Freeze-dried microsphere screening device
By designing a three-layer freeze-dried microsphere screening device, the problem of low efficiency of existing large-scale screening machines in small-scale experiments was solved, and efficient manual screening operation was achieved.
Patent Information
- Application Number
- CN202422812423.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-19
- Publication Date
- 2025-10-31
- Estimated Expiration
- 2034-11-19
AI Technical Summary
Existing freeze-dried microsphere screening devices are mainly industrial-type large-scale screening machines, which makes the screening process cumbersome and inefficient in small-scale experiments.
A screening device consisting of a three-layer structure was designed, including a top primary screening tank, a detachable middle central screening disc, and a bottom collection tank. The screen hole diameters are 5mm and 3mm, respectively. Screening is achieved by hand shaking, and the central screening disc can be quickly replaced for multiple screenings.
It improves the screening efficiency of small-scale experiments, simplifies the operation process, and meets the needs of small-scale experiments.
Smart Images
Figure CN223491364U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of biotechnology, specifically to a freeze-dried microsphere screening device. Background Technology
[0002] Freeze-dried microspheres are a technology that encapsulates bioactive substances or drugs within polymeric materials to form tiny spheres. This technology has wide applications, especially in the biomedical field. The fabrication process of freeze-dried microspheres can be summarized in the following steps: First, the bioactive substance or drug is uniformly mixed with the polymeric material; next, the mixture is formed into microspheres through a specific process; then, the microspheres are frozen; finally, they are heated under vacuum conditions to sublimate the water within the microspheres, thus obtaining freeze-dried microspheres; and finally, microspheres of the appropriate size are sieved using a screening device.
[0003] However, existing freeze-dried microsphere screening devices are mainly large-scale industrial screening machines. When used for small-scale experiments, the screening process is cumbersome and inefficient. Therefore, we propose a freeze-dried microsphere screening device to solve the problems mentioned above. Utility Model Content
[0004] The purpose of this invention is to provide a freeze-dried microsphere screening device to solve the problem mentioned in the background art that the existing freeze-dried microsphere screening devices are mainly industrial large-scale screening machines, which are cumbersome and inefficient when used for small-scale experiments.
[0005] To achieve the above objectives, this utility model provides the following technical solution: a freeze-dried microsphere screening device, comprising a screening device body, a central groove inside the screening device body, a collection groove below the central groove, a primary screening groove at the upper end of the screening device body, a first sieve hole inside the primary screening groove, and multiple first sieve holes, sliding grooves on both sides of the central groove, a central sieve plate between the two sliding grooves, a second sieve hole inside the central sieve plate, and multiple second sieve holes, a sieve plate frame at the upper edge of the central sieve plate, and the central sieve plate is slidably connected to the sliding groove through the sieve plate frame.
[0006] Preferably, the diameter of the first sieve hole is 5 mm and the diameter of the second sieve hole is 3 mm.
[0007] Preferably, a limiting plate is provided at the front end of the chute, and one end of the limiting plate is rotatably connected to the main body of the screening device through a damping shaft.
[0008] Preferably, a rubber pad is provided on the inner wall of the limiting piece, and the rubber pad is bonded to the limiting piece.
[0009] Preferably, the main body of the screening device is equipped with handles on both sides.
[0010] Preferably, the outer wall of the grip handle is provided with a rubber anti-slip sleeve.
[0011] Compared with the prior art, the beneficial effects of this utility model are:
[0012] 1. The main body of the screening device of this utility model consists of a three-layer structure. The top layer is a primary screening trough with a 5mm aperture, the middle layer is a detachable central screening disc with a 3mm aperture, and the bottom layer is a flat-bottomed collection trough. The device is small in size and can be handheld and shaken to complete the screening, which meets the needs of small-scale experiments. It solves the problem that the existing freeze-dried microsphere screening devices are mainly industrial-type large-scale screening machines, which are cumbersome and inefficient when used for small-scale experiments.
[0013] 2. By making the central sieve disc detachable, after one screening is completed, if the central sieve disc already contains a certain amount of microspheres, the limiting plate at the front of the device can be rotated to move it away from the chute. Then, the central sieve disc can be pulled outwards, and a new central sieve disc can be inserted along the chute. The limiting plate can be rotated again to block the front of the chute to fix the central sieve disc. Then, the new microspheres can be poured into the primary screening tank, and the next screening can be started quickly, thus improving screening efficiency. Attached Figure Description
[0014] Figure 1 This is a schematic diagram of the overall structure of this utility model;
[0015] Figure 2 This is a schematic diagram of the rear structure of this utility model;
[0016] Figure 3 This is a schematic diagram of the structure of the central sieve disc in the pulled-out state of this utility model;
[0017] Figure 4 This is a partial enlarged view of point A of this utility model;
[0018] In the figure: 1. Main body of the screening device; 2. Central trough; 3. Collection trough; 4. Primary screening trough; 5. First sieve hole; 6. Slide chute; 7. Central sieve plate; 8. Second sieve hole; 9. Sieves plate frame; 10. Handle; 11. Rubber anti-slip sleeve; 12. Damping shaft; 13. Limiting plate; 14. Rubber pad. Detailed Implementation
[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.
