one embodiment, the end of the second part of the first sealing ring and the second sealing ring is configured with a sealing reinforcing part, and the sealing reinforcing part is configured as an annular structure which can surround the cleaning part;

[0030] In the cross section where the axis of the first sealing ring or the second sealing ring is located, the sealing reinforcing part is circular and the diameter of the circle is greater than the thickness of the second part.

[0031] In one embodiment, the front end of the cleaning part is configured as a stepped first sealing part formed by changing the diameter, the bottom end of the cleaning part is configured as a second sealing part with equal diameter, and the step surface of the first sealing part is configured as part of the front end surface of the cleaning part;

[0032] The first sealing part is used to fit the first sealing ring, and the second sealing part is used to fit the second sealing ring.

[0033] In one embodiment, the first sealing ring and the second sealing ring are made of fluororubber.

[0034] In one embodiment, the supporting assembly is provided with a through hole configured to allow the main body of the transducing assembly to pass through so that the bottom end of the cleaning part abuts against the surface of the supporting assembly.

[0035] In one embodiment, the supporting assembly is provided with a supporting table protruding from the surface of the supporting assembly, the through hole is configured in the supporting table, the table top of the supporting table is capable of supporting the cleaning part, and the supporting table is configured so that at least the part of the supporting table close to the table top is capable of being embedded in the assembly cavity.

[0036] In one embodiment, the table top of the supporting table is provided with a supporting groove, the through hole is configured in the groove bottom of the supporting groove, the supporting groove is configured to accommodate the bottom end of the cleaning part, and the second sealing ring is arranged between the groove bottom of the supporting groove and the bottom end surface of the cleaning part.

[0037] In one embodiment, the outer circumferential surface of the supporting table is provided with a sealing ring groove, the sealing ring groove is used to arrange a third sealing ring, and the third sealing ring is configured to be in sealing contact with the cavity wall of the assembly cavity when the supporting table is at least partially embedded in the assembly cavity.

[0038] In one embodiment, the inside of the assembly cavity is provided with a second step close to the bottom surface of the medium circulating assembly, and the second step is configured to abut against the table top of the supporting table.

[0039] In one embodiment, the supporting assembly is provided with a plurality of connecting holes located at the periphery of the through hole, and the bottom surface of the medium circulating assembly is provided with a plurality of screw holes located at the periphery of the assembly cavity, the screw holes are configured to be threadedly connected with the connecting members passing through the connecting holes.

[0040] The supporting assembly is provided with a fixing hole, the fixing hole is located outside the region of the supporting assembly used to connect with the medium circulating assembly, and the fixing hole is used to fixedly connect the ultrasonic cleaning device with an external supporting part.

[0041] The utility model provides a kind of ultrasonic cleaning device, including cleaning part, transducing component, medium circulation component and support component, the cleaning part is structured with the cleaning pool for accommodating cleaning liquid, the transducing component is used to emit ultrasonic wave to the cleaning liquid in the cleaning pool, the medium circulation component is structured with the assembly cavity for accommodating the cleaning part, the assembly cavity is structured with the first step capable of abutting the front end of the cleaning part, the support component is used to support the cleaning part, the support component is structured as being able to be fixed to the bottom surface of the medium circulation component, to make the cleaning part remain in the assembly cavity.

[0042] Wherein, the front end surface of the cleaning part and the first step, the bottom end surface of the cleaning part and the support component are respectively provided with first sealing ring and second sealing ring, the first sealing ring and the second sealing ring are in the position that the local amplitude of the cleaning part is less than or equal to the preset amplitude when the transducing component generates vibration.

[0043] In one embodiment, the preset amplitude is close to 0 in value.

[0044] In one embodiment, 3-5 liquid inlet holes are arranged on the pool wall of the cleaning pool near the pool bottom.

[0045] In one embodiment, the first sealing ring and the second sealing ring are both structured as corner structure.

[0046] The first part of the first sealing ring is located between the first step and the front end surface of the cleaning part, and the second part is located between the cavity wall of the assembly cavity and the front end side surface of the cleaning part.

[0047] The first part of the second sealing ring is located between the surface of the support component and the bottom surface of the cleaning part, and the second part is located between the cavity wall of the assembly cavity and the bottom end side surface of the cleaning part.

[0048] In one embodiment, the end of the second part of the first sealing ring and the second sealing ring is structured with sealing reinforcement part, and the sealing reinforcement part is structured as annular structure capable of surrounding the cleaning part.

[0049] Wherein, in the cross section of the axis of the first sealing ring or the second sealing ring, the sealing reinforcement part is circular and the diameter of the circle is greater than the thickness of the second part.

[0050] In one embodiment, the front end of the cleaning part is structured as stepped first sealing part formed by variable diameter, the bottom end of the cleaning part is structured as second sealing part with equal diameter, and the step surface of the first sealing part is structured as part of the front end surface of the cleaning part.

[0051] The first sealing part is used for matching the first sealing ring, and the second sealing part is used for matching the second sealing ring.

[0052] In a third aspect, the utility model provides a cleaning method, which is applied to the sample analyzer or the ultrasonic cleaning device, and comprises the following steps:

[0053] The cleaning liquid is continuously circulated to the cleaning pool, the pipette needle to be cleaned is inserted into the cleaning pool, and the part of the pipette needle to be cleaned reaches a predetermined position in the cleaning pool, and the predetermined position is a region with a distance of 1-10 mm from the bottom surface of the cleaning pool.

[0054] The ultrasonic transducer unit corresponding to the cleaning pool is started to clean the pipette needle for a predetermined length of time.

[0055] The above technical features can be combined in various suitable ways or replaced by equivalent technical features, as long as the purpose of the utility model can be achieved.

[0056] Compared with the prior art, the ultrasonic cleaning device, the sample analyzer and the cleaning method provided by the utility model have at least the following beneficial effects:

[0057] The ultrasonic cleaning device, the sample analyzer and the cleaning method provided by the utility model have the following beneficial effects: the positions of the first sealing ring and the second sealing ring are smaller than the preset amplitude, which is equivalent to the position of a pitch surface, sealing assembly is performed at the position, the reliability of the transducer assembly is ensured, and the waterproof performance of the transducer assembly is ensured; and since the position is a pitch surface, the transducer assembly and the medium circulating assembly are fixedly connected through the supporting assembly, the performance of the transducer assembly as a whole is not affected, and in turn, when the transducer assembly is subjected to load fluctuation, the vibration mode of the cleaning pool will not change greatly. BRIEF DESCRIPTION OF DRAWINGS

[0058] In the following, the utility model will be described in more detail based on the embodiments and with reference to the drawings. Wherein:

[0059] Figure 1 An exploded view of the ultrasonic cleaning device in the sample analyzer of the utility model is shown;

[0060] Figure 2 An assembly view of the ultrasonic cleaning device in the sample analyzer of the utility model is shown;

[0061] Figure 3 An exploded view of the ultrasonic cleaning device in the sample analyzer of the utility model is shown; Figure 2 A schematic view of the structure shown in another view is shown;

[0062] Figure 4 An exploded view of the ultrasonic cleaning device in the sample analyzer of the utility model is shown; Figure 2 A sectional view of the structure shown (adopting one kind of sealing structure design) is shown;

[0063] Figure 5 A sectional view of the structure shown (with another sealing structure design) is shown. Figure 2

[0064] Figure 6 A schematic view of the transducing assembly and the cleaning part of the ultrasonic cleaning device of the utility model is shown.

