Arm fixing mechanism for microscopic Raman spectrometer

Abstract

The utility model relates to an arm fixing mechanism for a microscopic Raman spectrometer, which is mounted on a movable sample table moved to the outside of the microscopic Raman spectrometer, and comprises an arm fixing shell provided with an inner cavity and an upward opening, an opening is formed in the arm fixing shell, an arm to be detected passes through the opening so as to accommodate the arm to be detected in the inner cavity, a plurality of flexible belts are arranged along the longitudinal axis of the arm fixing shell, and the flexible belts are used for fixing the arm to be detected in the inner cavity of the arm fixing shell. According to the arm fixing mechanism for the microscopic Raman spectrometer, the arm of a human body is fixed in an adjustable mode through a semi-solid and semi-soft structure (the semi-arc-shaped fixing shell serves as a solid structure, and the flexible belt serves as a soft structure), it is guaranteed that an experiment is completed under the condition of minimum vibration, and an image with a good effect is obtained.

Description

Technical Field

[0001] This utility model belongs to the field of skin detection and relates to a micro Raman spectrometer, specifically to an arm fixation mechanism for a micro Raman spectrometer. Background Technology

[0002] The 1930 Nobel Prize in Physics was awarded to Raman, the Indian scientist who discovered Raman spectroscopy, after whom the technique is named. Raman discovered that when light interacts with molecules, the wavelength of some light changes (the color changes), and by studying this scattered light with its changed color, information about the molecular structure can be obtained.

[0003] In the cosmetics industry, Raman spectroscopy can determine and analyze the content and distribution of moisture and compounds in the skin, and it is a layer-by-layer analysis process. This ability to analyze layer-by-layer distribution is essential for studying skin mechanisms in humans, as transdermal absorption, skin lipid content, and the orderliness of skin lipids are all distributed layer by layer at different skin depths.

[0004] Due to the characteristics of Raman scanning technology, all current depth imaging is limited to ex vivo skin. In vivo detection only allows for point testing and cannot achieve depth imaging. Specifically, existing Raman scanning technology uses the classic micro-Raman spectrometer structure to perform depth focusing detection on skin samples. There are generally two modes: ex vivo skin, which allows for omnidirectional imaging, including planar and depth imaging; and in vivo skin, limited to specific areas (e.g., the back of the hand), for single-point depth detection, which cannot achieve effective imaging. This is mainly due to limitations imposed by the optical path structure and sample placement method. Specifically, depth testing at a fixed single location involves changing the test focus by moving the objective lens up and down to obtain the Raman spectrum at that location. This testing method is relatively fixed and requires the skin to be in close contact with the test objective lens, which can cause skin compression and inaccurate test data. Utility Model Content

[0005] Therefore, the purpose of this invention is to provide an arm fixing mechanism for a micro Raman spectrometer, which enables the placement and fixing of the arm to avoid the influence of minute vibrations on the imaging effect during Raman imaging. It is particularly suitable for installation on a movable sample stage that has been moved outside the micro Raman spectrometer.

[0006] To address the problems of existing technologies, this utility model provides an arm fixing mechanism for a micro Raman spectrometer, which is installed on a movable sample stage that is moved outside the micro Raman spectrometer. Its main feature is that the arm fixing mechanism includes an arm fixing housing, which has an inner cavity and an upward-facing opening. The opening is used to allow the arm to be tested to pass through and be accommodated in the inner cavity. Several flexible bands are arranged along the longitudinal axis of the arm fixing housing, which are used to fix the arm to be tested within the inner cavity of the arm fixing housing.

[0007] Preferably, the arm fixing housing is a semi-circular rigid housing.

[0008] Preferably, the arm fixing mechanism includes a fixing plate, through which the arm fixing housing is fixed to the upper surface of the movable sample stage.

[0009] Preferably, the longitudinal axis of the arm fixing housing is inclined relative to the length direction of the fixing plate.

[0010] Preferably, the bottom of the inner cavity of the arm fixing housing is provided with mounting holes evenly distributed along the longitudinal axis parallel to the arm fixing housing. The mounting holes are used to install fasteners, and the arm fixing housing is fixed to the fixing plate through the mounting holes and the fasteners.

[0011] Preferably, fixing hooks are provided on both sides of the opening of the arm fixing housing for fixing the flexible belt.

[0012] Preferably, the fixing hooks are evenly distributed along the longitudinal axis parallel to the arm fixing housing.

[0013] Preferably, the length of the arm fixing housing is 250mm to 350mm and the diameter is 70mm to 90mm.

