High-flux liquid sample introduction system
By designing a high-throughput liquid sample introduction system and employing an XYZ axis robotic arm and upflow rinsing technology, the problems of high labor intensity and low accuracy in sample introduction of inductively coupled plasma mass spectrometry were solved, achieving automated and unattended high-efficiency sample processing.
Patent Information
- Application Number
- CN202423006817.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-06
- Publication Date
- 2025-11-07
- Estimated Expiration
- 2034-12-06
AI Technical Summary
Existing inductively coupled plasma mass spectrometry (ICP-MS) methods for liquid sample introduction are labor-intensive, error-prone, and difficult to achieve high-throughput testing. Imported equipment is expensive and lacks versatility, while domestically produced equipment has limited positioning accuracy and capacity.
A high-throughput liquid injection system was designed, comprising a sample tray, injection arm, injection probe, and peristaltic pump. A stepper motor drives the XYZ axis robotic arm to achieve precise movement. Combined with upflow rinsing and waste liquid recovery, automated injection and cleaning are achieved.
It enables automated, flexible, and unattended high-throughput sample introduction, reduces manual labor, improves sample processing capacity and analytical accuracy, meets the needs of high-throughput testing, and has a waste liquid recovery function, thus reducing labor costs.
Smart Images
Figure CN223527125U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to the technical field of sample feeding device in analytical instrument, more particularly to a kind of high flux liquid sample feeding system. BACKGROUND
[0002] Inductively coupled plasma mass spectrometry (ICP-MS) is a widely used trace element accurate determination technology, with high sensitivity, low detection limit, wide dynamic linear range, high precision, fast analysis and other superior analysis characteristics.
[0003] The analysis object of analytical instruments such as inductively coupled plasma mass spectrometer is liquid. The traditional manual sampling has high labor intensity, is prone to errors, and is difficult to achieve high-throughput testing.
[0004] Currently, many detection fields begin to use automatic sampling systems, which are intelligent, flexible, convenient, unattended, reduce physical labor, increase sample processing capacity, improve daily work precision, and greatly improve work efficiency. However, imported liquid automatic samplers are expensive, have high transportation costs, do not have separate debugging software, and are not universal. Domestic automatic samplers have low positioning accuracy and sampling accuracy, small sample disc capacity, and other shortcomings.
[0005] Therefore, it is urgent to independently develop a high flux liquid sample feeding system to meet the detection and research of trace elements in various fields. UTILITY MODEL CONTENT
[0006] Therefore, the utility model provides a high flux liquid sample feeding system with automatic, flexible, convenient, unattended characteristics, reduces physical labor, increases sample processing capacity, improves daily work precision, and greatly improves work efficiency.
[0007] To achieve the above purpose, the utility model adopts the following technical solutions:
[0008] A high flux liquid sample feeding system comprises:
[0009] A base;
[0010] A sample tray is fixed at the top end surface of the base, and a plurality of standard sample slots and a plurality of sample tube racks are placed on the sample tray. The sample tube rack is located on one side of the standard sample slot.
[0011] A support table is fixed on the top end surface of the base and located on one side of the sample tray.
[0012] A sample feeding arm is arranged on the top end surface of the support table, and the sample feeding arm is electrically connected to the analyzer.
[0013] A sample probe is fixed on the moving end of the sample arm, and is connected with a suction port of a pump body on the analyzer, for respectively sucking the liquid in the standard sample tank and the sample tube rack to an atomization chamber on the analyzer for analysis.
[0014] Compared with the prior art, the high-throughput liquid sample injection system provided by the utility model has the advantages that when in use, the sample arm drives the sample probe to first move to the position of the standard sample tank, then the sample probe sucks the standard sample from the standard sample tank, the pump body sucks the standard sample sucked by the sample probe into the analyzer, the standard sample is first tested to establish a standard curve, then the sample probe moves to the position of the sample tube rack to suck the measured sample, the pump body sucks the measured sample sucked by the sample probe into the analyzer, and then the measured sample is quantitatively analyzed according to the standard curve.
[0015] Therefore, the system is provided with a large-capacity sample tray which can accommodate a large number of standard sample tanks and sample tube racks, has the characteristics of automation, flexibility, convenience and unattended operation, reduces physical labor, increases the sample processing amount, improves the daily work precision, greatly improves the work efficiency, and meets the high-throughput testing requirements of analyzers such as inductively coupled plasma mass spectrometers.
[0016] Further, a peristaltic pump fixed on the support table, a probe cleaning tank fixed on the top end face of the sample tray, a flushing liquid bottle and a waste liquid recovery bottle placed on the base are further included, the probe cleaning tank is internally provided with a probe cleaning cavity and a waste liquid backflow cavity, the waste liquid backflow cavity is located on one side of the probe cleaning cavity, an upper cavity opening of the probe cleaning cavity is in communication with an upper cavity opening of the waste liquid backflow cavity, a flushing liquid inlet and a waste liquid backflow port are respectively formed in the outer tank wall of the probe cleaning tank, the flushing liquid inlet is located below the waste liquid backflow port, the flushing liquid inlet is in communication with the bottom of the probe cleaning cavity, and the waste liquid backflow port is in communication with the bottom of the waste liquid backflow cavity.