[0065] Figure 7 A schematic view of the structure shown in another view is shown. Figure 6

[0066] Figure 8 A sectional view of the cleaning part in the structure shown is shown. Figure 6

[0067] Figure 9 A schematic view of the vibration mode of the transducing assembly of the ultrasonic cleaning device of the utility model in different situations is shown; wherein (a) is a schematic view of the vibration mode of the transducing assembly with four liquid inlet holes and the cleaning pool when vibrating freely; (b) is a schematic view of the vibration mode of the transducing assembly with four liquid inlet holes and the cleaning pool in the actual simulation vibration of the simulation actual constraint state.

[0068] Figure 10 A schematic view of the sound field transmission in the cleaning pool of the ultrasonic cleaning device of the utility model is shown.

[0069] Figure 11 A schematic view of the flow state of the cleaning liquid in the cleaning pool of the ultrasonic cleaning device of the utility model is shown.

[0070] Figure 12 A schematic view of the medium circulating assembly of the ultrasonic cleaning device of the utility model is shown.

[0071] Figure 13 A schematic view of the structure shown in another view is shown. Figure 12

[0072] Figure 14 A sectional view of the structure shown is shown. Figure 12

[0073] A schematic view of the supporting assembly of the ultrasonic cleaning device of the utility model is shown. Figure 15

[0074] A sectional view of the structure shown is shown. Figure 16 Figure 15

[0075] A schematic view of the cleaning of the pipette needle in the ultrasonic cleaning device is shown. Figure 17

[0076] A schematic view of the cleaning of the pipette needle in the ultrasonic cleaning device is shown.​​​​​Figure 18 Fig. 2 shows the flow state of the cleaning liquid in the cleaning pool when the height of the liquid inlet hole is too high;

[0077] Figure 19 Fig. 3 shows the sound intensity distribution range in the cleaning pool when the height of the liquid inlet hole is too low;

[0078] Figure 20 Fig. 4 shows the sound intensity distribution range in the cleaning pool when the height of the liquid inlet hole is adopted in the utility model;

[0079] Figure 21 Fig. 5 shows the vibration mode of the transducer assembly of the existing cleaning pool with thick bottom and thin wall;

[0080] Figure 22 Fig. 6 shows the structure of one of the embodiments of the sample analyzer of the utility model.

[0081] In the drawings, the same components are designated by the same reference numerals. The drawings are not drawn according to the actual scale.

[0082] Reference numerals:

[0083] 1 - medium circulating assembly, 101 - assembly cavity, 1011 - first assembly section, 1012 - second assembly section, 1013 - third assembly section, 1014 - screw hole, 102 - liquid inlet, 103 - liquid outlet, 104 - overflow platform, 105 - overflow pool;

[0084] 2 - liquid inlet connector, 3 - first sealing ring;

[0085] 4 - front cover plate, 40 - cleaning part, 401 - first sealing part, 402 - second sealing part, 403 - liquid inlet hole, 404 - cleaning pool, 4041 - first cavity, 4042 - second cavity, 4043 - third cavity, 4044 - sound field energy concentration area;

[0086] 5 - second sealing ring;

[0087] 6 - supporting assembly, 60 - supporting platform, 601 - supporting groove, 602 - sealing ring groove, 603 connecting hole, 604 - fixing hole;

[0088] 7 - ultrasonic transducer unit, 8 - electrode sheet, 9 - rear cover plate, 10 - fastener, 11 - piezoelectric ceramic, 12 - sealing reinforcing part, 13 - third sealing ring, 14 - liquid outlet connector, 15 - liquid inlet cavity, 16 - pipette needle;

[0089] 17-incubation tray, 170-reaction vessel, 18-reagent storage device, 180-reagent kit, 19-first reagent dispensing arm, 20-second reagent dispensing arm, 21-optical detection device, 22-sample rack, 220-sample tube, 23-sample loading track, 24-recovery track, 25-sample transfer device, 26-sample reagent mixing device. DETAILED DESCRIPTION

[0090] The utility model will be further described below with reference to the drawings.

[0091] The embodiment of the utility model provides a kind of sample analyzer, it includes pipette needle 16, ultrasonic cleaning device, needle moving assembly and cleaning liquid supply device.Pipette needle 16 is used to suck sample or reagent and inject reaction vessel;Ultrasonic cleaning device is used to ultrasonic cleaning to pipette needle 16;Needle moving assembly is used to drive pipette needle 16 moves to ultrasonic cleaning device, to carry out ultrasonic cleaning;Cleaning liquid supply device is used to provide cleaning liquid to ultrasonic cleaning device.

[0092] Ultrasonic cleaning device includes cleaning part 40, transducer assembly, medium circulation assembly 1 and support assembly 6, cleaning part 40 is structured with the cleaning pool 404 for accommodating cleaning liquid, transducer assembly is used to emit ultrasonic wave to cleaning liquid in cleaning pool 404, medium circulation assembly 1 is structured with the assembly cavity 101 for accommodating cleaning part 40, first step capable of abutting the front end of cleaning part 40 is structured in assembly cavity 101, support assembly 6 is used to support cleaning part 40, support assembly 6 is structured as being capable of being fixed to the bottom surface of medium circulation assembly 1, to make cleaning part 40 remain in assembly cavity 101.

[0093] Wherein, the front end surface between cleaning part 40 and first step, the bottom end surface between cleaning part 40 and support assembly 6 are provided with first sealing ring 3 and second sealing ring 5, first sealing ring 3 and second sealing ring 5 are all in the position of local amplitude of cleaning part 40 less than or equal to preset amplitude when transducer assembly generates vibration.

[0094] Specifically, in the sample analyzer of the utility model, ultrasonic cleaning device is used to clean pipette needle 16 (or other similar cleaning pieces) that sucks sample or reagent, cleaning state is as shown in the drawing Figure 17The principle of ultrasonic cleaning is that high-frequency ultrasonic waves act on the cleaning liquid to generate a large number of small bubbles. The small bubbles will constantly undergo movement, enlargement and rupture during the oscillation process, i.e. cavitation effect. At the moment of bubble rupture, high temperature, high pressure and high-speed jet flow will be generated, acting on the surface of the pipette needle 16 to destroy the attachments on the pipette needle 16, so as to remove the contaminants from the surface or inner wall of the pipette needle 16. The pipette needle 16 is driven by the needle moving assembly to enter and exit the ultrasonic cleaning device for cleaning or transfer after cleaning. The needle moving assembly is not shown in the drawings and can adopt an existing driving structure, for example, a linear driving mechanism (linear motor mechanism, screw and slider mechanism, etc.) capable of driving the pipette needle 16 to move up and down. The needle moving assembly can also be further matched with a mechanical arm to realize large-range movement of the pipette needle 16. The cleaning liquid supply device is connected with the ultrasonic cleaning device through a pipeline for supplying cleaning liquid to the ultrasonic cleaning device and providing power for continuous flow of the cleaning liquid in the ultrasonic cleaning device.

