High performance liquid chromatograph for bilastine raw material determination

Abstract

The utility model discloses a high performance liquid chromatograph for bilastine raw material determination, which relates to a liquid chromatograph, and comprises a liquid chromatograph main body, a placing groove arranged at the top of the liquid chromatograph main body and used for placing a reagent bottle, and a positioning frame fixedly arranged at one side of the top of the liquid chromatograph main body and internally provided with a driving piece; the two positioning plates are symmetrically arranged on one side of the positioning frame; the center of the C-shaped piece can abut against the reagent bottle by starting the driving piece, then the first micro electric push rod is started, the driving end of the first micro electric push rod extends, and the C-shaped piece is made of aluminum which is soft, so that the C-shaped piece is not prone to falling off. Therefore, the driving end of the first micro electric push rod can push the two ends of the C-shaped piece to deform and wrap the reagent bottle, the stability of the reagent bottle is improved, in addition, the deformation of the C-shaped piece can position the reagent bottles with different curvatures, and the application range is widened.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography technology, specifically a high-performance liquid chromatograph for the determination of bilastine raw materials. Background Technology

[0002] Bilastin is a non-sedating, long-acting antihistamine primarily used to treat allergic rhinitis and urticaria. Bilastin raw material analysis can be performed using high-performance liquid chromatography (HPLC), a highly efficient, rapid, and sensitive biochemical analytical instrument. Its working principle involves utilizing the difference in the distribution ratio of a mixture between a liquid and a solid or between two immiscible liquids to first separate the mixture and then analyze and identify it.

[0003] For example, an existing patent (publication number: CN214011153U) discloses a liquid chromatograph. This liquid chromatograph uses a first arc-shaped plate, a first screw, a second square rod, and a ball bearing in combination. A second knob drives a third moving rod to move via the second screw. The third moving rod drives a second L-shaped rod to slide on the second square rod. The third moving rod drives the ball bearing to press against the inclined surface of the triangular plate. The triangular plate drives a moving plate to slide on the second fixed rod. The moving plate drives the corresponding first arc-shaped plate to move via the second connecting rod. At this time, the first arc-shaped plate and the corresponding second arc-shaped plate cooperate to fix the test bottle.

[0004] However, the liquid chromatograph designed above still has some drawbacks in actual use: although the liquid chromatograph can use the clamping structure to clamp the reagent bottle, the curvature of different reagent bottles is also different, and the clamping structure cannot change its own curvature, so it cannot be adapted to clamp reagent bottles with different curvatures.

[0005] To address these issues, we designed a high-performance liquid chromatograph for the determination of bilastine raw materials. Utility Model Content

[0006] The purpose of this invention is to provide a high-performance liquid chromatograph for the determination of bilastine raw materials, so as to solve the problems mentioned in the background art.

[0007] To solve the above-mentioned technical problems, the present invention provides a high-performance liquid chromatograph for the determination of bilastine raw materials, comprising a liquid chromatograph body and a placement slot formed on the top of the liquid chromatograph body for placing reagent bottles, including...

[0008] The positioning frame is fixedly installed on one side of the top of the liquid chromatograph body and has a drive mechanism inside.

[0009] There are two positioning plates, symmetrically arranged on one side of the positioning frame, and C-shaped parts are fixedly installed on the opposite side. The C-shaped parts are made of aluminum. The driving component is used to drive the positioning plates and C-shaped parts to clamp the reagent bottle.

[0010] The first micro electric push rod is two groups, each group has two first micro electric push rods, and the two first micro electric push rods are symmetrically installed between the positioning plate and the C-shaped piece and used for pushing the C-shaped piece to deform and wrap the reagent bottle.

[0011] Further, the positioning plate and the C-shaped piece are respectively fixedly installed with a mounting seat and a fixing seat on opposite sides.

[0012] Further, the mounting seat is provided with a first pin shaft, the fixing seat is provided with a second pin shaft, and the two ends of the first micro electric push rod are respectively rotatably sleeved on the first pin shaft and the second pin shaft.

[0013] Further, the number of the placing grooves is two, the number of the positioning frames is the same as that of the placing grooves, and the positioning frames and the placing grooves are symmetrically arranged on the top of the liquid chromatograph main body.

[0014] Further, the driving member includes two sliding blocks, the two sliding blocks are symmetrically and slidably installed on one side of the positioning frame, the sliding blocks are fixedly connected with the positioning plate, the positioning frame is fixedly installed with second micro electric push rods on the front and rear sides, and the driving ends of the second micro electric push rods are fixedly connected with the sliding blocks.

[0015] Further, the positioning frame is provided with a sliding groove on one side, and the sliding blocks are slidably inserted into the sliding groove.

[0016] Further, the positioning frame is provided with a wire port for inserting the infusion tube.

[0017] Further, the front side of the liquid chromatograph main body is provided with a display screen, and the bottom of the liquid chromatograph main body is provided with a base.

