Concentrated bovine serum albumin ultrafiltration device

Abstract

The utility model discloses a concentrated bovine serum albumin ultrafiltration device which comprises a main body mechanism and an adjusting mechanism, the main body mechanism comprises two symmetrically arranged shells, ultrafiltration membranes mounted on the inner walls of the shells, an input end adjusting cylinder arranged above the shells, a first connecting pipe for connecting the input end adjusting cylinder with inner cavities of the two shells, an input pipeline mounted in the middle of the input end adjusting cylinder, and an output end adjusting cylinder arranged on one side of the input end adjusting cylinder; the shell is cylindrical and is used for forming a closed space, the ultrafiltration membrane is annular, the top end of the ultrafiltration membrane is fixed to the inner top wall of the shell, the bottom end of the ultrafiltration membrane is fixed to the inner bottom wall of the shell, and the shell is provided with a first connecting pipe and a second connecting pipe which are connected with the output end adjusting cylinder and the inner cavities of the two shells, the output pipeline is installed in the middle of the output end adjusting cylinder, and the flow sensor is installed on the output pipeline. The concentrated bovine serum albumin ultrafiltration device has the advantages that the ultrafiltration membranes can be automatically switched, and the concentrated bovine serum albumin ultrafiltration device can be automatically cleaned.

Description

Technical Field

[0001] This utility model relates to the field of ultrafiltration device technology, specifically to an ultrafiltration device for concentrating bovine serum albumin. Background Technology

[0002] Bovine serum albumin (BSA) is a functional factor widely used in animal cell culture, diagnostic reagents, and food emulsification. It can increase the number of human T lymphocytes and antioxidant activity. Ultrafiltration is required to extract BSA.

[0003] The existing bovine serum albumin ultrafiltration devices have the following drawbacks during use: when the ultrafiltration device is clogged, the input end needs to be disconnected, the ultrafiltration membrane needs to be disassembled for backwashing, and then reassembled, which is quite troublesome, time-consuming and labor-intensive. Therefore, there is room for improvement. Utility Model Content

[0004] This utility model aims to solve one of the technical problems existing in the prior art or related technologies.

[0005] Therefore, the technical solution adopted by this utility model is as follows: a concentrated bovine serum albumin ultrafiltration device, comprising: a main body and an adjustment mechanism. The main body includes two symmetrically arranged shells, an ultrafiltration membrane installed on the inner wall of the shell, an input end adjustment cylinder arranged above the shell, a first connecting pipe connecting the input end adjustment cylinder to the inner cavities of the two shells, an input pipe installed in the middle of the input end adjustment cylinder, an output end adjustment cylinder arranged on one side of the input end adjustment cylinder, a second connecting pipe connecting the output end adjustment cylinder to the inner cavities of the two shells, an output pipe installed in the middle of the output end adjustment cylinder, and a flow sensor installed on the output pipe.

[0006] The adjustment mechanism includes a sealing plug movably disposed in the inner cavity of the input end adjustment cylinder and the output end adjustment cylinder, a round rod fixed to the end of the sealing plug and extending outward, a discharge component installed at the end of the round rod corresponding to the input end adjustment cylinder, an injection component installed at the end of the round rod corresponding to the output end adjustment cylinder, and a control component installed between the input end adjustment cylinder and the output end adjustment cylinder and fixedly connected to the round rod.

[0007] The sealing plug has a groove at the bottom, and the round rod has a flow channel inside. One end of the flow channel is connected to the groove, and the other end is connected to the injection or discharge component.

[0008] In a preferred embodiment, the present invention can be further configured such that: the ultrafiltration membrane divides the inner cavity of the housing into an inner cavity and an outer cavity; one end of the first connecting tube is connected to the input regulating cylinder, and the other end is connected to the inner cavity of the housing; one end of the second connecting tube is connected to the output regulating cylinder, and the other end is connected to the outer cavity of the housing.

[0009] In a preferred embodiment, the present invention can be further configured such that the discharge component includes a water outlet pipe fixed to the end of a round rod and communicating with the inner flow channel of the round rod, and a first electric valve installed on the water outlet pipe.

[0010] In a preferred embodiment, the present invention can be further configured such that the injection component includes an inlet pipe fixed to the end of a round rod and communicating with the inner flow channel of the round rod, and a second electric valve installed on the inlet pipe.

[0011] In a preferred embodiment, the present invention can be further configured such that the control component includes a bracket fixed on the input end adjusting cylinder and the output end adjusting cylinder, an electric telescopic rod mounted on the bracket, and a connecting frame fixed to the end of the electric telescopic rod and fixedly connected to the round rod on both sides.