[0095] As shown in the drawings Figure 1 and Figures 6 to 8 The ultrasonic cleaning device includes a cleaning part 40, a transduction assembly, a medium circulation assembly 1 and a supporting assembly 6 in structure. The transduction assembly includes an ultrasonic transduction unit 7 for generating ultrasonic waves. The cleaning part 40 is arranged in the transduction assembly. The supporting assembly 6 is used for mounting the transduction assembly on the medium circulation assembly 1. The medium circulation assembly 1 is mainly used for realizing delivery and circulating flow of the cleaning liquid in the cleaning pool 404. As shown in the drawings Figure 4 or Figure 5 A first step is constructed at the top end of the assembly cavity 101, which can abut the front end of the cleaning part 40, for limiting the depth of the cleaning part inserted into the assembly cavity 101. A first sealing ring 3 is arranged at the first step. After the cleaning part 40, the supporting assembly 6 and the medium circulation assembly 1 are fixedly connected, a second sealing ring 5 is arranged at the intersection of the cleaning part 40, the supporting assembly 6 and the medium circulation assembly 1.

[0096] In this embodiment, the first and second sealing rings 3 and 5 are located at a position where the local vibration amplitude of the cleaning portion 40 is less than or equal to a predetermined amplitude when the transducer assembly vibrates (the amplitude affects sealing performance, so the predetermined amplitude should meet sealing requirements). Preferably, the predetermined amplitude approaches zero. Therefore, the first and second sealing rings 3 and 5 have the lowest vibration and effectively correspond to a nodal point. Sealing assembly at this location ensures the sealing reliability and waterproofing of the transducer assembly. Furthermore, because this is a nodal point, the transducer assembly is fixedly connected to the medium circulation assembly 1 via the support assembly 6 without affecting the overall performance of the transducer assembly. Conversely, when the transducer assembly load fluctuates, the vibration mode of the cleaning tank 404 does not significantly change. Furthermore, the first and second sealing rings 3 and 5 also provide a certain degree of damping and absorption, preventing ultrasonic vibrations from being further transmitted to the medium circulation assembly 1, the support assembly 6, and the entire sample analyzer. This prevents loosening and fatigue failure of the assembly structure of the medium circulation assembly 1 and the fixing structure of the support assembly 6, ensuring a secure and reliable connection.

[0097] Preferably, the first sealing ring 3 and the second sealing ring 5 are made of fluororubber.

[0098] Optionally, depending on cleaning requirements, the cleaning liquid includes but is not limited to pure water, and other special liquid cleaning media may also be used.

[0099] In one embodiment, 3 to 5 liquid inlet holes 403 are provided on the wall of the cleaning pool 404 near the bottom of the pool; preferably, the number of the liquid inlet holes 403 is 4.

[0100] Specifically, as shown in the accompanying drawings Figure 8 As shown, the liquid inlet 403 is arranged near the bottom of the cleaning tank 404. On the one hand, it allows the input cleaning liquid to directly reach the position near the bottom of the tank where the ultrasonic sound field is most concentrated, thereby cooperating to ensure the cleaning effect; on the other hand, it realizes the cleaning liquid flowing from bottom to top in the cleaning tank 404, avoiding the flow dead corners in the cleaning tank 404 and ensuring that the flowing cleaning liquid can carry away the pollutants cleaned by the pipette needle 16. The multiple liquid inlet holes 403 are evenly distributed in the circumferential direction. In this way, the cleaning liquid can enter the cleaning tank 404 simultaneously through the liquid inlet holes 403 at different positions, rather than entering the cleaning tank 404 through only one liquid inlet hole 403. This makes the liquid inflow in the cleaning tank 404 more stable and uniform, avoids excessive liquid inflow velocity, and ensures the uniformity of the flow distribution of the cleaning liquid at different positions in the cleaning tank 404.

[0101] More importantly, the design of multiple evenly distributed liquid inlet holes 403 makes the cleaning part 40 as a whole present a central symmetrical structure, so that the transducer component itself presents a good longitudinal vibration form and a symmetrical distribution of vibration modes, which is conducive to improving the uniformity and stability of the sound field distribution in the cleaning tank 404. The vibration mode of the transducer component is shown in the attached figure. Figure 9 As shown (the black line represents the outline of the transducer component, and the red line represents the deformation distribution of the transducer component when it vibrates).

[0102] Among them, the attached drawings Figure 9 (a) is a schematic diagram of the vibration mode of the transducer assembly with four liquid inlet holes 403 and the cleaning tank 404 in a free state, that is, the vibration mode distribution in the absence of cleaning liquid load and fixed constraints; Figure 9 Middle (b) is a schematic diagram of the vibration mode of the transducer component with four liquid inlet holes 403 and the cleaning tank 404, which is located in the reference actual constraint state, that is, the vibration mode distribution under the conditions of cleaning liquid load and external fixed constraint; it can be seen that regardless of whether there is load or constraint, the vibration mode of the transducer component has basically not changed significantly, and the overall vibration mode is still in the state of axial longitudinal vibration and symmetrical distribution, which is still a good vibration form. The amplitude is small at the step surface where the black line and the red line basically coincide, which can be regarded as the node position of the transducer component. Sealing at the step surface not only ensures the reliability of the sealing of the transducer component, but also does not affect the overall performance of the transducer component.

[0103] Furthermore, by setting the bottom thickness of the cleaning pool 404 to be smaller than the thickness of the pool wall, not only can the amplitude of the bottom of the cleaning pool 404 be large and the amplitude of the top be small, thus preventing the cleaning liquid from being ultrasonically atomized and splashing, which would endanger the operation of the equipment, but also the amplitude of the step sealing position at the front and rear ends of the cleaning part 40 can be made extremely small, which can be regarded as a node position. Sealing assembly is performed here to ensure the reliability of the seal without affecting the performance of the transducer component. Figure 21 A schematic diagram of the vibration mode of an existing cleaning pool 404 with a thick bottom and thin walls is shown. It can be seen that at the step sealing position corresponding to the front and rear ends of the cleaning portion 40 of the present invention, the red line is significantly offset from the black line position, indicating that a large vibration has occurred here and it is no longer a nodal position. Therefore, this place is no longer conducive to sealing assembly.

[0104] Preferably, the height of the liquid inlet hole 403 relative to the bottom surface of the cleaning tank 404 is 0.3mm~0.7mm; more preferably, the height of the liquid inlet hole 403 relative to the bottom surface of the cleaning tank 404 is 0.4mm~0.6mm.

[0105] Further, the hole diameter of the liquid inlet hole 403 should be designed according to the liquid inlet flow rate requirement. The height of the liquid inlet hole 403 from the bottom surface of the pool affects the cleaning effect. If the height is too high, the liquid replacement at the bottom of the cleaning pool 404 will be insufficient, and there will be a dead angle area as circled in the flow state diagram shown in FIG. 8. If the height is too low, the sound intensity distribution range in the cleaning pool 404 will be reduced, as shown in FIG. 9, which is obviously smaller than the sound intensity distribution range shown in FIG. 8 using an appropriate height. The flow state diagram of the liquid inlet hole 403 using an appropriate height is shown in FIG. 10. Figure 18 Figure 19 Figure 20 Figure 11

[0106] In one embodiment, the internal space of the cleaning pool 404 is configured to sequentially communicate in the direction from the pool opening to the pool bottom of the cleaning pool 404 into a first cavity 4041, a second cavity 4042, and a third cavity 4043; wherein the diameter of the second cavity 4042 gradually increases in the direction from the pool opening to the pool bottom of the cleaning pool 404, so that the cavity wall of the second cavity 4042 forms a slope towards the third cavity 4043.

