Skin extrusion / ink-jet composite printing device

Abstract

The utility model discloses a skin extrusion / ink-jet composite printing device, which belongs to the technical field of biological tissue printing and comprises a computer, a three-dimensional motion system, an ink box, an ink-jet printing head, an extrusion printing head, a temperature control substrate, an air pump and a pressure controller. The ink box is installed on the ink-jet printing head, and the ink-jet printing head and the extrusion printing head are installed on the three-dimensional motion system. The pressure controller is mounted on the air pump; the pressure controller is in air connection with the ink box and the extrusion printing head; the computer is electrically connected with the three-dimensional motion system, the ink-jet printing head and the pressure controller. The computer is used for controlling the three-dimensional motion system to move and further used for controlling ink jet of the ink jet printing head and controlling the pressure controller to output the air pressure value. The personalized skin printing device provided by the utility model is low in manufacturing cost and high in efficiency.

Description

TECHNICAL FIELD

[0001] The utility model belongs to biological tissue printing technical field, concretely relates to a kind of extrusion / ink-jet composite printing device of skin. BACKGROUND

[0002] In recent years, a large number of patients with large area of skin serious injury are caused by fire, earthquake, traffic accident and other reasons. The main methods for clinical treatment of large area of skin serious injury are autologous skin transplantation, allogeneic skin transplantation, xenogeneic skin transplantation and dressing covering. Autologous skin transplantation is mainly for patients with small wound area. If the wound is too large, it is often difficult to find a suitable skin donor site, and autologous skin grafting will cause damage to the skin donor site. Allogeneic skin transplantation and xenogeneic skin transplantation have the problem of immune rejection, and the survival rate after transplantation is not high. The commonly used skin dressing only has the function of temporarily covering the wound surface, and has no repair effect.

[0003] At present, the main method for manufacturing artificial skin is through tissue engineering. By mixing biological materials and human skin cells in vitro for culture, skin tissue is constructed. Tissue engineered skin has certain effect on wound repair, but there are still many problems in the clinical treatment of large area of skin serious injury. On the one hand, the culture period of tissue engineered skin is long, the cost is high, and the standardization of product is difficult to realize; on the other hand, tissue engineered skin does not have the ability to construct complex skin structure, and cannot reconstruct blood vessels, hair follicles, sweat glands and other skin appendages. The construction of these appendages is often the key to whether the transplanted skin can survive and whether the skin function can be reconstructed. UTILITY MODEL CONTENT

[0004] The utility model provides a kind of extrusion / ink-jet composite printing device of skin to solve the technical problems of skin printing difficulty, high cost and unstable printing in prior art.

[0005] In order to solve the above technical problems, the utility model is realized by the following technical scheme:

[0006] An extrusion / ink-jet composite printing device of skin, comprising a three-dimensional motion system, an inkjet printhead and an extrusion printhead are arranged on the three-dimensional motion system, the inkjet printhead and the extrusion printhead are connected with an air pump, the three-dimensional motion system, the inkjet printhead, the extrusion printhead and the air pump are connected with a computer.

[0007] The lower end of the three-dimensional motion system is fixed on a temperature control substrate. The three-dimensional motion system can realize the movement of X-axis, Y-axis and two Z-axes. The movement resolution of the three-dimensional motion system is less than 1 μm.

[0008] The three-dimensional motion system comprises two Y-axis guides, which are fixed at two ends of the temperature control base plate, and an X-axis guide is horizontally arranged on the two Y-axis guides and can move along the Y-axis on the Y-axis guides.

[0009] A Z-axis guide is vertically arranged on the X-axis guide, the Z-axis guide moves along the X-axis on the X-axis guide, and the inkjet print head and the extrusion print head are installed at the lower end of the Z-axis guide and can move along the Z-axis on the Z-axis guide.

[0010] The inkjet print head is provided with an ink cartridge, and the capacity of the ink cartridge is 2ml-200ml.

[0011] The inner diameter of the inkjet print head nozzle is 20-200μm, and the jet frequency is 100-10000Hz.

[0012] The outlet inner diameter of the extrusion print head is 20-1000μm.

[0013] The temperature adjustment range of the temperature control base plate is 4-37℃.

[0014] The pressure range provided by the air pump is 0-1000Kpa, and the adjustment accuracy is 0.01Kpa.