[0012] By adopting the above technical solution, the beneficial effects achieved by this utility model are as follows:

[0013] 1. In this utility model, two opposing shells are provided, and an ultrafiltration membrane is disposed within the inner cavity of each shell. An input regulating cylinder and an output regulating cylinder are disposed above the shells, respectively connected to the two shells via a first connecting pipe and a second connecting pipe. A sealing plug is movably disposed within the inner cavity of both the input and output regulating cylinders. A fixed round rod extends outward from the end of each sealing plug, and a control component is fixedly connected to the round rod. A discharge component is disposed at the end of the round rod corresponding to the input regulating cylinder, and an injection component is disposed at the end of the round rod corresponding to the output regulating cylinder. When the ultrafiltration membrane becomes clogged, the control component activates. The mechanism moves the sealing plug via a round rod, causing it to close the first and second connecting pipes corresponding to the ultrafiltration membrane on one side and open the first and second connecting pipes corresponding to the ultrafiltration membrane on the other side. This alternating setting effectively avoids the drawback of needing to disconnect the input when cleaning the ultrafiltration membrane, ensuring the stability during bovine serum albumin extraction. Simultaneously, clean water is injected into the inner cavity of the housing corresponding to the clogged ultrafiltration membrane through the injection component to backwash the ultrafiltration membrane. The wastewater generated during backwashing is discharged through the discharge component, automatically completing the cleaning of the ultrafiltration membrane and further increasing its practicality.

[0014] 2. In this utility model, a flow sensor is installed on the output pipe to monitor the flow rate in the output pipe in real time. When the flow rate in the output pipe is lower than the set value, it is determined that the ultrafiltration membrane is blocked. At this time, the control unit is activated to switch the ultrafiltration membrane, which can realize the automatic switching and cleaning of the ultrafiltration membrane, further increasing the level of intelligence and automation. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the structure of this utility model;

[0016] Figure 2 This is a cross-sectional view of the present invention;

[0017] Figure 3 This is a side sectional view of the present invention;

[0018] Figure 4 This is a schematic diagram of the cross-sectional structure of the sealing plug of this utility model.

[0019] Figure label:

[0020] 100. Main body; 110. Housing; 120. Ultrafiltration membrane; 130. Input regulating cylinder; 140. First connecting pipe; 150. Input pipe; 160. Output regulating cylinder; 170. Second connecting pipe; 180. Output pipe; 190. Flow sensor;

[0021] 200. Adjustment mechanism; 210. Round rod; 211. Flow channel; 220. Sealing plug; 221. Groove; 230. Discharge part; 231. Water outlet pipe; 232. First electric valve; 240. Injection part; 241. Water inlet pipe; 242. Second electric valve; 250. Control part; 251. Bracket; 252. Electric telescopic rod; 253. Connecting frame. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to specific embodiments and accompanying drawings. It should be noted that, unless otherwise specified, the embodiments and features of the present utility model can be combined with each other.

[0023] Some embodiments of this utility model are described below with reference to the accompanying drawings.

[0024] Example 1:

[0025] Combination Figure 1-4 As shown, this embodiment provides a concentrated bovine serum albumin ultrafiltration device, including: a main body 100 and an adjustment mechanism 200.

[0026] The main body 100 includes two symmetrically arranged housings 110, an ultrafiltration membrane 120 installed on the inner wall of the housing 110, an input end regulating cylinder 130 disposed above the housing 110, a first connecting pipe 140 connecting the input end regulating cylinder 130 to the inner cavity of the two housings 110, an input pipe 150 installed in the middle of the input end regulating cylinder 130, an output end regulating cylinder 160 disposed on one side of the input end regulating cylinder 130, a second connecting pipe 170 connecting the output end regulating cylinder 160 to the inner cavity of the two housings 110, an output pipe 180 installed in the middle of the output end regulating cylinder 160, and a flow sensor 190 installed on the output pipe 180.

[0027] The shell 110 is cylindrical and is used to form a closed space. The ultrafiltration membrane 120 is annular, with its top end fixed to the inner top wall of the shell 110 and its bottom end fixed to the inner bottom wall of the shell 110. The inner cavity of the shell 110 is divided into an inner cavity and an outer cavity. After the bovine serum albumin enters the inner cavity, it is filtered by the ultrafiltration membrane 120, and the product enters the outer cavity.