[0107] Specifically, as shown in FIG. 11, the internal space of the cleaning pool 404 is divided into multiple cavities, wherein the third cavity 4043 closest to the pool bottom has the largest volume, serving as the main cleaning cavity, and the pipette tip 16 is inserted into the third cavity 4043 of the cleaning pool 404 for cleaning. The pool wall thickness and the pool bottom thickness mentioned above both correspond to the third cavity 4043, as shown in FIG. 12, and the pool wall thickness at the first cavity 4041 and the second cavity 4042 is greater than or equal to the pool wall thickness of the third cavity 4043. The cavity wall of the second cavity 4042 forms a slope towards the third cavity 4043, which can enhance the reflection effect of the ultrasonic wave and improve the concentration of the sound field in the third cavity 4043. Figure 8 Figure 8

[0108] Specifically, as shown in FIG. 13, the first cavity 4041 and the third cavity 4043 are both configured as a cylindrical structure with a constant diameter at any axial position, and the diameter of the first cavity 4041 is smaller than that of the third cavity 4043; wherein the diameter of the second cavity 4042 at the end close to the first cavity 4041 is equal to the diameter of the first cavity 4041, and the diameter of the second cavity 4042 at the end close to the third cavity 4043 is smaller than or equal to the diameter of the third cavity 4043.

[0109] Specifically, as shown in FIG. 13, the first cavity 4041 and the third cavity 4043 are both configured as a cylindrical structure with a constant diameter at any axial position, and the diameter of the first cavity 4041 is smaller than that of the third cavity 4043; wherein the diameter of the second cavity 4042 at the end close to the first cavity 4041 is equal to the diameter of the first cavity 4041, and the diameter of the second cavity 4042 at the end close to the third cavity 4043 is smaller than or equal to the diameter of the third cavity 4043. Figure 8 ​​​​​​As shown, by setting the diameters of the first cavity 4041 and the third cavity 4043 to have a difference, the second cavity 4042 is designed to have a gradually changing diameter, so that the cavity wall of the second cavity 4042 forms an inclined surface. According to the needs, the diameter of the first end of the second cavity 4042 connected to the third cavity 4043 can be smaller than the diameter of the third cavity 4043 (but larger than the diameter of the first cavity 4041), or can be equal to the diameter of the third cavity 4043. The difference lies in that the angle of the inclined surface of the cavity wall of the second cavity 4042 corresponding to the different diameters of the first end of the second cavity 4042 is different, thereby the reflection angle of the ultrasonic wave is different, and the angle of the inclined surface can be controlled by controlling the diameter of the first end of the second cavity 4042 according to the specific situation.

[0110] In one embodiment, the transduction assembly comprises a front cover plate 4, an ultrasonic transduction unit 7 and a rear cover plate 9 arranged in sequence, and the front cover plate 4, the ultrasonic transduction unit 7 and the rear cover plate 9 are connected as a whole by a fastener 10 passing from the rear cover plate 9 to the front cover plate 4; wherein the cleaning part 40 is integrally formed with the front cover plate 4, and the cleaning part 40 is the end of the front cover plate 4 away from the ultrasonic transduction unit 7, and the pool bottom of the cleaning pool 404 corresponds to the ultrasonic transduction unit 7.

[0111] The ultrasonic transduction unit 7 comprises a plurality of electrode sheets 8 and a plurality of piezoelectric ceramics 11 arranged in overlap.

[0112] Specifically, as shown in the accompanying drawings Figure 1 , Figure 6 and Figure 7 In this embodiment, the ultrasonic transduction unit 7 comprises two electrode sheets 8 and two piezoelectric ceramics 11, the material of the electrode sheet 8 is selected to be brass, the front cover plate 4, the electrode sheet 8, the piezoelectric ceramic 11 and the rear cover plate 9 are connected as a whole by the fastener 10 (screws can be used), realizing the transmission of ultrasonic vibration to the front cover plate 4, and finally to the cleaning part 40. Due to the high energy transmission efficiency, the size of the piezoelectric ceramic 11 does not need to be very large, so the overall size of the transduction assembly can be reduced, which is beneficial to the application of miniaturization. The cleaning part 40 is integrally formed on the front cover plate 4 of the transduction assembly, and the integrally formed structure does not need additional connection process, on the one hand, it reduces the uncertainty error caused by the manufacturing process, and improves the parameter consistency between the transduction assemblies; on the other hand, it avoids the connection interface, and reduces the interface loss of acoustic energy transmission.

[0113] Preferably, the ultrasonic transducer unit 7 is configured to emit ultrasonic waves towards the center of the bottom of the cleaning tank 404, and the sound field energy of the ultrasonic waves is concentrated in the area where the axis of the third cavity 4043 is located. The emission direction of the ultrasonic transducer unit 7 is configured to be towards the center of the bottom of the cleaning tank 404, so that the sound field energy of the ultrasonic waves can be ensured to be concentrated in the middle of the third cavity 4043 from the emission end, and in combination with the reflection concentrating effect of the inclined surface of the second cavity 4042 on the ultrasonic waves, the concentration of the sound field energy of the ultrasonic waves can be further ensured.

[0114] In one embodiment, the medium circulation assembly 1 is configured with an overflow tank 105, the overflow tank 105 is configured with an overflow platform 104 which is higher than the bottom surface of the overflow tank 105, the assembly cavity 101 is configured on the overflow platform 104, and the two ends of the assembly cavity 101 respectively penetrate the platform surface of the overflow platform 104 and the bottom surface of the medium circulation assembly 1, and the bottom of the overflow tank 105 is provided with a liquid outlet 103; wherein the cleaning part 40 is contained in the assembly cavity 101, and the cleaning tank 404 is configured such that the cleaning medium therein can overflow to the platform surface of the overflow platform 104, so that the cleaning medium flows into the bottom of the overflow tank 105 through the platform surface and is discharged through the liquid outlet 103.

[0115] Specifically, the medium circulation assembly 1 mainly includes an overflow tank 105, and the tank body of the overflow tank 105 is the main body of the medium circulation assembly 1. As shown in the drawings Figure 3 、 Figures 12 to 14 , the overflow tank 105 has a height difference, the higher part is the platform surface of the overflow platform 104, and the lower part is the bottom of the overflow tank 105. The first end of the assembly cavity 101 penetrates the platform surface of the overflow platform 104, and the other end penetrates the bottom surface of the medium circulation assembly 1. The part of the ultrasonic cleaning device where the cleaning part 40 is located can be installed by inserting the assembly cavity 101 from below the medium circulation assembly 1.

[0116] In this embodiment, the medium circulation assembly 1 mainly realizes the circulation flow of the cleaning liquid through the overflow tank 105, that is, the cleaning liquid enters the bottom of the cleaning tank 404 through the liquid inlet hole 403 on the tank wall of the cleaning tank 404, flows upward to the tank opening of the cleaning tank 404, overflows to the platform surface of the overflow platform 104, and finally flows naturally from the platform surface to the bottom of the overflow tank 105 and is discharged through the liquid outlet 103, forming a circulation flow path with concentrated flow direction and one-way flow of the cleaning liquid, improving the displacement efficiency of the cleaning liquid, ensuring the cleaning effect and the pollutant carrying-out effect, and avoiding the secondary pollution of the pipette tip 16 by the pollutants cleaned.

[0117] In one embodiment, the cavity wall of the assembly cavity 101 is configured with a liquid inlet 102 which communicates with the assembly cavity 101, and when the cleaning tank 404 is fitted in the assembly cavity 101, the liquid inlet 102 communicates with the liquid inlet hole 403 configured on the tank wall of the cleaning tank 404.