[0015] The air pump is provided with a pressure controller, the pressure controller comprises 1-6 pressure adjustment channels, the pressure adjustment range is 0-600kPa, and the adjustment accuracy is 0.01kPa.

[0016] Compared with the prior art, the utility model has at least the following beneficial effects:

[0017] The utility model provides a kind of extrusion / ink-jet composite printing device of skin, when specific operation, according to the skin bionic model of design or the skin defect model obtained from wound scanning, printing device can customize printing personalized artificial skin, compared with the past skin manufacturing mode, the utility model is more suitable for the manufacture of personalized skin model, save the biological ink of printing skin, simplify the manufacturing step of skin, reduce manufacturing cost, improve manufacturing efficiency, according to the stable control of printing skin quality more easily realized according to standardization printing step.In addition, skin is a multilayer structure, the mechanical environment required for the growth of each layer of skin cells presents gradient change, the utility model combines extrusion and ink-jet two biological printing technologies, and shows stronger manufacturing capacity in the mechanical microenvironment required for the growth of skin cells is constructed.The diameter of extrusion printing microfilament or ink-jet droplet can be adjusted to adjust the pore size and porosity in skin, and different cell growth environment can be personalized printed according to the needs of the utility model.The utility model can also print tubular structure according to demand, or accurately print skin hair follicle and sweat gland cells, according to the density of the designed accessory organs such as blood vessels and sweat glands of skin is reconstructed.The utility model can accurately print personalized skin, and cost is low, efficiency is high.

[0018] Further, the three-dimensional motion system can realize the motion of X-axis, Y-axis and at least two Z-axes, and the motion resolution is less than 1 μm, so that the skin cells can be accurately printed to the designed position, and the two Z-axes are suitable for printing two kinds of cell inks.

[0019] Further, the capacity of the ink cartridge is 2 ml-200 ml, and the appropriate ink cartridge can be selected according to the size of the printed skin, so that the adaptability is stronger.

[0020] Further, the temperature adjustment range of the temperature control substrate is 4-37 ℃, so that the temperature of the temperature-sensitive skin ink can be adjusted after printing to solidify the ink, and the stability of the printed skin structure is more beneficial to guarantee.

[0021] Further, the pressure controller includes 1-6 pressure adjustment channels, the pressure adjustment range is 0-600 kPa, the adjustment accuracy is 0.01 Kpa, the pressure control range is wide, the adaptability is stronger when printing biological inks with different viscosities, and the adjustment accuracy of pressure is higher, which is more beneficial to guarantee the stability of printing. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1 A structure diagram of a kind of extrusion / ink-jet composite printing device of skin.

[0023] Labeling Explanation: 1. Computer; 2. 3D Motion System; 3. Ink Cartridge; 4. Inkjet Printhead; 5. Extrusion Printhead; 6. Temperature Control Board; 7. Air Pump; 8. Pressure Controller; 9. X-axis Guide Rail; 10. Y-axis Guide Rail; 11. Z-axis Guide Rail. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0025] like Figure 1 As shown, a skin extrusion / inkjet composite printing device includes a temperature control substrate 6. A three-dimensional motion system 2 is fixed on the temperature control substrate 6. With a spatial rectangular coordinate system O-xyz as a reference, the three-dimensional motion system 2 has X-axis guide rails 9, Y-axis guide rails 10, and Z-axis guide rails 11 in the Ox, Oy, and Oz directions, respectively. The X-axis guide rails 9, Y-axis guide rails 10, and Z-axis guide rails 11 are perpendicular to each other. There are two Y-axis guide rails 10, and the bottoms of the two Y-axis guide rails 10 are fixed to both ends of the upper surface of the temperature control substrate 6. The X-axis guide rails 9 are horizontally placed above the two Y-axis guide rails 10. Two Z-axis guide rails 11 are vertically arranged on the X-axis guide rails 9. The lower end of one Z-axis guide rail 11 is connected to the inkjet print head 4, and the lower end of the other Z-axis guide rail 11 is connected to the extruder. The printhead 5 has an ink cartridge 3 mounted on its upper end. Both the inkjet printhead 4 and the extrusion printhead 5 are connected to a pressure controller 8, which is mounted on an air pump 7. The skin extrusion / inkjet printing device also includes a computer 1, which is connected to the X-axis guide rail 9 and Y-axis guide rail 10 in the three-dimensional motion system 2. The computer 1 is also connected to the inkjet printer 4 at the lower end of the Z-axis guide rail 11 and the pressure controller 8. The computer 1 controls the movement of the three-dimensional motion system 2 and the inkjet printhead 4 through the printing control software installed on the computer 1. The computer 1 adjusts the pressure controller 8 through the pressure control software installed on the computer 1. The pressure controller 8 controls the air pump 7 to output appropriate pressure to the inkjet printhead 4 and the extrusion printhead 5 respectively.

