Magnetic rod sleeve suitable for high-flux cell sorting and extracting plate

Abstract

The utility model provides a magnetic bar sleeve suitable for a high-flux cell sorting and extracting plate, which comprises a tube body, the bottom of the tube body is sealed, and the top of the tube body is opened; the sealing opening is in a smooth semicircular curved surface shape; and the edge of the opening extends outwards to form an edge for an external manipulator to grab. According to the utility model, as long as the magnetic bar sleeve is placed in a specified hole position of the extraction plate, the mechanical arm of the extraction instrument can automatically grab the magnetic bar sleeve, and the magnetic bar sleeve can be flexibly placed according to the number of samples, so that the cost of experimental consumables is greatly reduced. And meanwhile, the magnetic bar sleeve is independently used corresponding to one hole site of the extraction plate, so that the mutual pollution among the hole sites is effectively avoided.

Description

Technical Field

[0001] This utility model relates to the field of nucleic acid detection technology, and in particular to a magnetic rod sleeve suitable for high-throughput cell sorting and extraction plates. Background Technology

[0002] Currently, in cell sorting experiments, the enrichment of target cells is mainly accomplished by magnetic activation cell sorting, which is the simplest, most time-saving, and most affordable method, and can separate multiple samples simultaneously. However, most of the techniques used today are manually operated by experimenters, and when the sample volume is in the double digits or more, the cell sorting operation will consume a lot of time. To solve this problem, automated high-throughput cell sorting and extraction plates have emerged.

[0003] Currently, the mainstream 96-well extraction plate magnetic rod sleeves are available in two types: strip-type 8-packs and full 96-well plate magnetic rod sleeves. Both types of sleeves have the drawback of not being able to flexibly adjust the sample volume. When the sample volume is less than 8 wells, a single magnetic rod sleeve must still be used, which increases experimental costs. Furthermore, since the magnetic rod sleeves are controlled by the same robotic arm, if one well in the sleeve is damaged or deformed, the entire extraction process must be restarted. More seriously, this could contaminate other samples, leading to experimental failure. Utility Model Content

[0004] The purpose of this invention is to provide a magnetic rod sleeve suitable for high-throughput cell sorting and extraction plates, which can solve the problems of high experimental costs in the two existing magnetic rod sleeves when the sample volume is less than 8, and the inability of strip-type and whole-plate magnetic rod sleeves to flexibly adjust the sample number.

[0005] The objective of this utility model is achieved through the following technical solution:

[0006] A magnetic rod sleeve suitable for high-throughput cell sorting and extraction plates includes a tube body with a sealed bottom and an open top; the sealed bottom is a smooth semi-circular curved surface; the edge of the open top extends outward to form an edge for external robotic gripping.

[0007] Preferably, the tube has a length of 3.8 cm and a diameter of 0.5 cm.

[0008] The advantages of this utility model over the prior art are as follows:

[0009] 1. This magnetic rod sleeve is easy to operate. Simply place the magnetic rod sleeve into the designated hole in the extraction plate, and the extraction device's robotic arm will automatically grab the magnetic rod sleeve.

[0010] 2. This magnetic rod sleeve can be flexibly placed according to the number of samples, which greatly reduces the cost of experimental consumables.

[0011] 3. This magnetic rod sleeve is used individually for one hole of the extraction plate, effectively avoiding cross-contamination between each channel. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the structure of a magnetic rod sleeve for a high-throughput cell sorting and extraction plate according to the present invention.

[0013] The annotations in the attached figures are explained as follows:

[0014] 1: Pipe body, 11: Sealing, 12: Opening, 13: Edge. Detailed Implementation

[0015] The embodiments of this disclosure will now be described in detail with reference to the accompanying drawings.

[0016] The following specific examples illustrate the implementation of this disclosure. Those skilled in the art can easily understand the advantages and effects of this disclosure from the content disclosed in this specification. Obviously, the described embodiments are only a part of the embodiments of this disclosure, and not all of them. This disclosure can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of this disclosure. It should be noted that, in the absence of conflict, the following embodiments and features in the embodiments can be combined with each other. Based on the embodiments in this disclosure, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this disclosure.

[0017] Example 1

[0018] like Figure 1 The magnetic rod sleeve for a high-throughput cell sorting and extraction plate includes a tube 1, with a sealed bottom 11 and an open top 12; the sealed bottom 11 is a smooth semi-circular curved surface; the edge of the open top 12 extends outward to form an edge 13 for external robotic gripping.

[0019] Furthermore, the tube 1 has a length of 3.8 cm and a diameter of 0.5 cm. Both the length and diameter of the tube 1 are smaller than the size of the holes in the extraction plate, making it easier to insert into the holes of the extraction plate.

[0020] This magnetic rod sleeve is easy to operate. Simply place the magnetic rod sleeve into the designated hole on the extraction plate, and the extraction instrument's robotic arm will automatically grab the magnetic rod sleeve. It can be flexibly placed according to the number of samples, greatly reducing the cost of experimental consumables.

[0021] This magnetic rod sleeve is used individually for one hole on the extraction plate, effectively preventing cross-contamination between holes.

[0022] In the description of this utility model, it should be understood that the terms "middle", "length", "upper", "lower", "front", "rear", "vertical", "horizontal", "inner", "outer", "radial", "circumferential", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0023] In this invention, unless otherwise expressly specified and limited, the first feature "on" the second feature may be in direct contact with the first feature, or indirect contact with the first feature through an intermediate medium. "A plurality of" means at least two, such as two, three, etc., unless otherwise expressly and specifically limited.

[0024] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between them; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0025] The above description is merely illustrative of the embodiments of this utility model and is not intended to limit the scope of this utility model. For those skilled in the art, any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model without creative labor should be included within the protection scope of this utility model.

Claims

1. A magnetic rod sleeve suitable for high-throughput cell sorting and extraction plates, characterized in that, It includes a tube (1), the bottom of the tube (1) is sealed (11) and the top is open (12); the seal (11) is a smooth semi-circular curved surface; the edge of the opening (12) extends outward to form an edge (13) for external robotic arm to grasp.

2. The magnetic rod sleeve for a high-throughput cell sorting and extraction plate as described in claim 1, characterized in that, The tube (1) has a length of 3.8 cm and a diameter of 0.5 cm.

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