Constant volume control system

Abstract

The utility model discloses a constant volume control system which comprises a counter-current centrifugal machine, an input channel and an output channel are arranged on the two sides of the counter-current centrifugal machine respectively, a plurality of feeding pipelines are connected to the input channel, a plurality of separating pipelines are connected to the output channel, liquid bags are arranged at the ends of the separating pipelines, and the liquid bags are connected with the counter-current centrifugal machine. A driving pump is arranged on the input channel, and control valves are arranged on the multiple feeding pipelines. According to the utility model, the equivalent distribution of the supernatant is conveniently realized, and the supernatant is prevented from being polluted by bacteria.

Description

Technical Field

[0001] This utility model relates to the field of fluid processing technology, and in particular to a constant volume control system. Background Technology

[0002] Currently, cell culture, also known as cell cloning technology, is frequently required in the field of biotechnology. It is an indispensable process for both the broader field of bioengineering and its specific application in biological cloning. During cell culture, waste products, cell death debris, and poorly developed, low-density cells are generated. Failure to promptly remove these products can lead to cell contamination and death. In pharmaceutical manufacturing, it is necessary to separate impurities from the cell solution and extract the supernatant.

[0003] After the supernatant is extracted by a countercurrent centrifuge (rotary bowl), the separated supernatant needs to be divided into multiple cell bags or other containers in equal amounts. This operation needs to be carried out in a sterile environment. When the supernatant is taken out of the equipment and distributed after separation, it will be contaminated by bacteria in the outside air.

[0004] Therefore, how to efficiently achieve equal distribution of supernatant while ensuring a sterile environment has become an urgent technical problem to be solved. Utility Model Content

[0005] This application provides a volume control system that facilitates the equal distribution of supernatant and prevents supernatant from being contaminated by bacteria.

[0006] This application provides a constant volume control system, which adopts the following technical solution:

[0007] A constant volume control system includes a countercurrent centrifuge, with an input channel and an output channel respectively provided on both sides of the countercurrent centrifuge. Multiple feed pipes are connected to the input channel, and multiple separation pipes are connected to the output channel. A liquid bag is provided at the end of each separation pipe. A drive pump is provided on the input channel, and control valves are provided on each of the multiple feed pipes.

[0008] By adopting the above technical solution, this utility model designs a constant volume control system. In use, the raw liquid is transported to the input channel through the feed pipe, and then to the countercurrent centrifuge through the input channel. The countercurrent centrifuge is responsible for rapidly separating the raw liquid into different components under the action of centrifugal force. The supernatant after separation is evenly distributed through multiple separation pipes, and then enters the liquid bag for collection. This control system mainly ensures the stable delivery of the raw liquid through the drive pump on the input channel, while the design of multiple feed pipes, separation channels and control valves can accurately control the flow rate of the raw liquid in different channels, thereby ensuring the uniformity and controllability of the separation process.

[0009] Preferably, a slag discharge pipe is provided on one side of the countercurrent centrifuge. The slag discharge pipe is used to discharge particulate matter in the raw liquid and is connected to the input pipe.

[0010] By adopting the above technical solution, the slag discharge pipe is connected to the input pipe during use, which can effectively remove particulate matter generated in the raw liquid during the separation process, improve separation efficiency and purity, and ensure the cleanliness of the system.

[0011] Preferably, the countercurrent centrifuge is further provided with multiple buffer channels on one side, and the buffer channels are interconnected with the input channels.

[0012] By adopting the above technical solution, when a large amount of particulate matter is generated in the stock solution and sludge needs to be discharged, the stock solution is first fed into the buffer solution channel through the input channel for temporary storage. After the sludge discharge is completed, the stock solution in the buffer solution is then transported to the countercurrent centrifuge.

[0013] Preferably, an air intake pipe is connected to the output channel, an air intake valve is provided at the end of the air intake pipe, a sterile valve is provided on one side of the air intake valve, the sterile valve is connected to the air intake pipe, and a shut-off valve is also provided on the air intake pipe.

[0014] By adopting the above technical solution, during use, the air inlet valve on the air inlet pipe can deliver gas into the countercurrent centrifuge. Before slag discharge, the air inlet valve and the shut-off valve are opened to allow air to enter the countercurrent centrifuge. The particles separated in the countercurrent centrifuge will flow into the bottom of the countercurrent centrifuge under gravity and then be extracted by the drive pump. The addition of the shut-off valve allows the operator to cut off the gas supply when needed, increasing the safety and controllability of the system. The aseptic valve can effectively prevent external microorganisms from entering the system and ensure a sterile environment during the separation process.

[0015] Preferably, the buffer solution channel and the slag discharge pipe are equipped with the same control valves as those on the input channel.

[0016] By adopting the above technical solution, the same control valves as those on the input channel are installed on the buffer solution channel and slag discharge pipeline during use. This enables precise control of the liquid flow in each channel, ensuring the stability and safety of system operation. Specifically, the control valves allow operators to adjust the flow rate of the buffer solution channel and slag discharge pipeline according to actual needs.