[0026] The skin extrusion / inkjet composite printing device of this invention is used for skin printing, and the printing method is as follows:

[0027] Step 1: Based on the skin to be printed, prepare bio-ink for printing the dermis and bio-ink for printing the epidermis. Generally, extrusion printing is used to print the dermis, and inkjet printing is used to print the epidermis.

[0028] The dermis layer bio-ink needs to meet the requirements of printing. The storage modulus and loss modulus of the dermis layer printing ink are measured by a rheometer. When the storage modulus of the bio-ink is slightly greater than the loss modulus, the bio-ink has better extrusion printing performance. After obtaining the sterile ink suitable for extrusion printing, a certain amount of dermis cells is added to prepare the dermis printing ink.

[0029] The epidermis layer bio-ink needs to meet the rheological requirements, that is, the value of the dimensionless parameter Z describing the behavior of the fluid in the inkjet printing process needs to be between 1 and 10, wherein p : the density of the solution, g: : the surface tension of the solution, h : the viscosity of the solution; α : the diameter of the nozzle of the inkjet printhead 4. The density, viscosity and surface tension of the epidermis layer bio-ink are measured, and the Z value of the ink is calculated. The ink can be printed only when the Z value meets the requirements. Preferably, the viscosity of the epidermis layer bio-ink is 2 mPa·s to 18 mPa·s, and the surface tension of the epidermis layer bio-ink is 25 mN / m to 60 mN / m. After obtaining the sterile ink suitable for inkjet printing, a certain amount of epidermis cells is added to prepare the epidermis printing ink. The prepared epidermis printing ink is placed in the ink cartridge 3. h g

[0030] Step 2: The entire printing device is subjected to ultraviolet irradiation under ultraviolet light for more than 30 minutes. The inkjet printhead 4 is filled with 70% alcohol, and is allowed to stand for more than 5 minutes. Then, the alcohol is washed away, and the inkjet printhead 4 is washed clean with sterile deionized water. The ink cartridge 3 and the extrusion printing head 5 installed on the inkjet printhead 4 are soaked in 70% alcohol for more than 5 minutes, and are washed clean with sterile deionized water. The dermis layer printing ink is loaded into the extrusion printing head 5. The pressure controller 8 is adjusted using the pressure control software on the computer 1. The pressure controller 8 controls the extrusion pressure provided by the air pump 7 to the extrusion printing head 5. When the extrusion printing head 5 extrudes uniform microfilaments, the printing can be started. The epidermis layer printing ink is loaded into the ink cartridge 3 connected to the inkjet printhead 4. Then, the pressure controller 8 is adjusted using the pressure control software in the computer 1. The pressure controller 8 controls the inkjet pressure provided by the air pump 7 to the inkjet printhead 4. The balance of the epidermis layer printing ink ejected from the nozzle of the inkjet printhead 4 is achieved, that is, the epidermis layer printing ink at the nozzle of the inkjet printhead 4 neither converges into drops nor is sucked back. The pressure adjustment range of the pressure controller 8 for the inkjet printhead 4 and the extrusion printing head 5 is 0 to 600 kPa, and the adjustment accuracy is 0.01 kPa. The inner diameter of the nozzle of the inkjet printhead 4 is 20 ~200 , and the ejection frequency is 100 Hz to 10,000 Hz. The inner diameter of the outlet of the extrusion printing head 5 is 20 ​​~1000 .

[0031] It should be noted that all the above operations need to be carried out in a hundred-level clean space, and the operator needs to wear sterile gloves and a mask.