[0118] Specifically, as shown in the drawingsFigure 14 As shown, the liquid inlet 102 on the cavity wall of the assembly cavity 101 is used to connect the cleaning liquid supply device through a pipeline. When the cleaning part 40 is fitted in the assembly cavity 101, the liquid inlet hole 403 of the cleaning pool 404 is connected to the liquid inlet 102 of the assembly cavity 101, and the connection here includes direct connection and indirect connection. Direct connection means that the liquid inlet hole 403 directly aligns with the liquid inlet 102, the outer wall of the cleaning part 40 is fitted with the cavity wall of the assembly cavity 101, or the liquid inlet hole 403 and the liquid inlet 102 are connected through a liquid inlet pipeline, and the like, so that the cleaning liquid can directly enter the liquid inlet hole 403 from the liquid inlet 102; indirect connection means that the cleaning liquid first enters the assembly cavity 101 from the liquid inlet 102, and then enters the liquid inlet hole 403.

[0119] In this embodiment, the indirect connection mode is preferably adopted, as shown in the accompanying drawings Figure 4 As shown, an annular space is formed between the cleaning part 40 and the cavity wall of the assembly cavity 101, which serves as a liquid inlet cavity 15. The cleaning liquid first enters the liquid inlet cavity 15 from the liquid inlet 102, and then enters the liquid inlet hole 403 from the liquid inlet cavity 15. The purpose of this design is to realize uniform liquid inlet in cooperation with the plurality of liquid inlet holes 403 described above. Specifically, the cleaning pool 404 can be provided with a plurality of liquid inlet holes 403 uniformly distributed in the circumferential direction. The plurality of liquid inlet holes 403 are all connected to the annular liquid inlet cavity 15. The liquid inlet 102 is staggered with the liquid inlet holes 403, so that the cleaning liquid in the liquid inlet cavity 15 can enter the cleaning pool 404 through the liquid inlet holes 403 at different positions at the same time, thereby ensuring the uniformity of the flow distribution of the cleaning liquid at different positions of the cleaning pool 404. In order to improve the cleaning efficiency, the water flow needs to be guaranteed to replace the water in the cleaning pool a predetermined number of times within a predetermined time. Such a design can not only realize rapid and uniform and sufficient liquid replacement, but also avoid the splashing of cleaning liquid caused by too high liquid inlet flow rate, which endangers the operation of the equipment.

[0120] In addition, the number of liquid inlet holes 403 is 3-5; preferably, the number of liquid inlet holes 403 is 4; in the circumferential direction of the cleaning pool 404, the liquid inlet 102 corresponds to the position between the adjacent two liquid inlet holes 403, and the distance from the liquid inlet 102 to the two liquid inlet holes 403 is the same.

[0121] Specifically, the liquid inlet 102 corresponds to a point on the outer wall of the cleaning part 40 in the radial direction of the cleaning pool 404. The point is located between the adjacent two liquid inlet holes 403, and the distance to the two liquid inlet holes 403 in the circumferential direction of the cleaning pool 404 is the same. In this way, when the cleaning liquid entering the cleaning cavity from the liquid inlet 102 flows to both sides, the distance to the corresponding liquid inlet hole 403 and the required time are the same, so that the flow rates of the cleaning liquid at the liquid inlet holes 403 on both sides can be kept basically the same.

[0122] Moreover, the more liquid inlet holes 403 there are and the denser the distribution of the liquid inlet holes 403, the shorter the distance between the liquid inlet port 102 and the nearest liquid inlet hole 403, and the farther the distance between the liquid inlet port 102 and the farthest liquid inlet hole 403, resulting in a greater difference in distance and a greater difference in flow distribution between liquid inlet holes 403 at different positions. Actual tests have found that when the number of liquid inlet holes 403 is greater than 5, the difference in flow distribution between different liquid inlet holes 403 will substantially affect the cleaning effect. Therefore, the maximum number of liquid inlet holes 403 shall not exceed 5.

[0123] The actual test results show that 3 to 5 liquid inlet holes 403 can ensure the uniformity of liquid inlet and the actual cleaning effect. Figure 8 The four liquid inlet holes 403 shown are a better choice. At this time, the angle between the axis of the liquid inlet 102 (parallel to the radial direction of the cleaning tank 404) and the axis of the liquid inlet hole 403 closest to both sides (parallel to the radial direction of the cleaning tank 404) is 45 degrees.

[0124] Optionally, as shown in the accompanying figure Figure 14 As shown, the liquid inlet 102 and the liquid outlet 103 are respectively equipped with a liquid inlet connector 2 and a liquid outlet connector 14 to facilitate connection to corresponding pipelines.

[0125] In one embodiment, the first sealing ring 3 and the second sealing ring 5 are both constructed as a corner structure; the first part of the first sealing ring 3 is located between the first step and the front end face of the cleaning part 40, and the second part is located between the cavity wall of the assembly cavity 101 and the front end side face of the cleaning part 40; the first part of the second sealing ring 5 is located between the surface of the supporting component 6 and the bottom face of the cleaning part 40, and the second part is located between the cavity wall of the assembly cavity 101 and the bottom end side face of the cleaning part 40.

[0126] Specifically, this embodiment is one of the optional implementations of the sealing structure between the cleaning portion 40 and the assembly cavity 101 of the present invention. Figure 4 As shown, a first sealing ring 3 is provided at the first step; after the supporting assembly 6 where the cleaning portion 40 is located is fixedly connected to the medium circulation assembly 1, a second sealing ring 5 is provided at the intersection of the cleaning portion 40, the supporting assembly 6 and the medium circulation assembly 1. In this embodiment, the surface of the supporting assembly 6 is a plane that fits with the bottom surface of the medium circulation assembly 1; the first sealing ring 3 and the second sealing ring 5 are actually fitted at the front corner and the rear corner of the cleaning portion 40, respectively.

[0127] In this embodiment, the first sealing ring 3 and the second sealing ring 5 are both configured as a corner structure, that is, in the cross section where the sealing ring axis is located, the sealing ring is L-shaped and has two parts perpendicular to each other. Figure 4As shown, the first sealing ring 3 is used to seal the corner area between the front end of the cleaning part 40 and the first step of the assembly cavity 101, and the second sealing ring 5 is used to seal the corner area between the rear end of the cleaning part 40 and the assembly cavity 101 and the supporting assembly 6. Based on the sealing structure composed of the first sealing ring 3 and the second sealing ring 5, the cleaning part 40 and the inner wall of the assembly cavity 101 are spaced from each other, forming an annular liquid inlet cavity 15, so that an indirect communication structure is formed between the liquid inlet hole 403 and the liquid inlet 102.

[0128] Preferably, the end of the second part of the first sealing ring 3 and the second sealing ring 5 is configured with a sealing reinforcing part 12, and the sealing reinforcing part 12 is configured as an annular structure capable of surrounding the cleaning part 40; wherein, in the cross section of the axis of the first sealing ring 3 or the second sealing ring 5, the sealing reinforcing part 12 is circular and the diameter of the circle is greater than the thickness of the second part.

[0129] Specifically, as shown in the drawings Figure 4 The end of the second part of the first sealing ring 3 and the second sealing ring 5 is expanded to form a sealing reinforcing part 12, and the cross section of the sealing reinforcing part 12 is circular, so that the degree of extrusion between the sealing reinforcing part 12 and the cleaning part 40 and the assembly cavity 101 is greater, and thus the sealing effect of the first sealing ring 3 and the second sealing ring 5 between the cleaning part 40 and the assembly cavity 101 can be further guaranteed, that is, the sealing of the liquid inlet cavity 15 can be guaranteed.