[0018] Compared with the prior art, the C-shaped piece can be centered with the reagent bottle by opening the driving member, and then the first micro electric push rod is opened to make the driving end of the first micro electric push rod elongate. Since the material of the C-shaped piece is aluminum and aluminum is relatively soft, the driving end of the first micro electric push rod can push the two ends of the C-shaped piece to deform and wrap the reagent bottle, thereby improving the stability of the reagent bottle. In addition, the deformation of the C-shaped piece can position the reagent bottles with different curvatures, thereby improving the application range. Since the reagent bottle can be stably positioned, the liquid chromatograph can be efficiently operated.

[0019] Compared with the prior art, the beneficial effects of this utility model are: by setting two placement slots, two reagent bottles can be positioned at the same time, which can improve the detection effect; by setting wire openings, the pipes connected to the reagent bottles can be easily managed. Attached Figure Description

[0020] Fig. 1 This is a three-dimensional structural diagram of the overall external structure of this utility model;

[0021] Fig. 2 This is a three-dimensional structural diagram of the external C-shaped component of this utility model;

[0022] Fig. 3 This is a three-dimensional structural diagram of the external side of this utility model.

[0023] In the diagram: 1. Liquid chromatograph body; 2. Placement slot; 3. Positioning frame; 4. Positioning plate; 5. C-shaped part; 6. First micro electric actuator; 7. Mounting base; 8. Fixing base; 9. Slide groove; 10. Slider; 11. Second micro electric actuator; 12. Lead wire port; 13. Display screen; 14. Base. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Please see Figs. 1-3 This utility model provides a technical solution: a high-performance liquid chromatograph for determining bilastine raw materials, comprising a liquid chromatograph body 1 and a placement slot 2 formed on the top of the liquid chromatograph body 1 for placing reagent bottles, including...

[0026] The positioning frame 3 is fixedly installed on one side of the top of the liquid chromatograph body 1, and has a drive component inside;

[0027] Positioning plates 4, two in number, are symmetrically arranged on one side of positioning frame 3, and C-shaped parts 5 are fixedly installed on the opposite side. The C-shaped parts 5 are made of aluminum. The driving component is used to drive the positioning plates 4 and C-shaped parts 5 to clamp the reagent bottle.

[0028] The first micro electric push rod 6 is in two sets, with two first micro electric push rods 6 in each set. The two first micro electric push rods 6 are symmetrically rotated and installed between the positioning plate 4 and the C-shaped part 5, and are used to push the C-shaped part 5 to deform and wrap the reagent bottle.

[0029] Mounting plate 4 and C-shaped part 5 are respectively fixedly installed on opposite sides of mounting base 7 and fixed base 8. The two ends of the first micro electric push rod 6 are respectively rotatably set in mounting base 7 and fixed base 8. The mounting base 7 is provided with a first pin, and the fixed base 8 is provided with a second pin. The two ends of the first micro electric push rod 6 are respectively rotatably sleeved on the first pin and the second pin. The driving component includes two sliders 10. The two sliders 10 are symmetrically slidably installed on one side of positioning frame 3, and the sliders 10 are fixedly connected to positioning plate 4. The front and rear sides of positioning frame 3 are fixedly installed with second micro electric push rods 11. The driving end of the second micro electric push rod 11 is fixedly connected to the slider 10.

[0030] In practice, when positioning the reagent bottle, the reagent bottle is first placed in the placement slot 2. Then, the two second micro electric actuators 11 are activated, causing the driving ends of the two second micro electric actuators 11 to extend and move the slider 10, positioning plate 4, and C-shaped part 5 closer to the reagent bottle, so that the center of the C-shaped part 5 can abut against the reagent bottle. Subsequently, the first micro electric actuator 6 is activated, causing the driving end of the first micro electric actuator 6 to extend. Since the C-shaped part 5 is made of aluminum, and aluminum is relatively soft, the driving end of the first micro electric actuator 6 can push the two ends of the C-shaped part 5 to deform and wrap around the reagent bottle, improving the stability of the reagent bottle. In addition, the deformation of the C-shaped part 5 can position reagent bottles with different curvatures, increasing the applicability.

[0031] See Figs. 1-3 As shown, there are two placement slots 2, and the number of positioning racks 3 is the same as that of placement slots 2, both symmetrically arranged on the top of the liquid chromatograph body 1. By setting two placement slots 2, two reagent bottles can be positioned simultaneously, which improves the detection effect.

[0032] See Figs. 1-3 A groove 9 is provided on one side of the positioning frame 3, and the slider 10 is slidably inserted into the groove 9. This facilitates the sliding of the slider 10 on one side of the positioning frame 3 and avoids motion interference.

[0033] See Figs. 1-3 The positioning frame 3 has a wire inlet 12 for connecting infusion tubing. The wire inlet 12 facilitates the arrangement of tubing connected to the reagent bottle.