[0014] The arm fixation mechanism for a micro Raman spectrometer of this invention uses a semi-solid, semi-soft structure (a semi-circular arc-shaped fixing shell as the solid structure and a flexible band as the soft structure) to fix the human arm in an adjustable manner, ensuring that the experiment is completed with minimal vibration and that a good imaging image is obtained. Attached Figure Description

[0015] Figure 1 This is a perspective view of the arm fixing mechanism for a micro Raman spectrometer according to the present invention.

[0016] Figure 2 This is a top view of the arm fixing mechanism for a micro Raman spectrometer according to the present invention.

[0017] Figure 3 This is a schematic diagram of a micro Raman spectrometer that utilizes the arm fixation mechanism of this invention. Detailed Implementation

[0018] The present invention will be further described below with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of application of the present invention. The specific embodiments of the present invention will be described in detail below with reference to the technical solutions and accompanying drawings.

[0019] like Figures 1 to 2 The image shows a specific embodiment of the arm fixing mechanism for a micro Raman spectrometer according to this invention. The arm fixing mechanism includes an arm fixing housing 1, which has an inner cavity 5 and an upward-facing opening. The opening is used to allow the arm to be tested to pass through and be accommodated within the inner cavity 5. Several flexible bands are arranged along the longitudinal axis of the arm fixing housing 1, and these flexible bands are used to fix the arm to be tested within the inner cavity of the arm fixing housing 1.

[0020] like Figures 1 to 2 As shown, the arm fixing housing 1 is a semi-circular arc-shaped rigid housing. This rigid housing can be manufactured using injection molding.

[0021] The arm fixing mechanism includes a fixing plate 3, through which the arm fixing housing 1 is fixed to the upper surface of the movable sample stage. Specifically, the bottom of the inner cavity 5 of the arm fixing housing 1 is provided with mounting holes 2 evenly distributed along the longitudinal axis parallel to the arm fixing housing. The mounting holes 2 are used to install fasteners, and the arm fixing housing 1 is fixed to the fixing plate 3 through the mounting holes 2 and the fasteners. The fixing plate can be made of stainless steel.

[0022] The longitudinal axis of the arm fixing housing 1 is inclined relative to the length direction of the fixing plate 3.

[0023] like Figure 1 As shown, fixing hooks 4 are provided on both sides of the opening of the arm fixing housing 1 for fixing the flexible strap. The fixing hooks 4 are evenly distributed along the longitudinal axis parallel to the arm fixing housing 1.

[0024] The arm fixing housing has a length of 250mm to 350mm and a diameter of 70mm to 90mm. For example, the length is 300mm and the diameter / width is 82mm. The corresponding fixing plate can be about 160mm long and about 109mm wide.

[0025] like Figure 3As shown, the arm fixing mechanism for the micro Raman spectrometer of this invention is installed on a movable sample stage 8 that is moved outside the micro Raman spectrometer. The micro Raman spectrometer 6 is used in conjunction with the optical path extraction device 7 and is installed on the stage to perform various skin tests. In skin penetration testing, it is necessary to perform precise positioning tests on the skin surface from the stratum corneum to the dermis, including planar imaging in the XY plane and depth imaging in the longitudinal dimension of the Z axis. Conventional micro Raman spectrometers are equipped with a highly integrated movable sample stage with high-precision stepping for spatial positioning. That is, through the position movement of the high-precision automatic movable sample stage and the confocal characteristics of the Raman spectrometer, the test spot is accurately positioned in three-dimensional space to obtain Raman data at that position, which is then analyzed and processed by software to achieve visualization imaging. However, the movable sample stage of conventional micro Raman spectrometers is placed directly under the microscope eyepiece, that is, directly on the platform. The space is small, making it inconvenient to place human body parts, making it almost impossible to conduct imaging experiments, and it is not suitable for placing large-volume samples. By using the optical path extraction device 7, the detection light is moved to the outside of the main body of the micro Raman spectrometer, thus solving the problem of placement on human body parts.