[0017] Preferably, the control valve, air intake valve, sterile valve, and shut-off valve are all connected to the control system center and are opened or closed by the control system.

[0018] By adopting the above technical solution, during operation, the control valve, inlet valve, aseptic valve, and shut-off valve are all connected to the control system center. This allows operators to centrally manage the opening and closing status of these valves, thereby ensuring the stability and safety of system operation. Simultaneously, this centralized control method reduces human error and improves production efficiency.

[0019] Preferably, both the input channel and the output channel are equipped with flow meters, which are used to detect the volume of raw liquid and supernatant passing through the input channel and the output channel.

[0020] By adopting the above technical solution, the flow meter can detect the flow rates of the raw liquid and supernatant in the input and output channels in real time during use, ensuring precise control during system operation. Accurate flow measurement allows for timely adjustment of the control valve's opening and closing degree, guaranteeing the system's stability and reliability.

[0021] Preferably, the connection between the separation pipe and the liquid bag is sealed to prevent the separated liquid from flowing out and to prevent bacteria from entering and contaminating the liquid.

[0022] By adopting the above technical solution, the connection between the separation pipe and the liquid bag is sealed during use, which effectively prevents the separated liquid from flowing out, ensuring the stable operation and safety of the system. At the same time, the sealing process also prevents external bacteria from entering the liquid bag, avoiding liquid contamination.

[0023] In summary, this application has the following beneficial effects:

[0024] 1. The present invention provides a constant volume control system, which, by setting up multiple feed pipes and separation pipes and installing control valves on each pipe, can accurately control the flow rate of each pipe, ensuring the stability and consistency of the separation process;

[0025] 2. The constant volume control system designed in this utility model ensures stable material supply through the input channel by setting up a drive pump. Combined with the adjustment function of the control valve, it effectively avoids pipeline blockage and flow fluctuation, and improves the separation effect.

[0026] 3. The volume control system designed in this utility model adopts a sealing treatment between the separation pipe and the liquid bag and the setting of a sterile valve, which not only prevents the leakage of the separated liquid, but also prevents the invasion of external bacteria, thus ensuring the sterility of the product. Attached Figure Description

[0027] Figure 1 The system flowchart is shown in the embodiment.

[0028] Figure 2 This is a schematic diagram showing the structure of the flow meter in the embodiment;

[0029] Explanation of reference numerals in the attached diagram: 1. Countercurrent centrifuge; 2. Input channel; 3. Output channel; 4. Feed pipe; 5. Separation pipe; 6. Liquid bag; 7. Drive pump; 8. Control valve; 9. Slag discharge pipe; 10. Buffer channel; 11. Air inlet pipe; 12. Air inlet valve; 13. Aseptic valve; 14. Shut-off valve; 15. Flow meter. Detailed Implementation

[0030] The present invention will be further described in detail below with reference to the accompanying drawings. Identical components are indicated by the same reference numerals. It should be noted that the terms "front," "rear," "left," "right," "upper," "lower," "bottom," and "top" used in the following description refer to directions in the accompanying drawings, while the terms "inner" and "outer" refer to directions toward or away from the geometric center of a specific component, respectively.

[0031] Example 1

[0032] This utility model discloses a constant volume control system, such as Figure 1 As shown, the centrifuge includes a countercurrent centrifuge 1. The countercurrent centrifuge 1 has multiple layers of centrifugal discs inside, which separate different components in the liquid through centrifugal force generated by high-speed rotation. The countercurrent centrifuge 1 has an input channel 2 and an output channel 3 on both sides. Multiple feed pipes 4 are connected to the input channel 2, and multiple separation pipes 5 are connected to the output channel 3. Liquid bags 6 are attached to the ends of the separation pipes 5. The connection between the separation pipes 5 and the liquid bags 6 is sealed to prevent the separated liquid from flowing out and to prevent bacteria from entering and contaminating the liquid. A drive pump 7 is installed on the input channel 2 to provide power for the liquid to enter the countercurrent centrifuge 1. The drive pump 7 can be a centrifugal pump, which has a simple structure, is easy to maintain, and is suitable for high-flow-rate transmission. Control valves 8 are installed on each of the multiple feed pipes 4. The control valves 8 can be electric control valves, which are precisely controlled by electrical signals.

[0033] A slag discharge pipe 9 is provided on one side of the countercurrent centrifuge 1. The slag discharge pipe 9 is used to discharge particulate matter from the raw liquid and is connected to the input pipe. Multiple buffer channels 10 are also provided on one side of the countercurrent centrifuge 1. The buffer channels 10 are connected to the input channel 2. The buffer channels 10 and the slag discharge pipe 9 are equipped with the same control valves 8 as those on the input channel 2.

[0034] An air inlet pipe 11 is connected to the output channel 3. An air inlet valve 12 is installed at the end of the air inlet pipe 11, and a sterile valve 13 is installed on one side of the air inlet valve 12. The sterile valve 13 is connected to the air inlet pipe 11 and is used to ensure the sterility of the gas and prevent external bacteria from entering the system and affecting the separation effect. The sterile valve 13 can be a diaphragm valve, which has good sealing performance and is easy to clean and disinfect. A shut-off valve 14 is also installed on the air inlet pipe 11.