[0020] Please see Figure 1-4The present invention provides an embodiment of a freeze-dried microsphere screening device, comprising a screening device body 1, a central groove 2 inside the screening device body 1, a collection groove 3 below the central groove 2, a primary screening groove 4 at the upper end of the screening device body 1, a first sieve hole 5 inside the primary screening groove 4, and multiple first sieve holes 5, a sliding groove 6 on both sides of the central groove 2, a central sieve plate 7 between the two sliding grooves 6, a second sieve hole 8 inside the central sieve plate 7, and multiple second sieve holes 8, a sieve plate frame 9 on the upper edge of the central sieve plate 7, and the central sieve plate 7 is slidably connected to the sliding groove 6 through the sieve plate frame 9.
[0021] Furthermore, the diameter of the first sieve hole 5 is 5mm, and the diameter of the second sieve hole 8 is 3mm. The primary sieve trough 4 can isolate freeze-dried microspheres with a diameter greater than 5mm through the first sieve hole 5, and the second sieve hole 8 can screen out target microspheres with a diameter of 3-5mm.
[0022] Please see Figure 4 The front end of the chute 6 is provided with a limiting piece 13. One end of the limiting piece 13 is rotatably connected to the main body 1 of the screening device through a damping shaft 12. After the central screen plate 7 is slidably connected to the chute 6 through the screen plate frame 9, the limiting piece 13 can be rotated through the damping shaft 12 to block the front end of the chute 6 and fix the central screen plate 7. When the central screen plate 7 needs to be replaced, simply rotate the limiting piece 13 to move it away from the position of the chute 6, and then pull the central screen plate 7 outward.
[0023] Please see Figure 4 A rubber pad 14 is provided on the inner wall of the limiting piece 13, and the rubber pad 14 is bonded to the limiting piece 13. The rubber pad 14 can increase the friction between the limiting piece 13 and the contact surface by relying on its elasticity.
[0024] Please see Figure 1 Both sides of the main body 1 of the screening device are equipped with handles 10, which can be used to manually shake the device to achieve screening.
[0025] Please see Figure 1 A rubber anti-slip sleeve 11 is provided on the outer wall of the handle 10. The rubber anti-slip sleeve 11 can increase the friction between the handle 10 and the hand and prevent slippage.
[0026] Working principle: During use, the freeze-dried microspheres to be screened are poured into the primary screening tank 4 on the upper layer of the main body 1 of the screening device. After completion, the operator holds the handles 10 from both sides and shakes the main body 1 of the screening device. During the process, freeze-dried microspheres with a diameter greater than 5mm remain in the primary screening tank 4. The freeze-dried microspheres that fall into the central screening plate 7 are screened out under the shaking action, and the target microspheres with a diameter of 3-5mm are separated. Microspheres smaller than 3mm and impurities fall into the collection tank 3 at the bottom. After one screening is completed, if the central screening plate 7 already contains a certain amount of microspheres, the limiting plate 13 at the front end of the device can be rotated to move it away from the position of the slide 6. Then, the central screening plate 7 is pulled outward and a new central screening plate 7 is inserted along the slide 6. The limiting plate 13 is rotated again to block the front end of the slide 6 to fix the central screening plate 7. Then, the new microspheres are poured into the primary screening tank 4, and the next screening can be started quickly, which improves the screening efficiency.
[0027] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.
Claims
1. A freeze-dried microsphere screening device, comprising a screening device body (1), characterized in that: The main body (1) of the screening device is provided with a central groove (2) inside. A collection groove (3) is provided below the central groove (2). A primary screening groove (4) is provided at the upper end of the main body (1). A first sieve hole (5) is provided inside the primary screening groove (4), and multiple first sieve holes (5) are provided. A sliding groove (6) is provided on both sides of the central groove (2). A central sieve plate (7) is provided between the two sliding grooves (6). A second sieve hole (8) is provided inside the central sieve plate (7), and multiple second sieve holes (8) are provided. A sieve plate frame (9) is provided on the upper edge of the central sieve plate (7), and the central sieve plate (7) is slidably connected to the sliding groove (6) through the sieve plate frame (9).
2. The freeze-dried microsphere screening device according to claim 1, characterized in that: The diameter of the first sieve hole (5) is 5 mm, and the diameter of the second sieve hole (8) is 3 mm.
3. The freeze-dried microsphere screening device according to claim 1, characterized in that: The front end of the chute (6) is provided with a limiting piece (13), and one end of the limiting piece (13) is rotatably connected to the main body (1) of the screening device through a damping shaft (12).
4. The freeze-dried microsphere screening device according to claim 3, characterized in that: A rubber pad (14) is provided on the inner wall of the limiting piece (13), and the rubber pad (14) is bonded to the limiting piece (13).
5. The freeze-dried microsphere screening device according to claim 3, characterized in that: Both sides of the main body (1) of the screening device are equipped with handles (10).
6. The freeze-dried microsphere screening device according to claim 5, characterized in that: A rubber anti-slip sleeve (11) is provided on the outer wall of the grip handle (10).