[0017] The suction pipe of the peristaltic pump is in communication with the flushing liquid bottle and the flushing liquid inlet, respectively, and the liquid return pipe of the peristaltic pump is in communication with the waste liquid backflow port and the waste liquid recovery bottle, respectively.
[0018] The beneficial effects produced by the above technical scheme are as follows: after sampling by the sampling probe, the sampling arm drives the sampling probe to move to the position of the probe cleaning tank and is inserted into the probe cleaning cavity, at this time, the peristaltic pump works, the suction pipe on the peristaltic pump sucks the washing liquid in the washing liquid bottle to the bottom of the probe cleaning cavity through the washing liquid inlet, the washing liquid flows from the bottom to the top of the probe cleaning cavity to perform up-flow washing on the sampling probe, and the waste liquid after washing flows into the waste liquid reflux cavity through the upper cavity opening of the probe cleaning cavity and the liquid return pipe under the pump pressure of the peristaltic pump to flow into the waste liquid recovery bottle, thereby realizing collection of the waste liquid.
[0019] Therefore, the system can clean the sampling probe after each sampling and sampling, which can prevent cross infection between samples and affect the analysis accuracy of the samples.
[0020] Further, the sampling arm is an XYZ axis mechanical arm driven by a stepping motor.
[0021] The beneficial effects produced by the above technical scheme are as follows: the XYZ axis mechanical arm driven by the stepping motor can realize free movement of the sampling probe in X, Y and Z directions, and then can accurately move to the positions of the standard sample tank and the sample tube rack to realize accurate sample sampling.
[0022] Further, a working indicator lamp and an emergency stop button which are electrically connected with the analyzer are mounted on one side wall of the support table.
[0023] The beneficial effects produced by the above technical scheme are as follows: the emergency stop button can protect the instrument when a fault occurs in the instrument, and the indicator lamp can prompt the running state of the instrument to enable the operator to know the working state of the instrument in real time, so that the system running can be stopped in time through the emergency stop button when an emergency occurs. BRIEF DESCRIPTION OF DRAWINGS
[0024] In order to more clearly illustrate the technical scheme in the embodiments of the present application or the prior art, the drawings needed in the following embodiment or prior art description will be briefly introduced. Obviously, the drawings in the following description are only embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor on the basis of the provided drawings.
[0025] Figure 1 A structure schematic view of the front face of the high-throughput liquid sampling system provided by the present application.
[0026] Figure 2 The back structure schematic view of the high-throughput liquid sample injection system is provided.
[0027] Figure 3 The flow direction schematic view of the flushing liquid and the waste liquid.
[0028] Figure 4 The structure schematic view of the probe cleaning tank. DETAILED DESCRIPTION
[0029] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the utility model.
[0030] As shown in Figures 1-4 The utility model discloses a high-throughput liquid sample injection system, which comprises:
[0031] A base 1;
[0032] A sample tray 2 is fixed at the top end face of the base 1, a plurality of standard sample grooves 3 and a plurality of sample tube racks 4 are placed on the sample tray 2, and the sample tube racks 4 are located on one side of the standard sample grooves 3.
[0033] A support table 5 is fixed on the top end face of the base 1 and located on one side of the sample tray 2.
[0034] A sample injection arm 6 is arranged on the top end face of the support table 5, and the sample injection arm 6 is electrically connected with an analyzer 7, for example, the two can be connected through a USB serial port 17 arranged on the side face of the support table 5, and the universality is strong.
[0035] A sample injection probe 8 is fixed on the moving end of the sample injection arm 6, the sample injection probe 8 is connected with the suction port of the pump body on the analyzer 7, and is used for respectively sucking the liquid in the corresponding standard sample groove 3 and sample tube rack 4 to the atomizing chamber on the analyzer 7 for analysis and processing.
[0036] The high-flux liquid sample feeding system further comprises a peristaltic pump 9 fixed on the support table 5, a probe cleaning tank 10 fixed on the top end surface of the sample tray 2 and a flushing liquid bottle 11 and a waste liquid recovery bottle 12 placed on the base 1 in another embodiment.
[0037] The suction pipe 13 of the peristaltic pump 9 is communicated with the flushing liquid bottle 11 and the flushing liquid inlet 103 respectively, and the liquid return pipe 14 of the peristaltic pump 9 is communicated with the waste liquid backflow port 104 and the waste liquid recovery bottle 12 respectively.
[0038] Of course, the probe cleaning tank 10 can be installed on the sample tray 2 in a bonding mode, a screw mode or a buckle mode, so that the probe cleaning tank 10 can be detached and cleaned conveniently.
[0039] The sample feeding arm 6 is an XYZ axis mechanical arm driven by a stepping motor, which ensures the movement accuracy, i.e., the X axis mechanical arm 61 is fixed on the top end surface of the support table 5, the Y axis mechanical arm 62 is fixed on the moving end of the X axis mechanical arm 61, the Z axis mechanical arm 63 is fixed on the moving end of the Y axis mechanical arm 62, and the sample feeding probe 8 is fixed on the moving end of the Z axis mechanical arm 63, so that the sample feeding probe 8 can move accurately in the X, Y and Z directions.