[0035] Control valve 8, inlet valve 12, aseptic valve 13, and shut-off valve 14 are all connected to the control system center and are opened or closed by the control system. The control system can use a PLC to automatically control the opening and closing of each valve through a preset program, achieving intelligent management. The control system can also be equipped with a touch screen, allowing operators to monitor the system's operating status in real time and make necessary adjustments and maintenance.

[0036] The volumetric control system provided in this application includes the following steps: The liquid to be separated is fed into the input channel 2 of the countercurrent centrifuge 1 via the feed pipe 4. The flow rate of each feed pipe 4 is adjusted by the control valve 8 on the feed pipe 4 to ensure that the liquid enters the countercurrent centrifuge 1 uniformly. The countercurrent centrifuge 1 is started, causing the multi-layer centrifugal discs inside the countercurrent centrifuge 1 to rotate at high speed, using centrifugal force to separate the different components in the liquid. The separated liquid enters the liquid bag 6 through the separation pipe 5. The volume of the separated liquid is monitored by the flow meter 15 to ensure precise control of the separation process. During the separation process, when a large amount of particulate matter is separated from the original liquid, it needs to be discharged. First, the control valve 8 of the buffer solution pipe is opened, driving the drive pump 7 to transport the remaining original liquid to the buffer solution pipe. Then, the shut-off valve 14 and the air inlet valve 12 are opened, and the separated particulate matter flows into the bottom of the countercurrent centrifuge 1 under gravity. The drive pump 7 discharges these particulate matter from the input channel 2 to the slag discharge pipe 9. The control system center automatically adjusts the opening and closing degree of each valve according to the feedback signal from the flow meter 15 to ensure the stability and precise control of the separation process.

[0037] Working Principle: This invention relates to a constant volume control system that effectively separates different components in a liquid through the high-speed rotation of a countercurrent centrifuge 1. The drive pump 7 on the input channel 2 provides stable feed power, and the control valve 8 regulates the flow rate of each feed pipe 4, ensuring that the liquid enters the countercurrent centrifuge 1 uniformly. The separated liquid enters the liquid bag 6 through the separation pipe 5, achieving efficient and precise separation.

[0038] Example 2

[0039] like Figure 2As shown, this embodiment differs from the previous embodiment in that a flow meter 15 is installed on both the input channel 2 and the output channel 3. The flow meter 15 is used to detect the volume of the raw liquid and the supernatant passing through, ensuring precise control of the separation process. The flow meter 15 can be a turbine flow meter 15, which has high measurement accuracy and fast response speed and is suitable for various liquids; or an ultrasonic flow meter 15, which provides non-contact measurement and is suitable for high viscosity and corrosive liquids. The data from the flow meter 15 is transmitted to the control system center via a data cable. The control system automatically adjusts the opening and closing degree of each valve according to the feedback signal from the flow meter 15 to ensure precise control of the separation process.

[0040] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A constant-volume control system, characterized in that: The system includes a countercurrent centrifuge (1), with an input channel (2) and an output channel (3) on both sides of the countercurrent centrifuge (1). Multiple feed pipes (4) are connected to the input channel (2), and multiple separation pipes (5) are connected to the output channel (3). A liquid bag (6) is provided at the end of the separation pipe (5). A drive pump (7) is provided on the input channel (2), and a control valve (8) is provided on each of the multiple feed pipes (4).

2. The constant-volume control system according to claim 1, characterized in that: The countercurrent centrifuge (1) is provided with a slag discharge pipe (9) on one side. The slag discharge pipe (9) is used to discharge particulate matter in the raw liquid. The slag discharge pipe (9) is connected to the input pipe.

3. The constant-volume control system according to claim 1, characterized in that: The countercurrent centrifuge (1) is also provided with multiple buffer channels (10) on one side, and the buffer channels (10) are connected to the input channel (2).

4. A constant-volume control system according to claim 1, characterized in that: An air intake pipe (11) is connected to the output channel (3). An air intake valve (12) is provided at the end of the air intake pipe (11). A sterile valve (13) is provided on one side of the air intake valve (12). The sterile valve (13) is connected to the air intake pipe (11). A shut-off valve (14) is also provided on the air intake pipe (11).

5. A constant-volume control system according to claim 3, characterized in that: The buffer channel (10) and the slag discharge pipe (9) are equipped with the same control valve (8) as the input channel (2).

6. A constant-volume control system according to claim 1, characterized in that: The control valve (8), air intake valve (12), sterile valve (13), and shut-off valve (14) are all connected to the control system center and are opened or closed by the control system.

7. A constant-volume control system according to claim 1, characterized in that: Both the input channel (2) and the output channel (3) are equipped with flow meters (15), which are used to detect the volume of raw liquid and supernatant passing through the input channel (2) and the output channel (3).

8. A constant-volume control system according to claim 1, characterized in that: The connection between the separation pipe (5) and the liquid bag (6) is sealed to prevent the liquid after separation from flowing out and to prevent bacteria from entering and contaminating the liquid.

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