[0026] The optical path extraction device 7 may include a first corner reflector accessory, a lens tube, a second corner reflector accessory, an objective lens, and a support. The lens tube is connected to both the first and second corner reflector accessories. The first corner reflector accessory reflects the light beam emitted by the micro Raman spectrometer to the lens tube, and the second corner reflector accessory reflects the light beam from the lens tube to the objective lens. The support supports both the lens tube and the objective lens. A movable sample stage is positioned below the objective lens. Through the secondary reflection of the light beam emitted by the micro Raman spectrometer by the first corner reflector accessory, the lens tube, and the second corner reflector accessory, the movable sample stage is positioned independently of the micro Raman spectrometer body. The movable sample stage is connected to a lifting assembly for raising and lowering the movable sample stage. Thus, this optical path extraction device can adapt the movable sample stage, which is standard with the micro Raman spectrometer, to accommodate large-volume samples while simultaneously performing Raman imaging tests. Therefore, when using the optical path extraction device of this utility model for testing, the testing mode is not limited to the area and position. Single-point testing, XY-axis plane testing, YZ-axis plane testing, and XYZ-axis 3D testing can be performed. The testing is completed by an automatic platform controlled by software. Furthermore, the testing can be performed non-destructively and without contact, avoiding the impact of external factors on the data.

[0027] Both the first and second corner reflector accessories include a right-angle optical adjustment frame and a reflector mounted on the right-angle optical adjustment frame, reflecting a light beam at 90°±10°, preferably 90°±2°, and most preferably 90°. Each corner reflector accessory can be equipped with a conventional light source incident angle adjustment device with a reflector, enabling optical path adjustment at an angle of 90°±10°. That is, through the principle of two-stage reflection, the movable sample platform can be moved away from the main body of the micro Raman spectrometer, greatly expanding the applicable range of test object shapes, sizes, and spaces. By combining the corner reflector accessories and lens tubes, arbitrary angle and length adjustment of the optical path can be achieved. Ultimately, through optical path adjustment, the white light microscopy observation position can be made consistent with the laser testing position. The lens tube can be composed of several individual lens tubes to adjust the length, and the objectives include objectives with different magnifications.

[0028] The support includes a horizontally arranged X-axis support rod and a vertically arranged Y-axis support rod. Both the X-axis and Y-axis support rods have retaining rings at their ends. The other end of the X-axis support rod is adjustablely mounted on the Y-axis support rod. By simultaneously fixing the objective lens and the lens tube, the vibration problem of the external optical path is solved.

[0029] The arm fixation mechanism for a micro Raman spectrometer of this invention uses a semi-solid, semi-soft structure (a semi-circular arc-shaped fixing shell as the solid structure and a flexible band as the soft structure) to fix the human arm in an adjustable manner, ensuring that the experiment is completed with minimal vibration and that a good imaging image is obtained.

[0030] In this specification, the present invention has been described with reference to specific embodiments thereof. However, it will be apparent that various modifications and variations can be made without departing from the spirit and scope of the present invention. Therefore, the specification and drawings should be considered illustrative rather than restrictive.

Claims

1. An arm fixing mechanism for a micro Raman spectrometer, mounted on a movable sample stage moved outside the micro Raman spectrometer, characterized in that, The arm fixing mechanism includes an arm fixing housing with an inner cavity and an upward opening. The opening is for the arm to be tested to pass through and be accommodated in the inner cavity. Several flexible bands are arranged along the longitudinal axis of the arm fixing housing to fix the arm to be tested in the inner cavity of the arm fixing housing.

2. The arm fixing mechanism for a micro Raman spectrometer according to claim 1, characterized in that, The arm fixing shell is a semi-circular arc-shaped rigid shell.

3. The arm fixing mechanism for a micro Raman spectrometer according to claim 1, characterized in that, The arm fixing mechanism includes a fixing plate, through which the arm fixing housing is fixed to the upper surface of the movable sample stage.

4. The arm fixing mechanism for a micro Raman spectrometer according to claim 3, characterized in that, The longitudinal axis of the arm fixing housing is inclined relative to the length direction of the fixing plate.

5. The arm fixing mechanism for a micro Raman spectrometer according to claim 3, characterized in that, The bottom of the inner cavity of the arm fixing housing is provided with mounting holes evenly distributed along the longitudinal axis of the arm fixing housing. The mounting holes are used to install fasteners, and the arm fixing housing is fixed to the fixing plate through the mounting holes and the fasteners.

6. The arm fixing mechanism for a micro Raman spectrometer according to claim 1, characterized in that, The arm fixing housing has fixing hooks on both sides of the opening for fixing the flexible belt.

7. The arm fixing mechanism for a micro Raman spectrometer according to claim 6, characterized in that, The fixing hooks are evenly distributed along the longitudinal axis parallel to the arm fixing housing.

8. The arm fixing mechanism for a micro Raman spectrometer according to claim 1, characterized in that, The arm fixing housing has a length of 250mm to 350mm and a diameter of 70mm to 90mm.

Images