Capillary tube array type biological chip

Abstract

The utility model discloses a capillary tube array type biochip, which comprises a plurality of capillary tubes, a planar substrate, a substrate and a cover plate, a groove is arranged on the upper side of the substrate, the cover plate is arranged on the upper side of the substrate, so that a substrate cavity is formed between the substrate and the cover plate, and the plurality of capillary tubes are arranged in the substrate cavity. The array type biochip integrated by the plurality of capillary tubes has the advantages of small volume, low cost, convenience in carrying, high analysis speed and few required samples, and in addition, laser scattered by the capillary tubes can be reduced through the filling layer, so that the precision is effectively improved.

Description

Technical Field

[0001] This utility model relates to the field of gene detection, and in particular to a capillary array biochip. Background Technology

[0002] Commonly used substrates for existing biochips include organic and inorganic polymer films, glass slides, silicon wafers, and ceramic wafers. These substrates are typically modified by chemically bonding various active groups onto their surface using different activating agents. This allows them to covalently bind to biomolecules in the sample, forming biochips with different biological specificities. Some substrates even incorporate various microstructures, such as micropits, microgrooves, microchannels, and microtubes, to facilitate sample processing. However, existing biochips have very high material requirements and complex manufacturing processes, often resulting in losses and affecting their detection sensitivity. Furthermore, as detection throughput increases, crosstalk between adjacent capillaries significantly intensifies, leading to a marked decrease in the stability and accuracy of the biochip. Utility Model Content

[0003] This invention provides a capillary array biochip, which can at least solve one of the problems mentioned in the background art.

[0004] A capillary array biochip includes a substrate, a cover plate, and multiple capillaries. The substrate has a groove on its upper side, and the cover plate is disposed on the upper side of the substrate to form a substrate cavity between the substrate and the cover plate. Multiple capillaries are arranged in the substrate cavity, and the substrate cavity has openings on both sides so that the two ends of the capillaries extend out of the substrate.

[0005] The cavity is also provided with a filling layer.

[0006] Preferably, at least one planar substrate is further disposed within the substrate cavity, the planar substrate being located above the plurality of capillaries.

[0007] Preferably, two symmetrically distributed planar substrates are disposed within the substrate cavity.

[0008] Preferably, both the substrate and the cover plate are made of quartz.

[0009] Preferably, the multiple capillaries in the substrate cavity are arranged in at least one layer.

[0010] Preferably, the filling layer is water or an optical coupling agent.

[0011] Compared with the prior art, the beneficial effects of this utility model are: the array-type biochip with multiple capillaries integrated in this utility model has the advantages of small size, low cost, easy portability, fast analysis speed and small sample requirement. In addition, the filling layer can reduce the laser scattered by the capillaries, effectively improving the accuracy. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the structure of this utility model;

[0013] Figure 2 This is a schematic diagram of the structure of this utility model after the cover plate has been removed;

[0014] Figure 3 This is a schematic diagram of the structure of the present invention after removing the cover plate and the planar substrate.

[0015] Explanation of reference numerals in the attached figures:

[0016] 1-Substrate, 2-Cover plate, 3-Capillary tube, 4-Planar substrate, 5-Substrate cavity. Detailed Implementation

[0017] The following describes a specific embodiment of the present invention in detail with reference to the accompanying drawings. However, it should be understood that the scope of protection of the present invention is not limited to the specific embodiment.

[0018] like Figures 1 to 3 As shown in the figure, the capillary array biochip provided in this embodiment includes multiple capillaries 3, a planar substrate 4, a substrate 1, and a cover plate 2. Both the substrate 1 and the cover plate 2 are made of quartz material.

[0019] A groove is provided on the upper side of the substrate 1, and a cover plate 2 is disposed on the upper side of the substrate 1 so that a substrate cavity 5 is formed between the substrate 1 and the cover plate 2. Multiple capillaries 3 are arranged in the substrate cavity 5, so a cavity with multiple capillaries 3 is formed inside the chip. The substrate cavity 5 has openings on both sides so that the two ends of the capillaries 3 extend out of the substrate 1 respectively. The detection sample can be sucked into the capillary cavity 3 from the opening end of the capillary 3.

[0020] The planar substrate 4 is located on the upper side of the multiple capillaries 3, and there is at least one of them. In this embodiment, two planar substrates 4 are symmetrically distributed as an example.

[0021] In addition, the multiple capillaries 3 in the substrate cavity 5 are arranged in at least one layer, and this embodiment takes one layer as an example;

[0022] like Figure 1As shown, the laser can be injected into the biochip from both sides of the substrate 1. The laser passes through multiple capillaries 3, one after another. Due to the different refractive indices of the laser on different surfaces, the laser will attenuate during the process of passing through multiple capillaries 3, resulting in a decrease in accuracy. To solve this problem, a filling layer is provided in the area inside the substrate cavity 5. The filling layer can be a liquid, such as water or an optical coupling agent, or a non-fluorescent refractive liquid, which fills the space around the capillaries 3. This can reduce the laser scattered by the capillaries 3 and improve the stability of the biochip. In addition, some grooves can be formed in the cover plate 2 to prevent air bubbles in the liquid.

[0023] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit and essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0024] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A capillary array biochip, characterized in that, It includes a substrate, a cover plate, and multiple capillaries. The substrate has a groove on its upper side, and the cover plate is disposed on the upper side of the substrate so that a substrate cavity is formed between the substrate and the cover plate. Multiple capillaries are arranged in the substrate cavity, and the substrate cavity has openings on both sides so that the two ends of the capillaries extend out of the substrate respectively. A filling layer is also provided inside the substrate cavity.

2. The capillary array biochip as described in claim 1, characterized in that, At least one planar substrate is also disposed inside the substrate cavity, and the planar substrate is located on the upper side of the multiple capillaries.

3. The capillary array biochip as described in claim 1, characterized in that, The substrate cavity contains two symmetrically distributed planar substrates.

4. The capillary array biochip as described in claim 1, characterized in that, Both the substrate and the cover plate are made of quartz.

5. The capillary array biochip as described in claim 1, characterized in that, The substrate cavity contains multiple capillaries arranged in at least one layer.

6. The capillary array biochip as described in claim 1, characterized in that, The filling layer is water or an optical coupling agent.

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