[0034] See Figs. 1-3 The liquid chromatograph body 1 has a display screen 13 on its front side and a base 14 made of rubber on its bottom. Because rubber has elasticity, it helps absorb vibrations generated during operation, thus improving stability.

[0035] In addition, the main body of the liquid chromatograph 1 usually includes a pump, injector, chromatographic column, detector, recorder and other parts; among them, the high performance liquid chromatograph also includes an injection system, a liquid delivery system, a separation system, a detection system and a data processing system, while the bilastine raw material is put into the injection system and the liquid delivery system performs liquid delivery detection. Since the main body of the liquid chromatograph 1 is a well-known technology, it will not be described in detail in this specification.

[0036] Working principle: When in use, first connect all electrical components inside and outside the liquid chromatograph to an external power source. Alternatively, a battery can be installed on the rear side of the liquid chromatograph body 1 in an area that does not obstruct the operation of other components. Connect the battery to the electrical circuits inside and outside the liquid chromatograph body 1 to provide power to the electrical components, thereby ensuring that the electrical components can operate normally.

[0037] When positioning the reagent bottle, the reagent bottle is first placed in the placement slot 2. Then, the two second micro electric push rods 11 are activated, causing the driving ends of the two second micro electric push rods 11 to extend and drive the slider 10, positioning plate 4 and C-shaped part 5 to approach the reagent bottle, so that the center of the C-shaped part 5 can abut against the reagent bottle. Then, the first micro electric push rod 6 is activated, causing the driving end of the first micro electric push rod 6 to extend. Since the C-shaped part 5 is made of aluminum, and aluminum is relatively soft, the driving end of the first micro electric push rod 6 can push the two ends of the C-shaped part 5 to deform and wrap around the reagent bottle, which improves the stability of the reagent bottle. In addition, the deformation of the C-shaped part 5 can position reagent bottles with different curvatures, which improves the applicability.

[0038] It should be noted that by setting two placement slots 2, two reagent bottles can be positioned simultaneously, which improves the detection effect. By setting the wire inlet 12, it is convenient to manage the pipes connected to the reagent bottles.

Claims

1. A high-performance liquid chromatograph for determining bilastine raw materials, comprising a liquid chromatograph body (1) and a placement slot (2) formed on the top of the liquid chromatograph body (1) for placing reagent bottles, characterized in that, include, The positioning frame (3) is fixedly installed on one side of the top of the liquid chromatograph body (1), and a driving component is provided inside; Positioning plates (4), two in number, are symmetrically arranged on one side of the positioning frame (3), and C-shaped parts (5) are fixedly installed on the opposite side. The C-shaped parts (5) are made of aluminum. The driving component is used to drive the positioning plates (4) and C-shaped parts (5) to clamp the reagent bottle. The first micro electric push rod (6) is in two sets, with two first micro electric push rods (6) in each set. The two first micro electric push rods (6) are symmetrically rotated and installed between the positioning plate (4) and the C-shaped part (5) to push the C-shaped part (5) to deform and wrap the reagent bottle.

2. The high-performance liquid chromatograph for determining bilastine raw materials as described in claim 1, characterized in that: The positioning plate (4) and the C-shaped part (5) are respectively fixedly installed on opposite sides with mounting base (7) and fixing base (8), and the two ends of the first micro electric push rod (6) are respectively rotatably set in mounting base (7) and fixing base (8).

3. The high-performance liquid chromatograph for determining bilastine raw materials as described in claim 2, characterized in that: The mounting base (7) is provided with a first pin, and the fixing base (8) is provided with a second pin. The two ends of the first micro electric push rod (6) are respectively rotatably sleeved on the first pin and the second pin.

4. The high-performance liquid chromatograph for determining bilastine raw materials as described in claim 1, characterized in that: There are two placement slots (2), and the number of positioning frames (3) is the same as that of placement slots (2), and they are symmetrically arranged on the top of the liquid chromatograph body (1).

5. The high-performance liquid chromatograph for determining bilastine raw materials as described in claim 1, characterized in that: The driving component includes two sliders (10), which are symmetrically slidably mounted on one side of the positioning frame (3). The sliders (10) are fixedly connected to the positioning plate (4). A second micro electric push rod (11) is fixedly mounted on both the front and rear sides of the positioning frame (3). The driving end of the second micro electric push rod (11) is fixedly connected to the slider (10).

6. The high-performance liquid chromatograph for determining bilastine raw materials as described in claim 5, characterized in that: The positioning frame (3) has a groove (9) on one side, and the slider (10) is slidably inserted into the groove (9).

7. The high-performance liquid chromatograph for determining bilastine raw materials as described in claim 1, characterized in that: The positioning frame (3) has a wire inlet (12) for connecting an infusion tube.

8. The high-performance liquid chromatograph for determining bilastine raw materials as described in claim 1, characterized in that: The liquid chromatograph body (1) is provided with a display screen (13) on the front side and a base (14) on the bottom of the liquid chromatograph body (1).

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