[0130] In one embodiment, the front end of the cleaning part 40 is configured as a stepped first sealing part 401 formed by variable diameter, the bottom end of the cleaning part 40 is configured as a second sealing part 402 of equal diameter, and the step surface of the first sealing part 401 is configured as a part of the front end surface of the cleaning part 40; wherein, the first sealing part 401 is used to cooperate with the first sealing ring 3, and the second sealing part 402 is used to cooperate with the second sealing ring 5.

[0131] Specifically, as shown in the drawings Figure 4 The first sealing part 401 and the second sealing part 402 are used to adapt to the first sealing ring 3 and the second sealing ring 5 of the corner structure, and the first sealing part 401 and the second sealing part 402 correspond to positions with vibration amplitudes less than a preset amplitude.

[0132] In one embodiment, the supporting assembly 6 is provided with a through hole configured to allow the main body of the transduction assembly to pass through so that the bottom end of the cleaning part 40 abuts against the surface of the supporting assembly 6.

[0133] Specifically, as shown in the drawings Figures 1 to 5 The supporting assembly 6 is used to realize the cooperation of the transduction assembly and the medium circulation assembly 1 in structure. As shown in the drawings Figure 15 and Figure 16As shown, a through hole structure is configured on the supporting assembly 6 for passing the transducing assembly, but the outer diameter of the cleaning part 40 configured at the end of the transducing assembly is larger than the through hole, and then the bottom end of the cleaning part 40 abuts against the surface of the supporting assembly 6, and after the supporting assembly 6 is fixed with the bottom surface of the medium circulating assembly 1, the cleaning part 40 can be kept in the assembly cavity 101.

[0134] In one embodiment, the supporting assembly 6 is configured with a supporting table 60 protruding from the surface of the supporting assembly 6, and a through hole is configured in the supporting table 60, the table surface of the supporting table 60 can support the cleaning part 40, and the supporting table 60 is configured such that at least the part close to the table surface of the supporting table 60 can be embedded into the assembly cavity 101.

[0135] Specifically, as shown in the accompanying drawings Figure 15 As shown, the supporting assembly 6 has a protruding supporting table 60, which can be fitted into the assembly cavity 101, further limiting the fitting of the supporting assembly 6 and the medium circulating assembly 1, and can be fitted with other types of sealing rings to form another optional embodiment of the sealing structure between the cleaning part 40 of the utility model and the assembly cavity 101.

[0136] Further, the supporting table 60 is configured with a supporting groove 601 on the table surface, a through hole is configured in the groove bottom of the supporting groove 601, and the supporting groove 601 is configured to accommodate the bottom end of the cleaning part 40, and the second sealing ring 5 is arranged between the groove bottom of the supporting groove 601 and the bottom end surface of the cleaning part 40.

[0137] Specifically, another optional embodiment of the sealing structure between the cleaning part 40 of the utility model and the assembly cavity 101 is shown in the accompanying drawings Figure 5 As shown, the rear end of the assembly cavity 101 is directly fitted with the supporting table 60 of the supporting assembly 6 without directly fitting with the rear end of the cleaning part 40. Based on this structure, the first sealing ring 3 and the second sealing ring 5 directly adopt a circular ring structure, the first sealing ring 3 is fitted between the front end surface of the cleaning part 40 and the step surface of the first step, and the second sealing ring 5 is fitted between the groove bottom of the supporting groove 601 and the bottom end surface of the cleaning part 40.

[0138] Preferably, a sealing ring groove 602 is opened on the outer peripheral surface of the supporting table 60, the sealing ring groove 602 is used to arrange a third sealing ring 13, and the third sealing ring 13 is configured to be in sealing contact with the cavity wall of the assembly cavity 101 when the supporting table 60 is at least partially embedded into the assembly cavity 101.

[0139] Specifically, as shown in the accompanying drawings Figure 5 , Figure 15 And Figure 16 As shown, the outer peripheral surface of the supporting table 60 is further provided with a sealing ring groove 602 and a third sealing ring 13, and the third sealing ring 13 is used to further maintain the sealing between the supporting table 60 and the assembly cavity 101.

[0140] In one embodiment, the inside of the assembly cavity 101 is configured with a second step on the side close to the bottom surface of the medium circulation assembly 1, the second step is configured to abut with the table surface of the supporting table 60, the second step is used to limit the supporting table 60, and the third sealing ring 13 can also be arranged between the table surface of the supporting table 60 and the step surface of the second step.

[0141] In one embodiment, a plurality of connecting holes 603 are arranged on the supporting assembly 6 and located on the periphery of the through hole, and a plurality of screw holes 1014 are arranged on the bottom surface of the medium circulation assembly 1 and located on the periphery of the assembly cavity 101, the screw holes 1014 are configured to be threadedly connected with the connecting members passing through the connecting holes 603; the fixing hole 604 is arranged on the supporting assembly 6 and located outside the region of the supporting assembly 6 used for connecting with the medium circulation assembly 1, and the fixing hole 604 is used for fixedly connecting the ultrasonic cleaning device with the external supporting member. Through the fixing hole 604 of the supporting assembly 6, the whole ultrasonic cleaning device can be fixedly installed on the movement path of the pipetting needle 16 to perform ultrasonic cleaning.

[0142] Specifically, as shown in the drawings Figure 15 , the connecting holes 603 and the fixing hole 604 are arranged on the supporting assembly 6. The plurality of connecting holes 603 surround the through hole and are used for connecting with the screw holes 1014 (as shown in the drawings Figure 13 ) on the bottom surface of the medium circulation assembly 11 through connecting members (screws or bolts, etc.). After the supporting assembly 6 is connected with the medium circulation assembly 1, the fixing hole 604 is exposed outside and can be connected with the external supporting member, so that the ultrasonic cleaning device is supported by the external supporting member.

[0143] In one embodiment, no matter whether the sealing scheme shown in the drawings Figure 4 or the sealing scheme shown in the drawings Figure 5 , the first sealing ring and the second sealing ring are located at positions with an amplitude less than a preset amplitude on the ultrasonic cleaning device, according to the structural design of the present application, the preset amplitude tends to be 0, so the positions where the first sealing ring and the second sealing ring are located are actually equivalent to the pitch surface positions.

[0144] In one embodiment, a sample analyzer is provided, which is an instrument for injecting a sample and a reagent into a plurality of reaction containers 170 to make them react, and measuring the liquid that has reacted. Referring to the drawings Figure 22 , the sample analyzer can further include an incubation tray 17, a reagent storage device 18, a reagent transfer device, and an optical detection device 21.

[0145] The incubation tray 17 is used to accommodate multiple reaction containers 170 (in this embodiment, cuvettes are used) and provide the required environment for the reaction of samples and reagents in the reaction containers 170. The reagent storage device 18 (in this embodiment, a reagent storage structure is used as a storage structure) is used to store the reagent kit 180 and provide the required environment for the reagent storage. Figure 22 The first reagent dispensing arm 19 and the second reagent dispensing arm 20 in the reagent storage device 18 are used to draw reagents from the reagent bottles in the reagent storage device 18 and inject them into the reaction container 170; in some embodiments, the reagent transfer device includes a reagent needle, a reagent needle moving device, a syringe and a reagent needle cleaning device; of course, the reagent transfer device is not limited to the embodiments discussed above, and in other embodiments, appropriate changes can be made according to specific needs; in this embodiment, the reagent needle cleaning device in the reagent transfer device can be an ultrasonic cleaning device, and the corresponding cleaning part is located on the rotational motion trajectory of the sampling needle. The optical detection device 21 is used to perform optical measurement analysis on the mixed liquid to be tested in the reaction container 170 to obtain the reaction data of the sample.