[0032] Step 3: Set the distance between the extrusion printing head 5 and the temperature control substrate 6, the movement speed of the extrusion printing head 5, the distance between the inkjet printing head 4 and the temperature control substrate 6, the ejection frequency of the inkjet printing head 4, and the temperature of the temperature control substrate 6. The height of the lower end of the extrusion printing head 5 from the temperature control substrate 6 is set to 0.5mm-1mm, and the printing speed of the extrusion printing head 5 is set to 5mm / s-30mm / s. The height of the lower end of the inkjet printing head 4 from the temperature control substrate 6 is set to 1mm~2mm, and the ejection frequency of the inkjet printing head 4 is 1000Hz~4000Hz. Set the temperature of the temperature control substrate 6, and the temperature control substrate 6 is below the inkjet printing head 4 and the extrusion printing head 5, and the temperature control substrate 6 is used to carry the printed skin and adjust the temperature, and the temperature of the temperature control substrate 6 is adjusted in the range of 4℃~37℃.

[0033] Step 4: According to the input skin model, the computer 1 controls the X-axis guide rail 9 to move forward and backward on the Y-axis guide rail 10, and controls the Z-axis guide rail 11 to move left and right on the X-axis guide rail 9, while controlling the inkjet printing head 4 and the extrusion printing head 5 on the two Z-axis guide rails 11 to move up and down on the Z-axis guide rail 11, the movement range of the three-dimensional motion system 2 in the Ox direction, the Oy direction and the Oz direction is not less than 300mm, and the movement resolution of the three-dimensional motion system 2 in the Ox direction, the Oy direction and the Oz direction is not greater than 1μm. That is, the movement range of the three-dimensional motion system 2 is not less than 300mm×300mm×300mm, and the movement resolution in each coordinate direction is not greater than 1μm. While the three-dimensional motion system 2 moves, the computer 1 controls the Z-axis guide rail 11 where the extrusion printing head 5 is located to move downward to touch the surface of the temperature control substrate 6, and controls the pressure controller 8 to adjust the gas pump 7 to output appropriate pressure to the extrusion printing head 5, so that the extrusion printing head 5 prints the dermis layer on the surface of the temperature control substrate 6, at this time, the inkjet printing head 4 is above the Z-axis guide rail 11 and does not contact the surface of the temperature control substrate 6; after the dermis layer is printed, the computer 1 controls the extrusion printing head 5 to rise along the Z-axis guide rail 11 and move away from the surface of the temperature control substrate 6, at this time, the inkjet printing head 4 descends along the Z-axis guide rail 11 until the inkjet printing head 4 contacts the surface of the dermis layer, and the computer 1 controls the three-dimensional motion system 2 to move in the Ox direction, the Oy direction and the Oz direction according to the input skin model, and controls the pressure controller 8 to adjust the gas pump 7 to output appropriate pressure to the inkjet printing head 4, so that the inkjet printing head 4 sprays to print the epidermis layer, that is, the personalized printing of the multi-layer skin is completed.

[0034] The utility model will be explained in more detail in combination with specific embodiments.

[0035] Example 1

[0036] The dermal layer printing ink was prepared as a 4% (w / v) sodium alginate and dermal fibroblast (10 6 cells / ml) sterile aqueous solution; the epidermal layer printing ink was a 1% (w / v) sodium alginate and epidermal keratinocyte (2 x 10 6 cells / ml) sterile aqueous solution.

[0037] Dermal layer printing ink preparation method:

[0038] At room temperature, 4 g of sodium alginate powder was placed in a centrifuge tube, which was then placed in a vertical pressure steam sterilizer and heated to 125°C for 25 min. After that, the sterilized 4 g of sodium alginate powder was dissolved in 80 ml of sterile ultrapure water, which was sealed and placed in a 50°C water bath for 24 hours to obtain a 5% (w / v) sodium alginate sterile aqueous solution, which was removed and placed in a 37°C water bath. 80 ml of 5% (w / v) sodium alginate solution was mixed with 20 ml of 5 x 10 6 cells / ml dermal fibroblast suspension at a ratio of 4:1 to obtain a 4% (w / v) sodium alginate and dermal fibroblast (10 6 cells / ml) sterile aqueous solution.