[0040] The side wall of the support table 5 is provided with a working indicator lamp 15 and an emergency stop button 16 which are electrically connected with the analyzer 7.
[0041] The sample tray 2, the standard sample tank 3, the sample tube rack 4 and the probe cleaning tank 10 are made of tetrafluoroethylene material, which is corrosion-resistant and improves the service life.
[0042] The automatic sample feeding system is intelligent and automatic, and only needs to set parameters in the analyzer, put standard samples in the standard sample tube and put samples to be detected in the tube body of the sample tube rack 4, so that the automatic sampling and feeding process can be completed. After receiving the control instruction and signal of the analyzer, the sample feeding arm generates a sample feeding action, and can sequentially or randomly sample, which is flexible. The basic working process of the automatic sample feeding system comprises: sample feeding arm movement-probe sampling, sample feeding-withdrawal of the probe-needle cleaning-resetting, and the actual operation sequence can be changed through software programming. The specific detailed process is as follows:
[0043] a) the analyzer sends instructions and parameters (set sample installation number, bit number, sample amount, etc. parameters) to control the sample arm to move to the corresponding sample bit number position;
[0044] That is, the sample arm drives the sample probe to first move to the position of the standard sample tank, then the sample probe extracts the standard sample from the standard sample tank, the pump body sucks the standard sample extracted by the sample probe into the analyzer, the standard sample is tested first to establish a standard curve, then the sample probe moves to the position of the probe cleaning tank under the driving of the sample arm for cleaning, then moves to the position of the sample tube rack to extract the corresponding measured sample, the pump body sucks the measured sample extracted by the sample probe into the analyzer, and then the measured sample is quantitatively analyzed according to the standard curve;
[0045] b) then, the sample probe moves to the position of the probe cleaning tank again for cleaning;
[0046] c) the sample probe cleaning ends and resets, waiting for the next sampling.
[0047] The various embodiments in the specification are described in a progressive manner, and each embodiment focuses on the difference from other embodiments, and the same and similar parts between the various embodiments can be referred to each other. For the device disclosed by the embodiments, since it corresponds to the method disclosed by the embodiments, the description is relatively simple, and the related parts can be referred to the method part.
[0048] The above description of the disclosed embodiments enables a person skilled in the art to implement or use the present application. Various modifications to the embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.
Claims
1. A high throughput liquid sample introduction system, characterized by, It comprises: a base (1); a sample tray (2) fixed at the top end of the base (1), a plurality of standard sample grooves (3) and a plurality of sample tube racks (4) being placed on the sample tray (2), the sample tube racks (4) being located on one side of the standard sample grooves (3); a support table (5) fixed on the top end of the base (1) and located on one side of the sample tray (2); a sample feeding arm (6) arranged on the top end of the support table (5), the sample feeding arm (6) being electrically connected with an analyzer (7); a sample probe (8) fixed on the moving end of the sample feeding arm (6), the sample probe (8) being connected with the suction port of a pump body on the analyzer (7) for respectively sucking the liquid in the standard sample grooves (3) and the sample tube racks (4) into an atomization chamber on the analyzer (7) for analysis and processing.
2. A high throughput liquid sample injection system as defined in claim 1, wherein, It also comprises a peristaltic pump (9) fixed on the support table (5), a probe cleaning tank (10) fixed on the top end of the sample tray (2), and a flushing liquid bottle (11) and a waste liquid recovery bottle (12) placed on the base (1), the probe cleaning tank (10) being internally provided with a probe cleaning cavity (101) and a waste liquid backflow cavity (102), the waste liquid backflow cavity (102) being located on one side of the probe cleaning cavity (101), the upper cavity opening of the probe cleaning cavity (101) being in communication with the upper cavity opening of the waste liquid backflow cavity (102), the outer tank wall of the probe cleaning tank (10) being respectively provided with a flushing liquid inlet (103) and a waste liquid backflow port (104), the flushing liquid inlet (103) being located below the waste liquid backflow port (104), the flushing liquid inlet (103) being in communication with the bottom of the probe cleaning cavity (101), and the waste liquid backflow port (104) being in communication with the bottom of the waste liquid backflow cavity (102); the suction pipe (13) of the peristaltic pump (9) being respectively in communication with the flushing liquid bottle (11) and the flushing liquid inlet (103), and the liquid return pipe (14) of the peristaltic pump (9) being respectively in communication with the waste liquid backflow port (104) and the waste liquid recovery bottle (12).
3. A high throughput liquid sample injection system as defined in claim 1, wherein, The sample feeding arm (6) is an XYZ-axis mechanical arm driven by a stepping motor.
4. A high throughput liquid sample injection system as defined in claim 1, wherein, A work indicator light (15) and an emergency stop button (16) are mounted on one side wall of the support table (5) and are electrically connected with the analyzer (7).