[0146] In addition, referring to the accompanying drawings Figure 22 The sample analyzer may further include a sample transport device, which includes a sample transport track (composed of an injection track 23 and a recovery track 24) for transporting sample tubes 220. The sample analyzer may further include a sample rack 22 and a sample transfer device 25. The sample rack 22 is used to accommodate the sample tubes 220, and the sample transfer device 25 is used to collect samples from the sample tubes 220 and inject them into the reaction vessel 170. In certain embodiments, the sample transfer device 25 includes a sampling needle, a sampling needle moving device, a syringe, and a sampling needle cleaning device. Of course, the sample transfer device 25 is not limited to the embodiments discussed above and can be configured as needed. For example, in certain other embodiments, the sample transfer device 25 may also include an automatic sampler, a sample diluting device, etc. In this embodiment, the sampling needle cleaning device in the sample transfer device 25 may be an ultrasonic cleaning device, with the corresponding cleaning portion located on the rotational motion trajectory of the sampling needle.

[0147] Based on the above content, the pipetting needle mentioned in the sample analyzer of the present invention can be the sampling needle and / or reagent needle mentioned above.

[0148] Furthermore, the sample analyzer may also include a sample reagent mixing device 26 and a reaction container 170 transport device (not shown in the figure); the reaction container 170 transport device is used to move the reaction container 170 to complete the switching between the sample adding position, reagent adding position, mixing position, optical detection position and reaction container 170 cleaning position of the incubation plate 17.

[0149] The embodiment of the utility model provides a kind of ultrasonic cleaning device, and the specific structure and technical principle of ultrasonic cleaning device of the ultrasonic cleaning device can refer to the ultrasonic cleaning device in the sample analyzer of the preceding text, and the corresponding content is not repeated here.

[0150] The embodiment of the utility model provides a kind of cleaning method, it is applied to the sample analyzer or ultrasonic cleaning device of any one embodiment above, and the cleaning method includes the following steps:

[0151] Step S100: keep cleaning fluid circulating delivery to cleaning pool 404, make the pipette needle 16 to be cleaned to be inserted into cleaning pool 404, make the part of pipette needle 16 to be cleaned reach the predetermined position in cleaning pool 404, and the predetermined position is the area with the distance of 1~10mm from the pool bottom surface of cleaning pool 404.

[0152] Step S200: start the ultrasonic transducer unit 7 corresponding to cleaning pool 404, and clean pipette needle 16 for a predetermined length of time.

[0153] Preferably, in step S100, the predetermined position is the area with the distance of 2~5mm from the pool bottom surface of cleaning pool 404, and the acoustic field energy of the ultrasonic wave is specifically more concentrated in the area.

[0154] Preferably, in step S200, the predetermined length of time is 1~8s, according to actual test results, the cleaning time within 1~8s can basically complete the cleaning of pipette needle, and the cleanliness after cleaning meets the requirements. It can also be seen that, based on the technical scheme of the utility model, the cleaning of the inner and outer walls of pipette needle can be completed in a very short time, energy loss is small, and the cleaning effect can be guaranteed, and carrying pollution can be avoided.

[0155] Optionally, in step S200, the cleaning process can also not start the ultrasonic transducer unit according to needs, i.e. running the conventional cleaning mode.

[0156] In the description of the utility model, it is understood that the orientation or position relationship indicated by the terms "upper", "lower", "bottom", "top", "front", "rear", "inner", "outer", "left", "right" and the like is the orientation or position relationship shown in the drawing, and is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, therefore it cannot be understood as a limitation on the utility model.

[0157] While the application has been described with reference to particular embodiments thereof, it is to be understood that these embodiments are merely illustrative of the principles and applications of the present application. It will thus be appreciated that numerous modifications can be made to the illustrative embodiments and that other arrangements can be devised without departing from the spirit and scope of the present application as defined by the appended claims. It will be understood that the features described in relation to one embodiment can be used in combination with features described in relation to another embodiment.

Claims

1. A sample analyzer characterized by, include: A pipette needle, which is used to draw samples or reagents and inject them into the reaction container; An ultrasonic cleaning device, used for ultrasonically cleaning the pipette needle; a needle moving assembly, used for driving the pipetting needle to move into the ultrasonic cleaning device for ultrasonic cleaning; and a cleaning liquid supply device, configured to supply cleaning liquid to the ultrasonic cleaning device; The ultrasonic cleaning device includes a cleaning portion, a transducer assembly, a medium circulation assembly, and a supporting assembly. The cleaning portion is configured with a cleaning tank for accommodating the cleaning liquid. The transducer assembly is configured to emit ultrasonic waves to the cleaning liquid in the cleaning tank. The medium circulation assembly is configured with an assembly cavity for accommodating the cleaning portion. A first step capable of abutting against the front end of the cleaning portion is configured in the assembly cavity. The supporting assembly is configured to support the cleaning portion and is configured to be fixed to the bottom surface of the medium circulation assembly so as to keep the cleaning portion in the assembly cavity. Among them, a first sealing ring and a second sealing ring are respectively arranged between the front end surface of the cleaning part and the first step, and between the bottom end surface of the cleaning part and the supporting assembly. The first sealing ring and the second sealing ring are both located at a position where the local amplitude of the cleaning part is less than or equal to the preset amplitude when the transducer assembly vibrates.

2. The sample analyzer of claim 1, wherein, The preset amplitude is close to 0 in value.

3. The sample analyzer of claim 1, wherein, 3 to 5 liquid inlet holes are arranged on the wall of the cleaning pool near the bottom of the pool.

4. The sample analyzer of claim 1, wherein, The internal space of the cleaning pool is constructed as a first cavity, a second cavity and a third cavity which are sequentially connected in the direction from the pool opening to the pool bottom; The diameter of the second cavity gradually increases from the pool opening to the pool bottom of the cleaning pool, so that the cavity wall of the second cavity forms an inclined surface toward the third cavity.

5. The sample analyzer of claim 4, wherein, The first cavity and the third cavity are both constructed as columnar structures with a constant diameter at any position in the axial direction, and the diameter of the first cavity is smaller than that of the third cavity; The diameter of the second cavity at one end close to the first cavity is equal to the diameter of the first cavity, and the diameter of the second cavity at one end close to the third cavity is less than or equal to the diameter of the third cavity.

6. The sample analyzer of claim 4, wherein, The transducer assembly includes a front cover plate, an ultrasonic transducer unit, and a rear cover plate, which are sequentially arranged, and the front cover plate, the ultrasonic transducer unit, and the rear cover plate are connected as a whole by a fastener passing through the rear cover plate to the front cover plate; The cleaning portion is integrally formed with the front cover plate, and the cleaning portion is an end of the front cover plate away from the ultrasonic transducer unit, and the bottom of the cleaning pool corresponds to the ultrasonic transducer unit.

7. The sample analyzer of claim 6, wherein, The ultrasonic transducer unit is configured to emit ultrasonic waves toward the center of the bottom of the cleaning tank, and the sound field energy of the ultrasonic waves is concentrated in the area where the axis of the third cavity is located.