[0039] Epidermal layer printing ink preparation method:

[0040] At room temperature, 1 g of sodium alginate powder was placed in a centrifuge tube, which was then placed in a vertical pressure steam sterilizer and heated to 125°C for 25 min. After that, the sterilized 1 g of sodium alginate powder was dissolved in 80 ml of sterile ultrapure water solution, which was sealed and placed in a 50°C water bath for 24 hours to obtain a sterile 1.25% (w / v) sodium alginate solution, which was removed and placed in a 37°C water bath. 80 ml of 1.25% (w / v) sodium alginate solution was mixed with 20 ml of 10 x 10 6 cells / ml epidermal keratinocyte suspension at a ratio of 4:1 to obtain a 1% (w / v) sodium alginate and dermal fibroblast (2 x 10 6 cells / ml) sterile aqueous solution.

[0041] The whole printing device is irradiated with ultraviolet light for more than 30 minutes, 70% alcohol is poured into the inkjet print head 4, and it is left to stand for more than 5 minutes, then the alcohol is washed clean and sterilized deionized water is used to wash clean. The ink cartridge 3 installed on the inkjet print head 4 and the extrusion print head 5 must be soaked in 70% alcohol for more than 5 minutes and sterilized deionized water is used to wash clean. The dermal layer printing ink is loaded into the extrusion print head, the extrusion pressure is adjusted using the pressure control software on the computer 1, and printing can be performed when the print head extrudes uniform microfilaments. The epidermal layer printing ink is loaded into the ink cartridge connected to the inkjet print head, and then the pressure controller 8 is controlled using the pressure control software, the pressure controller 8 adjusts the air pump 7 to output appropriate pressure to the inkjet print head 4, and the balance of the epidermal layer printing ink in the inkjet print head 4 is achieved, that is, the epidermal layer printing ink in the inkjet print head 4 will not gather into drops or be sucked back. All operations must be carried out in a hundred-level clean space, and the operator must wear sterile gloves and a mask.

[0042] The height of the bottom of the extrusion print head 5 from the temperature control substrate 6 is set to 0.6 mm, and the printing speed is set to 15 mm / s. The height of the bottom of the inkjet print head 4 from the temperature control substrate 6 is set to 1.2 mm, and the ejection frequency is 2000 Hz. The temperature of the temperature control substrate 6 is set to 37°C, a sterile culture dish is placed below the print head, and the computer 1 controls the X-axis guide rail, Y-axis guide rail and Z-axis guide rail in the three-dimensional motion system 2 to move in the manner described in step 4 above to complete the personalized printing of the multi-layer skin.

[0043] Example Two

[0044] The dermal layer printing ink contains a sterile ultrapure water solution of 1% (w / v) collagen and dermal fibroblasts (10 6 cells / ml); the epidermal layer printing ink is a sterile ultrapure water solution of 0.4% (w / v) collagen and epidermal keratinocytes (2 x 10 6 cells / ml).

[0045] Method for preparing dermal layer printing ink:

[0046] At room temperature, 1 g of sterile collagen is dissolved in 80 ml of 0.1% (v / v) acetic acid solution, and dissolved at 4°C for 48 hours. Then a small amount of sodium hydroxide is added to adjust the pH to 7~7.4. Then 80 ml of 1.25% (w / v) collagen solution is mixed with 20 ml of epidermal keratinocyte suspension with a concentration of 5 x 10 6 cells / ml at a ratio of 4:1 to obtain a sterile ultrapure water solution of 0.4% (w / v) collagen and dermal fibroblasts (10 6 cells / ml).

[0047] Preparation method of epidermis layer printing ink:

[0048] At room temperature, 0.4 g of sterile collagen was dissolved in 80 ml of 0.1% (v / v) acetic acid solution, and dissolved at 4°C for 48 hours. Then a small amount of sodium hydroxide was added to adjust the pH to 7-7.4. Then 80 ml of 1.25% (w / v) collagen solution was mixed with 20 ml of 10×10 6 cells / ml keratinocyte suspension at a ratio of 4:1 to obtain a sterile ultrapure water solution of 1% (w / v) collagen and keratinocytes (2×10 6 cells / ml).