[0028] The input regulating cylinder 130 is connected to the two housings 110 through two first connecting pipes 140, and the output regulating cylinder 160 is connected to the two housings 110 through two second connecting pipes 170. One end of the first connecting pipe 140 is connected to the input regulating cylinder 130 and the other end is connected to the inner cavity of the housing 110. One end of the second connecting pipe 170 is connected to the output regulating cylinder 160 and the other end is connected to the outer cavity of the housing 110.

[0029] The input pipe 150 is used to feed bovine serum albumin into the input regulating cylinder 130, and the output pipe 180 is used to output the product filtered by the ultrafiltration membrane 120. The flow sensor 190 is used to monitor the flow rate in the output pipe 180 in real time. When the flow rate in the output pipe 180 is lower than the set value, it is determined that the ultrafiltration membrane 120 is blocked. At this time, the regulating mechanism 200 is activated to switch the ultrafiltration membrane 120, which can realize the automatic switching of the ultrafiltration membrane 120, thereby ensuring the stability of the bovine serum albumin filtration process.

[0030] The regulating mechanism 200 can switch the operation of the ultrafiltration membrane 120 according to the data of the flow sensor 190. It includes a sealing plug 220 movably disposed in the inner cavity of the input regulating cylinder 130 and the output regulating cylinder 160, a round rod 210 fixed to the end of the sealing plug 220 and extending outward, a discharge component 230 installed at the end of the round rod 210 corresponding to the input regulating cylinder 130, an injection component 240 installed at the end of the round rod 210 corresponding to the output regulating cylinder 160, and a control component 250 installed between the input regulating cylinder 130 and the output regulating cylinder 160 and fixedly connected to the round rod 210.

[0031] The sealing plug 220 inside the input regulating cylinder 130 can seal the first connecting pipe 140 on one side, so that the bovine serum albumin in the input regulating cylinder 130 can enter the housing 110 on the other side through the connecting pipe on the other side for ultrafiltration. The sealing plug 220 inside the output regulating cylinder 160 can seal the second connecting pipe 170 on one side, so that the ultrafiltration product in the housing 110 on the other side can enter the output regulating cylinder 160 and then be sent out through the output pipe 180.

[0032] The round rod 210 is used to drive the sealing plug 220 to move. The control component 250 includes a bracket 251 fixed on the input end adjusting cylinder 130 and the output end adjusting cylinder 160, an electric telescopic rod 252 installed on the bracket 251, and a connecting frame 253 fixed to the end of the electric telescopic rod 252 and fixedly connected to the round rod 210 on both sides. The bracket 251 is used to ensure the stability of the electric telescopic rod 252. The connecting frame 253 is used to fix the round rods 210 on both sides to the end of the electric telescopic rod 252, so that when the electric telescopic rod 252 extends or retracts, it can drive the round rods 210 on both sides to move synchronously, that is, drive the sealing plug 220 in the input end adjusting cylinder 130 and the output end adjusting cylinder 160 to move synchronously.

[0033] A groove 221 is provided at the bottom of the sealing plug 220, and a flow channel 211 is provided inside the round rod 210. One end of the flow channel 211 is connected to the groove 221, and the other end is connected to the injection part 240 or the discharge part 230, so that clean water can be injected into the inner and outer cavities of the housing 110 through the flow channel 211 and the groove 221 to backwash the ultrafiltration membrane 120. At the same time, it is convenient for the wastewater generated during cleaning to be discharged outward through the groove 221 and the flow channel 211.

[0034] The injection unit 240 is used to inject clean water into the housing 110 to backwash the ultrafiltration membrane 120. It includes an inlet pipe 241 fixed to the end of the round rod 210 and connected to the flow channel 211 inside the round rod 210, and a second electric valve 242 installed on the inlet pipe 241. The inlet pipe 241 is connected to the water pump to facilitate the injection of clean water. The second electric valve 242 is used to control the opening and closing of the inlet pipe 241.

[0035] The discharge component 230 is used to discharge the wastewater generated by backwashing. It includes a water outlet pipe 231 fixed to the end of the round rod 210 and communicating with the inner flow channel 211 of the round rod 210, and a first electric valve 232 installed on the water outlet pipe 231. The first electric valve 232 is used to control the opening and closing of the water outlet pipe 231.