8. The sample analyzer of claim 6, wherein, The ultrasonic transducer unit includes a plurality of electrode sheets and a plurality of piezoelectric ceramics that are overlapped, and the electrode sheets and the piezoelectric ceramics are alternately arranged in an overlapping direction.

9. The sample analyzer of claim 1, wherein, The medium circulating assembly is configured with an overflow pool, the overflow pool is configured with an overflow table which is higher than the pool bottom surface of the overflow pool, the assembly cavity is configured on the overflow table, and two ends of the assembly cavity respectively penetrate the table surface of the overflow table and the bottom surface of the medium circulating assembly, and the pool bottom of the overflow pool is provided with a liquid discharge port; The cleaning part is accommodated in the assembly cavity, and the cleaning pool is configured so that the cleaning medium therein can overflow to the table surface of the overflow table, so that the cleaning medium flows into the pool bottom of the overflow pool through the table surface and is discharged through the liquid discharge port.

10. The sample analyzer of claim 9, wherein, The cavity wall of the assembly cavity is configured with a liquid inlet port which is in communication with the assembly cavity, and the liquid inlet port is in communication with a liquid inlet hole which is configured on the pool wall of the cleaning pool when the cleaning pool is fitted in the assembly cavity.

11. The sample analyzer of claim 10, wherein, The liquid inlet port and the liquid discharge port are respectively fitted with a liquid inlet joint and a liquid discharge joint.

12. The sample analyzer of claim 1, wherein, The first sealing ring and the second sealing ring are both configured as a corner structure; The first part of the first sealing ring is located between the first step and the front end surface of the cleaning part, and the second part is located between the cavity wall of the assembly cavity and the front end side surface of the cleaning part; The first part of the second sealing ring is located between the surface of the supporting assembly and the bottom surface of the cleaning part, and the second part is located between the cavity wall of the assembly cavity and the bottom end side surface of the cleaning part.

13. The sample analyzer of claim 12, wherein, The end of the second part of the first sealing ring and the second sealing ring is configured with a sealing reinforcing part, and the sealing reinforcing part is configured as an annular structure which can surround the cleaning part; In the cross section where the axis of the first sealing ring or the second sealing ring is located, the sealing reinforcing part is circular and the diameter of the circle is greater than the thickness of the second part.

14. The sample analyzer of claim 12, wherein, The front end of the cleaning part is configured as a stepped first sealing part formed by variable diameter, the bottom end of the cleaning part is configured as a second sealing part with equal diameter, and the step surface of the first sealing part is configured as part of the front end surface of the cleaning part; The first sealing part is used to cooperate with the first sealing ring, and the second sealing part is used to cooperate with the second sealing ring.

15. The sample analyzer of claim 12, wherein, The material of the first sealing ring and the second sealing ring is fluorine rubber.

16. The sample analyzer of claim 1, wherein, The supporting assembly is provided with a through hole which is configured so that the main body of the transducer assembly can pass through so that the bottom end of the cleaning part abuts against the surface of the supporting assembly.

17. The sample analyzer of claim 16, wherein, The supporting assembly is configured with a supporting table which protrudes from the surface of the supporting assembly, the through hole is configured in the supporting table, the table surface of the supporting table can support the cleaning part, and the supporting table is configured so that at least the part of the supporting table close to the table surface thereof can be embedded in the assembly cavity.

18. The sample analyzer of claim 17, wherein, The table surface of the supporting table is configured with a supporting groove, the through hole is configured in the groove bottom of the supporting groove, the supporting groove is configured to accommodate the bottom end of the cleaning part, and the second sealing ring is arranged between the groove bottom of the supporting groove and the bottom end surface of the cleaning part.

19. The sample analyzer of claim 17, wherein, The outer peripheral surface of the supporting table is provided with a sealing ring groove, the sealing ring groove is used to arrange a third sealing ring, and the third sealing ring is configured to be in sealing contact with the cavity wall of the assembly cavity when the supporting table is at least partially embedded in the assembly cavity.

20. The sample analyzer of claim 17, wherein, A second step is formed inside the assembly cavity on a side close to the bottom surface of the medium circulation assembly. The second step is configured to abut against the table surface of the supporting platform.

21. The sample analyzer of claim 16, wherein, The supporting assembly is provided with a plurality of connecting holes located at the periphery of the through hole, and the bottom surface of the medium circulation assembly is configured with a plurality of screw holes located at the periphery of the assembly cavity, and the screw holes are configured to be threadedly engaged with the connecting pieces passing through the connecting holes; The supporting assembly is provided with a fixing hole, which is located outside the area of ​​the supporting assembly used for connecting with the medium circulation assembly. The fixing hole is used to fix the ultrasonic cleaning device to an external supporting component.

22. An ultrasonic cleaning device, characterized in that: The cleaning device comprises a cleaning portion, a transducer assembly, a medium circulation assembly, and a supporting assembly. The cleaning portion is configured with a cleaning tank for accommodating a cleaning liquid. The transducer assembly is configured to emit ultrasonic waves to the cleaning liquid in the cleaning tank. The medium circulation assembly is configured with an assembly cavity for accommodating the cleaning portion. A first step is configured in the assembly cavity to abut against the front end of the cleaning portion. The supporting assembly is configured to support the cleaning portion. The supporting assembly is configured to be fixed to the bottom surface of the medium circulation assembly to keep the cleaning portion in the assembly cavity. Among them, a first sealing ring and a second sealing ring are respectively arranged between the front end surface of the cleaning part and the first step, and between the bottom end surface of the cleaning part and the supporting assembly. The first sealing ring and the second sealing ring are both located at a position where the local amplitude of the cleaning part is less than or equal to the preset amplitude when the transducer assembly vibrates.

23. The ultrasonic cleaning apparatus of claim 22, wherein, The preset amplitude is close to 0 in value.

24. The ultrasonic cleaning apparatus of claim 22, wherein, 3 to 5 liquid inlet holes are arranged on the wall of the cleaning pool near the bottom of the pool.

25. The ultrasonic cleaning apparatus of claim 22, wherein, The first sealing ring and the second sealing ring are both configured as corner structures; The first portion of the first sealing ring is located between the first step and the front end surface of the cleaning portion, and the second portion is located between the cavity wall of the assembly cavity and the front end side surface of the cleaning portion; The first portion of the second sealing ring is located between the surface of the supporting assembly and the bottom surface of the cleaning portion, and the second portion is located between the cavity wall of the assembly cavity and the bottom end side surface of the cleaning portion.

26. The ultrasonic cleaning apparatus of claim 25, wherein, The ends of the second parts of the first sealing ring and the second sealing ring are both configured with a sealing reinforcement portion, and the sealing reinforcement portion is configured as an annular structure that can surround the cleaning portion; Wherein, in the cross section where the axis of the first sealing ring or the second sealing ring is located, the sealing reinforcement portion is circular and the diameter of the circle is greater than the thickness of the second portion.

27. The ultrasonic cleaning apparatus of claim 25, wherein, The front end of the cleaning portion is configured as a stepped first sealing portion formed by a diameter change, the bottom end of the cleaning portion is configured as a second sealing portion of equal diameter, and the stepped surface of the first sealing portion is configured as a part of the front end surface of the cleaning portion; The first sealing portion is used to cooperate with the first sealing ring, and the second sealing portion is used to cooperate with the second sealing ring.

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