[0049] The entire printing device was ultraviolet irradiated for more than 30 minutes, the inkjet print head 4 was filled with 70% alcohol, and stood for more than 5 minutes, then the alcohol was washed clean and washed clean with sterile deionized water. The ink cartridge 3 installed on the inkjet print head 4 and the extrusion print head 5 must be soaked with 70% alcohol for more than 5 minutes and washed clean with sterile deionized water. The dermis layer printing ink was loaded into the extrusion print head 5, and the extrusion pressure was adjusted using the pressure control software on the computer 1, and the printing was completed when the extrusion print head 5 extruded uniform microfilaments. The epidermis layer printing ink was loaded into the ink cartridge connected to the inkjet print head, and then the pressure control software was used to control the pressure controller 8, which in turn adjusted the air pump 7 to deliver appropriate pressure to the inkjet print head 4, so that the epidermis layer printing ink was balanced at the nozzle of the inkjet print head 4, that is, the epidermis layer printing ink at the nozzle of the inkjet print head 4 would not gather into drops or be sucked back. All operations must be carried out in a hundred-level clean space, and the operator must wear sterile gloves and a mask.

[0050] The height of the bottom of the extrusion print head 5 from the temperature control base plate 6 was set to 0.5 mm, and the printing speed was set to 20 mm / s. The height of the bottom of the inkjet print head 4 from the temperature control base plate 6 was set to 1.5 mm, and the ejection frequency was 3000 Hz. The temperature of the temperature control base plate 6 was set to 37°C, and a sterile culture dish was placed below the print head. The computer controlled the X-axis guide rail, Y-axis guide rail and Z-axis guide rail in the three-dimensional motion system 2 according to the input skin model to move in the manner described in step 4 above, thereby completing the personalized printing of the multi-layer skin.

Claims

1. A skin extrusion / inkjet hybrid printing apparatus, characterized by, The three-dimensional motion system (2) is provided with an inkjet print head (4) and an extrusion print head (5), the inkjet print head (4) and the extrusion print head (5) are connected with an air pump (7), and the three-dimensional motion system (2), the inkjet print head (4), the extrusion print head (5) and the air pump (7) are connected with a computer (1).

2. The apparatus for combined extrusion / inkjet printing on skin according to claim 1, characterized in that The lower end of the three-dimensional motion system (2) is fixed on a temperature control base plate (6), the three-dimensional motion system (2) can realize X-axis, Y-axis and two Z-axis movements, and the movement resolution of the three-dimensional motion system (2) is less than 1μm.

3. The apparatus for composite printing of skin by extrusion / inkjet according to claim 2, characterized in that, The three-dimensional motion system (2) comprises two Y-axis guide rails, the two Y-axis guide rails are respectively fixed on the two ends of the temperature control base plate (6), and an X-axis guide rail (9) is transversely arranged on the two Y-axis guide rails (10).

4. The apparatus for composite printing of skin by extrusion / inkjet according to claim 3, characterized in that, A Z-axis guide rail (11) is vertically arranged on the X-axis guide rail (9), the inkjet print head (4) and the extrusion print head (5) are installed at the lower end of the Z-axis guide rail (11), and the inkjet print head (4) and the extrusion print head (5) can move along the Z-axis on the Z-axis guide rail (11).

5. The apparatus for composite printing of skin by extrusion / inkjet according to claim 4, characterized in that, An ink cartridge (3) is arranged on the inkjet print head (4), and the capacity of the ink cartridge (3) is 2ml-200ml.

6. The apparatus for composite printing of skin by extrusion / inkjet according to claim 5, characterized in that, The inner diameter of the inkjet print head (4) is 20μm-200μm, and the jet frequency is 100Hz-10000Hz.

7. The apparatus for combined extrusion / inkjet printing on skin according to claim 4, characterized in that, The outlet inner diameter of the extrusion print head (5) is 20μm-1000μm.

8. The apparatus for combined extrusion / inkjet printing on skin according to claim 2, characterized in that, The temperature adjustment range of the temperature control base plate (6) is 4℃-37℃.

9. The apparatus for combined extrusion / inkjet printing on skin according to claim 1, characterized in that, The air pump (7) provides a pressure range of 0-1000Kpa, and the adjustment accuracy is 0.01Kpa.

10. The apparatus for combined extrusion / inkjet printing on skin according to claim 1, characterized in that, A pressure controller (8) is installed on the air pump (7), the pressure controller (8) comprises 1-6 pressure adjustment channels, the pressure adjustment range is 0-600kPa, and the adjustment accuracy is 0.01kPa.

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