[0036] The working principle and usage process of this utility model are as follows: During use, bovine serum albumin is fed into the input regulating cylinder 130 through the input pipe 150, and then enters the corresponding inner cavity of the housing 110 through the first connecting pipe 140. After filtration by the ultrafiltration membrane 120, the product enters the output regulating cylinder 160 through the second connecting pipe 170, and is then discharged through the output pipe 180. Simultaneously, the flow sensor 190 monitors the flow rate in the output pipe 180 in real time. When the flow rate in the output pipe 180 falls below a set value, it is determined that the ultrafiltration membrane 120 is blocked. At this time, the electric telescopic rod 252 is activated. The activation of the electric telescopic rod 252 drives the round rod 210 to move through the connecting frame 253. The movement of the round rod 210 causes the sealing plug 220 to move, sealing the first connecting pipe 140 and the second connecting pipe 170 corresponding to the ultrafiltration membrane 120. At this point, the bovine serum albumin entering the input regulating cylinder 130... The ultrafiltration membrane 120 inside the housing 110 enters through the first connecting pipe 140 on the other side, and is filtered by the ultrafiltration membrane 120 inside the housing 110. It then enters the output regulating cylinder 160 through the second connecting pipe 170 on the other side. At the same time, the cleaning program for the clogged ultrafiltration membrane 120 is started. The first electric valve 232 and the second electric valve 242 are opened. Clean water is sent through the inlet pipe 241 and the flow channel 211 in the round rod 210 into the groove 221 of the sealing plug 220 in the output regulating cylinder 160. Then, it is injected back into the inner cavity of the housing 110 through the second connecting pipe 170 to backwash the clogged ultrafiltration membrane 120. The wastewater generated by backwashing enters the groove 221 on the sealing plug 220 in the input regulating cylinder 130 through the first connecting pipe 140, and then enters the outlet pipe 231 through the flow channel 211 in the round rod 210 to be discharged, thus realizing the automatic cleaning of the ultrafiltration membrane 120.

[0037] Although embodiments of the present invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A concentrated bovine serum albumin ultrafiltration device, comprising: The main body (100) and the regulating mechanism (200) are characterized in that the main body (100) includes two symmetrically arranged shells (110), an ultrafiltration membrane (120) installed on the inner wall of the shell (110), an input end regulating cylinder (130) arranged above the shell (110), a first connecting pipe (140) connecting the input end regulating cylinder (130) to the inner cavity of the two shells (110), an input pipe (150) installed in the middle of the input end regulating cylinder (130), an output end regulating cylinder (160) arranged on one side of the input end regulating cylinder (130), a second connecting pipe (170) connecting the output end regulating cylinder (160) to the inner cavity of the two shells (110), an output pipe (180) installed in the middle of the output end regulating cylinder (160), and a flow sensor (190) installed on the output pipe (180). The adjustment mechanism (200) includes a sealing plug (220) movably disposed in the inner cavity of the input end adjustment cylinder (130) and the output end adjustment cylinder (160), a round rod (210) fixed to the end of the sealing plug (220) and extending outward, a discharge component (230) installed at the end of the round rod (210) corresponding to the input end adjustment cylinder (130), an injection component (240) installed at the end of the round rod (210) corresponding to the output end adjustment cylinder (160), and a control component (250) installed between the input end adjustment cylinder (130) and the output end adjustment cylinder (160) and fixedly connected to the round rod (210). The sealing plug (220) has a groove (221) at the bottom, and the round rod (210) has a flow channel (211) inside. One end of the flow channel (211) is connected to the groove (221), and the other end is connected to the injection part (240) or the discharge part (230).

2. The ultrafiltration device for concentrating bovine serum albumin according to claim 1, characterized in that, The ultrafiltration membrane (120) divides the inner cavity of the housing (110) into an inner cavity and an outer cavity. One end of the first connecting tube (140) is connected to the input end regulating cylinder (130), and the other end is connected to the inner cavity of the housing (110). One end of the second connecting tube (170) is connected to the output end regulating cylinder (160), and the other end is connected to the outer cavity of the housing (110).

3. The ultrafiltration device for concentrating bovine serum albumin according to claim 1, characterized in that, The discharge component (230) includes a water outlet pipe (231) fixed to the end of the round rod (210) and communicating with the inner flow channel (211) of the round rod (210) and a first electric valve (232) installed on the water outlet pipe (231).

4. The ultrafiltration device for concentrating bovine serum albumin according to claim 1, characterized in that, The injection device (240) includes an inlet pipe (241) fixed to the end of the round rod (210) and communicating with the inner flow channel (211) of the round rod (210) and a second electric valve (242) installed on the inlet pipe (241).

5. The ultrafiltration device for concentrating bovine serum albumin according to claim 1, characterized in that, The control unit (250) includes a bracket (251) fixed on the input end regulating cylinder (130) and the output end regulating cylinder (160), an electric telescopic rod (252) mounted on the bracket (251), and a connecting frame (253) fixed on the end of the electric telescopic rod (252) and fixedly connected to the round rod (210) on both sides.

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